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Cardiac papillary fibroelastoma:The need for a timely diagnosis

World Journal of Clinical Cases 2017年第1期5卷 9-13页

作者： Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg sachin sule Wilbert S Aronow Department of Internal Medicine New York Medical College at Westchester Medical Center Department of Pathology New York Medical College at Westchester Medical Center Department of Cardiology New York Medical College at Westchester Medical Center

Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature.

关键词： Lambl’s excrescences Aortic valve Cardiac tumors Cardiac papillary fibroelastoma Sudden cardiac death

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Bilirubin in coronary artery disease:Cytotoxic or protective?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 469-476页

作者： Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin sachin sule Department of Medicine Westchester Medical CenterNew York Medical College Department of Medicine Cleveland Clinic Department of Medicine Sinai Hospital of BaltimoreJohns Hopkins University Department of Medicine University of Minnesota Department of Medicine University of Pittsburgh Einstein Healthcare Network Government Medical College Division of Gastroenterology and Hepatobiliary Disease New York Medical College

Bilirubin has traditionally been considered a cytotoxic waste ***,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative *** properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative *** fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of *** this article,we review the current literature exploring the association between levels of bilirubin and risk of *** conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.

关键词： Bilirubin Cytotoxic Protective Anti-oxidant Anti-inflammatory Anti coronary artery disease Lipid peroxidation Gilbert

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