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Enzymatic Formation of Gold Nanoparticles Using <i>Phanerochaete Chrysosporium</i>

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Advances in Chemical Engineering and Science 2011年第3期1卷 154-162页

作者： Rashmi Sanghi Preeti Verma sadhna puri 不详

When fungus Phanerochaete chrysosporium was challenged with gold ions under ambient aqueous conditions gold nanoparticles were formed within 90 minutes. Controlling experimental conditions like the age of fungus, incubation temperature and different concentration of gold chloride solution had drastic effect on the morphology of the nanoparticles formed. The enzyme assays indicated the role of enzyme as a reducing and shape directing agent. Laccase was the dominating enzyme in the case of fungal media for the synthesis of extracellular gold nanoparticles. Ligninase was responsible for the intracellular formation of nanoparticles on the fungal mycelium. The stabilization of the nanoparticles (NPs) via protein layer was evident by Atomic Force Microscopy (AFM) which revealed the nanoparticles to be spherical in the range of 10-100 nm. This study represents an important advancement in the use of fungal enzymes for the biosynthesis of highly stable gold nanoparticles by a green and mild technique in one pot in aqueous media.

关键词： Gold Nanoparticles Fungus Enzymes Protein

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面向听障老人心理需求的情感化交互设计策略

设计 2024年第10期37卷 107-110页

作者：冯燕 sadhna 伦敦艺术大学Camberwell学院

听觉障碍是老人群体在日常生活中需要面对的重要问题,听障老人不同于普通听障人士,他们具有无手语沟通能力且反应迟钝的特殊性,听障老人的因其特殊性所产生的心理问题值得被人们所关注。文章首先以需求层次理论进行分析,随后深入探究听... 详细信息

听觉障碍是老人群体在日常生活中需要面对的重要问题,听障老人不同于普通听障人士,他们具有无手语沟通能力且反应迟钝的特殊性,听障老人的因其特殊性所产生的心理问题值得被人们所关注。文章首先以需求层次理论进行分析,随后深入探究听障老人的生理及心理需求的特殊性,并将其归纳为“无助感、孤独感、焦虑感、不安感”4类心理特征。将这类心理特征与情感化设计方法论进行结合,最后从整体的层面提出情感化交互设计策略。研究结果为设计师提供了针对听障老人的产品设计策略,并为听障老人提供更为舒适的情感化交互体验,提高生活幸福感。

关键词：听障老人心理需求情感化交互设计设计策略

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Numerical analysis of LaBi at high temperature and pressure

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Journal of Rare Earths 2011年第3期29卷 271-276页

作者： Purvee Bhardwaj sadhna Singh High Pressure Physics Lab Department of Physics Barkatullah University

In this paper we focused on the structural,elastic and thermodynamic properties of the B1 phase of LaBi by using the modified TBP model,including the role of *** successfully obtained the phase transition pressure and volume change at different *** addition,elastic constants and bulk modulus of B1 phase of LaBi at different temperatures were *** results were comparable with the previous ones at high temperatures and *** thermodynamical properties of the B1 phase of LaBi were also predicted.

关键词： rare earth pnictides high-pressure crystal structure mechanical properties phase transition

Comparative study of CEA and CA19-9 in esophageal,gastric and colon cancers individually and in combination(ROC curve analysis)

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Cancer Biology & Medicine 2013年第3期10卷 148-157页

作者： Bhawna Bagaria sadhna Sood Rameshwaram Sharma Soniya Lalwani Department of Biochemistry S.M.S.Medical College & Hospital Department of Radiotherapy and Oncology S.M.S.Medical College & Hospital Advanced Bioinformatics Centre Birla Institute of Scientific Research

Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods： The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic （ROC） curves were plotted. Results： Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined： in esophageal cancer, sensitivity=28%, negative predictive value （NPV）=61.72%, and AUC=0.742 （SE=0.05）, with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 （SE=0.0S）, with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 （SE=0.04）, with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated： in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 （SE=0.05）, with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 （SE=0.05）, with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 （SE=0.05）, with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined： in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 （95% CI： 0.0159-0.322）; gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 （9$% CI： -0.0866-0.198）; and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 （9S% CI： 0.137-0.415）. Conclusion： CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.

关键词： Carcinoembryonic antigen carbohydrate antigen 19-9, human Receiver operating characteristic curve sensitivity andspecificity

UvWhi2 Is Required for Stress Response and Pathogenicity in Ustilaginoidea virens

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Rice science 2022年第1期29卷 47-54,I0018-I0023页

作者： MENG Shuai QIU Jiehua XIONG Meng LIU Zhiquan Jane sadhna JAGERNATH LIN Fucheng SHI Huanbin KOU Yanjun State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 311400China Key Laboratory of Horticultural Plant Biology Ministry of Education/College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Institute of Plant Protection and MicrobiologyZhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Institute of BiotechnologyZhejiang UniversityHangzhou 310058China

Some stress response-related genes have been identified in Ustilaginoidea virens,but it is not clear whether and how defects of stress responses affect the pathogenesis processes of *** this study,we identified a general stress response factor UvWHI2 as a homolog of Saccharomyces cerevisiae Whi2 in *** relative expression level of Uv Whi2 was significantly up-regulated during infection,suggesting that UvWHI2 may be involved in ***,knockout of Uv Whi2 showed decreased mycelial growth,increased conidiation in the potato sucrose medium and a defect in *** addition,the RNA-Seq and phenotypic analysis showed that UvWHI2 was involved in response to oxidative,hyperosmotic,cell wall stress and nutrient *** studies revealed that the defects of stress responses of the?Uvwhi2 mutant affected the formation of secondary spores on the nutrient limited surface and the rice surface,resulting in a significant reduction of pathogenicity of *** results suggest that UvWHI2 is necessary for fungal growth,stress responses and the formation of secondary spores in *** addition,the defects of stress responses can affect the formation of secondary spores on the rice surface,and then compromise the pathogenicity of ***.

关键词： Whi2 rice false smut Ustilaginoidea virens pathogenesis secondary spore

化学处理法对竹材阻燃、抗菌和防腐的影响(英文)

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林产化学与工业 2010年第4期30卷 7-14页

作者： sadhna Tripathi Wood Preservation Discipline Forest Products DivisionForest Research Institute

研究了6种用于印度勒竹防护的制剂,主要用于阻燃、防火防腐、抗真菌和白蚁的腐蚀。考察了阻燃剂和新型环保防腐剂ZiBOC用于印度勒竹防护的协同作用。将裂开的竹片用质量分数为15%的6种防护组分处理,即按照印度标准方法测试火焰穿透性、... 详细信息

研究了6种用于印度勒竹防护的制剂,主要用于阻燃、防火防腐、抗真菌和白蚁的腐蚀。考察了阻燃剂和新型环保防腐剂ZiBOC用于印度勒竹防护的协同作用。将裂开的竹片用质量分数为15%的6种防护组分处理,即按照印度标准方法测试火焰穿透性、可燃性和燃烧率。6种15%质量分数的组分分别为：1.硫酸铵＋磷酸铵＋ZiBOC;2.硫酸铵＋ZiBOC;3.磷酸铵＋ZiBOC;4.磷酸镁＋焦硫酸镁＋ZiBOC;5.磷酸镁＋ZiBOC;6.焦磷酸镁＋ZiBOC。结果表明,达到防护目的的不同化学组分的防护剂用量应为9～11.5kg/m3。用白腐菌的腐烂实验表明,配方为2、3、5和6的防护剂表现出较好的防腐作用（防护率达到95%,p〈0.05）,而用褐腐菌其防护率约为43%～67%。采用经2～6配方处理过的样品均能抗第一、二期的白腐腐蚀,而第二期的白蚁对配方4处理过的样品有轻微的腐蚀作用。少数几种配方对材料的耐火性有提高。

关键词：勒竹阻燃剂防腐剂褐腐菌白腐菌

Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas

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World Journal of Gastroenterology 2017年第6期23卷 1113-1118页

作者： Michael A Mederos Nicole Villafane sadhna Dhingra Carlos Farinas Amy Mc Elhany William E Fisher George Van Buren II Department of General Surgery Baylor College of Medicine Department of Pathology Baylor College of Medicine Department of Radiology Baylor College of Medicine

Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16cm×12cm×4cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. Here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas.

关键词： Pancreatic cyst Pancreatic endometrial cyst Endometriosis Mucinous cystic neoplasm of the pancreas Distal pancreatectomy

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作者： Jane sadhna Jagernath 中国农业科学院

学位级别：硕士

由稻瘟病菌引起的稻瘟病对全球水稻生产构成严重威胁。近年来,稻瘟病菌的致病相关基因已经被广泛鉴定,但是其致病机制仍有必要进一步分析。线粒体作为真核细胞中一种重要的细胞器,除了提供能量以外,还参与包括细胞信号转导、细胞分化、... 详细信息

由稻瘟病菌引起的稻瘟病对全球水稻生产构成严重威胁。近年来,稻瘟病菌的致病相关基因已经被广泛鉴定,但是其致病机制仍有必要进一步分析。线粒体作为真核细胞中一种重要的细胞器,除了提供能量以外,还参与包括细胞信号转导、细胞分化、衰老、细胞死亡、维持对细胞周期和细胞生长的控制等重要生命活动过程,这些功能使得线粒体成为有效控制疾病的靶标位点。本试验主要分析了Mo Uth1、Mo BI-1和Mo BI-1b等三个定位于线粒体的蛋白在稻瘟病菌致病过程中的功能。在前期研究中,我们发现Mo Whi2是稻瘟病菌致病所必需的。为了进一步分析Mo Whi2的功能,我们通过酵母双杂交筛选稻瘟病菌c DNA文库鉴定到了与Mo Whi2互作的一个SUN家族蛋白Mo Uth1。在酿酒酵母中Uth1调控线粒体活性,并参与多种细胞过程。敲除Mo UTH1后稻瘟病菌营养菌丝生长减缓,并且气生菌丝发白、产孢量显著降低及分生孢子形态存在缺陷。苗期喷雾接种实验表明Mo UTH1缺失后稻瘟病菌致病力显著下降,进一步通过叶鞘接种分析,显微镜下观察发现缺失突变株的侵染菌丝被限制在第一个被侵染的寄主细胞内,而不能够向临近细胞扩展。此外,本研究表明Mo UTH1缺失后,对氧化应激胁迫以及渗透胁迫表现更为敏感,暗示Mo UTH1参与氧化胁迫和细胞壁完整性过程。本实验结果表明:Mo UTH1在稻瘟病菌的生长、产孢、致病、应激反应及细胞壁完整性等过程中发挥重要作用。未来我们的研究重点将着重阐明稻瘟病菌侵染过程中Mo UTH1所发挥地确切作用和分子机制。此外,我们还分析了Bax-Inhibitor-1家族蛋白Mo BI-1和Mo BI-1b在稻瘟病菌致病过程中的功能。BI-1为促凋亡蛋白Bax的抑制剂,在动植物中能够抑制细胞的凋亡。在丝状真菌中,BI-1的同源基因分布广泛,但是其具体的生物学功能仍然未知。本研究中,我们在稻瘟病菌中鉴定到了两个Bax-Inhibitor-1的同源蛋白Mo BI-1和Mo BI-1b。敲除Mo BI-1和Mo BI-1b基因后,稻瘟病菌的产孢量下降和致病力减弱,且大部分附着胞仅可以分化形成初级侵染菌丝。亚细胞定位观察表明Mo BI-1和Mo BI-1b定位在线粒体上,进一步分析表明Mo BI-1和Mo BI-1b参与细胞内ATP的合成。Mo BI-1和Mo BI-1b的功能分析为植物真菌的致病分子机制提供了新的认识。

关键词：稻瘟病菌致病力线粒体 SUN家族程序性细胞死亡

Liver pathology of hepatitis C,beyond grading and stagingof the disease

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World Journal of Gastroenterology 2016年第4期22卷 1357-1366页

作者： sadhna Dhingra Stephen C Ward Swan N Thung Department of Pathology and Laboratory Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Hepatopathology Department of PathologyThe Mount Sinai Medical CenterNew YorkNY 10029United States

Liver biopsy evaluation plays a critical role in management of patients with viral hepatitis C. In patients with acute viral hepatitis, a liver biopsy, though uncommonly performed, helps to rule out other nonviral causes of deranged liver function. In chronic viral hepatitis C, it is considered the gold standard in assessment of the degree of necroinflammation and the stage of fibrosis, to help guide treatment and determine prognosis. It also helps rule out any concomitant diseases such as steatohepatitis, hemochromatosis or others. In patients with chronic progressive liver disease with cirrhosis and dominant nodules, a targeted liver biopsy is helpful in differentiating a regenerative nodule from dysplastic nodule or hepatocellular carcinoma. In the setting of transplantation, the liver biopsy helps distinguish recurrent hepatitis C from acute rejection and also is invaluable in the diagnosis of fibrosing cholestatic hepatitis, a rare variant of recurrent hepatitis C. This comprehensive review discusses the entire spectrum of pathologic findings in the course of hepatitis C infection.

关键词： Hepatitis C Liver pathology Biopsy Grading Staging Neoplasia