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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira saeed Linlin Ma Griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

Porosity prediction from seismic inversion of a similarity attribute based on a pseudo-forward equation(PFE):a case study from the North Sea Basin,Netherlands

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Petroleum Science 2015年第3期12卷 428-442页

作者： saeed Mojeddifar Gholamreza Kamali Hojjatolah ranjbar Department of Mining Engineering Shahid Bahonar University of Kerman

The objective of this work is to implement a pseudo-forward equation which is called PFE to transform data （similarity attribute） to model parameters （porosity） in a gas reservoir in the F3 block of North Sea. This equation which is an experimental model has unknown constants in its structure; hence, a least square solution is applied to find the best constants. The results derived from solved equa- tions show that the errors on measured data are mapped into the errors of estimated constants; hence, Tikhonov regularization is used to improve the estimated parameters. The results are compared with a conventional method such as cross plotting between acoustic impedance and porosity values to validate the PFE model. When the testing dataset in sand units was used, the correlation coefficient between two variables （actual and predicted values） was obtained as 0.720 and 0.476 for PFE model and cross-plotting analysis, respectively. Therefore, the testing dataset validates rela- tively well the PFE optimized by Tikhonov regularization in sand units of a gas reservoir. The obtained results indi- cate that PFE could provide initial information about sandstone reservoirs. It could estimate reservoir porosity distribution approximately and it highlights bright spots and fault structures such as gas chimneys and salt edges.

关键词： Keywords Porosity Seismic inversion Tikhonovregularization Similarity

Flood inundation extent in storage cell mode

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Science China(Technological Sciences) 2009年第11期52卷 3376-3381页

作者： G. Farahi saeed Reza Khodashenas B. Ghahraman K. esmaeeli Water Engineering Department Ferdowsi University of Mashhad Mashhad Iran

An understanding of floodplain processes in general and floodplains flooding in particular are vital issues for river engineers and managers. Insufficient observations of flood inundation extent and the infrequent nature of flood inundation necessitate some sort of predictive tools. In this paper flood inundation extent has been simulated by HEC-RAS software in two storage cell and normal modes and capabilities and limitations of the two models have been determined by comparing simulated and observed flood inundation extent which occurred in the study area on Feb 4th, 2004.

关键词： flood 1-D models HEC-RAS-Storage cell model

Condition Monitoring of an Industrial Oil Pump Using a Learning Based Technique

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Sound & Vibration 2020年第4期54卷 257-267页

作者： Amin ranjbar Amir Abolzafl Suratgar saeed Shiry Ghidary Jafar Milimonfared Distributed and Intelligent Optimization Research Laboratory Department of Electrical EngineeringAmirkabir University of TechnologyTehran***Iran Department of Computer Engineering Amirkabir University of TechnologyTehran***Iran Department of Electrical Engineering Amirkabir University of TechnologyTehran***Iran

This paper proposes an efficient learning based approach to detect the faults of an industrial oil *** proposed method uses the wavelet transform and genetic algorithm(GA)ensemble for an optimal feature extraction *** features,which are dominated through this method,can remarkably represent the mechanical faults in the damaged *** the aim of condition monitoring,we considered five common types of malfunctions such as casing distortion,cavitation,looseness,misalignment,and unbalanced mass that occur during the machine *** proposed technique can determine optimal wavelet parameters and suitable statistical functions to exploit excellent features via an appropriate distance criterion ***,our optimization algorithm chooses the most appropriate feature submatrix to improve the final accuracy in an iterative *** a case study,the proposed algorithms are applied to experimental data gathered from an industrial heavy-duty oil pump installed in Arak Oil Refinery *** experimental results are very promising.

关键词： Condition monitoring fault assessment industrial pump genetic algorithm wavelet packet decomposition

Bedload Sediment Rate Prediction for the Sand Transport Along Coastal Waters in Ocean Management Strategy

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China Ocean Engineering 2020年第6期34卷 840-852页

作者： saeed KHORRAM Department of Civil Engineering Marvdasht BranchIslamic Azad UniversityMarvdasht 73711-13119Iran

Interactions among different landforms and varied complicated physical processes cause sediment transport in coastal regions being the interest of ocean management planning studies. In coastal zones, the derivation of the bedload sediment transport rate and the flow velocity distribution is done by entropy theory which assumes the modified spatiotemporal disorder power index(MSTDPI) and the time-averaged flow velocity(as a random variable). Studying the deposition trend of bedload sediment transport rate for the sand particle(BLSTRS) and estimating the coastal erosion rate as a case study, the Makran coast is selected. To analyze the spatiotemporal patterns, the disorder power index(entropy-power) method is applied in this study where the monthly data of six Makran coastal sections from January 1970 to December 2015 are used. The studied data are mainly focused on the correlation of the flow rate of the sediment from the Makran River, and the spatiotemporal patterns of *** their meaningful spatiotemporal variability, it is not very easy to explain how the abovementioned variables perform together;the entropy-power index allows a better understanding of the combined performance of such parameters as the flow velocity and sediment transport by showing clearer signals for the assessment of coastal engineering issues at very large(coastal) scales.

关键词： flow velocity spatiotemporal entropy theory coastline zone

CTAB-assisted fabrication of hierarchical flower-like magnesium oxide adsorbent for enhanced removal performance towards phosphate

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Journal of Magnesium and Alloys 2023年第9期11卷 3231-3240页

作者： saeed Ahmed State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China Department of Chemistry The University of LahoreLahore 54590Pakistan Department of Chemistry University of ChakwalPakistan

In this work, a series of hierarchical flower-like magnesium oxide(MgO) adsorbents were successfully fabricated in a cetyltrimethylammonium bromide(CTAB) assisted solvothermal route using hexamethylenetetramine(HMTA) as a precipitating agent. Effects of CTAB feeding amount on the structure, morphology, pore structure, and corresponding adsorption behavior were investigated. The hierarchical gardenias flower-like MgO demonstrated a surface area of 336.54 m^(2)·g^(-1) at a minimum ratio of the CTAB/Mg^(2+)was 0.02 in the reaction system. The hierarchical MgO phosphate removal capacity was 348.32 mg·g^(-1), which followed the pseudo-second-order and Freundlich isotherm model obtained from the large surface area and appropriate pore size. The value of n also suggests the feasible nature of phosphate adsorption under the examined conditions. Indeed, this CTAB assisted solvothermal method can provide a new understanding to tune the desired properties of a material by merely adjusting the reaction parameters of MgO.

关键词： Adsorption CTAB-assisted Magnesium oxide Phosphate removal Solvothermal

Computational analysis of the flow of pseudoplastic power-law fluids in a microchannel plate

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1360-1368页

作者： saeed Mortazavi Department of Chemical Engineering Shahrood Branch Islamic Azad University Shahrood Iran

The flow of pseudoplastic power-law fluids with different flow indexes at a microchannel plate was studied using computational fluid dynamic *** velocity distribution along the microchannel plate and especially in the microchannel slits,flow pattern along the outlet arc and the pressure drop through the whole of microchannel plate were investigated at different power-law flow *** results showed that the velocity profile in the microchannel slits for low flow index fluids was similar to the plug flow and had uniform *** the power-law fluids with lower flow indexes had lower stagnation zones near the outlet of the microchannel *** pressure drop through the microchannel plate showed huge differences between the *** most interesting result was that the pressure drops for power-law fluids were very smaller than that of Newtonian *** addition,the heat transfer of the fluids through the microchannel with different channel numbers in a wide range of Reynolds number was *** power-law fluid with flow index(n=0.4),the Nusselt number increases continuously as the number of channels *** results highlight the potential use of using pseudoplastic fluids in the microheat exchangers which can lower the pressure drop and increase the heat transfer efficiency.

关键词： Power-law fluids Microchannel Pressure drop Flow distribution Heat transfer

Biochemical response to lamivudine treatment in HBeAg negative chronic hepatitis B patients in Iran

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World Journal of Gastroenterology 2006年第26期12卷 4203-4205页

作者： Amir Houshang Mohammad Alizadeh Mitra ranjbar Babak Karimi saeed Hatami Research Center for Gastroenterology and Liver Disease Shaheed Beheshti University of Medical Sciences TehranIran Infectious Disease Specialist Hamadan University of Medical Sciences and Health Services Iran General Practitioner Hamadan University of Medical Sciences and Health Services Iran

AIM： To study the effect of a one-year lamivudine regimen in patients with chronic hepatitis B. METHODS： Medical records of HBeAg negative hepatitis B patients who attended a hepatitis clinic in Tehran between March 2002-March 2004 were evaluated. The patients received 100 mg lamivudine tablets once daily for at least 12 mo. Liver enzymes and complete blood count were checked at baseline and the end of treatment （12th mo） and 6 mo after discontinuation of treatment. RESULTS： Of all patients, 24 were excluded. Of 71 patients left, 58 （81.7%） were men. Mean age of the patients was 38 ± 14 years. Mean level of ALT in serum was 1437 ± 205 nkat/L at baseline with a significant reduction at the end of treatment to a mean level of 723 ± 92 nkat/L （P = 0.002）. In 38 patients （53.5%）, the ALT level was normal after one-year treatment. Five patients （7.3%） relapsed （biochemically） within 6 mo after discontinuing lamivudine therapy （the patients with good end of treatment response）. Mean level of AST in serum was 1060 ± 105 nkat/L at baseline which decreased significantly to 652 ± 75 nkat/L at the end of treatment （P = 0.002）. CONCLUSION： Over half （53.5%） of chronic hepatitis B patients with HBeAg negative have normal liver enzyme level at 12-mo lamivudine therapy.

关键词： Chronic hepatitis B Lamivudine HBeAg

Thermo-mechanical simulation of frost heave in saturated soils

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Frontiers of Structural and Civil Engineering 2023年第9期17卷 1400-1412页

作者： saeed VOSOUGHIAN Romain BALIEU Department of Civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

Roads are exposed to various degradation mechanisms during their *** pavement deterioration caused by the surrounding environment is particularly severe in winter when the humidity and subfreezing temperatures *** heave-induced damage is one of the winter-related pavement *** occurs when the porewater in the soil is exposed to freezing *** study of frost heave requires conducting a multiphysics analysis,considering the thermal,mechanical,and hydraulic *** paper presents the use of a coupled thermo-mechanical approach to simulate frost heave in saturated soils.A function predicting porosity evolution is implemented to couple the thermal and mechanical field *** function indirectly considers the effect of the water seepage inside the *** frost heave scenarios with uniform and non-uniform boundary conditions are considered to demonstrate the capabilities of the *** results of the simulations indicate that the thermo-mechanical model captures various processes involved in the frost heave phenomenon,such as water fusion,porosity variation,cryogenic suction force generation,and soil *** characteristics and consequences of each process are determined and discussed ***,the results show that non-uniform thermal boundaries and presence of a culvert inside the soil result in uneven ground surface deformations.

关键词： frost heave multiphysics analysis thermo-mechanical approach saturated soils