检索结果-南通市图书馆

World Journal of Clinical Cases 2024年第15期12卷 2606-2613页

作者： Suhong Kim Jongsoo Park Young Hwii ko hee Jung Kwon Department of Radiology Yeungnam UniversityDaegu 42415South Korea Department of Urology Yeungnam UniversityDaegu 42415South Korea Department of Pathology Yeungnam UniversityDaegu 42415South Korea

BACKGROUND Ewing’s sarcoma(ES)is a neuroectodermal tumor that typically occurs in the bones and soft tissues of children and young *** renal ES is rare;only a few cases and a small case series have been documented,and only four cases involved primary renal ES in older people(>65 years old).CASE SUMMARY Herein,we describe the radiological and pathological features of primary renal ES in an older person.A 76-year-old man complained of poor oral intake and was found to have a large cystic renal mass with indistinct margins on computed ***-guided biopsy revealed that the tumor contained small round blue *** patient underwent a right radical *** tumor cells showed diffuse membranous CD99,and nuclear friend leukemia integration 1 transcription factor and NK2 Homeobox *** in situ hybridization revealed EWSR1 ***,18F-fluorodeoxyglucose positron emission tomography revealed no evidence of *** patient was diagnosed with primary renal *** months following the surgery,local recurrence and distant metastasis were *** renal ES is rare and often lethal in older *** specific imaging findings are unknown,and treatment protocols have not been *** This case report describes the radiological and pathological features of primary renal ES in an older person.

关键词： Ewing sarcoma Elder Renal Kidney Neuroectodermal Case report

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK SEUNG hee CHOI EUN-SU ko HYE JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

Immunoglobulin G4-related spinal pachymeningitis:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第32期12卷 6551-6558页

作者： Tae-Seok Chae Da-Sol Kim Gi-Wook Kim Yu Hui Won Myoung-Hwan ko Sung-hee Park Jeong-Hwan Seo Department of Physical Medicine&Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine&Rehabilitation Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal *** IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial *** SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized *** initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral *** the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower *** evaluation revealed findings consistent with acute motor sensory *** initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor *** the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal ***,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening *** IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.

关键词： Immunoglobulin G4 related disease Immunoglobulin G4 related spinal pachymeningitis Manual motor test Electromyography Magnetic resonance imaging Case report

PagMYB128 regulates secondary cell wall formation by direct activation of cell wall biosynthetic genes during wood formation in poplar

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第8期66卷 1658-1674页

作者： Yuanyuan Hao Fachuang Lu Seung-Won Pyo Min-Ha Kim Jae-Heung ko Xiaojing Yan John Ralph Quanzi Li State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Department of Biochemistry and DOE Great Lakes Bioenergy Research Center Wisconsin Energy InstituteUniversity of Wisconsin-MadisonWisconsin 53726USA Department of Plant&Environmental New Resources Kyung Hee UniversityYongin 17104Korea

The biosynthesis of cellulose,lignin,and hemicelluloses in plant secondary cell walls(SCWs)is regulated by a hierarchical transcriptional regulatory *** network features orthologous transcription factors shared between poplar and Arabidopsis,highlighting a foundational similarity in their genetic ***,knowledge on the discrepant behavior of the transcriptional-level molecular regulatory mechanisms between poplar and Arabidopsis remains *** this study,we investigated the function of PagMYB128 during wood formation and found it had broader impacts on SCW formation compared to its Arabidopsis ortholog,*** poplar trees overexpressing PagMYB128 exhibited significantly enhanced xylem development,with fiber cells and vessels displaying thicker walls,and an increase in the levels of cellulose,lignin,and hemicelluloses in the *** contrast,plants with dominant repression of PagMYB128 demonstrated the opposite *** sequencing and reverse transcription–quantitative polymerase chain reaction showed that PagMYB128 could activate SCW biosynthetic gene expression,and chromatin immunoprecipitation along with yeast one-hybrid,and effector–reporter assays showed this regulation was *** analysis revealed that PagSND1(SECONDARY WALL-ASSOCIATED NAC-DOMAIN PROTEIN1)directly regulates PagMYB128 but not cell wall metabolic genes,highlighting the pivotal role of PagMYB128 in the SND1-driven regulatory network for wood development,thereby creating a feedforward loop in SCW biosynthesis.

关键词： cellulose hemicellulose lignin PagMYB128 Populus transcription factor wood formation

干细胞在表皮创伤修复中的作用：我们到底了解多少？

在线全文

学校读者我要写书评

暂无评论

中国美容整形外科杂志 2011年第7期22卷 I0012-I0012页

作者： sae hee ko Allison Nauta Victor Wong Jason Glotzbach Geoffrey C. Gurtner Michael T. Lonzaker 魏峰(译) 高景恒(译) 张晨(译) 美国加利福尼亚州斯坦福斯坦福大学医学院干细胞生物学与再生医学学院整形再造外科中心Hagey儿科与再生医学研究室俄勒冈大学医学中心匹兹堡大学医学中心乔治城大学医院外科北卡罗来纳州大学《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

创伤修复是一个复杂的过程，包括多种生长因子、细胞因子、化学因子和多种类型细胞的交互作用。这一过程的失调可导致许多问题，如过度愈合（瘢痕疙瘩，增生性瘢痕）及慢性不愈合伤VI。全球范围都面临这些问题。干细胞有巨大的增强损伤... 详细信息

创伤修复是一个复杂的过程，包括多种生长因子、细胞因子、化学因子和多种类型细胞的交互作用。这一过程的失调可导致许多问题，如过度愈合（瘢痕疙瘩，增生性瘢痕）及慢性不愈合伤VI。全球范围都面临这些问题。干细胞有巨大的增强损伤后的组织修复和再生能力的潜能。干细胞生物学和皮肤组织工程学领域的迅速发展为新型的以干细胞为基础的创伤修复治疗的转变创造了机会。

关键词：干细胞生物学创伤修复皮肤组织工程学表皮增生性瘢痕生长因子细胞因子交互作用

Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2017年第3期15卷 192-201页

作者： JANG Sun-hee PARK Jisang KIM sae-Hae CHOI Kyung-Min ko Eun-Sil CHA Jeong-Dan LEE Young-Ran JANG Hyonseok JANG Yong-Suk Department of Molecular Biology and Institute for Molecular Biology and Genetics Chonbuk National UniversityJeonju 54896Korea Department of Bioactive Material Sciences and Research Center of Bioactive Materials Chonbuk National UniversityJeonju 54896Korea Department of Efficacy Research Institute of Jinan Red GinsengJinan 55442Korea Department of Mathematics Sogang UniversitySeoul 04107Korea Department of Oral Maxillofacial Surgery Korea University Ansan HospitalAnsan 15355Korea

Red ginseng is a well-known alternative medicine with anti-inflammatory *** exerts pharmacological effects through the transformation of saponin into metabolites by intestinal *** that intestinal microflora vary among individuals,the pharmacological effects of red ginseng likely vary among *** order to produce homogeneously effective red ginseng,we prepared probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium(DSS)-induced colitis model in *** analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis,compared with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics *** analysis of the levels of serum IL-6 and TNF-α,inflammatory biomarkers that are increased at the initiation stage of colitis,were significantly decreased in probiotic-fermented red ginseng-treated groups in comparison to the control *** levels of inflammatory cytokines and mR NAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated ***,oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model,suggesting that it can be used as a uniformly effective red ginseng product.

关键词： Colitis Fermentation Inflammation Probiotics Red ginseng

Emission of particulate and gaseous pollutants from household laser processing machine

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2021年第5期33卷 148-156页

作者： Hyun Sik ko Sang Bin Jeong Sooyeol Phyo Jiwon Lee Jae hee Jung Department of Mechanical Engineering Sejong UniversitySeoul 05006Republic of Korea Center for Environment Healthand Welfare ResearchKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Graduate School of Energy and Environment Korea UniversitySeoul 02841Republic of Korea Department o f Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Indoor air quality(IAQ) directly affects the health of occupants. Household manufacturing equipment(HME) used for hobbies or educational purposes is a new and unexplored source of air pollution. In this study, we evaluated the characteristics of particulate and gaseous pollutants produced by a household laser processing equipment(HLPE). Various target materials were tested using a commercial HLPE under various operating conditions of laser power and sheath air flow rate. The mode diameters of the emitted particles gradually decreased as laser power increased, while the particle number concentration(PNC) and particle emission rate(PER) increased. In addition, as the sheath air flow rate quadrupled from 10 to 40 L/min, the mode diameter of the emitted particles decreased by nearly 25%, but the effect on the PNC was insignificant. When the laser induced the target materials at 53 m W, the mode diameters of particles were 2.0 × 10^(4) particles/cm^(3). Particularly, analyses of sampled aerosols indicated that harmful substances such as sulfur and barium were present in particles emitted from leather. The carcinogenic gaseous pollutants such as acrylonitrile, acetaldehyde, 1,3-butadiene, benzene, and C 8 aromatics(ethylbenzene) were emitted from all target materials. In an actual indoor environment, the PNC of inhalable ultrafine particles(UFPs) was > 5 × 10^(4) particles/cm^(3) during 30 min of HLPE operation. Our results suggest that more meticulous control methods are needed, including the use of less harmful target materials along with filters or adsorbents that prevent emission of pollutants.

关键词： Indoor air quality(IAQ) Emission Laser processing Ultrafine particles(UFPs) Volatile organic compounds(VOCs)

Simulation of Suspended Sediment in the Yellow and East China Seas

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2005年第2期19卷 235-250页

作者： CHOI Byung-Ho MUN Jong-Yoon ko Jin-Seok YUK Jin-hee Department of Civil and Environmental Engineering Sungkyunkwan University Suwon 440-746 KoreaKorea Ocean Science and Engineering Corporation 175-9 Huam-dong Yongsan-gu Seoul 140-901 KoreaHyein Engineering and Construction Co. Ltd. 150-057 761 Shingil 7 dong Yungdungpogu Seoul KoreaDepartment of Civil and Environmental Engineering Sungkyunkwan University Suwon 440-746 Korea

Described is an initial attempt to simulate the suspended sediment dynamics relating to tidal and wave forcing during summertime in June 1980 and August 1981 for the Yellow and East China Seas continental shelf. The cohesive/non-cohesive sediment resuspension and movement generated by the interaction between current and wave are modeled by use of ECOMSED and WAM Cycle 4. Model results are compared with observations in US-China Marine Sedimentation Dynamics Program performed for 1980-81 at off the Changjiang estuary. The main features of simulations show that suspended sediment concentrations during the summer decreased markedly offshore as observed during the simulation periods. As for some discrepancies for the mouth of the estuary with high river discharges, i.e., the Changjiang River, the model did not properly reproduce the over-mixing situation in the summer; thus distinct vertical concentration variation in this local region is not agreeable with observation. However, general dispersal patterns of suspended sediment movement seem to be agreeably reproduced for the nearshore shallow region. Some of the procedures of simulation and results are presented and discussed.

关键词： Yellow Sea East China Sea sediment transport model time slice experiment sediment concentration

Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2013年第8期8卷 693-701页

作者： Kwang Taek Kim Kyung Jin Chung Han sae Lee Il Gyu ko Chang Ju Kim Yong Gil Na Khae Hawn Kim Department of Urology Gachon University Gil Medical CenterGachon University Department of Physiology College of MedicineKyung Hee University Department of Urology Chungnam National University HospitalChungnam National University School of Medicine

Impairment of dopamine function, which is known to have major effects on behaviors and cognition, is one of the main problems associated with cerebral ischemia. Tadalafil, a long-acting phosphodiesterase type-5 inhibitor, is known to ameliorate neurologic impairment induced by brain injury, but not in dopaminergic regions. We investigated the neuroprotective effects of treatment with tadalafil on cyclic guanosine monophosphate level and dopamine function following cerebral ischemia. Forty adult Mongolian gerbils were randomly and evenly divided into five groups （n = 8 in each group）： Sham-operation group, cerebral ischemia-induced and 0, 0.1, 1, and 10 mg/kg tadalafil-treated groups, respectively. Tadalafil dissolved in distilled water was administered orally for 7 consecutive days, starting 1 day after surgery. Cyclic guanosine monophosphate assay and immunohistochemistry were performed for thyrosine hydroxylase expression and western blot analysis for dopamine D2 receptor expression. A decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine D2 receptor expression in the striatum and substantia nigra region. However, treatment with tadalafil increased cyclic guanosine monophosphate expression, suppressed thyrosine hydroxylase expression and increased dopamine 92 receptor expression in the striatum and substantia nigra region in a dose-dependent manner. Tadalafil might ameliorate cerebral ischemia-induced dopaminergic neuron injury. Therefore, tadalafil has the potential as a new neuroprotective treatment strategy for cerebral ischemic injury.

关键词： neural regeneration brain injury cerebral ischemia Tadalafil phosphodiesterase type-5 inhibitor dopamine dopamine D2 receptor cyclic guanosine monophosphate grants-supported paper photographs-containing paper neuroregneration

Shockwave intravascular lithotripsy and drug-coated balloon angioplasty in calcified coronary arteries:preliminary experience in two cases

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第8期18卷 689-691页

作者： hee Hwa Ho Jin Hyun Lee Deanna Zhi Lin Khoo ko ko Soe Hpone Ki Fung Cliff Li Department of Cardiology Tan Tock Seng Hospital

Heavily calcified coronary arteries are extremely difficult to treat as calcium deposits "hardens" the arteries and alter vascular compliance. Intravascular lithotripsy (IVL)is a new technology consisting of a balloon-based system with miniaturized lithotripsy emitters that create a localised field effect to crack calcium in the arterial wall. Drug-coated balloon (DCB) angioplasty is an alternative treatment option in percutaneous coronary intervention (PCI) with an attractive strategy of leaving nothing behind combined with local drug delivery. In this brief clinical report, we described our early experience of using a novel combination of IVL and DCB angioplasty in two elderly patients with good angiographic results.

关键词：