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Off-Pump CABG for Mulitvessel Coronary Artery Disease-Safe Incorporation into Surgical Practice

Open Journal of Thoracic Surgery 2012年第3期2卷 78-86页

作者： Catharina Nesselmann sadia aftab Manikandan Chandran Fraser W. H. Sutherland Anaesthetic Department Royal Hospital for Sick Children Glasgow Scotland Department for Cardiothoracic Surgery Golden Jubilee National Hospital Glasgow Scotland Department of Cardiac Surgery University of Rostock Rostock Germany

Introduction: Since its revival two decades ago development of the surgical technique, along with evidence and clinical outcomes of off-pump coronary artery bypass surgery (OPCAB) were brought into focus. Methods: We report a single surgeon, single center experience of the first 37 consecutive patients undergoing off-pump surgery. Patients were selected for OPCAB (study group) individually and matched retrospectively to a control group of 113 patients performed over an identical time frame. Data were retrieved from a hospital data base (TOMCAT). Results: Mean Logistic European System of Cardiac Operative Risk Stratification (EuroSCORE) was slightly higher in the off-pump group (3.8% versus 2.9%). One patient died during the study and this was in the off-pump CAB group (OPCAB-30 day mortality 2.7%). Operating time was slightly shorter in the off-pump group (3 hours 28 minutes versus 3 hours 49 minutes, p = 0.15). After exclusion of outliers, total hospital stay was significantly shorter for off-pump cases (mean 6.8 days versus 8.37 days), while Intensive Care Unit (ICU) stay (1.2 versus 1.4 days) and ventilation time were only slightly shorter (9.35 hours versus 10.6 hours) for off-pump cases. Chest tube drainage was significantly lower in the off-pump group (484 ml versus 744 ml, p = 0.04) with correspondingly slightly lower transfusion requirements and significantly increased discharge haemoglobin concentrations in OPCAB. There was one cerebrovascular accident (CVA) in the off-pump group and none in the on-pump group. Conclusion: In this study we show short term outcomes for introduction of off-pump into surgical technique. Length of ICU stay, ventilation times, chest tube drainage, transfusion re0 quirements and pre-discharge haemoglobin concentration all appeared superior in the off pump group. The off-pump technique was safely introduced into the surgeon`s service with relatively little mortality. Experience of surgeon was considered advantageous for fast adapti

关键词： Off-Pump Versus On-Pump Coronary Artery Bypass Grafting Without Cardiopulmonary Bypass Cardiac Surgery

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Enhancing Secure Development in Globally Distributed Software Product Lines: A Machine Learning-Powered Framework for Cyber-Resilient Ecosystems

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Computers, Materials & Continua 2024年第6期79卷 5031-5049页

作者： Marya Iqbal Yaser Hafeez Nabil Almashfi Amjad Alsirhani Faeiz Alserhani sadia Ali Mamoona Humayun Muhammad Jamal University Institute of Information Technology PMAS-Arid Agriculture UniversityRawalpindiPakistan Department of Software Engineering College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Computer Engineering&Networks College of Computer and Information SciencesJouf UniversityAl Jouf72388Saudi Arabia Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaAl Jouf72388Saudi Arabia Department of Mathematics Pir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

Embracing software product lines(SPLs)is pivotal in the dynamic landscape of contemporary software ***,the flexibility and global distribution inherent in modern systems pose significant challenges to managing SPL variability,underscoring the critical importance of robust cybersecurity *** paper advocates for leveraging machine learning(ML)to address variability management issues and fortify the security of *** the context of the broader special issue theme on innovative cybersecurity approaches,our proposed ML-based framework offers an interdisciplinary perspective,blending insights from computing,social sciences,and ***,it employs ML for demand analysis,dynamic feature extraction,and enhanced feature selection in distributed settings,contributing to cyber-resilient *** experiments demonstrate the framework’s superiority,emphasizing its potential to boost productivity and security in *** digital threats evolve,this research catalyzes interdisciplinary collaborations,aligning with the special issue’s goal of breaking down academic barriers to strengthen digital ecosystems against sophisticated attacks while upholding ethics,privacy,and human values.

关键词： Machine Learning variability management cybersecurity digital ecosystems cyber-resilience

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Results of Trans-Urethral Resection of Bladder (TURB) for the Treatment of Non-Infiltrating Bladder Tumors (NMIBT) in Musk in Bouake

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Open Journal of Urology 2024年第2期14卷 39-49页

作者： Kouassi Patrice Avion N’diamoi Akassimadou Venance Alloka sadia Kamara Koffi Dje Urology Department Bouaké University Hospital (CHU) Bouaké Ivory Coast

Background: bladder tumors rank 2nd among urological tumors in sub-Saharan Africa, particularly in Côte d’Ivoire. Objective: to report the results of transurethral resection of the bladder (TURB) for the treatment of non-muscle-infiltrating bladder tumors (NMIBT) in Bouaké. Patients and methods: we conducted a cross-sectional, descriptive study of transurethral resection of the bladder (TURB) for the treatment of non-muscle-infiltrating bladder tumors (NMIBT) between January 2022 and April 2023. All patients and their families were informed in advance and had signed an informed consent form. All patients with a non-muscle-invasive bladder tumor confirmed by an initial TURB were included, and patients with a bladder tumor infiltrating the bladder muscle were excluded. Diagnosis was based on cystoscopy and anatomopathological examination of resection shavings. Parameters studied were: age, sex, risk factors, reason for consultation, clinical signs, cystoscopy findings, stage, grade, Evolution. Results: 17 patients with a mean age of 53.7 years (22-73 years) underwent trans-ureteral bladder resection to treat a non-muscle-infiltrating bladder tumor (NMIBT). Male gender predominated with 88.23% (n = 15), the majority of patients came from the ME region with 47.05% (n = 8), farmers were the most numerous (52.94%;n = 9). The most frequent reason for consultation was macroscopic hematuria with 64.1% (n = 11), risk factors were dominated by urinary bilharziasis with 70.58% (n = 12), physical examination was normal in 47.05% (n = 8). Hemoglobin (HB) levels were between 7.5 and 8.5 g/dl in 52.94% (n = 9). On cystoscopy, the tumor was budding in 76.45% (n = 13), the localization was trigonal in 52.9% (n = 9) and the base of implantation was sessile in 70.52% (n = 12). On ultrasound, the tumor was 3 cm or larger in 70.52% (n = 12). Therapeutically, 82.35% (n = 14) of patients received a blood transfusion. TURB was complete in the majority of cases 88.23% (n = 15). Squamous cell

关键词： Bladder Tumor NMIBT TURB Squamous Cell Carcinoma

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Transurethral Resection of the Prostate (TRUP) for the Treatment of Benign Prostatic Hyperplasia (BPH) in Central Cote D’Ivoire: Indications and Results

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Open Journal of Urology 2024年第2期14卷 27-38页

作者： Kouassi Patrice Avion N’diamoi Akassimadou Venance Alloka sadia Kamara Koffi Dje Urology Department Bouaké University Hospital Bouaké C&#244te d’Ivoire

Background: Benign prostatic hyperplasia (BPH) is defined histologically as adenomyofromatous hyperplasia of the transitional zone of the prostate. It remains the most common benign tumour in men over the age of 50, and transurethral resection of the prostate (TURP) remains the surgical treatment of choice. Objectives: To determine the indications and present our results of transurethral resection of the prostate. Patients and Methods: After obtaining approval from the ethics committee of the private hospital and the university hospital of Bouaké (Côte d’Ivoire), we conducted a cross-sectional study of transurethral resection of the prostate (TURP) to treat benign prostatic hyperplasia (BPH) between January 2021 and April 2023. All patients and their families were informed beforehand and had signed an informed consent form. All patients with benign prostatic hyperplasia (BPH) with ultrasound weight of less than 80 grams were included. The following parameters were studied: age, reason for consultation, ultrasound prostate weight of benign prostatic hyperplasia, indication for TURP, duration of operation, blood loss, duration of post-PRT urinary drainage, length of hospital stay, morbidity and mortality, and outcome. Results: 39 patients with a mean age of 58.3 years (57-77 years) underwent transurethral resection of the prostate (TURP). TURP was indicated in 46.15% (n = 18) of cases of refractory acute urinary retention with failure of the urinary catheter removal test, 17.94% (n = 7) of cases of lower urinary tract disorders that were incapacitating despite treatment, 15.38% (n = 6) of cases of refractory or recurrent urinary tract infection, 10.25% (n = 4) of cases of failure of medical treatment and 10.25% (n = 4) of cases of iterative hematuria. The mean duration of TURP was 53.68 min (48-57), the mean weight of the resected prostate was 58.7 g (35 and 83 g), blood loss was minimal in 92.30% (n = 36), the mean duration of irrigation-washing was 2. 5 days (1-3 da

关键词： BPH TURP Endo-Urology Prostate

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Nature’s Pharmacy under Siege: Investigating Antibiotic Resistance Pattern in Endophytic Bacteria of Medicinal Plants

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Advances in Microbiology 2024年第4期14卷 183-208页

作者： Bonoshree Sarkar Afroza Sultana Nabila Nawar Binti Farhana Tasnim Chowdhury sadia Afrin Mohammad Fahim Taibur Rahman Atiqur Rahman Infection Biology Laboratory Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Department of Pathology University of Alabama at Birmingham Birmingham USA

Antibiotic resistance poses a significant global health threat, necessitating a thorough understanding of its prevalence in various ecological contexts. Medicinal plants, renowned for their therapeutic properties, host endophytic bacteria that produce bioactive compounds. Understanding antibiotic resistance dynamics in these bacteria is vital for human health and antibiotic efficacy preservation. In this study, we investigated antibiotic resistance profiles in endophytic bacteria from five medicinal plants: Thankuni, Neem, Aparajita, Joba, and Snake plant. We isolated and characterized 113 endophytic bacteria, with varying resistance patterns observed against multiple antibiotics. Notably, 53 strains were multidrug-resistant (MDR), with 14 exhibiting extensive drug resistance (XDR). Thankuni-associated bacteria displayed 44% MDR and 11% XDR, while Neem-associated bacteria showed higher resistance (60% MDR, 13% XDR). Aparajita-associated bacteria had lower resistance (22% MDR, 6% XDR), whereas Joba-associated bacteria exhibited substantial resistance (54% MDR, 14% XDR). Snake plant-associated bacteria showed 7% MDR and 4% XDR. Genus-specific distribution revealed Bacillus (47%), Staphylococcus (21%), and Klebsiella (11%) as major contributors to MDR. Our findings highlight diverse drug resistance patterns among plant-associated bacteria and underscore the complexity of antibiotic resistance dynamics in diverse plant environments. Identification of XDR strains emphasizes the severity of the antibiotic resistance problem, warranting further investigation into contributing factors.

关键词： Antibiotic Resistance Endophytic Bacteria Medicinal Plants Drug Resistance

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Are developing countries prepared to face Ebola-like outbreaks?

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Virologica Sinica 2015年第3期30卷 234-237页

作者： aftab Ahmad sadia Ashraf Shoji Komai Graduate School of Biological Sciences Nara Institute of Science and Technology National Academy of Young Scientists (NAYS) Pakistan University of the Punjab

Ebola virus disease has caused havoc in West Africa,with 11,162deaths and more than 27,181 cases(as of May 31,2015)being reported since the virus emerged in early2014 in *** maximum number of cases has been reported in Sierra Leone(12,827),while most of the reported deaths have occurred in Liberia(4,806),according to the Center for Disease Control

关键词： deaths Africa Sierra Sudan emerged infra officials infected http reservoir

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Why the"sugars"in traditional Unani formulations are a pivotal component:A viewpoint perspective

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Journal of Integrative Medicine 2022年第2期20卷 91-95页

作者： Mohammad Fazil sadia Nikhat Hakim Ajmal Khan Institute for Literary and Historical Research in Unani Medicine Central Council for Research in Unani MedicineJamia Millia Islamia CampusNew Delhi 110025India Department of Ilaj bit Tadbeer School of Unani Medical Education and ResearchJamia HamdardNew Delhi 110062India

Traditional medicine systems around the globe,like Unani,Ayurveda and traditional Chinese medicine,include a number of sugar-based formulations,which contain a large amount of saccharide-containing sweetener,such as honey,sucrose or *** pervasive lifestyle disorders throughout the world,there have been discussions to consider alternative sweetening ***,from the perspective of Unani medicine,we discuss how the saccharide-based sweeteners may be an essential component of these traditional preparations,like electuaries,which may be deprived of their bioactivities without these *** contemporary researches,it is known that apart from their own therapeutic effects,saccharides also form deep eutectic solvents which help in enhancing the bioactivity of other ingredients present in crude *** addition,they provide energy for fermentation which is essential for biotransformation of ***,the sugars also increase the shelf-life of these compound drugs and act as natural *** the basis of this review,we strongly believe that saccharide-based sweeteners are an essential component of traditional medicines and not merely an excipient.

关键词： Saccharides Sugar-based formulations Eutectic solvents Traditional medicine

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Viral hepatitis in Pakistan:challenges and priorities

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Asian Pacific Journal of Tropical Biomedicine 2015年第3期5卷 190-191页

作者： sadia Ashraf aftab Ahmad National Academy of Young Scientists(NAYS) University of the PunjabQuaid-i-Azam Campus

Hepatitis B and C are big health issues worldwide as more than 400 million people arc suffering from chronic hepatitis B and C which result in more than 1.4 million deaths each *** to a study done by Pakistan Medical Research Council in 2007-08,7.6%Pakistani population suffered with hepatitis B and *** around 4.8%with hepatitis C *** of Pakistan has taken different initiatives like vaccination,patient safety,blood screening,education and awareness about disease but still there is high prevalence of hepatitis in *** to some studies injecting drug users have the highest prevalence of hepatilis B and C in the *** follow-up studies and documentation of hepatitis patients was not very good which need to be *** is no recent large scale study on risk factors and prevalence of hepatitis B and C in Pakistan so it should be done on an urgent *** government set up regional laboratories for prevalence study and also a central institute for hepatitis research and treatment,the disease could be prevented in better and proper *** treatment of hepatitis is very costly and a developing country like Pakistan cannot afford such high *** more focus should be on preventive measures.

关键词： Hepatitis Prevalence Treatment Laboratories Risk groups

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Vertex-Edge Degree Based Indices of Honey Comb Derived Network

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Computer Systems Science & Engineering 2022年第1期40卷 247-258页

作者： Muhammad Ibrahim sadia Husain Nida Zahra Ali Ahmad Centre for Advanced Studies in Pure and Applied Mathematics Bahauddin Zakariya UniversityMultanPakistan College of Computer Sciences and Information Technology Jazan UniversityJazanSaudi Arabia

Chemical graph theory is a branch of mathematics which combines graph theory and *** reaction network theory is a territory of applied mathematics that endeavors to display the conduct of genuine compound *** pulled the research community due to its applications in theoretical and organic chemistry since ***,it also increases the interest the mathematicians due to the interesting mathematical structures and problems are *** structure of an interconnection network can be represented by a *** the network,vertices represent the processor nodes and edges represent the links between the processor *** invariants play a vital feature in graph theory and distinguish the structural properties of graphs and *** this paper,we determined the newly introduced topological indices namely,first ve-degree Zagreb?index,first ve-degree Zagreb?index,second ve-degree Zagreb index,ve-degree Randic index,ve-degree atom-bond connectivity index,ve-degree geometric-arithmetic index,ve-degree harmonic index and ve-degree sum-connectivity index for honey comb derived *** the analysis of the quantitative structure property relationships(QSPRs)and the quantitative structure-activity relationships(QSARs),graph invariants are important tools to approximate and predicate the properties of the biological and chemical ***,we give the numerical and graphical representation of our outcomes.

关键词： Honey comb derived network ev-degree topological indices

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Wi-Fi Positioning Dataset with Multiusers and Multidevices Considering Spatio-Temporal Variations

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Computers, Materials & Continua 2022年第3期70卷 5213-5232页

作者： Imran Ashraf sadia Din Soojung Hur Yongwan Park Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si38541Korea

Precise information on indoor positioning provides a foundation for position-related customer *** the emergence of several indoor positioning technologies such as ultrawideband,infrared,radio frequency identification,Bluetooth beacons,pedestrian dead reckoning,and magnetic field,Wi-Fi is one of the most widely used ***,Wi-Fi fingerprinting is the most popular method and has been researched over the past two ***-Fi positioning faces three core problems:device heterogeneity,robustness to signal changes caused by human mobility,and device attitude,i.e.,varying *** existing methods do not cover these aspects owing to the unavailability of publicly available *** study introduces a dataset that includes the Wi-Fi received signal strength(RSS)gathered using four different devices,namely Samsung Galaxy S8,S9,A8,LG G6,and LG G7,operated by three surveyors,including a female and two *** addition,three orientations of the smartphones are used for the data collection and include multiple buildings with a multifloor *** levels of human mobility have been considered in dynamic *** analyze the time-related impact on Wi-Fi RSS,data over 3 years have been considered.

关键词： Wi-fi positioning dataset smartphone sensors benchmark analysis indoor positioning and localization spatio-temporal data

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