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Photonic Sensors 2019年第1期9卷 11-18页

作者： Atsushi MOTOGAito Yusuke ito Graduate School of Engineering Mie UniversityMie 514-8507Japan Iga Satellite Mie UniversityMie 518-0131Japan

The excitation mechanism of surface plasmon polaritons(SPPs)in a surface plasmon sensor with a one-dimensional(1D)Au diffraction grating on a glass substrate is studied *** sensitivity of the sensor for application to a refractometer is also *** SPPs are excited at the following two types of interface:one between the Au grating and the glass substrate and the other between the Au grating and the *** simulation data for the transmittance spectra and the transmittance mapping are consistent With the experimental data even when the refractive index of the solution medium is ***,the excitation mechanism of the SPPs in a surface plasmon sensor is capable of detecting the medium(n=1.700),in which the sensor is used and clarified.

关键词： Surface plasmon diffraction grating high refractive index chemical sensor

Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS

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Acta Pharmacologica Sinica 2005年第3期26卷 359-363页

作者： Yoshimasa ito Japan Osaka 577-8502 School of Pharmacy Pharmaceutical Research und Technology Institute Kinki University

Aim:To investigate the biological activity of human lens epithelial cells (HLEC)in producing inducible nitric oxide synthase (iNOS) and nitric oxide (NO),and toassesse the effect of diethyldithiocarbamate (DDC) on iNOS mRNA levels andexpression of ***:The human lens epithelial cell line SRA 01/04 wasused in this ***-quantitative reverse transcription polymerase chainreaction (RT-PCR) and Western blotting were used to detect,respectively,iNOSmRNA expression and protein ***:A costimulation by inter-feron gamma (IFN-γ) and lipopolysaccharide (LPS) was necessary for iNOS ex-pression in *** expression of iNOS was significantly reduced in a dose-dependent manner by adding DDC from 10 μmol/L to 1 mmol/***:The expression of iNOS in HLEC needs co-stimulation with IFN-γ and LPS and itis inhibited by DDC.

关键词： human lens epithelial cells inducible nitric oxide synthase interferon gamma lipopolysaccharide diethyldithiocarbamate

Effect of the backbone structure of bidentate ligands in palladiumand nickel-catalyzed polar monomer copolymerization

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Science China Chemistry 2018年第11期61卷 1349-1350页

作者： Shingo ito Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University

Coordination-insertion copolymerization of non-polar olefins and polar monomers by late transition metal catalysts is a powerful method to synthesize functionalized polyolefins[1]. Seminal successes in this copolymerization have been achieved by using group-10 metal catalysts bearing a bidentate ligand such as phosphine-sulfonate and bisphosphine monoxide (BPMO)(Figure 1)[1]. These ligands typically consist of a strongσ-donor and a weakσ-donor and have an arylene linker between the two coordination sites (Figure 1,middle). Although a variety of coordination sites have thus far been investigated, less attention has been paid to the influence of the backbone structure. Recent papers shed light on this issue.

关键词：金属催化剂梁结构镍氧化物

Current advances in humanized mouse models

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Cellular & Molecular Immunology 2012年第3期9卷 208-214页

作者： Ryoji ito Takeshi Takahashi Ikumi Katano Mamoru ito Central Institute for Experimental Animals Kawasaki Japan

Humanized mouse models that have received human cells or tissue transplants are extremely useful in basic and applied human disease research. Highly immunodeficient mice, which do not reject xenografts and support cell and tissue differentiation and growth, are indispensable for generating additional appropriate models. Since the early 2000s, a series of immunodeficient mice appropriate for generating humanized mice has been successively developed by introducing the IL-2Rynull gene （e.g., NOD/SCID/7c＂uu and Rag2nu＂ycnun mice）. These strains show not only a high rate of human cell engraftment, but also generate well-differentiated multilineage human hematopoietic cells after human hematopoietic stem cell （HSC） transplantation. These humanized mice facilitate the analysis of human hematology and immunology in vivo. However, human hematopoietic cells developed from HSCs are not always phenotypically and functionally identical to those in humans. More recently, a new series of immunodeficient mice compensates for these disadvantages. These mice were generated by genetically introducing human cytokine genes into NODISCIDI？cn＂u and Rag2nulITcnUll mice. In this review, we describe the current knowledge of human hematopoietic cells developed in these mice. Various human disease mouse models using these humanized mice are summarized.

关键词： animal model immunodeficient mice immunology hematology humanized mice

Enhanced bifunctional catalytic activities of N-doped graphene by Ni in a 3D trimodal nanoporous nanotubular network and its ultralong cycling performance in Zn-air batteries

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Journal of Energy Chemistry 2022年第3期31卷 466-473,I0013页

作者： Yanyi Zhang Xiang-Peng Kong Xiaorong Lin Kailong Hu Weiwei Zhao Guoqiang Xie Xi Lin Xingjun Liu Yoshikazu ito Hua-Jun Qiu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055GuangdongChina Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials Shenzhen 518055GuangdongChina State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Blockchain Development and Research Institute Harbin Institute of TechnologyShenzhen 518055GuangdongChina Institute of Applied Physics Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukuba 305-8573Japan

Free-standing and fexible air electrodes with long-lasting bifunctional activities for both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)are crucial to the development of wearable Zn-air rechargeable *** this work,we synthesize a fexible air electrode consisting of 3D nanoporous N-doped graphene with trimodal shells and Ni particles through repeated chemical vapor deposition(CVD)and acidic etching *** results indicate that such trimodal graphene morphology significantly enhances the active N-dopant sites and graphene-coated Ni surface,which consequentially boosts both the ORR and OER activities,as well as catalytic ***-principles density functional theory(DFT)calculations reveal the synergetic effects between the Ni and the N-doped graphene;namely,the Ni nanoparticles boost the bifunctional activities of the coated N-doped graphene,and in turn the graphene-covering layers enhance the stability of *** to the better protection from the triple graphene shells,our trimodal N-doped graphene/Ni-based Zn-air battery can be stably discharged/recharged beyond 2500 h with low *** is reasonable to expect that such freestanding trimodal graphene/Ni would be promising in many fexible energy conversion/storage devices.

关键词： Triple shells Bifunctional Hierarchical Cycling durability ORR/OER

2,2′-Biazulene diimide-based conjugate polymers for highperformance field-effect transistors

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Science China Chemistry 2018年第8期61卷 973-974页

作者： Taku Shoji Shunji ito Graduate School of Science and Technology Shinshu University Graduate School of Science and Technology Hirosaki University

Azulene,which is one of the non-alternating 10π-electron aromatic compounds,has attracted the interest of many research groups due to the application to material sciences utilizing the unique optoelectronic properties[1,2].Therefore,the construction ofπ-conjugated system incorporating azulene skeleton is actively researched in recent *** and co-workers[3,4]at Shanghai Institute of Organic Chemistry have demonstrated the preparation of

关键词：聚合物晶体管材料科学混合物

Field emission characteristics of nano-sheet carbon films deposited by quartz-tube microwave plasma chemical vapour deposition

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Chinese Physics B 2008年第4期17卷 1467-1471页

作者：顾广瑞金哲 ito Toshimichi Department of Physics College of ScienceYanbian University Division of Electrical Electronic and Information EngineeringGraduate School of EngineeringOsaka University

Nano-sheet carbon films are prepared on Si wafers by means of quartz-tube microwave plasma chemical vapour deposition （MPCVD） in a gas mixture of hydrogen and methane. The structure of the fabricated films is investigated by using field emission scanning electron microscope （FESEM） and Raman spectroscopy. These nano^carbon films are possessed of good field emission （FE） characteristics with a low threshold field of 2.6 V/μm and a high current density of 12.6 mA/cm^2 at an electric field of 9 V/μm. As the FE currents tend to be saturated in a high E region, no simple Fowler-Nordheim （F-N） model is applicable. A modified F N model considering statistic effects of FE tip structures and a space-charge-limited-current （SCLC） effect is applied successfully to explaining the FE data observed at low and high electric fields, respectively.

关键词： field emission carbon films nano-sheet microwave plasma chemical vapour deposition

Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8304-8311页

作者： Yu Ohkura Hironori Uruga Masato Shiiba Shinji ito Hayato Shimoyama Makiko Ishihara Masaki Ueno Harushi Udagawa Department of Gastroenterological Surgery Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Pathology Toranomon HospitalTokyo 105-8470Japan Department of Diagnostic Imaging Center Toranomon HospitalTokyo 105-8470Japan

BACKGROUND Phosphoglyceride crystal deposition disease(PCDD)is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery,trauma,or repeated *** SUMMARY A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years *** the masses showed marked fluorodeoxyglucose(FDG)uptake on ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)F-FDGPET)and were strongly suspected to be malignant *** biopsies were performed,and the abdominal masses were found to be aligned vertically,three in a row,along the tissue layers cut in the patient’s previous *** finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like *** crystals were confirmed as phosphoglyceride by Raman spectroscopy,and PCDD was *** our knowledge,this is the first report of PCDD diagnosed by Raman *** We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on ^(18)F-FDG-PET by incisional biopsy and composition analysis using Raman spectroscopy,a method that has not previously been reported for the diagnosis of PCDD.

关键词： Phosphoglyceride crystal deposition disease Raman spectroscopy Positron emission tomography Foreign body granuloma with crystal deposition Surgical scar Case report

Synchronous multiple lung cancers with hilar lymph node metastasis of small cell carcinoma:A case report

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世界临床病例杂志 2023年第25期11卷 5919-5925页

作者： Ryusei Yoshino Nana Yoshida Shunsuke Yasuda Akane ito Masaki Nakatsubo Sayaka Yuzawa Masahiro Kitada Thoracic Surgery and Breast Surgery Asahikawa Medical UniversityAsahikawa 078-8510Japan Diagnostic Pathology Asahikawa Medical University HospitalHokkaido 078-8510Japan

BACKGROUND Synchronous multiple lung cancers are rare and refer to the simultaneous presence of two or more primary lung tumors,which present significant challenges in terms of diagnosis and *** SUMMARY We report a case of multiple synchronous lung cancers with hilar lymph node metastasis of small cell carcinoma of unknown origin in a 73-year-old *** lung biopsy revealed squamous cell *** enlargement of lymph node 12u was detected,no distant metastases were *** patient was preoperatively diagnosed with T1cN0M0 and underwent thoracoscopic right upper lobectomy with nodal dissection(ND2a).Based on histopathological findings,the primary lesion was squamous cell carcinoma.A microinvasive adenocarcinoma was also observed on the cranial side of the primary *** were detected in two resected lymph nodes(#12u and#11s).Both tumors were pathologically diagnosed as small cell *** primary lesion of the small cell carcinoma could not be identified even by whole-body imaging;however,chemotherapy was initiated for hilar lymph node metastasis of the small cell carcinoma of unknown *** Multiple synchronous lung cancers can be accompanied by hilar lymph node metastasis of small cell carcinomas of unknown origin.

关键词： Small cell carcinoma Synchronous multiple lung cancers Squamous cell carcinoma Adenocarcinoma Chemotherapy Case report

Imbricate structure of the Otakeyama area, Okayama Permian Yoshii Group in the Prefecture, southwest Japan

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Frontiers of Earth Science 2015年第1期9卷 152-163页

作者： Tsuyoshi ito Atsushi MATSUOKA State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Wuhan 430074 China Department of Geology Faculty of Science Niigata University Niigata 950-2181 Japan

The Yoshii Group of the Akiyoshi terrane is distributed over the Otakeyama area, Okayama Prefecture, southwest Japan. The Yoshii Group is composed of siliceous rocks and clastics, comprising chert-clastic sequences. The Yoshii Group is divided into four structural units （Units Ot 1, Ot 2, Ot 3, and Ot 4） in structurally ascending order. Lithological similarities and radiolarian age suggest that these units exhibit almost identical ocean plate stratigraphy. These units are structurally-repeated to form an imbricate structure. This structure was possibly formed by off-scrape accretion at a toe of an accretionary complex. Additionally, a review of previous studies indicates that an imbricate structure is common in the Akiyoshi terrane. The presence of an imbricate structure in the Akiyoshi terrane, Permian accretionary complex, indicates the possibility that a specific horizon of Permian pelagic sequences acted as a drcollement zone.

关键词： accretionary complex imbricate structure,Permian radiolafia Yoshii Group Okayama Prefecture,southwest Japan