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Protection of Viola odorata *** Neurodegenerative Diseases:Potential of the Extract and Major Phytoconstituents

Clinical Complementary Medicine and Pharmacology 2023年第3期3卷 78-89页

作者： Sunny Dhiman Shivali Singla Inder Kumar Priyankul Palia Pankaj Kumar sachin goyal Department of Pharmacology School of PharmacyAbhilashi UniversityChail-Chowk 175028Himachal PradeshIndia Department of Pharmaceutics School of PharmacyAbhilashi UniversityChail-Chowk 175028Himachal PradeshIndia Department of Pharmaceutical Chemistry School of PharmacyAbhilashi UniversityChail-Chowk 175028Himachal PradeshIndia

Background:Neurodegenerative diseases cause cognitive impairment owing to neuronal death and *** a few brain-protecting chemical investigations yielded neuroprotective *** odoata *** a traditional medicinal herb that has lately been shown to have strong pharmacological effectiveness against major neurological illnesses with fewer adverse ***:The objective of the current review is to provide a thorough overview of the key biologically active components and extract of Viola odorata *** their capacity to safeguard nerve ***:Science Direct,PubMed,Springer Nature,and Google Scholar were scoured for relevant articles using the terms“Viola odorata L.”,and in the heading and abstract or main text,“neuroprotective activity”,“neurode-generative disease”,“pharmacological potential”,and“therapeutic activity”along with“extract”or“phytocon-stituents”.Neuroprotective activity of Viola odorata *** or phytoconstituents were used to classify and investigate the articles that passed the screening ***:A total of one hundred twenty one papers were reviewed based on the collected *** following topics have been elaborated upon in the text:pathological factors of neurodegenerative diseases;role of medic-inal plants in neurodegenerative diseases;Viola odorata ***,pharmacological activities,toxicity and adverse effect;neuroprotective activity of extract and various active components of Viola odorata *** primary phytocomponents of Viola odorata *** discovered to be anthocyanins,flavonoids,melatonin,salicylic acid,cumarins and various alkaloids,which are primarily responsible for its neuroprotective *** natural plant compounds can boost antioxidant levels,reduce harmful oxidants,alleviate nerve pain,decrease the pro-duction of pro-inflammatory cytokines such as IL-6,IL-1β,and TNF-α𝛼,lower the total amount of nitrite produced,and trigger various neuroprotective mechanisms in the nervous ***

关键词： Viola odorat L. Neuroprotective effect Antioxidant activity Neurological disease

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Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells

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World Journal of Stem Cells 2016年第9期8卷 279-287页

作者： sachin goyal Pratima Nangia-Makke Lulu Farhana Yingjie Yu Adhip PN Majumdar Department of Internal Medicine John D Dingell VA Medical Center Detroit MI 48201 United States Department of Internal Medicine Wayne State University Detroit MI 48201 United States Karmanos Cancer Institute Wayne State University School of Medicine Detroit MI 48201 United States

Over the past two decades there has been remarkable progress in cancer diagnosis, treatment and screening. The basic mechanisms leading to pathogenesis of various types of cancers are also understood better and some patients, if diagnosed at a particular stage go on to lead a normal pre-diagnosis life. Despite these achievements, racial disparity in some cancers remains a mystery. The higher incidence, aggressiveness and mortality of breast, prostate and colorectal cancers(CRCs) in AfricanAmericans as compared to Caucasian-Americans are now well documented. The polyp-carcinoma sequence in CRC and easy access to colonic epithelia or colonic epithelial cells through colonoscopy/colonic effluent provides the opportunity to study colonic stem cells early in course of natural history of the disease. With the advent of metagenomic sequencing, uncultivable organisms can now be identified in stool and their numbers correlated with the effects on colonic epithelia. It would be expected that these techniques would revolutionize our understanding of the racial disparity in CRC and pave a way for the same in other cancers as well. Unfortunately, this has not happened. Our understanding of the underlying factors responsible in African-Americans for higher incidence and mortality from colorectal carcinoma remains minimal. In this review, we aim to summarize the available data on role of microbiome and cancer stem cells in racial disparity in CRC. This will provide a platform for further research on this topic.

关键词： Colorectal cancer Cancer stem cells Racial disparity Microbiome MiRNA

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Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample

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World Journal of Gastrointestinal Endoscopy 2019年第10期11卷 504-514页

作者： Tooba Tariq Patrick Karabon Furqan B Irfan sachin goyal Matthew Masaru Mayeda Austin Parsons Stephanie Judd Murray Ehrinpreis Department of Internal Medicine Western Michigan University Homer Stryker M.D.School of MedicineKalamazooMI 49008United States Oakland University William Beaumont School of Medicine Oakland UniversityDetroitMI 48309United States College of Osteopathic Medicine Michigan State UniversityEast LansingMI 48824United States 不详 Department of Internal Medicine Division of GastroenterologyJohn D Dingell VA Medical CenterDetroitMI 48201United States

BACKGROUND Chronic kidney disease is associated with angiodysplasia of gastrointestinal tract leading to increased risk of gastrointestinal *** To determine the nationwide prevalence,trends,predictors and resource utilization of angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease *** The Nationwide Inpatient Sample database from 2009 to 2014,was utilized to conduct a retrospective study on patients with angiodysplasia associatedgastrointestinal bleeding and end-stage renal *** with endstage renal disease were included in the Nationwide Inpatient Sample database and a subset of hospitalizations with end-stage renal disease and angiodysplasiaassociated gastrointestinal bleeding were identified with International Classification of Diseases,9th revision,Clinical Modification codes for both endstage renal disease(585.6)and angiodysplasia(569.85,537.83).RESULTS The prevalence of angiodysplasia-associated gastrointestinal bleeding was 0.45%(n=24709)among all end-stage renal disease patients(n=5505252)that were *** analysis indicated that the following were significant factors associated with higher odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease patients:an increasing trend from 2009-2014(P<0.01),increasing age(P<0.0001);African American race(P=0.0206);increasing Charlson-Deyo Comorbidity Index(P<0.01);hypertension(P<0.0001);and tobacco use(P<0.0001).Diabetes mellitus(P<0.0001)was associated with lower odds of angiodysplasia associated-gastrointestinal bleeding in end-stage renal disease *** comparison with urban teaching hospitals,rural and urban nonteaching hospitals were associated with decreased odds of angiodysplasia associated-gastrointestinal *** Angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease patients showed an increasing trend from *** age,African American

关键词： Angiodysplasia Renal Gastrointestinal Hemorrhage

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Giant idiopathic renal arteriovenous fistula managed by coils and amplatzer device:Case report and literature review

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World Journal of Clinical Cases 2016年第11期4卷 364-368页

作者： Prashant Nagpal Girish Bathla sachin S Saboo Ashish Khandelwal Abhishek goyal Frank J Rybicki Michael L Steigner Department of Radiology University of Iowa Hospitals and Clinics Department of Radiology Brigham and Women’s HospitalHarvard Medical School Department of Radiology Cardiothoracic ImagingUT Southwestern Medical Center Department of Internal Medicine Westchester Medical CenterNew York Medical College

An idiopathic renal arteriovenous(AV) fistula is a rare malformation of the kidney that may present insidiously with heart failure or *** treatment may be challenging due to large fistula size that may limit endovascular *** authors report a case of an 85-year-old Caucasian woman who presented with acute heart failure and was found to have a right renal AV *** she had no prior history of renal intervention or trauma,a diagnosis of idiopathic renal AV fistula was *** was managed by endoluminal occlusion using multiple stainless steel coils and Amplatzer vascular plug II *** follow-up computed tomography showed complete occlusion of the *** report highlights the late presentation of this rare disease and presents the utility of the combination of coils and Amplatzer device for management of a large *** also reiterates that even if large,these fistulas can be managed by endovascular occlusion.

关键词： Heart failure Idiopathic Arteriovenous fistula Endovascular management Amplatzer device

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Malignant peripheral nerve sheath tumor of proximal third tibia

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World Journal of Clinical Oncology 2015年第5期6卷 179-183页

作者： Arunkumar Rao sachin B Ingle Pawan Rajurkar Vishav goyal Nikhil Dokrimare Department of Orthopedics Maharashtra Institute of Medical Sciences and ResearchMedical College Department of Pathology Secretary Research and Development and Institutional Review BoardMaharashtra Institute of Medical Sciences and ResearchMedical College

A 16-year-old man had aswelling over the anterior aspect of the proximal third of the tibia for 1 year, which was peanut size initially and progressively increased to its present size of 10 cm × 8 cm. He underwent fine needle aspiration cytology(FNAC) twice during this period and reported aspindle cell sarcoma. Malignant peripheral nerve sheath tumor(MPNST) is a malignancy of the connective tissue surrounding the nerves. Previously, MPNST was also known as neurofibrosarcoma, malignant schwannoma, andneurogenic sarcoma. We are reporting this case for its rarity and peculiar mode of presentation. FNAC/core biopsy can be used as an effective tool to achievethe correct pathological diagnosis.

关键词： Tibial malignant peripheral nerve sheath tumor Fine needle aspiration cytology Histopathology

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