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Toward carbon neutrality by artificial photosynthesis

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Frontiers in Energy 2024年第1期18卷 54-55页

作者： Baowen ZHOU Minhua SHAO Sharif Md.sadaf Shuhui SUN key Laboratory for Power Machinery and Engineering of the Ministry of Education Research Center of Renewable Synthetic FuelSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemical and Biological Engineering Energy InstituteThe Hong Kong University of Science and TechnologyHong KongChina Institut National de la Recherche Scientifique(INRS)-CenterÉnergie Matériaux Télécommunications VarennesQuebec J3X 1P7Canada

CO_(2)is not only the primary cause of climate change but also an abundant and recyclable carbon *** breakthrough in emerging disruptive technologies such as carbon capture and storage(CCS),power-to-X,and direct air capture(DAC)is fundamental to achieving carbon *** these technologies,artificial photosynthesis offers an attractive method for recycling carbon dioxide and water into fuels and chemicals using solar energy(CO_(2)+H_(2)O+sunlight→fuels+chemicals).It holds great promise for addressing the critical challenges associated with elevated CO_(2)concentrations and securing a sustainable supply of fuels and chemicals for economic sectors.

关键词： neutral holds breakthrough

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar sadaf.k.baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

A combined tectono-climatic control on Holocene sedimentation in Ladakh Himalaya,India: Clues from Anisotropy of Magnetic Susceptibility(AMS) of lake sediments

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Journal of Palaeogeography 2024年第4期13卷 738-753页

作者： B.V.Lakshmi k.Deenadayalan Md.Mujahed baba Saumitra Misra Indian Institute of Geomagnetism Discipline of Geological Sciences SAEESUniversity of Kwa Zulu-Natal

Anisotropy of Magnetic Susceptibility(AMS) data from a ～27.8 m thick soft sedimentary mud sequence(～10.5-3.25 k yrs) from the Spituk Palaeolake Sequence(SPSS) of Holocene age, located in the northern bank of the Indus River in the Leh-Ladakh Himalaya, show effects of tectonic versus climate dynamics responsible for the Himalayan sedimentation. The sedimentary sequence, consisting of alternating of aeolian sand and glacio-fluvial mud flow deposits, has been subdivided into an older Last Glacier Phase I(LGP 1) and a younger Last Glacier Phase II(LGP 2), where the termination of each phase is marked by the occurrence of gravel beds of thickness ≤1 m, which were deposited due to glacial melting. The present AMS data along with previously published information on sedimentology confirm that the mudflow deposits of the LGP 1 and LGP 2phases were deposited in a lacustrine environment under glacio-fluvial conditions. However, a weak fluvial flow towards NW and NE could have existed for the LGP 1 and LGP 2, respectively. The glacial beds terminating LGP 1 and LGP 2 appear to have formed by climatic warming and tectonic activity, respectively. Hence, the Holocene Himalayan sedimentation was influenced by both climatic and tectonic activities. However, the thickness of the gravel bed(～0.8 m) terminating LGP 2 occupies only ～ 2.8 vol % of the total studied thickness～28 m, of the SPSS in the present study, which indicated a lesser control of tectonism in the growth of the Himalaya in and around the study area.

关键词： Holocene palaeolake sequence AMS studies Gravel beds Deglaciation Tectonic instability

Divergent consequences of bio-resources on morphological plasticity and biochemical responses in early-stage leguminous species:Sustainable productivity approaches

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Geoscience Frontiers 2024年第3期15卷 312-321页

作者： Taimoor Hassan Farooq Muhammad Farrakh Nawaz Muhammad Qasid Awais Shakoor Irfan Ahmad sadaf Gul khuram Shahzad Xiaoyong Chen Bangor College China A Joint Unit of Bangor University and Central South University of Forestry and TechnologyChangsha 410004China Institute of Environmental Studies University of KarachiKarachi 75270Pakistan Department of Forestry and Range Management University of Agriculture FaisalabadPakistan Hawkesbury Institute for the Environment Western Sydney UniversityPenrithNSW 2751Australia Department of Botany University of KarachiKarachi 75270Pakistan Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesChaoyang DistrictBeijing 100101China College of Arts and Sciences Governors State UniversityUniversity ParkIL 60484USA

Inorganic resources can be detrimental to the environment when *** comparison,organic resources help balance the soil’s carbon and nitrogen(C/N)ratio,enhance soil fertility and benefit ecological *** climate crises,rapid urbanization,and fast population growth are causing many natural forests to be converted to agricultural and industrial lands to fulfill ever-increasing food and developmental *** of different bio-resources becomes necessary for sustainable productivity of available *** study explores the effects of various organic amendments on the growth,morpho-physiological and biochemical attributes of three leguminous tree species:Dalbergia sissoo,Vachellia nilotica,and Acacia ampliceps,concerning sustainable ***-year-old healthy,disease-free,and homogenous seedlings were used as study material in a greenhouse pot *** organic amendments,i.e.,compost(CMP),cow dung(CD),poultry manure(PM),and biochar(BC),along with a control(Ck)treatment,were *** showed that all the organic amendments performed significantly better(Pkes these two biofertilizers a powerful tool for sustainable agricultural *** study contributes toward an enhanced understanding of plant’

关键词： Bio-fertilizers Crop productivity Ecological sustainability Nitrogen fixation Organic cultivation Physiological responses

Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

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Protein & Cell 2024年第9期15卷 661-685页

作者： sadaf Hasan Nabil Ghani Xiangli Zhao Julia Good Amanda Huang Hailey Lynn Wrona Jody Liu Chuan-ju Liu Department of Orthopedic Surgery New York University Grossman School of MedicineNew YorkNY 10016United States Department of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cornell University IthacaNew YorkNYUnited States Department of Biomedical Engineering University of North Carolina Chapel HillChapel HillNC 27599United States New York University NY 14853United States Department of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Department of Orthopedics&Rehabilitation Yale University School of MedicineNew HavenCT 06510United States

Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation,known as *** state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver *** is a glycolytic metabolite and a crucial node in various metabolic ***,its role and molecular mechanism in obesity and associated complications are *** this study,we reported that pyruvate substantially inhibited adipogenic differentiation in vitro and its administration significantly prevented HFD-induced weight gain,white adipose tissue inflammation,and metabolic *** identify the target proteins of pyruvate,drug affinity responsive target stability was employed with proteomics,cellular thermal shift assay,and isothermal drug response to detect the interactions between pyruvate and its molecular ***,we identified cytosolic phospholipase A2(cPLA2)as a novel molecular target of pyruvate and demonstrated that pyruvate restrained diet-induced obesity,white adipose tissue inflammation,and hepatic steatosis in a cPLA2-dependent *** with global ablation of cPLA2 in mice showed that the protective effects of pyruvate were largely abrogated,confirming the importance of pyruvate/cPLA2 interaction in pyruvate attenuation of inflammation and ***,our study not only establishes pyruvate as an antagonist of cPLA2 signaling and a potential therapeutic option for obesity but it also sheds light on the mechanism of its ***’s prior clinical use indicates that it can be considered a safe and viable alternative for obesity,whether consumed as a dietary supplement or as part of a regular diet.

关键词： metabolic disease pyruvate cytosolic phospholipase obesity

Serological Detection,Risk Factor Analysts and Statistical Mapping of Brucellosts in Females of kP Pakistan

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IJLAI Transactions on Science and Engineering

IJLAI Transactions on Science and Engineering 2024年第2期2卷 59-73页

作者： Sidra sadaf Niaz Saddam Hussain Abdul Wali khan University Mardan The University of Agriculture Peshawar

Among the most well-known zoonotic maladies,Brucellosis is the one having a lot of clinical *** is a disease which is caused by a type of bacteria of the genus *** is common in people who work as shepherd,milkman,butcher,knackers and vertinary *** different types of the tests are used to diagnose brucellosis such as(ELISA)Enzyme Linked Immunosorbent Assay,(RBPT)Rose Bengal Plate Test and many *** literature it is evident that the picture of brucellosis is not clear in many countries including *** the aim of the study is to clear the exact status of the disease in the women of agro ecological zones of kP Pakistan.A multistage sampling will be used by dividing kP in different agro ecological zones and blood will be collected from the women who are in close contact with *** serum will be isolated and the samples will be tested for Brucella by commercial serological kits *** kit in the laboratory for the comparison of the disease status in women of different agro ecological zones of kP Pakistan.

关键词： Serological Detection Statistical Mapping Brucellosis Bacteria ELISA

Analyzing co-infection dynamics:A mathematical approach using fractional order modeling and Laplace-Adomian decomposition

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Journal of Biosafety and Biosecurity 2024年第2期6卷 113-124页

作者： Isa Abdullahi baba Fathalla A.Rihan Evren Hincal Department of Mathematical Sciences Bayero UniversityKanoNigeria Department of Mathematical Sciences College of ScienceUAE UniversityAl Ain 15551United Arab Emirates Department of Mathematics Faculty of ScienceHelwan UniversityCairo 11795Egypt Department of Mathematics Near East University TRNCMersin 10Turkey

The co-infection of HIV and COVID-19 is a pressing health concern,carrying substantial potential *** study focuses on the vital task of comprehending the dynamics of HIV-COVID-19 coinfection,a fundamental step in formulating efficacious control strategies and optimizing healthcare ***,we introduce an innovative mathematical model grounded in Caputo fractional order differential equations,specifically designed to encapsulate the intricate dynamics of *** model encompasses multiple critical facets:the transmission dynamics of both HIV and COVID-19,the host’s immune responses,and the influence of treatment *** approach embraces the complexity of these factors to offer an exhaustive portrayal of co-infection *** tackle the fractional order model,we employ the Laplace-Adomian decomposition method,a potent mathematical tool for approximating solutions in fractional order differential *** this technique,we simulate the intricate interactions between these variables,yielding profound insights into the propagation of ***,we identify pivotal contributors to its *** addition,we conduct a meticulous analysis of the convergence properties inherent in the series solutions acquired through the Laplace-Adomian decomposition *** examination assures the reliability and accuracy of our mathematical methodology in approximating *** findings hold significant implications for the formulation of effective control ***,healthcare professionals,and public health authorities will benefit from this research as they endeavor to curtail the proliferation and impact of HIV-COVID-19 co-infection.

关键词： COVID-19 Human immuno deficiency virus Co-infection Laplace-Adomian decomposition method Series solution Convergence

Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura kazuki komatsu kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACkGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

Exploring Critical Thinking Dispositions among Fourth Year BSc Nursing Students of Various Colleges of Nursing, Pakistan

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Open Journal of Nursing 2024年第6期14卷 267-281页

作者： sadaf Younis Najma Balquees Anwar Syeda Fakhar Batool College of Nursing Combined Military Hospital Quetta Pakistan

Background: Critical Thinking (CT) dispositions in nursing are prominent predictors of competence in delivering high-quality care, and of professionalism, in newly graduated nurses. CT skills, in isolation of CT dispositions, do not guarantee success in the workplace, because Critical Thinking Dispositions (CTD) are important elements of intellectual reasoning that simulate a person towards using the CT skills. Therefore, nursing educational programs should promote lifelong learning rather than focusing on transferring the content of nursing knowledge only. And for this purpose, quality education is the key. Education should focus on teaching from diverse perspectives, incorporating various teaching learning strategies that are congruent with the modern era. Purpose: The purpose of this study is to explore critical thinking dispositions among final year Baccalaureate Nursing students of various military colleges of nursing, in Pakistan. Methodology: A descriptive qualitative exploratory study design was used to investigate the CTD of BSc final year nursing students. The study population included twelve willing nursing students, from six military colleges across the country. Demographic information and consent was taken from the participants of the study. In-depth interviews, through a semi structured interview guide, and probes were used to obtain data related to personal experiences of CTD amongst the nursing students. Results: Data analysis showed two broad themes: 1) Perceptions of CT, and 2) Experiences of CT dispositions. In theme one, the emerging category was: Clarity of CT;whereas in theme two, the categories that emerged were: a) Truth Seeking, b) Open Mindedness, c) Inquisitiveness, and d) Self Organization. Conclusion: The findings of the study revealed positive dispositions towards truth seeking, open mindedness, and self-organization, whereas disposition towards inquisitiveness was weak. Self-confidence and maturity also emerged as positive factors that

关键词： Critical Thinking Critical Thinking Disposition Nursing Students