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Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience

World Journal of Gastroenterology 2009年第40期15卷 5080-5085页

作者： Muhammad Idrees Shazia Rafi que Irshad-ur Rehman Haji Akbar Muhammad Zubair Yousaf sadia butt Zunaira Awan Sobia Manzoor Madiha Akram Mahwish Aftab Bushra Khubaib Sheikh Riazuddin Division of Molecular Virology & Molecular Diagnostics National Centre of Excellence in Molecular BiologyUniversity of the Punjab Lahore National Centre of Excellence in Molecular Biology University of the Punjab Lahore

AIM: To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC ***: One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotype-specif ic PCR and conf irmed by HCV 5' noncoding region sequencing analysis. RESULTS: Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) forthe development of HCC. The time from HCV infection to appearance of cancer was 10-50 years. In the HCC patient population, broader distributions of genotypes were present with genotype 3a as the predominant genotype. Using the type-specific genotyping method, we found HCV genotype 3a in 40.96%, 3b in 15.66%, 1a in 9.63%, and 1b in 2.40% of HCC tissue samples. About 28% of cases were found with mixed genotypes. Two cases were unable to be genotyped because of low viral load. Sixty-six percent of treated patients with cirrhosis had an end of treatment response, but unfortunately they relapsed quickly when the treatment was discontin-ued, and HCC developed during a median 3.8 years. CONCLUSION: There was a strong association between chronic HCV infection and HCC in Pakistan, and between HCV genotype 3a and HCC.

关键词：丙型肝炎病毒巴基斯坦肝细胞癌基因型感染

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Enhancing Secure Development in Globally Distributed Software Product Lines: A Machine Learning-Powered Framework for Cyber-Resilient Ecosystems

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Computers, Materials & Continua 2024年第6期79卷 5031-5049页

作者： Marya Iqbal Yaser Hafeez Nabil Almashfi Amjad Alsirhani Faeiz Alserhani sadia Ali Mamoona Humayun Muhammad Jamal University Institute of Information Technology PMAS-Arid Agriculture UniversityRawalpindiPakistan Department of Software Engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Engineering&Networks College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72388Saudi Arabia Department of Mathematics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

Embracing software product lines(SPLs)is pivotal in the dynamic landscape of contemporary software ***,the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability,underscoring the critical importance of robust cybersecurity *** paper advocates for leveraging machine learning(ML)to address variability management issues and fortify the security of *** the context of the broader special issue theme on innovative cybersecurity approaches,our proposed ML-based framework offers an interdisciplinary perspective,blending insights from computing,social sciences,and ***,it employs ML for demand analysis,dynamic feature extraction,and enhanced feature selection in distributed settings,contributing to cyber-resilient *** experiments demonstrate the framework’s superiority,emphasizing its potential to boost productivity and security in *** digital threats evolve,this research catalyzes interdisciplinary collaborations,aligning with the special issue’s goal of breaking down academic barriers to strengthen digital ecosystems against sophisticated attacks while upholding ethics,privacy,and human values.

关键词： Machine Learning variability management cybersecurity digital ecosystems cyber-resilience

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Source parameters and aftershock pattern of the October 7,2021,M5.9 Harnai earthquake,Pakistan

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Earthquake Science 2024年第4期37卷 304-323页

作者： Mohammad Tahir Zeeshan Ahmad sadia Sabahat Muhammad Naveed Mushtaq Talat Iqbal Muhammad Ali Shah Alam Aftab Centre for Earthquake Studies National Centre for PhysicsIslamabad 44000Pakistan

On October 7,2021,a magnitude 5.9 earthquake struck the Harnai(Baluchistan)region of Pakistan,causing several fatalities and injuries within the epicentral ***-order tectonic deformation in this region is caused by the convergence of the Indian Plate with respect to the Eurasian *** Katwaz Block hinders the motion of the Indian Plate,resulting in the formation of strike-slip *** this study,the P-wave first-motion polarity technique was used to determine the mainshock faulting *** scanning of the polarity solutions was applied to determine the most suitable focal mechanism solution among the available solutions generated by the FOCMEC(focal mechanism)*** nodal planes correspond to different faulting styles(i.e.,thrust and strike-slip faulting).A nodal plane oriented in the NW-SE direction corresponded to a strike-slip mechanism,which was considered to be the fault ***,this earthquake was associated with the Harnai-Karahi strike-slip fault zone owing to the fault strike and direction of *** apparent stress drop,fault length,and moment magnitude of the Harnai earthquake were 35.4 bar,6.1 km,and 5.9,respectively.A lower b-value for the Gutenberg-Richter law was observed prior to the ***α-than b-values(α>b)indicate that this earthquake was governed by large events as opposed to small-magnitude *** Harnai sequence had a decay exponent close to unity,lasted for 145 days,and produced few *** study will help the future hazard mitigation in the region.

关键词： focal mechanism solution selection of fault plane FPFIT stress inversion oblique slip mechanism

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Results of Trans-Urethral Resection of Bladder (TURB) for the Treatment of Non-Infiltrating Bladder Tumors (NMIBT) in Musk in Bouake

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Open Journal of Urology 2024年第2期14卷 39-49页

作者： Kouassi Patrice Avion N’diamoi Akassimadou Venance Alloka sadia Kamara Koffi Dje Urology Department Bouaké University Hospital (CHU) Bouaké Ivory Coast

Background: bladder tumors rank 2nd among urological tumors in sub-Saharan Africa, particularly in Côte d’Ivoire. Objective: to report the results of transurethral resection of the bladder (TURB) for the treatment of non-muscle-infiltrating bladder tumors (NMIBT) in Bouaké. Patients and methods: we conducted a cross-sectional, descriptive study of transurethral resection of the bladder (TURB) for the treatment of non-muscle-infiltrating bladder tumors (NMIBT) between January 2022 and April 2023. All patients and their families were informed in advance and had signed an informed consent form. All patients with a non-muscle-invasive bladder tumor confirmed by an initial TURB were included, and patients with a bladder tumor infiltrating the bladder muscle were excluded. Diagnosis was based on cystoscopy and anatomopathological examination of resection shavings. Parameters studied were: age, sex, risk factors, reason for consultation, clinical signs, cystoscopy findings, stage, grade, Evolution. Results: 17 patients with a mean age of 53.7 years (22-73 years) underwent trans-ureteral bladder resection to treat a non-muscle-infiltrating bladder tumor (NMIBT). Male gender predominated with 88.23% (n = 15), the majority of patients came from the ME region with 47.05% (n = 8), farmers were the most numerous (52.94%;n = 9). The most frequent reason for consultation was macroscopic hematuria with 64.1% (n = 11), risk factors were dominated by urinary bilharziasis with 70.58% (n = 12), physical examination was normal in 47.05% (n = 8). Hemoglobin (HB) levels were between 7.5 and 8.5 g/dl in 52.94% (n = 9). On cystoscopy, the tumor was budding in 76.45% (n = 13), the localization was trigonal in 52.9% (n = 9) and the base of implantation was sessile in 70.52% (n = 12). On ultrasound, the tumor was 3 cm or larger in 70.52% (n = 12). Therapeutically, 82.35% (n = 14) of patients received a blood transfusion. TURB was complete in the majority of cases 88.23% (n = 15). Squamous cell

关键词： Bladder Tumor NMIBT TURB Squamous Cell Carcinoma

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Transurethral Resection of the Prostate (TRUP) for the Treatment of Benign Prostatic Hyperplasia (BPH) in Central Cote D’Ivoire: Indications and Results

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Open Journal of Urology 2024年第2期14卷 27-38页

作者： Kouassi Patrice Avion N’diamoi Akassimadou Venance Alloka sadia Kamara Koffi Dje Urology Department Bouaké University Hospital Bouaké C&#244te d’Ivoire

Background: Benign prostatic hyperplasia (BPH) is defined histologically as adenomyofromatous hyperplasia of the transitional zone of the prostate. It remains the most common benign tumour in men over the age of 50, and transurethral resection of the prostate (TURP) remains the surgical treatment of choice. Objectives: To determine the indications and present our results of transurethral resection of the prostate. Patients and Methods: After obtaining approval from the ethics committee of the private hospital and the university hospital of Bouaké (Côte d’Ivoire), we conducted a cross-sectional study of transurethral resection of the prostate (TURP) to treat benign prostatic hyperplasia (BPH) between January 2021 and April 2023. All patients and their families were informed beforehand and had signed an informed consent form. All patients with benign prostatic hyperplasia (BPH) with ultrasound weight of less than 80 grams were included. The following parameters were studied: age, reason for consultation, ultrasound prostate weight of benign prostatic hyperplasia, indication for TURP, duration of operation, blood loss, duration of post-PRT urinary drainage, length of hospital stay, morbidity and mortality, and outcome. Results: 39 patients with a mean age of 58.3 years (57-77 years) underwent transurethral resection of the prostate (TURP). TURP was indicated in 46.15% (n = 18) of cases of refractory acute urinary retention with failure of the urinary catheter removal test, 17.94% (n = 7) of cases of lower urinary tract disorders that were incapacitating despite treatment, 15.38% (n = 6) of cases of refractory or recurrent urinary tract infection, 10.25% (n = 4) of cases of failure of medical treatment and 10.25% (n = 4) of cases of iterative hematuria. The mean duration of TURP was 53.68 min (48-57), the mean weight of the resected prostate was 58.7 g (35 and 83 g), blood loss was minimal in 92.30% (n = 36), the mean duration of irrigation-washing was 2. 5 days (1-3 da

关键词： BPH TURP Endo-Urology Prostate

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Nature’s Pharmacy under Siege: Investigating Antibiotic Resistance Pattern in Endophytic Bacteria of Medicinal Plants

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Advances in Microbiology 2024年第4期14卷 183-208页

作者： Bonoshree Sarkar Afroza Sultana Nabila Nawar Binti Farhana Tasnim Chowdhury sadia Afrin Mohammad Fahim Taibur Rahman Atiqur Rahman Infection Biology Laboratory Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Department of Pathology University of Alabama at Birmingham Birmingham USA

Antibiotic resistance poses a significant global health threat, necessitating a thorough understanding of its prevalence in various ecological contexts. Medicinal plants, renowned for their therapeutic properties, host endophytic bacteria that produce bioactive compounds. Understanding antibiotic resistance dynamics in these bacteria is vital for human health and antibiotic efficacy preservation. In this study, we investigated antibiotic resistance profiles in endophytic bacteria from five medicinal plants: Thankuni, Neem, Aparajita, Joba, and Snake plant. We isolated and characterized 113 endophytic bacteria, with varying resistance patterns observed against multiple antibiotics. Notably, 53 strains were multidrug-resistant (MDR), with 14 exhibiting extensive drug resistance (XDR). Thankuni-associated bacteria displayed 44% MDR and 11% XDR, while Neem-associated bacteria showed higher resistance (60% MDR, 13% XDR). Aparajita-associated bacteria had lower resistance (22% MDR, 6% XDR), whereas Joba-associated bacteria exhibited substantial resistance (54% MDR, 14% XDR). Snake plant-associated bacteria showed 7% MDR and 4% XDR. Genus-specific distribution revealed Bacillus (47%), Staphylococcus (21%), and Klebsiella (11%) as major contributors to MDR. Our findings highlight diverse drug resistance patterns among plant-associated bacteria and underscore the complexity of antibiotic resistance dynamics in diverse plant environments. Identification of XDR strains emphasizes the severity of the antibiotic resistance problem, warranting further investigation into contributing factors.

关键词： Antibiotic Resistance Endophytic Bacteria Medicinal Plants Drug Resistance

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Why the"sugars"in traditional Unani formulations are a pivotal component:A viewpoint perspective

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Journal of Integrative Medicine 2022年第2期20卷 91-95页

作者： Mohammad Fazil sadia Nikhat Hakim Ajmal Khan Institute for Literary and Historical Research in Unani Medicine Central Council for Research in Unani MedicineJamia Millia Islamia CampusNew Delhi 110025India Department of Ilaj bit Tadbeer School of Unani Medical Education and ResearchJamia HamdardNew Delhi 110062India

Traditional medicine systems around the globe,like Unani,Ayurveda and traditional Chinese medicine,include a number of sugar-based formulations,which contain a large amount of saccharide-containing sweetener,such as honey,sucrose or *** pervasive lifestyle disorders throughout the world,there have been discussions to consider alternative sweetening ***,from the perspective of Unani medicine,we discuss how the saccharide-based sweeteners may be an essential component of these traditional preparations,like electuaries,which may be deprived of their bioactivities without these *** contemporary researches,it is known that apart from their own therapeutic effects,saccharides also form deep eutectic solvents which help in enhancing the bioactivity of other ingredients present in crude *** addition,they provide energy for fermentation which is essential for biotransformation of ***,the sugars also increase the shelf-life of these compound drugs and act as natural *** the basis of this review,we strongly believe that saccharide-based sweeteners are an essential component of traditional medicines and not merely an excipient.

关键词： Saccharides Sugar-based formulations Eutectic solvents Traditional medicine

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Vertex-Edge Degree Based Indices of Honey Comb Derived Network

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Computer Systems Science & Engineering 2022年第1期40卷 247-258页

作者： Muhammad Ibrahim sadia Husain Nida Zahra Ali Ahmad Centre for Advanced Studies in Pure and Applied Mathematics Bahauddin Zakariya UniversityMultanPakistan College of Computer Sciences and Information Technology Jazan UniversityJazanSaudi Arabia

Chemical graph theory is a branch of mathematics which combines graph theory and *** reaction network theory is a territory of applied mathematics that endeavors to display the conduct of genuine compound *** pulled the research community due to its applications in theoretical and organic chemistry since ***,it also increases the interest the mathematicians due to the interesting mathematical structures and problems are *** structure of an interconnection network can be represented by a *** the network,vertices represent the processor nodes and edges represent the links between the processor *** invariants play a vital feature in graph theory and distinguish the structural properties of graphs and *** this paper,we determined the newly introduced topological indices namely,first ve-degree Zagreb?index,first ve-degree Zagreb?index,second ve-degree Zagreb index,ve-degree Randic index,ve-degree atom-bond connectivity index,ve-degree geometric-arithmetic index,ve-degree harmonic index and ve-degree sum-connectivity index for honey comb derived *** the analysis of the quantitative structure property relationships(QSPRs)and the quantitative structure-activity relationships(QSARs),graph invariants are important tools to approximate and predicate the properties of the biological and chemical ***,we give the numerical and graphical representation of our outcomes.

关键词： Honey comb derived network ev-degree topological indices

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Wi-Fi Positioning Dataset with Multiusers and Multidevices Considering Spatio-Temporal Variations

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Computers, Materials & Continua 2022年第3期70卷 5213-5232页

作者： Imran Ashraf sadia Din Soojung Hur Yongwan Park Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si38541Korea

Precise information on indoor positioning provides a foundation for position-related customer *** the emergence of several indoor positioning technologies such as ultrawideband,infrared,radio frequency identification,Bluetooth beacons,pedestrian dead reckoning,and magnetic field,Wi-Fi is one of the most widely used ***,Wi-Fi fingerprinting is the most popular method and has been researched over the past two ***-Fi positioning faces three core problems:device heterogeneity,robustness to signal changes caused by human mobility,and device attitude,i.e.,varying *** existing methods do not cover these aspects owing to the unavailability of publicly available *** study introduces a dataset that includes the Wi-Fi received signal strength(RSS)gathered using four different devices,namely Samsung Galaxy S8,S9,A8,LG G6,and LG G7,operated by three surveyors,including a female and two *** addition,three orientations of the smartphones are used for the data collection and include multiple buildings with a multifloor *** levels of human mobility have been considered in dynamic *** analyze the time-related impact on Wi-Fi RSS,data over 3 years have been considered.

关键词： Wi-fi positioning dataset smartphone sensors benchmark analysis indoor positioning and localization spatio-temporal data

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Bayesian Multidimensional Scaling for Location Awareness in Hybrid-Internet of Underwater Things

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IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 496-509页

作者： Ruhul Amin Khalil Nasir Saeed Mohammad Inayatullah Babar Tariqullah Jan sadia Din IEEE Department of Electrical Engineering Faculty of Electrical and Computer EngineeringUniversity of Engineering and TechnologyPeshawar 25120Pakistan the Department of Electrical Engineering Northern Border UniversityArar 73222Saudi Arabia College of Science and Engineering Hamad Bin Khalifa UniversityDoha 34110Qatar

Localization of sensor nodes in the internet of underwater things(IoUT)is of considerable significance due to its various applications,such as navigation,data tagging,and detection of underwater ***,in this paper,we propose a hybrid Bayesian multidimensional scaling(BMDS)based localization technique that can work on a fully hybrid IoUT network where the nodes can communicate using either optical,magnetic induction,and acoustic *** communication technologies are already used for communication in the underwater environment;however,lacking localization *** and magnetic induction communication achieves higher data rates for short *** the contrary,acoustic waves provide a low data rate for long-range underwater *** proposed method collectively uses optical,magnetic induction,and acoustic communication-based ranging to estimate the underwater sensor nodes’final ***,we also analyze the proposed scheme by deriving the hybrid Cramer-Rao lower bound(H-CRLB).Simulation results provide a complete comparative analysis of the proposed method with the literature.

关键词： Bayesian multidimensional scaling(BMDS) hybrid Cramer-Rao lower bound(H-CRLB) internet of underwater things(IoUT) signals of opportunity(SOA)approach

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