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Recommender System for Configuration Management Process of Entrepreneurial Software Designing Firms

Computers, Materials & Continua 2021年第5期67卷 2373-2391页

作者： Muhammad Wajeeh Uz Zaman Yaser Hafeez Shariq Hussain Haris Anwaar Shunkun Yang sadia Ali Aaqif Afzaal Abbasi Oh-Young Song University Institute of Information Technology Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindi46000Pakistan Department of Software Engineering Foundation University IslamabadIslamabad44000Pakistan Department of Electrical Electronics and Telecommunication EngineeringUniversity of Engineering and TechnologyLahore54000Pakistan School of Reliability and Systems Engineering Beihang UniversityBeijing100191China Department of Software Sejong UniversitySeoul05006South Korea

The rapid growth in software demand incentivizes software development organizations to develop exclusive software for their customers *** problem is addressed by the software development industry by software product line(SPL)practices that employ feature ***,optimal feature selection based on user requirements is a challenging ***,there is a requirement to resolve the challenges of software development,to increase satisfaction and maintain high product quality,for massive customer needs within limited *** this work,we propose a recommender system for the development team and clients to increase productivity and quality by utilizing historical information and prior experiences of similar developers and *** proposed system recommends features with their estimated cost concerning new software requirements,from all over the globe according to similar developers’and clients’needs and *** system guides and facilitates the development team by suggesting a list of features,code snippets,libraries,cheat sheets of programming languages,and coding references from a cloud-based knowledge management ***,a list of features is suggested to the client according to their needs and *** experimental results revealed that the proposed recommender system is feasible and effective,providing better recommendations to developers and *** provides proper and reasonably well-estimated costs to perform development tasks effectively as well as increase the client’s satisfaction *** results indicate that there is an increase in productivity,performance,and quality of products and a reduction in effort,complexity,and system ***,our proposed system facilitates developers and clients during development by providing better recommendations in terms of solutions and anticipated ***,the increase in productivity and satisfaction level maximizes the benefits and usability of SPL in the

关键词： Feature selection recommender system software reuse configuration management

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JA-mediated transcriptional regulation of secondary metabolism in medicinal plants

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Science Bulletin 2015年第12期60卷 1062-1072,I0002页

作者： sadia Afrin Jing-Jia Huang Zhi-Yong Luo Molecular Biology Research Center State Key Laboratory of Medical Genetics School of Life Sciences Central SouthUniversity Changsha 410078 China

Plants produce a wide spectrum of secondary metabolites that play critical roles in plant-environment interactions and against biotic and abiotic stresses. Moreover, many secondary metabolites have pharmaceu- tical efficacy for a wide range of diseases （cancer, malaria, etc.）. Controlled transcription of biosynthetic genes is one of the major mechanisms regulating sec- ondary metabolism in plants. Several transcription factor families such as MYC, MYB, WRKY and AP2/ERF have been found to be involved in the regulation of secondary metabolism in different medicinal plants. In addition, the biosynthesis and proper accumulation of secondary metabolites are also induced by signaling molecule jasmonic acid （JA）. This review provides an insight into JA signaling pathway and JA-mediated transcriptional regu- lation of secondary metabolism （vinblastine, nicotine, artemisinin, taxol and ginsenoside） in a range of medicinal plant species.

关键词： Jasmonic acid Medicinal plant Secondary metabolite Transcription factor

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A Study on Heat Transfer Enhancement through Various Nanofluids in a Square Cavity with Localized Heating

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Energy Engineering 2021年第6期118卷 1659-1679页

作者： Sheikh Hassan Didarul Ahasan Redwan Md.Mamun Molla Sharaban Thohura M.Abu Taher sadia Siddiqa Department of Mathematics and Physics North South UniversityDhakaBangladesh Center for Applied and Scientific Computing(CASC) North South UniversityDhakaBangladesh Department of Mathematics Jagannath UniversityDhakaBangladesh Department of Mathematics Dhaka University of Engineering and TechnologyGazipurBangladesh Department of Mathematics COMSAT University IslamabadAttock CampusAttockPakistan

A two-dimensional(2D)laminar flow of nanofluids confined within a square cavity having localized heat source at the bottom wall has been *** governing Navier–Stokes and energy equations have been non dimensionalized using the appropriate non dimensional variables and then numerically solved using finite volume *** flow was controlled by a range of parameters such as Rayleigh number,length of heat source and nanoparticle volume *** numerical results are represented in terms of isotherms,streamlines,velocity and temperature distribution as well as the local and average rate of heat transfer.A comparative study has been conducted for two different base fluids,ethylene glycol and water as well as for two different solids Cu and Al_(2)O_(3).It is found that the ethylene glycol-based nanofluid is superior to the water-based nanofluid for heat transfer enhancement.

关键词： Nanofluids finite volume method heat transfer enhancement localized heating

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Role of secondary metabolites of wild marigold in suppression of Johnson grass and Sun spurge

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 708-712页

作者： Sehrish sadia Rahmatullah Qureshi Shahida Khalid Brian Gagosh Nayyar Jin-tun Zhang College of Life Sciences Beijing Normal University Department of Botany PMAS University of Arid Agriculture Institute of Plant and Environment Protection National Agricultural Research Center

Objective: To analyze the wild marigold [(Tagetes minuta L.)(T. minuta)] leaf extract with respect to phytochemicals and allelopathic activity. Methods: The aqueous extracts of T. minuta leaves at concentrations of 50%, 75% and 100% were prepared. Preliminary phytochemical analysis was carried out and then allelopathic ef ect of T. minuta on root length, shoot length, germination, fresh and dry weight of Johnson grass and Sun spurge was tested on i lter paper and in ***: Qualitative phytochemical analysis showed the presence of alkaloids, tannins, saponins, l avonoides and terpenoids. The higher concentrations proved to be signii cantly ef ective in reducing almost all the parameters of Sun spurge and Johnson grass in i lter paper bioassay. Supplemented with the soil, all concentrations of leaf extract showed reduction in germination, root and shoot growth, fresh and dry weight of Sun spurge; however, 100% concentration signii cantly reduced the germination of Johnson grass. Conclusions: This study suggests that marigold allelochemicals can be used as an integrated weed management for the production of better crop yield.

关键词： Allelopathy Weed suppression Sun spurge Johnson grass Wild marigold

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Pattern of hepatitis C virus genotypes and subtypes circulating in war-stricken Khyber Pakhtunkhwa,Pakistan:Review of published literature

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1037-1042页

作者： Abdul Waheed Khan sadia Nawab Zeeshan Nasim Abdul Haleem Khan Syed Ishfaq Ahmad Fazli Zahir Israr Ud Din Institute of Information Sciences Academia SinicaTaiwan Center for Biotechnology and Microbiology University of SwatPakistan Institute of Biotechnology and Genetic Engineering The University of AgriculturePeshawarPakistan 4Department of ZoologyIslamia College PeshawarPakistan

Infection due to hepatitis C virus(HCV) is a major cause of fibrosis and hepatocellular carcinoma in Pakistan. In the current review, pattern of HCV genotypes and subtypes in Khyber Pakhtunkhwa province was ascertained in light of the available literature. After thorough analysis, genotype 3(58.27%) was determined to be the leading HCV genotype,followed by genotypes 2(12.39%), 1(9.54%) and 4(0.86%). The proportions of genotypes 5 and 6 were recorded as 0.09% and 0.22% respectively. Subtype wise, 3 a accounted for 48.67%, followed by subtype 2 a(10.91%), 3 b(9.43%), 1 a(5.84%), 1 b(3.66%), 2 b(1.45%) and genotype 4 with its undefined subtypes contributed a portion of0.86%. The cumulative share of subtypes 1 c, 2 c, 3 c, 5 a and 6 a was less than 1%. In11.51% cases, the subtype was untypeable while in 7.17% cases mixed subtypes were recorded. Gender wise, proportions of most HCV subtypes were marginally higher among males as compared to females. On the basis of studied groups, 3 a was pervasive among all groups except in intravenous drug users where 2 a was the major HCV ***, based on various geographical locations(provincial divisions), subtype 3 a revealed a ubiquitous distribution. Conclusively, HCV 3 a persists to be the principal subtype across the province of Khyber Pakhtunkhwa. The considerable number of untypeable subtypes in most studies urges for an improved genotyping system on the basis of local sequence data and practice of sequencing for determination of underlying subtype in untypeable cases. Further, studies on identification of subtypes transmission pattern are imperative for assessment of transmission origin and reinforcement of efficient control strategies. In addition, the current review emphasizes the need of attention toward HCV risk groups and ignored southern side of Khyber Pakhtunkhwa province for better holistic understanding of HCV genotype distribution pattern in the province.

关键词： Hepatitis C Hepatitis C virus Genotype Subtype

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Curcumin:reclaiming the lost ground against cancer resistance

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Cancer Drug Resistance 2021年第2期4卷 298-320页

作者： Siraj Shaikh Javed Shaikh Yusufi sadia Naba Kailas Doke Khursheed Ahmed Mujahid Yusufi Post-Graduate Department of Chemistry and Research Center Abeda Inamdar Senior College of ArtsScience and Commerce(Affiliated to SPPU)Pune 411001India Advanced Scientific Research Laboratory Azam CampusPune 411001India.

Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial, antitubercular, cardioprotective and neuroprotective. Moreover, the anti-proliferative activities of Curcumin have been widely studied against several types of cancers due to its ability to target multiple pathways in cancer. Although Curcumin exhibited potent anticancer activity, its clinical use is limited due to its poor water solubility and faster metabolism. Hence, there is an immense interest among researchers to develop potent, water-soluble, and metabolically stable Curcumin analogs for cancer treatment. While drug resistance remains a major problem in cancer therapy that renders current chemotherapy ineffective, curcumin has shown promise to overcome the resistance and re-sensitize cancer to chemotherapeutic drugs in many studies. In the present review, we are summarizing the role of curcumin in controlling the proliferation of drug-resistant cancers and development of curcumin-based therapeutic applications from cell culture studies up to clinical trials.

关键词： Curcumin drug-resistant cancer signaling pathways clinical trials

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Morpholine hydrazone scaffold： Synthesis, anticancer activity and docking studies

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Chinese Chemical Letters 2017年第3期28卷 607-611页

作者： Muhammad Taha Syed Adnan Ali Shah Muhammad Afifi Manar Zulkeflee sadia Sultan Abdul Wadood Fazal Rahim Nor Hadiani Ismail Atta-ur-Rahman Institute for Natural Product Discovery (AuRlns) Universiti Teknologi MARA Puncak Alam Campus 42300 Bandar Puncak Alam SelangorD. E. Malaysia Faculty of Applied Science UiTM Shah Alam 40450 Shah Alam Selangor D.E. Malaysia Faculty of Pharrnacy Universiti Teknologi MARA Puncat~ Alam Campus 42300 Baadar Puncak Alam Selangor D.E. Malaysia Department of Biochemistry Abdul Wali Khan University Mardan 23200 Pakistan Department of Chemistry Hazara University Mansehra 21300 Pakistan

In this paper, synthesis and anticancer activities of morpholine hydrazones scaffold（1-17） thoroughly studied. Small series of morpholine hydrazones synthesized by treating 5-morpholinothiophene-2-carbaldehyde with different aryl hydrazides to form morpholine hydrazones scaffold（1-17）. The in vitro anticancer potential of all these compounds was checked against human cancer cell lines like Hep G2（human hepatocellular liver carcinoma） and MCF-7（human breast adenocarcinoma）. Analogs 13 had similar substantial cytotoxic effects towards Hep G2 with IC_（50） value 6.31±1.03μmmol/L when compared with the standard Doxorubicin（IC_（50）value 6.00±0.80μmmol/L）; while compounds 5,8 and 9 showed potent cytotoxicity against MCF-7 with IC_（50） value 7.08±0.42μmmol/L, 1.26±0.34μmmol/L and11.22±0.22μmmol/L respectively when compared with the standard Tamoxifen（IC_（50）= 11.00±0.40μmol/L）. Molecular docking studies also performed to understand the binding interaction.

关键词： Morpholine hydrazones Synthesis HepG2 MCF-7 Molecular docking

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Evolution and Fate of Haloacetic Acids before and after Chlorination within the Treatment Plant Using SPE-GC-MS

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American Journal of Analytical Chemistry 2011年第5期2卷 522-532页

作者： sadia Waseem Ijaz Ul Mohsin 不详

The previous research on the occurrence of disinfection by-products (DBPs) in drinking water has focused on trihalomethane (THMs) formation and evolution, in particular within distribution systems. In this study, the variability of occurrence of haloacetic acids (HAAs) before and after treatment was investigated. The investigation focused on point–to-point fluctuations of HAAs in different treatment stages within the treatment plant. The research was also carried out to find out the possible sources for the presence of HAAs before chlorination in the raw water. The results showed that the presence of HAAs from the raw water point until the filtered water occurred due to industrial waste and sewages. Subsequent formation of HAAs from treated point until service reservoir due to disinfection. The HAAs concentration was the highest and most variable in the plant where level of DBP precursor indicators and the chlorine dose were both higher. However, HAAs level and in particular dichloroacetic acids (DCAA) (the preponderant HAAs species in the waters under study), trichloroacetic acids (TCAA) decreased dramatically during filtration, very probably because of the biodegradation within the filter. An ANNOVA test was used to evaluate the level of significance of HAAs between treated water and service reservoir outlet water.

关键词： Haloacetic Acids Disinfection by-Products Drinking Water

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Polyethylene glycol functionalized carbon nanotubes/gelatin-chitosan nanocomposite: An approach for significant drug release

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Bioactive Materials 2018年第3期3卷 236-244页

作者： sadia Sharmeen A.F.M.Mustafizur Rahman Mostakima M.Lubna Kh Samaher Salem Rafiqul Islam Mubarak A.Khan Department of Applied Chemistry and Chemical Engineering University of DhakaDhaka 1000Bangladesh Institute of Radiation and Polymer Technology Bangladesh Atomic Energy CommissionDhaka 1000Bangladesh

This research work blooms the new idea of developing a safe and controlled drug releasing matrix using multi-walled carbon nanotubes(MWCNTs).In aqueous solution,uniform and highly stable dispersion of MWCNTs was obtained after secondary functionalization with polyethylene glycol(PEG)which was studied by Fourier transmission infrared spectroscopy(FTIR)and thermogravimetric analysis(TGA).Solution casting method was used to prepare MWCNTs/gelatin-chitosan nanocomposite films and the effect of MWCNTs on physico-mechanical,thermal and water uptake properties of the nanocomposites were *** of MWCNTs into the porous gelatin-chitosan matrix showed interesting stiffness and dampness along with developed microfibrillar structures within the pore walls intended at being used in tissue engineering of bone or cartilage.A common antibiotic drug,ciprofloxacin was incorporated into nanocomposite *** evaluation of the effect of MWCNTs on drug release rate by dissolution test and antimicrobial susceptibility test was *** release of the drug was found at early stages(~1 h),but the rate was reduced afterwards,showing a sustained *** was observed that for all microorganisms,the antibacterial activities of drug loaded MWCNTs/gelatin-chitosan nanocomposites were higher than that of drug loaded gelatin-chitosan composite films containing no *** statistical studies by ANOVA techniques also showed remarkable difference between the antibacterial activities,exhibited by MWCNTs-incorporated and non-incorporated composite films.

关键词： Carbon nanotubes Functionalization Nanocomposite Thermo-mechanical properties Drug dissolution Antibacterial activities

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Functional Genomics Approaches to Study At5g24290 Gene in Arabidopsis thaliana and Its Homologous in Brassica Species

Functional Genomics Approaches to Study At5g24290 Gene in Ar...

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第十二届全国植物基因组学大会

作者： sadia Tehrim Oil Crops Research Institute of The CAAS

The angiosperm family,Brassicaceae(mustard family) contains several key research and agricultural species,the foremost being the model species Arabidopsis thaliana and the Brassica crops including diverse agronomically crops such as oilseed rape,cabbage,broccoli and other leafy vegetables.A pattern of segmental chromosome co linearity has been well known in Brassica species and *** of the Arabidopsis genome sequence is the culmination of a remarkable decade of world-wide growth and collaboration in developing Arabidopsis as a model genetic and genomic *** the immense progress in functional characterization of plant genomes,over 30%Arabidopsis genes have not been functionally charac-

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