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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira saeed Linlin Ma Griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

Comprehensive Review and Analysis on Facial Emotion Recognition:Performance Insights into Deep and Traditional Learning with Current Updates and Challenges

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Computers, Materials & Continua 2025年第1期82卷 41-72页

作者： Amjad Rehman Muhammad Mujahid Alex Elyassih Bayan AlGhofaily saeed Ali Omer Bahaj Artificial Intelligence&Data Analytics Lab College of Computer&Information SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia MIS Department College of Business Administration Prince Sattam Bin Abdulaziz UniversityAlKharj11942Saudi Arabia

In computer vision and artificial intelligence,automatic facial expression-based emotion identification of humans has become a popular research and industry *** demonstrations and applications in several fields,including computer games,smart homes,expression analysis,gesture recognition,surveillance films,depression therapy,patientmonitoring,anxiety,and others,have brought attention to its significant academic and commercial *** study emphasizes research that has only employed facial images for face expression recognition(FER),because facial expressions are a basic way that people communicate meaning to each *** immense achievement of deep learning has resulted in a growing use of its much architecture to enhance *** review is on machine learning,deep learning,and hybrid methods’use of preprocessing,augmentation techniques,and feature extraction for temporal properties of successive frames of *** following section gives a brief summary of assessment criteria that are accessible to the public and then compares them with benchmark results the most trustworthy way to assess FER-related research topics *** this review,a brief synopsis of the subject matter may be beneficial for novices in the field of FER as well as seasoned scholars seeking fruitful avenues for further *** information conveys fundamental knowledge and provides a comprehensive understanding of the most recent state-of-the-art research.

关键词： Face emotion recognition deep learning hybrid learning CK+ facial images machine learning technological development

Review of Techniques for Integrating Security in Software Development Lifecycle

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Computers, Materials & Continua 2025年第1期82卷 139-172页

作者： Hassan saeed Imran Shafi Jamil Ahmad Adnan Ahmed Khan Tahir Khurshaid Imran Ashraf College of Electrical and Mechanical Engineering National University of Sciences and Technology(NUST)Rawalpindi46604Pakistan Department of Computer Science Abasyn University Islamabad CampusIslamabad45510Pakistan Military College of Signals National University of Sciences and Technology(NUST)Rawalpindi46600Pakistan Department of Electrical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Software-related security aspects are a growing and legitimate concern,especially with 5G data available just at our *** conduct research in this field,periodic comparative analysis is needed with the new techniques coming up *** purpose of this study is to review the recent developments in the field of security integration in the software development lifecycle(SDLC)by analyzing the articles published in the last two decades and to propose a way *** review follows Kitchenham’s review *** review has been divided into three main stages including planning,execution,and *** the selected 100 articles,it becomes evident that need of a collaborative approach is necessary for addressing critical software security risks(CSSRs)through effective risk management/estimation *** risks using a numeric scale enables a comprehensive understanding of their severity,facilitating focused resource allocation and mitigation *** a comprehensive understanding of potential vulnerabilities and proactive mitigation efforts facilitated by protection poker,organizations can prioritize resources effectively to ensure the successful outcome of projects and initiatives in today’s dynamic threat *** review reveals that threat analysis and security testing are needed to develop automated tools for the *** estimation of effort required to prioritize potential security risks is a big challenge in software *** accuracy of effort estimation can be further improved by exploring new techniques,particularly those involving deep *** is also imperative to validate these effort estimation methods to ensure all potential security threats are *** challenge is selecting the right model for each specific security *** achieve a comprehensive evaluation,researchers should use well-known benchmark checklists.

关键词： Software development lifecycle systematic literature review critical software security risks national institute of standards and technology DevSecOps open web application security project McGraw’s touch points

Bedload Sediment Rate Prediction for the Sand Transport Along Coastal Waters in Ocean Management Strategy

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China Ocean Engineering 2020年第6期34卷 840-852页

作者： saeed KHORRAM Department of Civil Engineering Marvdasht BranchIslamic Azad UniversityMarvdasht 73711-13119Iran

Interactions among different landforms and varied complicated physical processes cause sediment transport in coastal regions being the interest of ocean management planning studies. In coastal zones, the derivation of the bedload sediment transport rate and the flow velocity distribution is done by entropy theory which assumes the modified spatiotemporal disorder power index(MSTDPI) and the time-averaged flow velocity(as a random variable). Studying the deposition trend of bedload sediment transport rate for the sand particle(BLSTRS) and estimating the coastal erosion rate as a case study, the Makran coast is selected. To analyze the spatiotemporal patterns, the disorder power index(entropy-power) method is applied in this study where the monthly data of six Makran coastal sections from January 1970 to December 2015 are used. The studied data are mainly focused on the correlation of the flow rate of the sediment from the Makran River, and the spatiotemporal patterns of *** their meaningful spatiotemporal variability, it is not very easy to explain how the abovementioned variables perform together;the entropy-power index allows a better understanding of the combined performance of such parameters as the flow velocity and sediment transport by showing clearer signals for the assessment of coastal engineering issues at very large(coastal) scales.

关键词： flow velocity spatiotemporal entropy theory coastline zone

CTAB-assisted fabrication of hierarchical flower-like magnesium oxide adsorbent for enhanced removal performance towards phosphate

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Journal of Magnesium and Alloys 2023年第9期11卷 3231-3240页

作者： saeed Ahmed State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Department of Chemistry The University of LahoreLahore 54590Pakistan Department of Chemistry University of ChakwalPakistan

In this work, a series of hierarchical flower-like magnesium oxide(MgO) adsorbents were successfully fabricated in a cetyltrimethylammonium bromide(CTAB) assisted solvothermal route using hexamethylenetetramine(HMTA) as a precipitating agent. Effects of CTAB feeding amount on the structure, morphology, pore structure, and corresponding adsorption behavior were investigated. The hierarchical gardenias flower-like MgO demonstrated a surface area of 336.54 m^(2)·g^(-1) at a minimum ratio of the CTAB/Mg^(2+)was 0.02 in the reaction system. The hierarchical MgO phosphate removal capacity was 348.32 mg·g^(-1), which followed the pseudo-second-order and Freundlich isotherm model obtained from the large surface area and appropriate pore size. The value of n also suggests the feasible nature of phosphate adsorption under the examined conditions. Indeed, this CTAB assisted solvothermal method can provide a new understanding to tune the desired properties of a material by merely adjusting the reaction parameters of MgO.

关键词： Adsorption CTAB-assisted Magnesium oxide Phosphate removal Solvothermal

Computational analysis of the flow of pseudoplastic power-law fluids in a microchannel plate

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1360-1368页

作者： saeed Mortazavi Department of Chemical Engineering Shahrood Branch Islamic Azad University Shahrood Iran

The flow of pseudoplastic power-law fluids with different flow indexes at a microchannel plate was studied using computational fluid dynamic *** velocity distribution along the microchannel plate and especially in the microchannel slits,flow pattern along the outlet arc and the pressure drop through the whole of microchannel plate were investigated at different power-law flow *** results showed that the velocity profile in the microchannel slits for low flow index fluids was similar to the plug flow and had uniform *** the power-law fluids with lower flow indexes had lower stagnation zones near the outlet of the microchannel *** pressure drop through the microchannel plate showed huge differences between the *** most interesting result was that the pressure drops for power-law fluids were very smaller than that of Newtonian *** addition,the heat transfer of the fluids through the microchannel with different channel numbers in a wide range of Reynolds number was *** power-law fluid with flow index(n=0.4),the Nusselt number increases continuously as the number of channels *** results highlight the potential use of using pseudoplastic fluids in the microheat exchangers which can lower the pressure drop and increase the heat transfer efficiency.

关键词： Power-law fluids Microchannel Pressure drop Flow distribution Heat transfer

Thermo-mechanical simulation of frost heave in saturated soils

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Frontiers of Structural and Civil Engineering 2023年第9期17卷 1400-1412页

作者： saeed VOSOUGHIAN Romain BALIEU Department of Civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

Roads are exposed to various degradation mechanisms during their *** pavement deterioration caused by the surrounding environment is particularly severe in winter when the humidity and subfreezing temperatures *** heave-induced damage is one of the winter-related pavement *** occurs when the porewater in the soil is exposed to freezing *** study of frost heave requires conducting a multiphysics analysis,considering the thermal,mechanical,and hydraulic *** paper presents the use of a coupled thermo-mechanical approach to simulate frost heave in saturated soils.A function predicting porosity evolution is implemented to couple the thermal and mechanical field *** function indirectly considers the effect of the water seepage inside the *** frost heave scenarios with uniform and non-uniform boundary conditions are considered to demonstrate the capabilities of the *** results of the simulations indicate that the thermo-mechanical model captures various processes involved in the frost heave phenomenon,such as water fusion,porosity variation,cryogenic suction force generation,and soil *** characteristics and consequences of each process are determined and discussed ***,the results show that non-uniform thermal boundaries and presence of a culvert inside the soil result in uneven ground surface deformations.

关键词： frost heave multiphysics analysis thermo-mechanical approach saturated soils

Experimental study on the dynamic response of a 3-D wedge under asymmetric impact

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Journal of Hydrodynamics 2024年第2期36卷 263-274页

作者： saeed Hosseinzadeh Kristjan Tabri Maritime Engineering Research Group School of EngineeringUniversity of SouthamptonSouthamptonUK Department of Civil Engineering and Architecture Tallinn University of TechnologyTallinnEstonia Marine Technology Competence Center Tallinn University of TechnologyKuressaareEstonia

Water entry problems represent complex multiphase flows involving air,water,and structure interaction,occurring rapidly in rough seas,and potentially effecting structural integrity of floating *** paper experimentally investigates asymmetric slamming loads acting on a 3-D elastic wedge *** specimen,featuring two different bottom plates(stiffened and unstiffened),each 4 mm thick,aims to assess the effect of structural stiffness on dynamic *** experiments are conducted at different drop heights of 25 cm and 50 cm and varying heel angles from 5°to 25°.The paper describes the experimental conditions,including wedge geometry,material properties,and the test *** study explores the influence of heel angle on impact acceleration,revealing an increase in peak acceleration with a higher inclination angle,particularly in the vertical ***,the hydrodynamic pressure resulting from asymmetric slamming is *** pressure results analyzed and compared at different locations along the length of the *** experimental findings indicate that,despite the leeward side(stiffened)experiencing a smaller hydrodynamic load,the heel angle significantly affects pressure results on the windward side(unstiffened),leading to a more pronounced dynamic *** time history of pressure results emphasizes the effect of elastic vibrations,particularly noticeable on the unstiffened bottom *** study contributes to a deeper understanding of asymmetric slamming on aluminum structures,facilitating the enhancement of mathematical models and the validation of numerical simulations.

关键词： Flexible fluid structure interactions(FFSI) experimental study asymmetric impact hydrodynamic pressure slamming loads

Diamine-modified porous indium frameworks with crystalline porous materials(CPM)-5 structure for carbon dioxide fixation under co-catalyst and solvent free conditions

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Journal of Environmental Sciences 2023年第10期132卷 12-21页

作者： Naghmeh Bayati saeed Dehghanpour Department of Chemistry Faculty of Physics and ChemistryAlzahra UniversityTehran ***Iran

In the presentwork,functional diamine groups into indium frameworks to synthesize cyclic carbonates from CO_(2)and epoxides with efficient catalytic activity in the absence of cocatalyst and solvent are reported for the first *** porous materials(CPM)-5 modified with 1,2-phenylene diamine and ethylene diamine(CPM-5-PhDA and CPM-5-EDA),were prepared using a post-synthetic modification(PSM)*** properties of the modified CPM-5 were characterized by powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),N2-adsorption,scanning electron microscopy(SEM),CO_(2)adsorption,and temperature programmed desorption TPD *** presence of diamine groups as basic sites and indium Lewis acid sites in the framework structure were desirable for high catalytic *** a given catalyst weight,CPM-5-PhDA was the best candidate to appear with great catalytic activity and selectivity for the cycloaddition reaction at 100°C and1MPa CO_(2)under co-catalyst and solvent free ***-5-PhDA alsowas found to afford large and bulky *** catalyst can be easily separated and reused five times without any decline in activity.

关键词： Cyclic carbonate Metal-organic frameworks CO_(2)fixation Post-synthesis Co-catalyst free