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American Journal of Plant Sciences 2017年第3期8卷 602-614页

作者： Umme Amara Zia ur Rehman Mashwani Ahmad Khan sadaf Laraib Rahmat Wali Uzma Sarwar Qura Tul Ain Sana Shakeel Rahimullah Sohail Department of Botany PMAS-Arid Agriculture University Rawalpindi Pakistan Department of Soil Sciences and Soil Water Conservation PMAS-Arid Agriculture University Rawalpindi Pakistan

Plants from the start are being used for the welfare of human and animals. About 25,000 biological active compounds are reported by different scientists. Plants itself are a complete treatment bioagent. People are still using plants and their decoction for different diseases. Saussurea lappa Clarke is the member of family Compositae. This plant is famous due to its high medical importance. The plant is commonly named as Kuth root or costus and has wide use for anticancer, antiulcer, hepatoprotective, anti-viral, anticonvulsant, antiarthritic, activities. Biologically active substance of in this plant is lactone cynaropicrin, dehydrocostus, germacrene,?lappadilactone. This plant can be used to extract such bioactive compounds which can help the scientist to discover new and potential drugs. Due to such chemical composition and medicinal importance this review has been prepared for the awareness of the people to conserve their medicinal plants which can be used for potential drug discovery.

关键词： Saussurea lappa Biological Active Compounds Medicinal Uses Potential Drug Discovery

A probe into the medicinal potential of Viola canescens-A threatened medicinal plant from Himalaya

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Journal of Coastal Life Medicine 2016年第7期4卷 575-579页

作者： Sidra Sabir Abida Akram Naveed Iqbal Raja Zia-ur-Rehman Mashwani Sohail Huma Mehreen sadaf Mubashir Hussain Iqra Riaz Nabeela Ahmad Ejaz Ahmed Department of Botany PMAS-Arid Agriculture UniversityRawalpindiPakistan

Viola canescens *** *** a perennial herb belonging to family Violaceae,and it is almost cosmopolitan in *** plant is widely used in Ayurveda and Unani medicinal systems for curing various ailments,most commonly for cough and *** studies releaved that this plant is rich in secondary *** plant revealed significant antimicrobial,anti-inflamatory,antioxidant,hepatoprotective,laxative,analgesic as well as antitumor *** to all these important pharmacological activities,market demand of Viola canescens is increasing day by day and this plant is facing tremendous over exploitation and becomes a threatened plant according to International Union for Conservation of Nature and Natural *** present review compiles that the ethnobotanical,phytochemical and pharmacological aspects of the plant need to be conserved.

关键词： Viola canescens Medicinal systems Secondary metabolites Pharmacological activities

Intrinsic Bio-Enhancer Entities of <i>Fagonia cretica</i>for Synthesis of Silver Nanoparticles Involves Anti-Urease, Anti-Oxidant and Anti-Tyosinase Activity

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Advances in Bioscience and Biotechnology 2019年第12期10卷 455-468页

作者： Aqsa Yousaf Ayesha Zafar Muhammad Ali Snober Mona Bukhary Yasmeen Manzoor Tuba Tariq Asma Saeed Muhammad Akram Faryal Bukhari Muhammad Abdullah Syeda sadaf Zehra Shahbaz Gul Hassan Murtaza Hasan Department of Biochemistry and Biotechnology The Islamia University Bahawalpur Pakistan Department of Biological Sciences Gomal University Dera Ismail Khan Pakistan Department of Chemistry The Islamia University Bahawalpur Pakistan Cholistan Institute of Desert Studies (CIDS) The Islamia University Bahawalpur Pakistan Department of Botany The Islamia University Bahawalpur Pakistan College of Information Science and Engineering Zhongkai University of Agriculture and Engineering Guangzhou China

Objective: Evaluating the bio-reducing activity and various potential, annotates the biological entitties of Fagonia cretica. Method: By fractionating the crude extract with different ethanol-water fraction mixture. This substantiates the reduction potential for the biological synthesis of AgNPs, its antioxidant, anti-urease and anti-Tyrosinase activity. Results: UV-visible spectra confirm the bio-reducing potential for Ag NPs with the optimized 50% ethanol-water fraction mixture. Transmission electron microscopy (TEM) confirmed the round shaped AgNPs with an average size of 16 nm in optimized 50% fraction mixture. Further evaluating Ethanol-water fraction with 90% and 70% of plant extract showed more potentials for Anti-Tyrosinase and Anti-urease activity. Moreover, diluted 30% fraction exhibits two folds higher Anti-oxidant and Anti urease activity. Conclusion: Overall, this work showed that 50% Ethanol-water fraction has potentially active molecules (among all fractions) primarily involved in bio-reducing potential of Ag NPs and enzymatic assay while 90% mixture proved to be least active. This study suggested electing the optimum mixture fraction of 50% ethanol-water in order to screen the bioactive compounds and to inculcate their activity status for clinical trials.

关键词： Bioactivity Fagonia cretica Nanoparticles Enzymes Assay Bio Reducing Agent

Thyroglossal Duct Anomalies in Pediatric and Adult Population: A 10-Year Experience in a Tertiary Care Hospital

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Surgical Science 2021年第7期12卷 226-235页

作者： Montasir Junaid Ghaleb Al-Sayed Sayed Agha Ali Shah Hareem U. Khan Ali Mahdi Al Qannass Nadeem W. Malik Yahya Al Kahtani Ahmed Arghabi Abdul Aziz Ali Binhossan sadaf Qadeer Ahmed Department of Otolaryngology-Head and Neck Surgery Armed Forces Hospital Khamis Mushait KSA Department of Pathology Armed Forces Hospital Khamis Mushait KSA Department of Otolaryngology-Head and Neck Surgery Stanford University Palo Alto USA Department of Otolaryngology-Head and Neck Surgery Sir Syed University of Medical Sciences for Girls Karachi Pakistan

Introduction: Thyroglossal duct cyst is a well-recognized congenital midline neck swelling observed in early childhood and rarely in adults. It may reveal itself as a painless cyst, abscess, or as fistula. Several studies have been conducted across the world, but the literature is scarce on its presentation and complications in the Middle East. This indexing study aims to report a 10-year experience with thyroglossal duct cyst (TGDC) presentation, excision, and recurrence at a teaching hospital in Saudi Arabia (KSA). Methods: A retrospective chart review was conducted at the Armed Forces Hospital Southern Region, KSA from December 2008 to December 2018. Data were retrieved from the electronic medical record system of the hospital and validated with the histopathology records. A total of 48 patients diagnosed as TGDC, sinus or fistula were identified. Stata ver. 16.1 was used to analyze the data and results formulated using regression model and Pearson’s chi-square test. Results: The majority of our patients were female (60.4%), and the most common presentation was a midline neck swelling which moved with tongue protrusion. Surgical excision via Complete Sistrunk procedure was the operation of choice in 60.5% followed by excision of the cyst with tract and sinus tract. Previous infection and surgical history contributed to complications in our patients, but no association of age or gender was observed. Patients presenting with infected and discharging cysts were found to be much more likely to develop a recurrence (9 patients). Cysts deep to the hyoid showed more recurrence [n = 7 (78%)] compared to superficial cysts [n = 2 (22%)] and posterior and multi-tract lesions also showed significant recurrence. Conclusion: Despite being a common cause of neck swelling, thyroglossal duct cyst is often missed on physical exams. To reduce complications, timely diagnosis and treatment are necessary.

关键词： Midline Neck Swelling Thyroglossal Duct Cyst Sinus Tract Sistrunk Procedure

Recent advancements in surface plasmon polaritons-plasmonics subwavelength structures in microwave and terahertz regimes

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Digital Communications and Networks 2018年第4期4卷 244-257页

作者： Rana sadaf Anwar Huansheng Ning Lingfeng Mao School of Computer and Communication Engineering University of Science and Technology BeijingBeijing100083China

This paper presents a review of recent investigational studies on exciting Surface Plasmon Polaritous (SPPs)in MicroWave (MW)and TeraHertZ (THz)regimes by using subwavelength corrugated patterns on conductive or metal *** article also describes SPP Microstrip (MS)structures at microwave and terahertz frequencies, and compares their significance with that of conventional MS Transmission Lines (TL),in order to tackle the key challenges of high gain,bandwidth size,compactness,TL losses,and signal integrity in high-end electronic de- *** they have subwavelength properties,surface plasmon polaritous are gaining attention for their improved performance and ability for miniaturization in high-speed dense *** possess comparably minuscule wavelength compared to incident light (photons).Consequently,they can demonstrate stronger spatial confinement and higher local field intensity at optical *** addition to engineering spoof SPP waveguides,which are created by engraving grooves and slits on metal surfaces to allow operation on at low frequencies (microwave and terahertz),semiconductors with smaller permittivity values and thus lower free charge carrier concentration have been demonstrated as a potential candidate in plasmonic *** necessary,further tuning of semiconductor-based SPP structures is aided by controlling the charge carrier concentration through doping,or by external stimuli such as optical illumination or thermal excitation of charge carriers from valence to conduction *** article conclusively covers previously elucidated perspectives on manipulating SSPPs in the MW and THz ranges,and emphasizes how these could steer next-generation plasmonic devices.

关键词： Surface Plasmons Subwavelength Metamaterials Plasmonics Terahertz Microwave

Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence

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World Journal of Clinical Pediatrics 2016年第2期5卷 212-222页

作者： sadaf I Bhayat Harsha MS Gowda Michael Eisenhut Neonatal and Paediatric Department Luton and Dunstable NHS Foundation Trust

AIM: To determine if dopamine is effective in treating neonatal hypotension and safe to use comparing to other inotropes. METHODS: This is a review of evidence on inotropic treatment of neonatal hypotension. Databases searched were MEDLINE and the Cochrane Library, a total of 134 studies were identified. Only studies with high quality evidence(level 1a and b and 2a) were included. After review, only eight studies were included in the final analysis. Pooled risk ratios derived for each outcome [Mantel-Haenzel(M-H) fixed effect] with CI, as reported in the Cochrane reviews were plotted in forest plot form. RESULTS: Eight articles met inclusion criteria, which all included treatment in preterm infants. Dopamine increased mean arterial blood pressure(BP)(n = 163; r = 0.88, 95%CI: 0.76 to 0.94) and systolic BP(n = 142; r = 0.81, 95%CI: 0.42 to 0.94) comparing to placebo. Dopamine has been shown overall to be statistically more effective in increasing BP than dobutamine(n = 251, r = 0.26, 95%CI: 0.20-0.32). However there were no differences in short term outcomes(periventricular leucomalacia, periventricular haemorrhage) and mortality between both drugs. There is no statistical evidence of dopamine being more effective than adrenaline or corticosteroids. There was no difference in morbidity and mortality outcomes when dopamine was compared to hydrocortisone(RR 1.81, 95%CI: 0.18 to 18.39) or adrenaline. CONCLUSION: In preterms, dopamine is the most studied drug, and we suggest it could be used as first line treatment in hypotension.

关键词： Hypotension Preterm Inotrope Dopamine Dobutamine Adrenaline/epinephrine Corticosteroids

Pancreaticoduodenectomy:A study from India on the impact of evolution from a low to a high volume unit

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World Journal of Gastrointestinal Surgery 2016年第8期8卷 583-589页

作者： Omar J Shah Manmohan Singh Mohammad R Lattoo sadaf A Bangri Department of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences

AIM To analyse the impact of turning of our department from a low to a high volume provider of pancreaticoduodenectomy(PD) on surgical *** A retrospective collection of data was done for patients who underwent *** to the number of PDs undertaken per year,we categorized the volume into low volume( 25 PDs/year) *** From 2002 to 2013,200 patients underwent *** annual number of PD increased from 4 in 2002 to 34 in *** mean operative time,operative blood loss and need for intraoperative blood transfusion decreased considerably over the volume categories(P < 0.001,P < 0.001 and P < 0.001,respectively).Increased procedural volume was associated with a lower morbidity(P = 0.021) and shorter length of hospital stay(P < 0.001).Similarly the rate of mortality dropped from 10% for the low volume group to 2.2% for the medium volume group and 0.0% for the high volume group(P = 0.007).CONCLUSION The transformation from a low volume to a high volume provider of PD resulted in most favourable outcomes favouring the continued centralization of this high risk procedure.

关键词： Pancreaticoduodenectomy High volume centre

MRI导引下真空辅助乳腺活检所诊断的高危病灶:低估是否可预测?

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国际医学放射学杂志 2011年第3期 296-297页

作者： P.Crystal A.sadaf K.Bukhanov D.McCready F.Malley T.H.Helbich 孙海涛 Division of Breast Imaging Mount Sinai Hospital and University Health Network600 University AvenueM5G 1X5TorontoONCanada

目的评价MRI导引下真空辅助乳腺活检(MRgVABB)诊断高危病灶的频率和确定低估是否可被预测。方法回顾性分析161例MRgVABB病人的医学记录,其

关键词：真空辅助乳腺活检乳腺MRI MRI导引下乳腺活检高危乳腺病灶低估

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BlueGene／P的早期评估

中国教育网络 2009年第1期 31-31页

作者： sadaf Alam Richard Barrett

BlueGene/P（BCP）是IBM继BlueGen／L后的第二代BlueGene体系结构。BGP是一个单芯片系统（SoC），使用4个超级PC，450个850MHz、拥有双倍精度、双管道浮点运算单元的核心。这些芯片由多连接网络互相连接，包括一个3-D环．一个全局的共... 详细信息

BlueGene/P（BCP）是IBM继BlueGen／L后的第二代BlueGene体系结构。BGP是一个单芯片系统（SoC），使用4个超级PC，450个850MHz、拥有双倍精度、双管道浮点运算单元的核心。这些芯片由多连接网络互相连接，包括一个3-D环．一个全局的共享网络，一个全局的屏障网络。这篇论文我们汇报了BGP在一些重要科学程序上的验证，以及与其它目前使用的主要大规模超级计算机的对比。我们的调查证明BGP有很好的扩展性以及在某些内核上很低的单次浮点运算耗能，

关键词：单芯片系统评估早期共享网络超级计算机 BGP 体系结构第二代