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Chinese Journal of Chemical Engineering 2023年第12期64卷 49-63页

作者： Saptarshi ghosh Kamalesh Sen Priyanka Debnath Arghadip Mondal Naba kumar Mondal Aerosol and Nanoparticle Technology Laboratory Environmental Science and Engineering Department.Indian Institute of Technology BombayMumbai 400076India Environmental Chemistry Laboratory Department of Environmental ScienceThe University of BurdwanW.B 713104India

The objective in this study is to investigate the adsorption-degradation of the methylene blue(MB)dye using a fabricated heterojunction Ag@TiO_(2)*** batch factors used in photo catalytic reactions were pH,UV-irradiation time,temperature,catalytic dosage,and concentration of *** results showed that 0.2×10^(3) g·ml^(-1))of the catalytic dose caused the Ag@TiO_(2)adsorption to degrade by 96.67%with darks and UV *** the Langmuir-Hinshelwood model to determine the kinetic,the Ag@TiO_(2)displays a greater kinetic rate than TiO_(2)and silver nanoparticle(AgNPs).The photocatalytic degradation of MB,which is an endothermic reaction involving all catalysts,is shown by the thermodynamic parameter to have the positive value of enthalpy(ΔH°).The enthalpies observed were Ag@TiO_(2)(126.80 kJ·mol^(-1))

关键词： Heterojunction Ag@TiO_(2)nanocomposite Methylene blue dye Langmuir-Hinshelwood model Scavenger Density functional theoty

Targeting PD-1/PD-L1 in cancer immunotherapy:An effective strategy for treatment of triple-negative breast cancer(TNBC)patients

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Genes & Diseases 2023年第4期10卷 1318-1350页

作者： Sunny kumar Mouli Chatterjee Pratyasha ghosh Kirat K.Ganguly Malini Basu Mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata 700091JadavpurKolkataPIN 700032India Department of Economics Bethune CollegeUniversity of CalcuttaKolkataPIN 700006India Department of Microbiology Michael Madhusudan Memorial CollegeDurgapurPIN 713216India Department of Microbiology Dhruba Chand Halder CollegeUniversity of CalcuttaKolkataPIN 743372India

Maintaining the balance between eliciting immune responses against foreign pro-teins and tolerating self-proteins is crucial for maintenance of *** functions of programmed death protein 1(PD-1)and its ligand programmed death ligand 1(PD-L1)are to inhibit immune responses so that over-reacting immune cells does not cause any damage to its own body ***,cancer cells hijack this mechanism to attenuate immune cells functions and create an immunosuppressive environment that fuel their continuous growth and *** the past few years’rapid development in cancer immunotherapy has opened a new avenue in cancer *** of PD-1 and PD-L1 has become a potential strategy that rescue the functions of immune cells to fight against cancer with high ***,immune checkpoint monotherapies were not very successful,making breast cancer less ***,recent reports support the presence of tumor infiltrating lympho-cytes(TILs)in breast cancer that make it favorable for PD-1/PD-L1 mediated immunotherapy,which is effective in PD-L1 positive ***,anti-PD-1(pembrolizumab)and anti-PD-L1(atezolizumab)gets FDA approval for breast cancer treatment and make PD-1/PD-L1 immunotherapy is meaningful for further ***,this article gathered understand-ing of PD-1 and PD-L1 in recent years,their signaling networks,interaction with other mole-cules,regulations of their expressions and functions in both normal and tumor tissue microenvironments are crucial to find and design therapeutic agents that block this pathway and improve the treatment ***,authors collected and highlighted most of the important clinical trial reports on monotherapy and combination therapy.

关键词： Breast cancer Cancer Clinical trial Immunotherapy PD-1/PD-L1 TNBC

Composition of treatment alliance in bipolar disorder: A cross-sectional study of patients' perspectives

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World Journal of Psychiatry 2022年第6期12卷 814-826页

作者： Rajeet kumar Subho Chakrabarti Abhishek ghosh Department of Psychiatry Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Treatment alliance has an impact on several key patient outcomes in all psychiatric disorders,including bipolar disorder(BD).It has been suggested that the construct of treatment alliance is different among patients from routine psychiatric settings compared to psychotherapeutic ***,research on the composition of treatment alliance in psychiatric disorders,such as BD,is relatively *** To determine whether a broader construct of treatment alliance was prevalent among outpatients with *** This is a cross-sectional study,conducted in the psychiatric unit of a multispecialty hospital in north India over 12 mo(September 2018 to September 2019).A consecutive sample of 160 remitted adult outpatients with BD on mood stabilizers for at least a year were *** principal instrument to assess treatment alliance was the Working Alliance Inventory-client version(WAIClient).Other potential constituents of the alliance explored were perceived trust in clinicians assessed by the Trust in Physicians(TRIP)scale,perceived support from clinicians assessed by the Psychosocial Care by Physicians(PCP)scale,and perceived treatment satisfaction assessed by the Patient Satisfaction Questionnaire(PSQ).Associations between scores on all scales were determined by correlational and multiple regression *** factor analysis of combined items of all scales was conducted using a principal components *** Scores on all the three WAI-Client subscales were significantly correlated with each other(r=0.66-0.81;P<0.0001).The total TRIP scores were associated with the total WAI-Client scores(r=0.28;P<0.01).The total TRIP scores and the total PCP scores were also significantly associated with the WAI-Client scores on the Task subscale(r=0.28-0.29;P<0.01).The total TRIP scores were significantly associated with the total PSQ scores(r=0.45;P<0.0001).Factor analysis yielded two independent and coherent factors,which explained 69%of the va

关键词： Treatment alliance Bipolar disorder Composition Factor-analysis

Chaperone-assisted E3 ligase CHIP:A double agent in cancer

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Genes & Diseases 2022年第6期9卷 1521-1555页

作者： Sunny kumar Malini Basu Mrinal K.ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatSouth 24 ParaganasWest Bengal 743372India

The carboxy-terminus of Hsp70-interacting protein(CHIP)is a ubiquitin ligase and co-chaperone belonging to Ubox family that plays a crucial role in the maintenance of cellular homeostasis by switching the equilibrium of the folding-refolding mechanism towards the proteasomal or lysosomal degradation *** links molecular chaperones ***70,HSP70 and HSP90 with ubiquitin proteasome system(UPS),acting as a quality control *** contains charged domain in between N-terminal tetratricopeptide repeat(TPR)and C-terminal Ubox *** domain interacts with the aberrant client proteins via chaperones while Ubox domain facilitates the ubiquitin transfer to the client proteins for ***,CHIP is a classic molecule that executes ubiquitination for degradation of client ***,CHIP has been found to be indulged in cellular differentiation,proliferation,metastasis and ***,CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies,thus acting as a double ***,in this review,we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of *** addition,we discussed about its architectural alignment,tissue specific expression,sub-cellular localization,folding-refolding mechanisms of client proteins,E4 ligase activity,normal physiological roles,as well as involvement in various diseases and tumor ***,we aim to discuss its importance in HSP90 inhibitors mediated cancer ***,this report concludes that CHIP may be a promising and worthy drug target towards pharmaceutical industry for drug development.

关键词： Chaperones(HSC70/HSP70&HSP90) CHIP Oncogene Therapy Tumor suppressor Ubiquitin proteasome system(UPS)

Spectral narratives of microstructural restyling and their controls on hydrocarbon generation potential from coal

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International Journal of Coal Science & Technology 2023年第3期10卷 167-189页

作者： Tushar Adsul Santanu ghosh Anwita Ojha Sudip Bhattacharyya Atul kumar Varma Coal Geology and Organic Petrology Laboratory Department of Applied GeologyIndian Institute of Technology(Indian School of Mines)DhanbadJharkhand 826004India Department of Geology Mizoram UniversityAizawlMizoram 796004India Specialized Coal Petrography Laboratory Natural Energy ResourcesMission II-BGeological Survey of IndiaDK-6Sector-IlSalt Lake CityKolkataWest Bengal 700091India

The low to medium-rank Tertiary coals from Meghalaya,India,are explored for the first time for their comprehensive micro-structural characterization using the FTIR and Raman ***,results from these coals are compared with the Permian medium and high-rank coals to understand the microstructural restyling during coalification and its controls on hydrocarbon *** coal samples are grouped based on the mean random vitrinite reflectance values to record the transformations in spectral attributes with increasing coal *** aliphatic carbon and the apparent aromaticity respond sharply to the first coalification jump(R:0.50%)during low to medium-rank transition and anchizonal metamorphism of the high-rank ***,the Raman band intensity ratio changes during the first coalification jump but remains invari-able in the medium-rank coals and turns subtle again during the onset of pregraphitization in high-rank coals,revealing a polynomial trend with the coal *** Rock-Eval hydrogen index and genetic potential also decline sharply at the first coalification ***,an attempt to comprehend the coal microstructural controls on the hydrocarbon poten-tial reveals that the Tertiary coals comprise highly reactive aliphatic functionalities in the type I-S kerogen,along with the low paleotemperature(74.59-112.28℃)may signify their potential to generate early-mature ***,the presence of type II-II admixed kerogen,a lesser abundance of reactive moieties,and overall moderate paleotemperature(91.93-142.52℃)of the Permian medium-rank coals may imply their mixed hydrocarbon ***,anchizonal metamorphism,polycondensed aromatic microstructure,and high values of paleotemperature(~334.25 to~366.79℃)of the high-rank coals indicate a negligible potential of producing any hydrocarbons.

关键词： Early mature oil generation Meghalaya high-sulfur coal Type II-S kerogen Microstructural ordering Coalification jump Hydrocarbon generation potential

Scope of machine learning applications for addressing the challenges in next-generation wireless networks

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 395-418页

作者： Raj kumar Samanta Bikash Sadhukhan Hiranmay Samaddar Suvobrata Sarkar Chandan Koner Monidepa ghosh Department of CSE Dr.B.C.Roy Engineering CollegeDurgapurWest BengalIndia Department of CSE Techno International New TownKolkataWest BengalIndia

The convenience of availing quality services at affordable costs anytime and anywhere makes mobile technology very popular among *** to this popularity,there has been a huge rise in mobile data volume,applications,types of services,and number of ***,due to the COVID-19 pandemic,the worldwide lockdown has added fuel to this increase as most of our professional and commercial activities are being done online from *** massive increase in demand for multi-class services has posed numerous challenges to wireless network *** services offered through wireless networks are required to support this huge volume of data and multiple types of traffic,such as real-time live streaming of videos,audios,text,images etc.,at a very high bit rate with a negligible delay in transmission and permissible vehicular speed of the ***-generation wireless networks(NGWNs,i.e.5G networks and beyond)are being developed to accommodate the service qualities mentioned above and many ***,achieving all the desired service qualities to be incorporated into the design of the 5G network infrastructure imposes large challenges for designers and *** requires the analysis of a huge volume of network data(structured and unstructured)received or collected from heterogeneous devices,applications,services,and customers and the effective and dynamic management of network parameters based on this analysis in real *** the ever-increasing network heterogeneity and complexity,machine learning(ML)techniques may become an efficient tool for effectively managing these *** recent days,the progress of artificial intelligence and ML techniques has grown interest in their application in the networking *** study discusses current wireless network research,brief discussions on ML methods that can be effectively applied to the wireless networking domain,some tools available to support and customise efficient mobile system design,and some

关键词： machine learning network control next-generation wireless networks

Enhancement and Function of the Piezoelectric Effect in Polymer Nanofibers

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Accounts of Materials Research 2022年第9期3卷 900-912页

作者： Luana Persano Sujoy kumar ghosh Dario Pisignano NEST Istituto Nanoscienze-CNR and Scuola Normale SuperioreI-56127 PisaItaly Dipartimento di Fisica Universitàdi PisaI-56127 PisaItaly

CONSPECTUS:The realization of intelligent,self-powered compo-nents and devices exploiting the piezoelectric effect at large scale might greatly contribute to improve our efficiency in using resources,albeit a profound redesign of the materials and architectures used in current electronic systems would be *** is a property of certain materials to generate an electrical bias in response to a mechanical *** effect enables energy to be harvested from strain and vibration modes,and to sustain the power of actuators,transducers,and sensors in integrated networks,such as those necessary for the Internet of Thing.

关键词： fibers piezoelectric realization

Preparation of rice fermented food using root of Asparagus racemosus as herbal starter and assessment of its nutrient profle

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Systems Microbiology and Biomanufacturing 2022年第1期2卷 147-156页

作者： Papan kumar Hor Debabrata Goswami Kuntal ghosh Miklós Takó Suman kumar Halder Keshab Chandra Mondal Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biological Sciences Midnapore City CollegeMidnaporeIndia Department of Microbiology Faculty of Science and InformaticsUniversity of SzegedSzegedHungary

The popularity of traditional fermented food products is based on their *** addition of a starter brings consistent,desirable,and predictable food changes with improved nutritive,functional,and sensory *** addition of a mixture of plant residues as a starter or source of microbes is an age-old practice to prepare traditional fermented food and beverages,and most of the reported data on traditional foods were based on the analysis of the fnal *** contribution of an individual starter component(plant residue)is not experimentally substantiated for any traditional fermented food,but this data are very essential for the formulation of an efective *** this study,Asparagus racemosus,which used as a common ingredient of starter for preparation of rice fermented food in the Indian sub-continent,was used as a starter for the preparation of rice fermented food under laboratory scale,and its microbial and nutrient profle was *** fermented product was a good source of lactic acid bacteria,Bifdobacterium sp.,yeast,*** food product was acidic and enriched with lactic acid and acetic acid with titratable acidity of 0.65%.The content of protein,fat,minerals,and vitamins(water-soluble)was considerably *** notably,oligosaccharide(G3-matotriose),unsaturated fatty acids(ω3,ω6,ω7,andω9),and a pool of essential and non-essential amino acids were enriched in the newly formulated ***,the herbal starter-based rice fermented food would provide important macro-and *** could also deliver large numbers of active microorganisms for the sustainability of ***,the selected plant part conferred its suitability as an efective starter for the preparation of healthier rice-based food products.

关键词： Food fermentation Starter Asparagus racemosus LAB Bifdobacterium spp. Macro-and micronutrients

Modelling the potential risk zone of Lantana camara invasion and response to climate change in eastern India

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Ecological Processes 2022年第1期11卷 142-154页

作者： Sharad Tiwari S.N.Mishra Dharmendra kumar Basant kumar S.N.Vaidya Brojo Gopal ghosh Sk Mujibar Rahaman Masjuda Khatun Sanjoy Garai Amit kumar Institute of Forest Productivity LalgutwaRanchi 835303JharkhandIndia Department of IT Govt.of JharkhandJharkhand Space Application CentreRanchiIndia Department of Geoinformatics Central University of JharkhandRanchi 835205JharkhandIndia

Background:The aim of this study is to elucidate the potential risk zones prone to the invasion of perennial ornamental plant Lantana camara,which is native to South America and has invasive tendency in Jharkhand,eastern India,for present(2020)and the future(2050)climatic conditions under four different Representative Concentration Pathways scenarios(RCPs).We analysed the current distribution pattern of *** in the plateau region of eastern India and identified potentially suitable habitats prone to its further infestation in the future under the climate change ***:Results showed the presence of *** invasion in~13%of the geographical area of Jharkhand,Cho-tanagpur plateau which may expand up to 20–26%by 2050 depending upon emission scenarios as characterised by the four *** for the current scenario suggests the dominance of *** in sub-zone V(12.77%under high risk zones(HRZ)and 9.5%under critical risk zones(CRZ))followed by sub-zones IV(6.7%:HRZ;4.19%:CRZ)and VI(2.49%:HRZ;2.14%:CRZ).Future projection(2050)indicates a possible expansion of its distribution range across all agro-climatic sub-zones with dominance in sub-zones V and *** Bio_4(temperature seasonality)was observed as the most contributing factor for the distribution of *** for current and future scenarios across all *** habitat for *** mostly occurred under natural vegetation(66.05%of CRZ and 60.71%of HRZ)and agriculture landscape(29.51%of CRZ and 34.48%of HRZ).Conclusions:The study provides an insight of invasion of *** in the plateau region of eastern India,and reveals wide distribution across all the agro-climatic sub-zones of Jharkhand,mostly in open and disturbed areas under natural vegetation and agriculture *** projections for the year 2050 suggest a continuous increase in the expansion range of invasion across Jharkhand and call for urgent initiatives to combat its further invasion.

关键词： Climate change Forest Invasion Lantana camara Maxent RCPs

Superfluid density dominated junction resistance of bulk polycrystalline YBa_(2)Cu_(3)O_(7−δ) and DyBa_(2)Cu_(3)O_(7−δ) superconductors at low temperature

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Superconductivity 2023年第4期8卷 79-83页

作者： Doyel Rakshit Sourav Das Ajay kumar ghosh Department of Physics Jadavpur UniversityKolkata 700032India

Resistances of grain junctions of bulk polycrystalline YBa_(2)Cu_(3)O_(7−δ)(YBCO) and DyBa_(2)Cu_(3)O_(7−δ)(DyBCO) superconductors have been extracted following(i)Ambegaokar‐Baratoff(AB)and(ii)de Gennes(dG)***–voltage(IV)below the critical temperature(T_(c))has been used to extract transport critical current density(J_(c)).The variations of the junction resistances,(RN)with temperature(T)exhibit that below a critical value of the normalised superfluid density(NSD),junctions become very low resistive and exhibit *** of this feature of RN on the energy gaps has also been *** scattering limit is found to be compatible with the maximum of RN(T)as is observed from the corresponding NSD.

关键词： Junction resistance Superfluid density