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Analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents: A case study of Fars Province, Iran

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Chinese Journal of Traumatology 2019年第4期22卷 233-239页

作者： Saeed Lotfi Ali Reza Honarvar Saeid Gholamzadeh Department of Information Technology and Computer Engineering Safashahr Branch Islamic Azad University Safashahr Iran Legal Medicine Research Center Legal Medicine Organization Tehran Iran

Purpose: An analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents in Fars Province of Iran to prevent and reduce traffic accidents in the future. Methods: This cross-sectional study was conducted to integrate all the pervious researches performed on mortality rate of road traffic accidents in Fars Province from March 21,2013 to March 20,2017. In order to reveal the relationships between the factors affecting mortality rates of road traffic accidents, the data regarding road traffic accidents extracted from resources such as Legal Medicine Organization, Traffic Police, Accident & Emergency Department, as well as Department of Roads and Urban Development of Fars Province, then cleaned and the applicable attributes embedded in the data all aggregated for further analysis. It should be noted that the data not related to Fars Province were deleted, the data analyzed, converted and the aggregation between various attributes identified. The aggregation between these different attributes as well as the FP-growth algorithm and two indexes of support and confidence calculated and interesting and effective rules extracted. In the end, several accident-p「ovoking factors, the degree of consecutive and interdepende nee of each one in road accide nts identified and in traduced. The statistical analysis was conducted by using Rapid Miner software. Results: Of the 6216 people dead due to road traffic accidents, 4865 (79.02%) were male and 1292 (20.98%) were female, 59 of them have no clear gender. The largest portion of people died of road traffic accidents belonged to married and self-employed men who collided with motorcycles in autumn. Moreover, young individuals (aged 19-40 years) w让h secondary educational level who died of accidents in summer at 12:00 a.m. and then 5:00 p.m. in outer city main roads of Kazerun-Shiraz, then Darab- Shiraz, Fasa-Darab and in within-city main streets had the highest mortality rates. Among women, the middle-aged group (age

关键词： Road traffic accidents Mortality Vehicle Fars province Iran

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Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus

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World Journal of Diabetes 2015年第3期6卷 412-422页

作者： Javad Hami Fatemeh Shojae saeed Vafaee-Nezhad Nasim lotfi Hamed Kheradmand Hossein Haghir Department of Anatomy School of MedicineBirjand University of Medical Sciences Department of Anatomy and Cell Biology School of MedicineMashhad University of Medical Sciences Hazrat Rasoul Hospital Tehran University of Medical Sciences Medical Genetic Research Center School of MedicineMashhad University of Medical Sciences

Diabetes mellitus during pregnancy is associated with an increased risk of multiple congenital anomalies in progeny.There are sufficient evidence suggesting that the children of diabetic women exhibit intellectual and behavioral abnormalities accompanied by modification of hippocampus structure and function.Although,the exact mechanism by which maternal diabetes affects the developing hippocampus remains to be defined.Multiple biological alterations,including hyperglycemia,hyperinsulinemia,oxidative stress,hypoxia,and iron deficiency occur in pregnancies with diabetes and affect the development of central nervous system(CNS) of the fetus.The conclusion from several studies is that disturbance in glucose and insulin homeostasis in mothers and infants are major teratogenic factor in the development of CNS.Insulin and Insulin-like growth factor-1(IGF-1) are two key regulators of CNS function and development.Insulin and IGF-1 receptors(IR and IGF1 R,respectively) are distributed in a highly specific pattern with the high density in some brain regions such as hippocampus.Recent researches have clearly established that maternal diabetes disrupts the regulation of both IR and IGF1 R in the hippocampus of rat newborn.Dissecting out the mechanisms responsible for maternal diabetes-related changes in the development of hippocampus is helping to prevent from impaired cognitive and memory functions in offspring.

关键词： Maternal diabetes Cognition complications Teratogenic factor Hippocampus

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