检索结果-南通市图书馆

Inherited cardiomyopathies caused by troponin mutations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2013年第1期10卷 91-101页

作者： Qun-Wei Lu Xiao-Yan Wu sachio Morimoto Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and Technology Center for Human Genome Research Huazhong University of Science and Technology Wuhan 430074 China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Clinical Pharmacology Graduate School of Medical Sciences Kyushu University Fukuoka 812-8582 Japan

Genetic investigations of cardiomyopathy in the recent two decades have revealed a large number of mutations in the genes encoding sarcomeric proteins as a cause of inherited hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), or restrictive cardiomyopathy (RCM). Most functional analyses of the effects of mutations on cardiac muscle contraction have revealed significant changes in the Ca2+-regulatory mechanism, in which cardiac troponin (cTn) plays important structural and functional roles as a key regulatory protein. Over a hundred mutations have been identified in all three subunits of cTn, i.e., cardiac troponins T, I, and C. Recent studies on cTn mutations have provided plenty of evidence that HCM- and RCM-linked mutations increase cardiac myofilament Ca2+ sensitivity, while DCM-linked mutations decrease it. This review focuses on the functional consequences of mutations found in cTn in terms of cardiac myofilament Ca2+ sensitivity, ATPase activity, force generation, and cardiac troponin I phosphorylation, to understand potential molecular and cellular pathogenic mechanisms of the three types of inherited cardiomyopathy.

关键词： Calcium sensitivity Cardiomyopathy Muscle contraction Troponin

维普期刊数据库

The heat flow profile from Manzhouli to Suifenhe, China

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1995年第19期40卷 1634-1637页

作者：金旭 Ehara sachio 许惠平 Changchun University of Earth Sciences Changchun 130026 China Faculty of Engineering Kyushu University Fukuoka Japan

The transect from Manzhouli to Suifenhe is one of 11 geoscience transects in China,which are defined by Chinese Commission on the Lithosphere to practise the Global Geosciences Transects Project (GGT). It will help us establish lithosphere dynamics model of continental margin around the west Pacific ocean by investigating the structure

关键词： heat flow profile heat flow thermal structure mantle heat flow.

维普期刊数据库

Geochemical and stable isotopic studies of Gulf of Suez’s hot springs,Egypt

在线全文

学校读者我要写书评

暂无评论

Chinese Journal Of Geochemistry 2012年第2期31卷 120-127页

作者： Mohamed Abdel Zaher Hakim Saibi sachio Ehara Laboratory of Geothermics Department of Earth Resources EngineeringFaculty of EngineeringKyushu University Nathional Research Institute of Astronomy and Geophysics Laboratory of Exploration Geophysics Department of Earth Resources EngineeringFaculty of EngineeringKyushu University

The Gulf of Suez region is one of the most interesting geothermal areas in Egypt because of the high temperatures of its *** eastern and western shores of the Gulf of Suez are characterized by superficial thermal manifestations including a cluster of hot springs with varied *** of deuterium and oxygen-18 concentrations in thermal waters have been used to aid in describing the source of recharge in the Gulf of Suez hot *** and geochemical data for the Gulf of Suez thermal waters suggest that recharge to the hot springs may not be entirely from the Gulf of Suez water,but possibly from the meteoric water that comes from areas of higher altitude surrounding the hot springs.

关键词：地球化学资料苏伊士湾稳定同位素温泉水埃及高海拔地区海湾地区大气降水

维普期刊数据库

Cone-Beam Computed Tomography Evaluation of the Positions of Unerupted Maxillary Canines with Incisor Root Resorption

在线全文

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2017年第3期7卷 169-179页

作者： sachio Tamaoki Hiroyuki Ishikawa Kyoko Oka Masao Ozaki Akiko Abe Shunsuke Takata Shozaburo hata Section of Orthodontics Department of Oral Growth & Development Division of Clinical Dentistry Fukuoka Dental College Fu-kuoka Japan Fukuoka Dental College Fukuoka Japan Section of Pediatric Dentistry Department of Oral Growth & Development Division of Clinical Dentistry Fukuoka Dental College Fukuoka Japan

Purpose: To establish a new coordinate system using the incisive canal and incisive foramen in cases confirmed to have root resorption in the maxillary incisor region by cone beam computed tomography (CBCT) to investigate the positions of the central and lateral incisor roots and erupting maxillary canine tooth crowns in the horizontal plane. Methods: Nine patients (two males;mean age: 10.5 years old) with suspected incisor root resorption due to erupting maxillary canines on panoramic X-ray images and in whom incisor root resorption was confirmed on CBCT images were evaluated. A control group of 12 patients with a supernumerary tooth on one side (three males;mean age: 8.6 years old) was also examined. X, Y, and Z-axes were defined, and the positions of the centers of the central incisor root (U1) and lateral incisor root (U2) and the canine cusp (U3) were examined, along with alveolar process width and length. Results: In the control group, U1, U2, and U3 were located within a certain range without overlap, while, in the incisor root resorption group, U3 overlapped with U1 and U2 and tended to deviate centrally. U2 tended to be located further posteriorly than U3. The anteroposterior diameter of the alveolar process was 1.2 mm shorter in the incisor root resorption group (p < 0.05). Conclusions: The risk of incisor root resorption accompanying canine eruption can be evaluated early by investigating the canine position on a horizontal plane established on the upper anterior tooth dentition CT images with a coordinate system using the incisive canal and incisive foramen.

关键词： CBCT Incisor Root Resorption Maxillary Canine Incisive Canal Alveolar Process

DEVELOPMENT AND FUTURE PROSPECTS OF BIOSENSOR MEMBRANES FOR ANALYSIS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物工程学报 1986年第3期 1-15页

作者： Shuichi Suzuki sachio Hirose Saitama Institute of Technology Tokyo Mitsubishi Petrochemcal Co. Ltd. Japan

(一)INTRODUCTIONIn recent years,the development of a sensor capable of detecting andanalyzing a variety of components with little effort is being watched *** function of the chemical sensor,that of specifically identi-

关键词： BM DEVELOPMENT AND FUTURE PROSPECTS OF BIOSENSOR MEMBRANES FOR ANALYSIS

Application of Fe-Ni-W Plated Film Electrode to Zinc-Air Battery

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2019年第12期7卷 57-64页

作者： sachio Yoshihara Hikari Ohtake Jiu Sasaki Graduate School of Engineering Utsunomiya University Utsunomiya Japan

This study was aimed at the preparation of an electrode for Zinc–air battery, which had excellent catalytic activity by use of electroplating of alloys made of abundant metal, such as Fe and Ni. The oxygen overvoltage of the Fe-Ni-W alloy plated electrode was the smallest through the measurement. The elemental composition and the enlargement of the surface area were confirmed by SEM and EDX analysis. Involvement of Fe and W of Fe-Ni-W alloy plated electrode will be one factor for its high catalytic activity. Thus plated Fe-Ni-W alloy electrodes were compared with other Fe alloy plated elec-trodes considering to their cathode performance as Zinc-air battery. The catalytic activity of Fe-Ni-W plated electrode showed the best performance comparing to Fe-Ni alloy plated electrodes as cathode for Zinc-air battery. Also comparing to the platinum electrode which had been widely used as cathode in the field of Zinc-air battery, the Fe-based alloy plated electrode showed better performance as the electrodes considering to its oxygen evolution reaction.

关键词： Fe-Ni-W Alloy Electroplating Zinc-Air Battery Oxygen Evolution Reaction (OER)

Life prognosis of sentinel node navigation surgery for early-stage gastric cancer:Outcome of lymphatic basin dissection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第46期27卷 8010-8030页

作者： Shinichi Kinami Naohiko Nakamura Tomoharu Miyashita Hidekazu Kitakata sachio Fushida Takashi Fujimura Yasuo Iida Noriyuki Inaki Toru Ito Hiroyuki Takamura Department of Surgical Oncology Kanazawa Medical UniversityKahoku 920-0293IshikawaJapan Department of Gastroenterological Endoscopy Kanazawa Medical UniversityKahoku 920-0293IshikawaJapan Department of Gastrointestinal Surgery Kanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Surgery Toyama City HospitalToyama 939-8511ToyamaJapan Department of Mathematics Division of General EducationKanazawa Medical UniversityKahoku 920-0293IshikawaJapan

BACKGROUND Lymphatic basin dissection is a sentinel node biopsy method that is specific for gastric *** this method,the dyed lymphatic system is dissected en bloc,and sentinel nodes are identified at the back table(ex vivo).Even with lymphatic basin dissection,blood flow to the residual stomach can be preserved,and functionpreserving curative gastrectomy can be *** oncological safety of function-preserving curative gastrectomy combined with lymphatic basin dissection has not yet been fully *** hypothesized that the oncological safety of sentinel node navigation surgery(SNNS)is not inferior to that of the *** To investigate the life prognosis of SNNS for gastric cancer in comparison with guidelines *** This was a retrospective cohort *** were selected from gastric cancer patients who underwent sentinel node biopsy from April 1999 to March *** from April 1999 to August 2008 were from the Department of Surgery II,Kanazawa University Hospital,and patients from August 2009 to March 2016 were from the Department of Surgical Oncology,Kanazawa Medical University *** who were diagnosed with gastric cancer,which was preoperatively diagnosed as superficial type(type 0),5 cm or less in length,clinical T1-2 and node negative,and underwent various gastrectomies guided by sentinel node navigation were retrospectively *** overall survival(OS)and relapsefree survival(RFS)of these patients(SNNS group)were *** with gastric cancer of the same stage and who underwent guidelines gastrectomy with standard nodal dissection were also selected as the control *** A total of 239 patients in the SNNS group and 423 patients in the control group were *** nodal metastasis was observed in 10.5%and 10.4%of the SNNS and control groups,*** diagnostic abilities of sentinel node biopsy were 84%and 98.6%for sensitivity and accuracy,*** the

关键词： Early gastric cancer Sentinel node biopsy Function preserving surgery Lymph node dissection Gastrectomy Lymphatic basin dissection

The Difference in Gait Regulation Strategies Between Successful and Failed Pole Vault Performance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sports Science 2017年第4期5卷 211-214页

作者： Yuji Tamura Hiroyuki Nunome sachio Usui Faculty of Sports and Health Science Fukuoka University Jonan-ku Nanakuma Fukuoka 814-0180 Japan Graduate School of Integrated Arts and Science Hiroshima University Kagamiyama Higashi-Hiroshima 739-8521 Japan

This study aimed to investigate the difference in gait regulation strategy of pole vault approach runs between successful and failed trials. Five male junior pole vaulters completed full vaulting to 90%-95% personal best height. These trials were categorized into successful and failed trials. Step length and the distance from toe to the planting box were obtained using a two dimensional direct linear transformation procedure. In successful trials, standard deviations of the toe-box distance （SDTB） at the last step and take-off of were significantly smaller than those of failed trials （P 〈 0.05）. We observed a clear difference in gait regulation strategy between successful and failed trials, thereby suggesting that to minimize the fluctuations of the toe-box distance immediately before the take-off is a key gait regulation strategy for successful pole vault performance.

关键词： Approach run adjustment accurate pole vault.

Atypical lipomatous tumor in the ligamentum teres of liver:A case report and review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2018年第12期6卷 548-553页

作者： Daisuke Usuda Kento Takeshima Ryusho Sangen Kisuke Nakamura Kei Hayashi Hideyuki Okamura Yasuhiro Kawai Yuji Kasamaki Yoshitsugu Iinuma Hitoshi Saito Tsugiyasu Kanda sachio Urashima Department of Community Medicine Kanazawa Medical University Himi Municipal Hospital Department of Infectious Diseases Kanazawa Medical University Department of General and Digestive Surgery Kanazawa Medical University Himi Municipal Hospital Department of Gastroenterology Kanazawa Medical University Himi Municipal Hospital

A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Dynamic computed tomography revealed a highly enhanced effect from the portal-venous phase continuing to the equilibrium phase. T1-weighted gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced image revealed a high intensity effect at the early phase that continued to the next phase. On the other hand, it contained a low intensity area by a fat suppression of that image. In addition, a T2-weighted image did not show a high intensity effect. Laparotomy was performed on the second day of hospitalization. The tumor had arisen from the ligamentum teres of the liver, and no metastasis or invasion of other organs was noted. It consisted of a lipid component of mature adipocytes and a fibrous component of deep dyeing pleomorphic or multinuclear atypical stromal cells. Immunohistochemical study of the atypical stromal cells demonstrated that they were positive for MDM2 and CDK4. A pathological diagnosis of atypical lipomatous tumor(ALT) was made, and the patient was discharged on the eighth day following the procedure. At the 6-mo follow-up dynamic CT, the patient was free of recurrence or metastasis. We experienced a patient with ALT in the ligamentum teres of the liver. This case suggests the need for a careful and detailed examination when encountering patients presenting with a mass; when neoplastic lesion is confirmed by image inspection, we should thoroughly investigate, including further image investigations and pathologic examination. The latter is the most important.

关键词： Liposarcoma Atypical lipomatous tumor Malignant adipose mesenchymal tumor Ligamentum teres of liver Operation