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Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

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Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min Gon Kim Changhan Yoon Hyung ham Kim KKirk Shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

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Analysis and Programming of Kernel for Embedded Systems

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Journal of Software Engineering and Applications 2014年第1期7卷 14-26页

作者： Kyumann Im Woonchul ham Division of Electronics and Information Engineering of Chonbuk National University Duckjin-Dong Jeonju-city South Korea

In this study, we present a miniOS kernel implemented via analysis of the context switching, the scheduler, and the memory management of the original OS kernel for an embedded system based on ARM core. Since this is a large subject, we have limited our scope to them only that made up an embedded operating system. The implemented miniOS kernel is composed only by them, to the exclusion of all other functions of the original kernel. Our goal is to modify the OS kernel depending on the product function. The implementation method of the miniOS kernel can be applicable to any OS being mounted based on the ARM core. Modifying the kernel depending on the product function can improve the OS booting speed as well as save the system memory. The functions of the scheduler, the context switching, and the memory management are described with the source in each section. The miniOS kernel was implemented in the Assembly and C language and was verified through the build and the test. The results are shown in the Section 5.

关键词： Context Switching Scheduler Kernel OS Timer Embedded System

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Modification of tooth development by heat shock protein 60

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International Journal of Oral Science 2016年第1期8卷 24-31页

作者： Tamas Papp Angela Polyak Krisztina Papp Zoltan Meszar Roza Zakany Eva Meszar-Katona Paine Terdik Tiinde Chang Hwa ham Szabolcs Felszeghy Department of Anatomy Histologyand EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Scoliosis Research Institute Korea University Guro HospitalSeoul Department of Oral Anatomy Faculty of DentistryUniversity of DebrecenDebrecenHungary

several heat shock proteins have been investigated in relation to tooth development, no available information is available about the spatial and temporal expression pattern of heat shock protein 60 （Hsp 60）. To characterize Hsp 60 expression in the structures of the developing tooth germ, we used Western blotting, immunohistochemistry and in situ hybridization. Hsp 60 was present in high amounts in the inner and outer enamel epithelia, enamel knot （EK） and stratum intermedium （SI）. Hsp 60 also appeared in odontoblasts beginning in the bell stage. To obtain data on the possible effect of Hsp 60 on isolated lower incisors from mice, we performed in vitro culturing. To investigate the effect of exogenous Hsp 60 on the cell cycle during culturing, we used the 5-bromo-2- deoxyuridine （BrdU） incorporation test on dental cells. Exogenously administered Hsp 60 caused bluntness at the apical part of the 16.5-day-old tooth germs, but it did not influence the proliferation rate of dental cells. We identified the expression of Hsp 60 in the developing tooth germ, which was present in high concentrations in the inner and outer enamel epithelia, EK, SI and odontoblasts. High concentration of exogenous Hsp 60 can cause abnormal morphology of the tooth germ, but it did not influence the proliferation rate of the dental cells. Our results suggest that increased levels of Hsp 60 may cause abnormalities in the morphological development of the tooth germ and support the data on the significance of Hsp during the developmental processes.

关键词： enamel organ heat shock protein 60 inhibitor of κB kinase morphology mouse tooth development

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adi优势信号链技术方案助推国产伺服控制系统的崛起

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电子技术应用 2012年第3期38卷 12-13页

作者： adi公司 adi公司

现代工业自动化与运动控制的支撑性技术——伺服系统，在过去几十年中，中国本土企业实现了从起步到全面扩张的发展态势，例如数控系统企业中的广州数控、华中数控，电机和驱动企业中的南京埃斯顿、桂林星辰、东元、珠海运控、和利时电... 详细信息

现代工业自动化与运动控制的支撑性技术——伺服系统，在过去几十年中，中国本土企业实现了从起步到全面扩张的发展态势，例如数控系统企业中的广州数控、华中数控，电机和驱动企业中的南京埃斯顿、桂林星辰、东元、珠海运控、和利时电机、兰州电机厂，运动控制相关企业中的深圳步科、杭州中达，乃至以变频器为龙头产品的台达、汇川、英威腾等企业都已纷纷投身伺服产业并实现了批量化生产，而且占据了中低端市场的绝大部分市场份额，如今更是雄心勃勃地向中高端市场迈进，无不挑动着国际老牌工控巨头的神经。不过，西门子、安川、松下等国外领先供应商也开始大打“性价比”牌，以吸引更多客户，撼动其在中高端市场的地位并非易事。

关键词：伺服控制系统技术 adi 本土企业国产助推信号运动控制

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Effect of Rootstocks on Growth, Yield and Bean Quality of Coffea canephora Clones

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Journal of Agricultural Science and Technology(B) 2013年第6期3卷 429-438页

作者： Aloysius adi Prawoto Fitria Yuliasmara Indonesian Coffee and Cocoa Research Institute (ICCRI) PB. Sudirman 90 Jember Indonesia

Coffee cultivation on dry area lately faces more often drought condition because of global warming effect. One effort to solve the problem is by using tolerant clones or varieties as the rootstocks. The aim of this research is to observe influence of BP 308, BP 409, and Exelsa as rootstocks, on growth, yield and bean quality of BP 409, BP 534, BP 936 and BP 939 clones as scions. The research was conducted in Temanggung district of Central Java, Indonesia, using randomized complete block design with 5 replications 10 plants per replication. The result showed that rootstock influenced stem height and number of branches, leaf relative water content （RWC） during dry season, but not stem diameter. BP 308 and BP 409 rootstocks supplied water more than Exelsa, it seem RWC scion on both rootstocks were higher （82.0%） than that of Exelsa （80.0%）. Exelsa rootstock cause scion grow more slowly, so bean yield was lower than on BP 308 and BP 409. Yield accumulation until 4 years old on Exelsa was 55% to BP 308, and 52.2% to BP 409 rootstock. Yield of BP 939/BP 308 and BP 409/BP 409 （scion/rootstock） tend to the highest. Rootstocks did not influence percentage of normal and abnormal beans and the outturns. Bean outturn was more influenced by clones. Exelsa rootstock improves caffeine content, body, astringent and bitterness characters of scion cherries, but decreases fragrance and aroma characters of scion yield. It is concluded that farther taxonomical relationship of rootstock, their influence on scion growth, yield and cup test characters are stronger.

关键词： Coffeac anephora exelsa rootstock scion relative water content yield caffeine cup quality

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Unified deep learning model for El Niño/Southern Oscillation forecasts by incorporating seasonality in climate data

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Science Bulletin 2021年第13期66卷 1358-1366,M0004页

作者： Yoo-Geun ham Jeong-Hwan Kim Eun-Sol Kim Kyung-Yun On Department of Oceanography Chonnam National UniversityGwangju 61186South Korea Kakao Brain Bundang-guSeongnam-siGyeonggi-do 13494South Korea

Although deep learning has achieved a milestone in forecasting the El Niño-Southern Oscillation(ENSO),the current models are insufficient to simulate diverse characteristics of the ENSO,which depends on the calendar ***,a model was generated for specific seasons which indicates these models did not consider physical constraints between different target seasons and forecast lead times,thereby leading to arbitrary fluctuations in the predicted time *** overcome this problem and account for ENSO seasonality,we developed an all-season convolutional neural network(A_CNN)*** correlation skill of the ENSO index was particularly improved for forecasts of the boreal spring,which is the most challenging season to ***,activation map values indicated a clear time evolution with increasing forecast lead *** study findings reveal the comprehensive role of various climate precursors of ENSO events that act differently over time,thus indicating the potential of the A_CNN model as a diagnostic tool.

关键词： Deep learning ENSO forecasts Seasonality of the ENSO

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Equilibria of Al-N and Nb-N in Molten Iron

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Journal of Iron and Steel Research International 1994年第1期1卷 7-12页

作者： CHEN Xiao Yi, ham Qi Yong, SOMG Bo and WAHG Rong Zhu University of Science & Technology Beijing

The equilibria of Al-N and Nb-N in molten iron at 1600℃ to 1700℃ by using of samplingmethod have been conducted. The thermodynamic parameters obtained areFor the reaction of 1/2N_2=[N] , lgK=-1106/T-0. 771lgK_(aiN) =- 9909/T + 3. 81=- 1 89800- 73.0/T J/mol, =- 0. 530+ 936/TlgK_(NbN)= - 34700/T+ 1 8. 37= - 664650- 352T J/mol, =- 0. 090- 258. 8/T

关键词： liquid iron Al-N equilibrium Nb-N equilibrium thermodynamic parameters

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Comparison of transport coefficients before and after density pump-out induced by resonant magnetic perturbation using a BOUT++ six-field model on the EAST tokamak

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Plasma Science and Technology 2024年第6期26卷 111-119页

作者：邓成成刘子奚夏天阳刘彦君厉鹏程龙飞飞高翔王守信李国强刘海庆臧庆李玖瑛杨康宁吴茗甫尹晓宇李弘谢锦林兰涛毛文哲刘阿娣周楚丁卫星庄革刘万东 the EAST Team Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China

Many experiments have demonstrated that resonant magnetic perturbation(RMP) can affect the turbulent transport at the edge of the tokamak. Through the Experimental Advanced Superconducting Tokamak(EAST) density modulation experiment, the particle transport coefficients were calculated using the experimental data, and the result shows that the particle transport coefficients increase with RMP. In this study, the six-field two-fluid model in BOUT++ is used to simulate the transport before and after density pump-out induced by RMP,respectively referred as the case without RMP and the case with RMP. In the linear simulations,the instabilities generally decreases for cases with RMP. In the nonlinear simulation, ELM only appears in the case without RMP. Additionally, the particle transport coefficient was analyzed,and the result shows that the particle transport coefficient becomes larger for the case with RMP,which is consistent with the experimental conclusion. Moreover, its magnitude is comparable to the results calculated from experimental data.

关键词： BOUT++ resonant magnetic perturbation(RMP) transport coefficients

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GPRS无线数据传输技术

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电子技术应用 2009年第3期35卷 24-25页

作者： adi公司广州致远电子有限公司

上一期介绍了嵌入式系统中的短信技术，短信方式主要适用于数据量不大、交换数据不频繁的场合。这一期将介绍适用于数据传输量较大且交换频繁场合的GPRS数据传输技术。

关键词：无线数据传输技术 GPRS 嵌入式系统数据传输量短信技术短信方式交换数据数据量

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Kidney transplantation in Indonesia: An update

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Asian Journal of Urology 2019年第4期6卷 305-311页

作者： Tommy Supit Eriawan Agung Nugroho Ardy Santosa Moh adi Soedarso Nanda Daniswara Sofyan Rais Addin Department of General Surgery Faculty of Medicine Diponegoro UniversityDr.Kariadi General HospitalSemarangJawa TengahIndonesia Department of Urology Faculty of Medicine Diponegoro UniversityDr.Kariadi General HospitalSemarangJawa TengahIndonesia

Objective:Indonesia has overcome several barriers to the growth of kidney transplantation within the past ***,the procedure is increasingly performed in several centers across the *** there are limited publications on kidney transplantation from Indonesia,especially from centers outside *** study aims to give a brief overview on transplantation performed,discuss current efforts and progresses of transplantation in Indonesia and chiefly ***:Retrospective analysis of 20 transplant cases in Semarang during 2014e2018 was *** from other transplant centers was acquired through formal correspondences with 11 central teaching hospitals in Jakarta,Surabaya,Yogyakarta,Malang,Bali,Solo,Palembang,Aceh,Medan,Bandung,and ***:There were 629 recorded kidney transplantations performed in 12 centers,and we report on 245 cases with viable *** average age of kidney recipients were younger(35.4 years old)compared to the donors(41.3 years old).Approximately half of the kidneys were obtained from related donors(49.0%)and there was only one case of cadaveric *** three leading etiologies of end-stage renal disease were hypertension(37.4%),diabetes mellitus(26.1%),and autoimmune disease(11.3%).There is only one center that has performed more than 100 kidney transplants in ***:Indonesia has successfully overcome several major hurdles that had previously hindered the growth of *** improvement should concentrate on the development of integrated organ transplant infrastructure,decentralization of transplant professionals,establishment of National kidney transplant database and changing the Nation’s paradigm on cadaveric organ donor through public education.

关键词： Kidney transplantation End-stage renal disease Chronic kidney disease Indonesia Semarang Epidemiology Update

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