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Light(Science & Applications) 2019年第1期8卷 676-677页

作者： Wonseok choi Chulhong Kim Departments of Creative IT Engineering Electrical EngineeringMechanical EngineeringInterdisciplinary Bioscience and BioengineeringPohang University of Science and TechnologyPohangGyeongbuk 37673Republic of Korea

Super-resolution localization photoacoustic computed tomography has been successfully performed in live animals using an injection of unprecedentedly absorptive liquid-state dyed droplets,which promises a disruptive m... 详细信息

关键词： has translation dis

Projections of ocean climate for northwestern Pacific Ocean

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Acta Oceanologica Sinica 2005年第1期24卷 134-145页

作者： choi Byung Ho KIM Dong Hoon choi Young Jin YUK Jin Hee Department of Civil and Environmental Engineering Sungkyunkwan University Suwon KoreaAbiko Research Laboratory Central Research Institute of Electric Power Industry JapanResearch Institute of Applied Mechanics Kyushu University JapanDepartment of Civil and Environmental Engineering Sungkyunkwan University Suwon Korea

The long-term adjustment processes of atmosphere and ocean in response to gradually increased atmospheric CO2 concentration have been analyzed in 70 and 140 a integrations with NCAR fully-coupled climate system model (CSM). In these experiments the CO2 concentration has been increased to double and quadruples the initial concentration, respectively. After 70 a, at the time of CO2 doubling, the model predicts surface air temperature rises by 1.2 and 1.5 K for the globe and the northwestern Pacific Ocean, respectively. The behavior of the quadrupling run is similar: each global and regional mean surface air temperatures increase by 2.8 and 3.0 K at the time of CO2 quadrupling. From the experiments, surface air temperature changes in the northwestern Pacific Ocean will be more distinctive compared with the global average, mainly due to exceptionally large wanning and sea level change near the entrance of the Kuroshio extension.

关键词： Climate model simulation global warming northwestern Pacific Ocean

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Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Zar Chi Soe Bijay Kumar Poudel Hanh Thuy Nguyen Raj Kumar Thapa Wenquan Ou Milan Gautam Kishwor Poudel Sung Giu Jin Jee-Heon Jeong sae Kwang Ku Han-Gon choi Chul Soon Yong Jong Oh Kim College of Pharmacy Yeungnam University Department of Pharmaceutics University of Pharmacy (Yangon) Department of Pharmaceutical Engineering Dankook University College of Korean Medicine Haany University College of Pharmacy Hanyang University

Folate-targeting self-assembled nanoparticles(NPs) using biocompatible and biodegradable natural polymers chitosan(Cs) and chondroitin sulfate(Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib(Bor), into folic acid(FA)-conjugated Cs/Chs self-assembled NPs(Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were196.5 ± 1.2 nm and0.21 ± 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells(HCT-116 and HT-29) as compared to that in lung cancer cells(A549), which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the NPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.

关键词： Bortezomib Chitosan chondroitin sulfate Colorectal cancer Folic acid

Numerical simulation for thermal response test performance in closed-loop vertical ground heat exchanger

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Science China(Technological Sciences) 2011年第7期54卷 1668-1673页

作者： choi Jong Min LEE Chulho PARK Moonseo KANG Shin-Hyung choi Hangseok Department of Mechanical Engineering Hanbat National University School of Civil Environmental and Architectural Engineering Korea University Department of Mechanical Engineering Konyang University

In this study, a series of numerical analyses was performed in order to evaluate the performance of full-scale closed-loop vertical ground heat exchangers constructed in Wonju, South Korea. The circulating HDPE pipe, borehole and surrounding ground formation were modeled using FLUENT, a finite-volume method (FVM) program, for analyzing the heat transfer process of the ground heat exchanger system. Two user-defined functions (UDFs) accounting for the difference in the temperature of the circulating inflow and outflow fluid and the variation of ground temperature with depth were adopted in the FLUENT modeling. The thermal conductivities of grouts (cement vs. bentonite) measured in laboratory were used as input values in the numerical analyses to compare the thermal efficiency of the cement and bentonite grouts used for installing the closed-loop vertical ground heat exchanger. A series of numerical analyses was carried out to simulate in-situ thermal response tests performed in the construction site. From the comparison between the in-situ thermal response test results and numerical simulations, the average thermal conductivity of the ground formation in the construction site is back-calculated as approximately 4 W/mK. This value can be used in evaluating the long-term performance of the closed-loop vertical ground heat ex changer.

关键词： closed-loop vertical ground heat exchanger cement grout bentonite grout in-situ thermal response test finite-volumemethod thermal conductivity

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Toxocara optic neuropathy: clinical features and ocular findings

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 520-523页

作者： Kwang-Dong choi Jae-Hwan choi Seo-Young choi Jae Ho Jung Department of Neurology Pusan National University Hospital Medical Research Institute Pusan National University Department of Neurology Pusan National University Yangsan Hospital Department of Ophthalmology Pusan National University Yangsan Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients （66.7%） had a possible infection source to Toxocara. Six patients （50%） had painless acute optic neuropathy. Ten eyes had asymmetric, sectorial optic disc edema with peripapillary infiltration and three eyes had diffuse optic disc edema. Eosinophilia was noted in five patients （41.7%） and optic nerve enhancement was observed in eight of eleven eyes （72.7%） with available orbit magnetic resonance imaging （MRI）. Mean visual acuity significantly improved following treatment [mean logarithmic of the minimum angle of resolution （IogMAR） 0.94±0.56 at baseline and 0.47±0.59 at the final （P=0.02）]. Asymmetric optic disc edema with a peripapillary lesion and a history of raw meat ingestion were important clues for diagnosing Toxocara optic neuropathy. Additionally, Toxocara IgG enzymelinked immunosorbent assay （ELISA） test and evaluating eosinophil may be helpful for diagnosis.

关键词： optic neuropathy toxocariasis ocular toxocariasis Toxocara optic neuropathy

Management of bleeding from pseudoaneurysms following pancreaticoduodenectomy

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World Journal of Gastroenterology 2010年第10期16卷 1239-1244页

作者： Hyung Geun Lee Jin Seok Heo Seong Ho choi Dong Wook choi Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To review the clinical course and the management of pseudoaneurysms ***: Medical records of 907 patients who underwent pancreaticoduodenectomies from January 1995 to May 2007 were evaluated retrospectively. The clinical course, management strategy, and outcome of ruptured pseudoaneurysms cases were ***: Twenty-seven (3.0%) of 907 cases had post-operative hemorrhage from ruptured pseudoan-eurysms. Pancreatic fistula was evident in 12 (44%) cases. Sentinel ble...

关键词： Pseudoaneurysm Angi-ography Embolization Stent graft

Correlation between hydration properties and electrochemical performances on Ln cation size effect in layered perovskite for protonic ceramic fuel cells

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Journal of Energy Chemistry 2024年第1期88卷 1-9,I0001页

作者： Inhyeok Cho Jiwon Yun Boseok Seong Junseok Kim Sun Hee choi Ho-Il Ji Sihyuk choi Department of Mechanical Engineering Kumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Department of Aeronautics Mechanical and Electronic Convergence EngineeringKumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Center for Energy Materials Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Hydrogen and Fuel Cell Research Clean Technology Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Energy and Environmental Engineering University of Science and TechnologySeoul 02792Republic of Korea Nanomaterials Science and Engineering Korea University of Science and Technology(UST)KIST CampusSeoul 02792Republic of Korea

PrBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(PrBSCF) has attracted much research interest as a potential triple ionic and electronic conductor(TIEC) electrode for protonic ceramic fuel cells(PCFCs). The chemical formula for Pr BSCF is AA'B_(2)O_(5+δ), with Pr(A-site) and Ba/Sr(A'-site) alternately stacked along the c-axis. Due to these structural features, the bulk oxygen ion diffusivity is significantly enhanced through the disorder-free channels in the PrO layer;thus, the A site cations(lanthanide ions) play a pivotal role in determining the overall electrochemical properties of layered perovskites. Consequently, previous research has predominantly focused on the electrical properties and oxygen bulk/surface kinetics of Ln cation effects,whereas the hydration properties for PCFC systems remain unidentified. Here, we thoroughly examined the proton uptake behavior and thermodynamic parameters for the hydration reaction to conclusively determine the changes in the electrochemical performances depending on LnBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(LnBSCF,Ln=Pr, Nd, and Gd) cathodes. At 500 ℃, the quantitative proton concentration of PrBSCF was 2.04 mol% and progressively decreased as the Ln cation size decreased. Similarly, the Gibbs free energy indicated that less energy was required for the formation of protonic defects in the order of Pr BSCF < Nd BSCF < Gd BSCF. To elucidate the close relationship between hydration properties and electrochemical performances in LnBSCF cathodes, PCFC single cell measurements and analysis of the distribution of relaxation time were further investigated.

关键词： Protonic ceramic fuel cell Cathode Triple ionic and electronic conductor Hydration property Proton uptake Gibbs free energy

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Design, Implementation and Verification of Topology Network Architecture of Smart Home Tree

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Computers, Materials & Continua 2021年第8期68卷 2399-2411页

作者： Youbang Guan Bong Jun choi Department of Advanced Research and Development QingdaoChina Department of Engineering University of LeicesterLeicesterEngland School of Computer Science and Engineering Soongsil UniversitySeoulKorea

Smart home technology provides consumers with network connectivity,automation or enhanced services for home *** the Internet of Things era,a vast data flow makes business platforms have to own the same computing power to match their business *** achieves computing power through implementing big data algorithms deployed in the cloud data ***,because of the far long geographical distance between the client and the data center or the massive data capacity gap,potentially high latency and high packet loss will reduce the usability of smart home systems if service providers deploy all services in the cloud data *** computing and fog computing can significantly improve the utilization of network resources and reconstruct the network architecture for the user’s *** article enables a fog resource-based resource allocation management *** provides a method that can more reasonably allocate network resources through a virtualized middle-tier method to ensure low response time and configure Quality of Service to ensure the use of delay-sensitive critical applications to improve the reliability of smart home communication ***,the proposed method has is tested and verified by adjusting the variables of the network *** realize the optimization of resource allocation of client network without changing the hardware of client.

关键词： Topology network smart home tree resource allocation internet of things

Epigenetic alterations in gastric carcinogenesis

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Cell Research 2005年第4期15卷 247-254页

作者： In-Seon choi,Tsung-Teh WU Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Pathology The University of Texas MD Anderson Cancer Center Houston Texas USA

Gastric cancer is believed to result in part from the accumulation of multiple genetic alterations leading to oncogeneoverexpression and tumor suppressor loss. Epigenetic alterations as a distinct and crucial mechanism to silence a varietyof methylated tissue-specific and imprinted genes, have been extensively studied in gastric carcinoma and play impor-tant roles in gastric carcinogenesis. This review will briefly discuss the basic aspects of DNA methylation and CpGisland methylation, in particular the epigenetic alterations of certain critical genes implicated in gastric carcinogenesisand its relevance of clinical implications.

关键词： epigenetic alterations gastric carcinogenesis chronic gastritis intestinal metaplasia dysplasia/adenoma adenocarcinoma.

Analysis and Modeling of Mobile Phone Activity Data Using Interactive Cyber-Physical Social System

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Computers, Materials & Continua 2024年第9期80卷 3507-3521页

作者： Farhan Amin Gyu Sang choi School of Computer Science and Engineering Yeungnam UniversityGyeongsan38541Republic of Korea

Mobile networks possess significant information and thus are considered a gold mine for the researcher’s *** call detail records(CDR)of a mobile network are used to identify the network’s efficacy and the mobile user’s *** is evident from the recent literature that cyber-physical systems(CPS)were used in the analytics and modeling of telecom *** addition,CPS is used to provide valuable services in smart *** general,a typical telecom company hasmillions of subscribers and thus generatesmassive amounts of *** this aspect,data storage,analysis,and processing are the key *** solve these issues,herein we propose a multilevel cyber-physical social system(CPSS)for the analysis and modeling of large internet *** proposed multilevel system has three levels and each level has a specific ***,raw Call Detail Data(CDR)was collected at the first ***,the data preprocessing,cleaning,and error removal operations were *** the second level,data processing,cleaning,reduction,integration,processing,and storage were ***,suggested internet activity record measures were *** proposed system initially constructs a graph and then performs network *** proposed CPSS system accurately identifies different areas of internet peak usage in a city(Milan city).Our research is helpful for the network operators to plan effective network configuration,management,and optimization of resources.

关键词： Cyber-physical social systems big data cyber-physical systems pervasive computing smart city big data management techniques