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The potency of N,N′-diphenyl-1,4-phenylenediamine and adiposederived stem cell co-administration in alleviating hepatorenal dysfunction complications associated with type 1 diabetes mellitus in rats

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BIOCELL 2023年第8期47卷 1885-1895页

作者： HANY M.ABD EL-LATEEF safa H.QAHL EMAN FAYAD SARAH A.ALTALHI IBRAHIM JAFRI EL SHAIMAA SHABANA MARWA K.DARWISH REHAB MAHER SAAD SHAABAN SHADY G.EL-SAWAH Department of Chemistry College of ScienceKing Faisal UniversityAl-AhsaSaudi Arabia Chemistry Department Faculty of ScienceSohag UniversitySohagEgypt Department of Biology College of ScienceUniversity of JeddahJeddahSaudi Arabia Department of Biotechnology College of ScienceTaif UniversityTaifSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityMansouraEgypt Chemistry Department(Biochemistry Branch) Faculty of ScienceSuez UniversitySuezEgypt Department of Clinical Laboratories Sciences College of Applied Medical SciencesShaqra UniversityRiyadhSaudi Arabia Biology Department Faculty of ScienceMansoura UniversityMansouraEgypt Department of Chemistry Organic Chemistry DivisionCollege of ScienceMansoura UniversityMansouraEgypt Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt

Background:The increasing occurrence of diabetes mellitus(DM)noted worldwide has considerably elicited concern in the recent *** is associated with elevated vascular complications,morbidity,mortality,and poor quality of *** this context,mesenchymal stem cells(MSCs)have shown significant therapeutic potentialities in managing and curing type 1 DM owing to their self-renewable,immunosuppressive,and differentiation *** investigated the potential action of N,N′-diphenyl-1,4-phenylenediamine(DPPD),a well-known synthetic antioxidant to enhance the therapeutic ability of the adipose-derived stem cells(AD-MSCs)in alleviating kidney and liver complications in diabetic ***:Over the four weeks of experiments,albino male rats(n=36)were split into six test groups:control,DPPD(250 mg/kg,i.p.),STZ-diabetic(D),D+DPPD,D+AD-MSCs(1×10^(6)cell/rat,i.v.),and D+AD-MSCs+DPPD treated ***:Significant declines in the renal and hepatic oxidative stress markers(MDA,ROS,and AGEs)were observed coupled with a significant elevation in many antioxidant marker levels(GSH,SOD,CAT,GPx,HO-1,and TAC)in the diabetic rats treated with either DPPD or AD-MSCs or their co-administered injection compared to the diabetic untreated *** was suggested to be the leading cause of amelioration of the kidney functions(as measured by urea,uric acid,and creatine levels)and liver functions(as evidenced by the levels of AST,ALT,ALP,bilirubin,total proteins,albumin,and globulins).Conclusion:DPPD and AD-MSCs co-administration showed superior results in terms of the enhancement of the relative hepato-renal function,indicating the beneficial role of DPPD supplementation in increasing the therapeutic potential of AD-MSCs.

关键词： Antioxidants Diabetic nephropathy DPPD Oxidative stress Stem cells

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在高动态负载瞬时条件下优化供电质量

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今日电子 2014年第3期 28-28,30页

作者： Peyman safa 安捷伦科技有限公司

如今的集成电路运行速度要比以往快很多,这对电源在高动态功率工作条件下工作的稳定性提出了更高的需求。工程师如果利用普通的程控电源为被测件供电并进行测试时,往往会遇到巨大的挑战。集成电路高速变化的电流耗电波形会导致输入电压... 详细信息

如今的集成电路运行速度要比以往快很多,这对电源在高动态功率工作条件下工作的稳定性提出了更高的需求。工程师如果利用普通的程控电源为被测件供电并进行测试时,往往会遇到巨大的挑战。集成电路高速变化的电流耗电波形会导致输入电压出现瞬态压降。如果压降过高,将会导致微处理器测试结果异常,或出现重复启动的现象。本文将详细介绍压降产生的原因,以及如何有效减轻压降的方法。

关键词：供电质量动态负载程控电源压降瞬态运行速度旁路电容电压调整等效串联电阻直流电源

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Electro-Chemical Impedance Spectral (EIS) Study of Patinated Bronze Corrosion in Sulfate Media: Experimental Design Approach

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Journal of Materials Science and Chemical Engineering 2017年第10期5卷 44-54页

作者： Aymen Chaabani safa Aouadi Nébil Souissi X. Ramón Nóvoa Preparatory Institute For Engineering Studies El Manar University of Tunis El Manar Farhat Hached University Campus of El Manar Tunisia Faculty of Sciences of Bizerte University of Carthage Jarzouna Tunisia ENCOMAT Group E.E.I. University of Vigo Vigo Spain

The aim of the present investigation was to model the experimental conditions of tin bronze patination using full factorial experimental design. In this sense, a full factorial design approach was developed to model the corrosion behavior of patinated tin bronze alloy in sulfate electrolyte. Three experimental factors (the immersion time in the chloride electrolyte, the potential limit for the anodic sweep Elim, and the potential scan rate) were chosen to identify the significant factor on the patina growth process at the bronze substrate. The experimental responses were the kinetic parameters extracted from the electro-chemical spectra (EIS) for eight different experiments. An equivalent electrical circuit containing an electrolyte resistance (Re), a double layer capacitance (CPEdl), a charge transfer resistance (Rt) and Gerischer element (G), was developed to model the patinated bronze corrosion process. The electro-chemical spectra (EIS) show that the corrosion process of the patinated bronze alloy occurred from a chemical reaction is followed by an electrochemical one. Analysis of the experimental responses showed that while the scan rate is the most influent factor for the corrosion potential (Ecorr), the electrolyte resistance (Re), and the double layer capacitance CPEdl variation, the potential limit is the significant factor for charge transfer resistance Rt, reciprocal of the admittance parameter Y0 and the effective transfer rate of the chemical reaction k variation.

关键词： Bronze Corrosion Experimental Design Electrochemical Impedance Spectroscopy Gerischer Impedance

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Soliton Solutions and Numerical Treatment of the Nonlinear Schrodinger’s Equation Using Modified Adomian Decomposition Method

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Journal of Applied Mathematics and Physics 2016年第12期4卷 2215-2232页

作者： Abeer Al-Shareef Alyaa A. Al Qarni safa Al-Mohalbadi Huda O. Bakodah Department of Mathematics Faculty of Science King Abdulaziz University Jeddah Kingdom of Saudi Arabia Department of Mathematics Faculty of Science Blqarn Campus Bisha University Bisha Kingdom of Saudi Arabia Department of Mathematics Faculty of Science Al Faisaliah Campus King Abdulaziz University Jeddah Kingdom of Saudi Arabia

In this paper, the improved Adomian decomposition method (ADM) is applied to the nonlinear Schrödinger’s equation (NLSE), one of the most important partial differential equations in quantum mechanics that governs the propagation of solitons through optical fibers. The performance and the accuracy of our improved method are supported by investigating several numerical examples that include initial conditions. The obtained results are compared with the exact solutions. It is shown that the method does not need linearization, weak or perturbation theory to obtain the solutions.

关键词： Nonlinear Differential Equation Schrödinger Equation Adomian Decomposition Reliable Technique

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Using Magnetic Technique to Increase Efficiency of Organic Pollutants Biodegradation in Wastewater

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Journal of Life Sciences 2016年第1期10卷 21-32页

作者： Khalid Falih Hassan Suadad Awad Kadhim Noor Nihad Baqer Elaaf safa Al-deen Hassan Ministry of Science and Technology Directorate of Water and Environment Baghdad 10001 Iraq

The intensity of Magnetic field by 200, 300 and 400 gaos were selective to study their impacts on bacteria Bacillus, Pseudomonas and yeasts Candida dubliniensis, Candida glabrata, lssatchenkia orientalis and Rhodotorula mucilaginosa growth and to reduce organic pollutants in wastewater by COD, TOC, TN and TP in concentrations of 180, 75, 52 and 84 ppm in pH 7.6 and treatment periods of 2, 4, 6 and 18 h in batch system. Results showed that magnetic field 300 gaos had higher ability to increase bacterial and yeasts growth by 400-600% in 18 h and reduced COD, TOC, TN and TP by 88, 85, 90 and 98.5% in same period treatment. While, the intensity of magnetic field 200 and 400 gaos have no effect on microorganisms growth and reducing organic pollutants. This study is first record for showing and explaining the positive effective of magnetic field on microorganisms growth.

关键词： Magnetic yeast bacteria increase growth biodegradation wastewater.

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Undergraduate Medical Students＇ Perception about Learning in Small Group at University of Sharjah

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Journal of Health Science 2016年第4期4卷 207-214页

作者： Mousa Abu Ghoush Mohammed Abdul Qadir Zaharaa Al-Lami safa Al-Abdullah Nihar Dash College of Medicine University of Sharjah Sharjah 27272 United Arab Emirates

Learning in small groups is a key instructional strategy in medicine and more so in the problem based curriculum （PBL）. It is perceived that working in small groups enhances acquisition, processing and retention of the ever increasing medical knowledge. Learning in small group will help the students to be better learner and improve their personal, social and cognitive skills. The objective of this study is to describe undergraduate medical students＇ perception toward small group learning in a PBL curriculum. A cross-sectional descriptive study was conducted among the undergraduate medical students in the phase 2 of their MBBS program at University of Sharjah. A total of 277 undergraduate medical students participated in the study. The mean age of the study population was 20 years and 61% were female students. The most rewarding experiences as perceived by medical students were exposure to different views （71%）, making friends （57%） improving their grades （52%） and underwent personal development （46%）. The main disadvantages of small group learning were waste of time （55%）, side talks （16%）, and other distractions （14%）. Majority of students had a positive perception towards small group learning and agreed that it enhances their collaborative learning and team work skills. Small group learning was perceived as a key instructional method in the PBL curriculum [3] and it enhances their grades, learning outcomes, personal development and critical thinking abilities [4].

关键词： PBL small group learning University of Sharjah College of Medicine.

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Proteomics:Concepts and applications in human medicine

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World Journal of Biological Chemistry 2021年第5期12卷 57-69页

作者： safa Al-Amrani Zaaima Al-Jabri Adhari Al-Zaabi Jalila Alshekaili Murtadha Al-Khabori Department of Microbiology and Immunology Sultan Qaboos UniversityMuscat 123Oman Department of Human and Clinical Anatomy Sultan Qaboos UniversityMuscat 123Oman Department of Microbiology and Immunology Sultan Qaboos University HospitalMuscat 123Oman of Hematology Sultan Qaboos UniversityMuscat 123Oman

Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s *** spectrometry is an essential tool that is used for profiling proteins in the ***,biomarker discovery remains the major challenge of proteomics because of their complexity and ***,combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease ***,most studies have investigated a small part of the proteins in the *** review highlights the types of proteomics,the available proteomic techniques,and their applica-tions in different research fields.

关键词： Proteomics Biomarker Mass spectrometry Two-dimensional electrophoresis Drug discovery

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Auto Opening Door and Car Identification

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Journal of Computer and Communications 2016年第15期4卷 132-141页

作者： Sanner H. Mahmood Oulla G. Hassan Ayad M. Kwad safa F. Abass Department of Networks Engineering Al-Iraqia University Baghdad Iraq

Design an Automatic Door System using a unique wireless ID by using infrared ray or Bluetooth technology. That consists of a sensing unit, control unit and drive unit to open and close doors at the entrance of a car that has the unique ID. This process is controlled by using Arduino Leonard programmed with IDE free open source software, that receives the signal code from the car which sends the ID through IR LED or Bluetooth by using a mobile application, decode it. And switch ON the driver that controls the DC motor. This system was designed considering some factors such as low cost and low power requirements, availability of components and low distance so there is no interference. The hardware design and software development are described, and all of the tests indicate that all component goes according to the initial design of this research.

关键词： Automatic Auto Opening Car Door Identification Security

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Impact of Ferritin Load on Gonadal Reserve among Regular Transfused β-Thalassemia

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Open Journal of Blood Diseases 2017年第2期7卷 65-78页

作者： Hasnaa A. Abo-Elwafa safa A. Hamid Mena M. Heshmat Zahra S. Ahmed Clinical Pathology Department Faculty of Medicine Sohag University Sohag Egypt Pediatric Department Faculty of Medicine Sohag University Sohag Egypt

Background: Iron overload in association with persistent anemia is responsible for endocrine dysfunction in β-thalassemia patients, blood transfusion combined with iron-chelation can modify life quality in these children, but they tend to suffer from delayed maturity and endocrine dysfunction. Aim: This study aims to correlate degree of hypogonadism to ferritin load in regular transfused β-thalassemia patients. Methods: It was carried out on 30 β-thalassemia major (TM) patients aged 12 to 18 years, puberty was assessed clinically, blood picture on Cell-Dyne 2700, ferritin level and pattern of FSH, LH, testosterone and estradiol before and after gonadotropin (GnRH) analogue stimulation test, they were determined on ARCHITECT ABBOTT system. Results: Twenty patients had not yet achieved puberty, FSH level was 1.45 ± 1.88 mIU/ml before (GnRH) analogue and 3.78 ± 4.19 mIU/ml after 4 hours of injection. LH level was 1.91 ± 4.79 mIU/ml before (GnRH) test, while after 4 hours it was 6.52 ± 7.50 mIU/ml, 88.24% of males had low serum testosterone level, 84.6% of girls had low serum estradiol level, FSH, LH, estradiol, testosterone before and after GNRH analogue were statistically insignificant, mean ferritin level was 3344.32 ± 1142.142 ng/ml, with insignificant correlation to hormonal pattern before and after GnRH therapy. Conclusion: Iron overload and hypogonadism are the presenting data in this study, insignificant correlation between ferritin level and hormonal reserve pattern, there may be another etiology in pathophysiology of low gonadal reserve such as severe anemia, chronic disease and may be genetic predisposition underlying susceptibility to iron toxicity, which need further investigations.

关键词： Ferritin β-Thalassemia Hypogonadism

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Fine Structure Analysis of the Configuration System of V II. Part II: Odd-Parity Levels

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Journal of Modern Physics 2014年第7期5卷 511-522页

作者： safa Bouazza Richard A. Holt David S. Rosner Nathan M. R. Armstrong Department of Physics and Astronomy Mc Master University Hamilton Canada Department of Physics and Astronomy University of Western Ontario London Canada LISM Université de Champagne-Ardenne Reims France

The 3d34p, 3d35p and 3d24s4p odd configurations of the V II spectrum have been reanalysed and three 3d24s4p triplets are assigned higher energies than previously proposed. We have determined the fine structure parameters, the largest and next largest eigenvector percentages of levels, their calculated Landé gJ-factors and predicted positions for missing experimental levels up to 100,000 cm-1 for the 3d24s4p configuration. Furthermore for the first time a hyperfine structure (HFS) parametric treatment, involving levels of these two configurations has been carried out. The deduced single-electron HFS parameter values are successfully checked with those obtained by means of ab initio calculations.

关键词： Fine Structure Hyperfine Structure Energy Levels Ab Initio Calculations V II Spectrum

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