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Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer

World Journal of Gastroenterology 2015年第34期21卷 9887-9899页

作者： Jung Ho kim You-Jin Hwang Sang Hoon Han Young Eun Lee saerom kim Yoon Jae kim Jae Hee Cho Kwang An Kwon Ju Hyun kim Se-Hee kim Department of Internal Medicine Gachon University Gil Medical Center Division of Biological Science Gachon University of Medicine and Science Department of Internal Medicine Jeju National University School of Medicine Gachon Medical Research Institute Gachon University Gil Medical Center

AIM:To elucidate the effects of dexamethasone on hypoxia-induced epithelial-to-mesenchymal transition(EMT) in colon ***:Human colon cancer HCT116 and HT29 cells were exposed to normoxic(21%) and hypoxic(1%) conditions. First,the effect of dexamethasone on cell viability was examined by MTT cell proliferation assay. In order to measure the expression levels of EMT markers(Snail,Slug,Twist,E-cadherin,and integrin αVβ6) and hypoxia-related genes [Hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF)] by dexamethasone,quantitative real-time polymerase chain reaction and western blot analysis were performed. Furthermore,the morphological changes of colon cancer cells and the expression pattern of E-cadherin by dexamethasone were detected through immunocytochemistry. Finally,the effects of dexamethasone on the invasiveness and migration of colon cancer cells were elucidated using matrigel invasion,migration,and wound healing migration ***:Under hypoxia,dexamethasone treatment inhibited HIF-1α protein level and its downstream gene,VEGF m RNA level in the colon cancer cell lines,HCT116 and HT29. In addition,the presence of dexamethasone down-regulated the m RNA levels of hypoxia-induced Snail,Slug,and Twist,all transcriptional factors of EMT,as well as hypoxia-induced integrin αVβ6 protein level,a well-known EMT marker for colon cancer cells. Furthermore,reduced E-cadherin in hypoxic condition was found to be recoverable by treating with dexamethasone in both colon cancer cell lines. Similarly,under hypoxic conditions,dexamethasone restored the growth pattern and morphological phenotype reminiscent of colon cancer cells grown under normoxic conditions; dexamethasone blocked the migration and invasion of both colorectal cancer cell lines in ***:Our study suggested that dexamethasone has inhibitory effects on cell migration and invasion by suppressing EMT of colon cancer cell lines in hypoxic condition.

关键词： Dexamethasone Colon cancer Hypoxia Hypoxia-inducib

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Highly pixelated,untethered tactile interfaces for an ultra-flexible on-skin telehaptic system

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npj Flexible Electronics 2022年第1期6卷 809-819页

作者： Hanbit Jin Yunjeong kim Wooseup Youm Yulim Min saerom Seo Chaehyun Lim Chan-Hwa Hong Seyoung Kwon Gyeongseok Park Steve Park Hye Jin kim Electronics and Telecommunications Research Institute(ETRI) DaejeonKorea Korea University of Science and Technology(UST) DaejeonKorea Korea Advanced Institute of Science and Technology(KAIST) DaejeonKorea

Realizing highly immersive tactile interactions requires a skin-integrated,untethered,high-definition tactile transducer devices that can record and generate tactile ***,the rigid and bulky form factor,and insufficient resolution of existing actuators are hindering the reproduction of sophisticated tactile sensations and immersive user ***,we demonstrate an ultraflexible tactile interface with high spatial resolution of 1.8 mm for telehaptic communication on human *** mechanism sensors and sub-mm scale piezoceramic actuators are designed to record and generate the static and dynamic pressures in a wide frequency range(1 Hz to 1 kHz).Moreover,actuators are integrated on ultra-flexible substrate with chessboard pattern to minimize stress during mechanical ***,remote transmissions of various tactile stimuli,such as shapes,textures,and vibration patterns were demonstrated by the telehaptic system with low latency(<1.55 ms)and high fidelity as proven by the shorttime Fourier-transform analysis.

关键词： tile system Highly

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