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Hepatic endogenous defense potential of propolis after mercury intoxication

Integrative Zoology 2008年第4期3卷 311-321页

作者： Monika BHADAURIA Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL sadhana shrivastava Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA Reproductive Biology and Toxicology Laboratory Insect Physiology and Biochemistry School of Studies in ZoologyJiwaji UniversityGwaliorIndia Boston College for Professional Studies GwaliorIndia

Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in *** with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the *** of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis *** activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis *** observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent.

关键词： antioxidant enzymes glutathione hepatoprotection mercuric chloride propolis.

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Oncofertility:Treatment options from bench to bedside

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Cancer Pathogenesis and Therapy 2023年第4期1卷 284-289页

作者： Divya Gupta Shubham Singh Sangeeta Shukla sadhana shrivastava Reproductive Biology and Toxicology Lab SOS in ZoologyJiwaji UniversityGwaliorMadhya Pradesh 474011India Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur(C.G.)495009India

In recent years,there has been continuous improvement in the treatment and diagnosis of cancer,which has led to a significant improvement in the survival rate of cancer *** that include chemotherapy,radiotherapy,surgery,or combined therapy have several side effects that may lead to premature ovarian insufficiency in females or substantial male germ cell *** biologists recommend that all patients who are diagnosed with a malignant tumor must undergo a consultation for fertility protection and *** this review,we discuss the background knowledge,methods,and options for fertility preservation and how these new strategies help oncologists,surgeons,pediatricians,and hematologists,conserve fertility and be aware of the concepts,methods,and importance of fertility *** review may aid in the advancement of novel personalized methods for fertility preservation according to patients’conditions.

关键词： Cancer Fertility preservation Embryo cryopreservation Oncofertility

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