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Study of first orbit losses of 1 MeV tritons using the Lorentz orbit code in the LHD

Plasma Science and Technology 2019年第2期21卷 21-25页

作者： Kunihiro OGAWA Mitsutaka ISOBE Takeo NISHITANI sadayoshi murakami Ryosuke SEKI Hideo NUGA Neng PU Masaki OSAKABE LHD Experiment Group National Institute for Fusion Science National Institutes of Natural Sciences SOKENDAI (The Graduate University for Advanced Studies) Kyoto University Kyoto-city

Shot-integrated measurement of the triton burnup ratio has been performed in the Large Helical Device. It was reported that the triton burnup ratio, defined as total DT neutron yield divided by total DD neutron yield, increases significantly in inward shifted configurations. To understand the magnetic configuration dependence of the triton burnup ratio, the first orbit loss fraction of 1 MeV tritons is evaluated by means of the Lorentz orbit code for various magnetic configurations. The first orbit loss of 1 MeV tritons is seen at t of less than 10-5 s and loss points of the triton are concentrated on the side of the helical coil case where the magnetic field is relatively weak. The significant decrease of the first orbit loss fraction by 15% is obtained with the inward shift of the magnetic axis position from 3.90 to 3.55 m. It is found that the decrease of first orbit loss is due to the reduction of the first orbit loss of transition and helically trapped tritons.

关键词： the Large Helical Device tritons energetic ion first orbit loss Lorentz orbit code

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Compared with insulin glargine, insulin degludec narrows the day-to-day variability in the glucose-lowering effect rather than lowering blood glucose levels

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Journal of Diabetes Mellitus 2013年第4期3卷 244-251页

作者： Susumu Ogawa Kazuhiro Nako Masashi Okamura Miho Senda Takuya Sakamoto sadayoshi Ito Division of Nephrology Endocrinology and Vascular Medicine Tohoku University Hospital Sendai Japan

Background: Changes in the day-to-day variability in the glucose-lowering effect of insulin [fluctuations of blood glucose levels (BG) seen during the same time period] that occur when insulin glargine (glargine) is replaced with insulin degludec (degludec) have not been sufficiently evaluated. Subjects: Five diabetics with unstable BG undergoing basal-bolus treatment using insulin glargine as basal insulin. Methods: Basal insulin was changed from glargine to same-dose degludec. The subjects’ HbA1c, glycoalbumin, and 1.5-anhydro-D-glucitol were measured before and after the switchover. Fasting blood glucose concentration (FBG) and predinner blood glucose concentration (PDBG) were measured continuously for 28 days immediately before the switchover, and 28 days immediately thereafter, to compare and evaluate 1) the changes in their mean values and standard deviations (SDs) before and after the switchover, and 2) the frequency of appearance of BG of over 180 mg/dL (BG ≥ 180) and under 70 mg/dL (BG Results: The levels of HbA1c, glycoalbumin, FBG’s mean value, SDs, BG ≥ 180 and BG Conclusion: The possibility was shown that degludec, to a greater extent than glargine, suppressed daily fluctuations of FBG and PDBG, suppressed the occurrence frequency of hyperglycemia and hypoglycemia, and exerted more steady hypoglycemic actions.

关键词： Degludec Glargine Hyperglycemia Hypoglycemia The Day-to-Day Variability in the Glucose-Lowering Effect of Insulin

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Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes

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Journal of Diabetes Mellitus 2012年第4期2卷 413-426页

作者： Susumu Ogawa Masato Matsushima Masashi Okamura Miho Senda Takuya Sakamoto Kazuhiro Nako sadayoshi Ito Division of Clinical Epidemiology Jikei University School of Medicine Tokyo Japan Division of Nephrology Endocrinology and Vascular Medicine Tohoku University Hospital Sendai Japan

Aims: We evaluated whether urinary excretion of type IV collagen (U-COL) may predict an increase in the urinary albumin-to-creatinine ratio (ACR) and what factors regulate U-COL in 145 normoalbuminuric patients with type 2 diabetes. Methods: We measured HbA1c, systolic blood pressure (SBP), urinary 8-hydroxydeoxyguanosine (8-OHdG) and monocyte chemoattractant protein (MCP)-1 at start of this study (Baseline), ACR and U-COL in addition to these measurements at one year later (Evaluation-1), and ACR and SBP after two years of the Evaluation-1 (Evaluation-2). The relationships were investigated between the increase of ACR and the U-COL. The effect of angiotensin receptor blockers (ARB) treatment on the correlations between U-COL and ACR at Evaluation-2 on one hand, and between U-COL and percent change of ACR on the other, was also analyzed. Furthermore, we investigated whether the increase in 8-OHdG and in MCP-1 in a year prior to the Evaluation-1 were risk factors of the rise in U-COL levels. Results: Both U-COL and SBP at Evaluation-1, but not ARB treatment, were independent risk factors for an increased ACR after 2 years. ARB treatment significantly suppressed the increase in ACR after 2 years in patients with higher U-COL excretion. The percentage changes in 8-OHdG (%8-OHdG) and MCP-1 (%MCP-1) in one year prior to Evaluation-1 measurements are independent risk factors for U-COL. HbA1c and SBP values one year prior to Evaluation-1 are independent risk factors not only for %8-OHdG but also, for baseline U-COL. The %8-OHdG is an independent risk factor for %MCP-1. Conclusions: U-COL may predict an increase in the ACR. The U-COL seems to be increased with oxidative stress and inflammation induced by past hyperglycemia.

关键词： Type IV Collagen Diabetic Nephropathy Oxidative Stress Monocyte Chemoattractant Protein-1

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Mechanism of Fine Coke Generation under Drum Test

Mechanism of Fine Coke Generation under Drum Test

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Asia Steel International Conference 2012(Asia Steel 2012)

作者： sadayoshi Aizawa Kazuya Uebou Corporate Research ＆ Development Laboratories Sumitomo Metal IndustriesLTD.16-1 SunayamaKamisuIbaraki 314-0255 Japan

＜正＞The behavior of fine coke generation during the drum test was investigated considering the coke breakage mechanism.Change in fine generation rate,its Weibuil analysis and size distribution of fines were examined.Coke fines after the drum test were divided into the following three classes: （1） Under 0.5mm fines generated by compressive breakage of coke matrix. （2） 6 to 15mm fines generated by volume breakage induced by cracks and defects in coke lump. （3） 0.5 to 6mm fines influenced by both compressive breakage and volume breakage. Also,the amount of these fines was related to the coke properties.The amount of 0.5mm under fine and Brinell hardness, which represents the strength of the coke matrix,had good correlation.On the other hand,volume breakage was influenced by the volatile matter content and fluidity of raw coal.

关键词： coke drum index Brinell hardness Weibull analysis

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ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells

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World Journal of Hypertension 2014年第1期4卷 7-14页

作者： Masataka Kudo Ken Matsuda Kaori Sugawara Yuko Iki Naotaka Kogure Takako Saito-Ito Kyoko Shimizu Ikuko Sato Takeo Yoshikawa Akira Uruno Ryo Ito Atsushi Yokoyama Akiko Saito-Hakoda sadayoshi Ito Akira Sugawara Division of Nephrology Endocrinologyand Vascular Medicine Tohoku University Graduate School of Medicine Sendai 980-8574 Japan Department of Molecular Endocrinology Tohoku University Graduate School of Medicine Sendai 980-8575 Japan Department of Pharmacology Tohoku University Graduate School of Medicine Sendai 980-8575 Japan Department of Medical Biochemistry Tohoku University Graduate School of Medicine Sendai 980-8575 Japan

AIM: To investigate the effects of nicotine and nicotine plus angiotensin Ⅱ receptor blocker(ARB) on the gene expression profile of human coronary artery endothelial cells(HCAECs).METHODS: The changes in gene expression profiles in HCAECs treated with nicotine and nicotine plus ARB olmesartan were analyzed by DNA microarray. In nicotine-treated HCAECs, 432 genes selected by P < 0.01 were greater than 1.5-fold compared with the untreated cells. Data were analyzed using IPA(Ingenuity? Systems, ***).RESULTS: The gene expression levels of tumor necrosis factor-α, collagen type 1, matrix metalloproteinase-10, and disintegrin and metalloprotease domain 8, which are related to "cardiovascular function and disease", were significantly increased. In canonical pathway analyses using IPA, "atherosclerosis signaling" was strongly affected by nicotine treatment and this effect was reduced by co-incubation with ARB olmesartan. These data indicate that the deleterious cardiovascular consequences of cigarette smoking may, at least in part, be due to the nicotine-induced gene expression profile related to "atherosclerosis signaling".CONCLUSION: The inhibitory effect of ARB against the nicotine-induced gene expression profile may possibly induce anti-atherosclerotic effects that are independent of those from lowering the blood pressure.

关键词： AngiotensinⅡ Atherosclerosis Microarray Olmesartan Smoking

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