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World Journal of Gastroenterology 2014年第39期20卷 14420-14429页

作者： Shigeo Koido Toshifumi Ohkusa Shin Kan Kazuki Takakura Keisuke Saito Hideo Komita Zensho ito Hiroko Kobayashi Shinichiro Takami Kan Uchiyama Hiroshi Arakawa Masaki ito Masato Okamoto Mikio Kajihara Sadamu Homma Hisao Tajiri Division of Gastroenterology and Hepatology Department of Internal Medicine The Jikei University School of Medicine Chiba 277-8567 Japan Department of Oncology The Jikei University School of Medicine Tokyo 105-8461 Japan Department of Advanced Immunotherapeutics Kitasato University School of Pharmacy Tokyo 108-8641 Japan

AIM: To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation.

关键词： Commensal bacteria Corticotropin-releasing factor Dendritic cell Irritable bowel syndrome Inflammatory bowel disease Urocortin

Zircon SHRIMP U-Pb dating on plagiogranite from Kuerti ophiolite in Altay,North Xinjiang

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Chinese Science Bulletin 2003年第20期48卷 2231-2235页

作者： ZHANG Haixiang NIU Hecai Kentaro Terada YU Xueyuan Hiroaki Sato Jun抜chi ito Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China Graduate School of Science Hiroshima University Higashi-Hiroshima 739-8526 Japan Graduate School of Science and Technology Kobe University Kobe 657-8501 Japan

Field observation, petrological and geochemical characteristics of plagiogranite from Kuerti ophiolite indicate a similar origin to those in shearing zones. It isderived from partial melting of amphibolite that is developed from gabbro within the ocean layer 3 shear zone by the low-angle shearing deformation during the oceanic crustmigrating process. Zircon SHRIMP age of 372±19 Ma for the plagioganite from Kuerti ophiolite indicates that thisophiolite formed in the Devonian period and it alsorepresented the time of extension of the Kuerti backarc basin that is relevant to the northwards subduction of thePaleo-Asian oceanic crust. Therefore, the northwardssubduction of the Paleo-Asian Ocean beneath the Siberian Plate began in the early stage of the Late Paleozoic era.

关键词：新疆北部斜长花岗岩蛇绿岩锆石U-Pb测年古生代

Adsorption,selectivity,and phase behavior in organic nanopores for shale gas and oil development

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Petroleum Research 2021年第3期6卷 187-203页

作者： Jinrong Cao Yunfeng Liang Yoshihiro Masuda Kohei Tamura Hiroyuki Tanaka Tomoaki Ishiwata Yoshiharu ito Toshifumi Matsuoka Department ofSystemsInnovation TheUniversityofTokyoTokyo113-8656Japan Japan Oil GasandMetalsNationalCorporation(JOGMEC)Chiba261-0025Japan Fukada GeologicalInstitute Tokyo113-0021Japan

In a shale gas and oil reservoir,hydrocarbon fluids are stored in organic nanopores with sizes on the order of~1-100 *** adsorption,selectivity,and phase behavior of hydrocarbons in the nanopores are crucial for estimating the gas-in-place and predicting the *** this study,to understand the characteristics of the phase behavior of multicomponent hydrocarbon systems in shale reservoirs,the phase behavior of a CH_(4)/n-C_(4)H_(10)binary mixture in graphite nanopores was investigated by Grand Ca-nonical Monte Carlo(GCMC)molecular *** method for determining the dew-point pressure and bubble-point pressure in the nanopores was *** condensation phenomenon was observed owing to the difference in the adsorption selectivities of the hydrocarbon molecules on the nanopore surfaces,and hence the dew-point pressure(and bubble-point pressure)of hydrocarbon mixtures in the nanopores significantly *** GCMC simulations reproduced both the higher and lower bubble-point pressures in nanopores in previous *** work highlights the crucial role of the selec-tivity in the phase behavior of hydrocarbons in nanopores.

关键词： Shale gas and oil Nanopores Adsorption Selectivity Phase behavior Bubble point pressure Dew point pressure Molecular simulation

Comparison of the low-density lipoprotein cholesterol target value and the preventive effect of statins in elderly patients and younger patients

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Journal of Geriatric Cardiology 2017年第6期14卷 383-391页

作者： Akihiro Endo Taiji Okada Misun Pak Yuzo Kagawa Shimpei ito Hirotomo Sato Kenji Kageshima Yasuyuki Yoshida Kazuaki Tanabe Division of Cardiology Shimane University Faculty of Medicine Izumo Japan Division of Cardiology Tottori Prefectural Central Hospital Tottori Japan

Objective To assess whether the low-density lipoprotein cholesterol （LDL-C） target value and preventive effect of statins are different between elderly and younger patients. Methods We investigated 304 patients with previous percutaneous coronary intervention who underwent coronary angiography from January 2007 to December 2016 for examination of recurrent ischemia beyond the early restenosis. Patients were classified into two groups： age ≥ 75 years （elderly group： n = 140） and 〈 75 years （younger group： n = 164）. Relationships between the achieved LDL-C level, incidence of late coronary events, and the effectiveness of statins were evaluated. Results During follow-up, 179 patients underwent late coronary revascularization. Recurrent ischemia presenting as acute coronary syndrome （ACS） occurred in 83 cases. Kaplan-Meier curve analysis revealed that in the younger group, recurrent ACS was significantly lower in patients with LDL-C 〈 70 mg/dL than in those with LDL-C ranging from 70 to 〈 100 mg/dL （P = 0.035）; however, there was no difference between these in the elderly group （P = 0.863）. Instead, recurrent ACS was less frequent in patients with LDL-C ranging from 70 mg/dL to 〈 100 mg/dL than in those with LDL-C ≥ 100 mg/dL in the elderly group （v = 0.033）. Statin use was associated with decreased recurrent ACS （P = 0.005）; moreover, only using statins was an independent predictor in the elderly group （HR： 0.375; P = 0.007）. Conclusions Strict control of LDL-C to 〈 70 mg/dL was effective for reducing the incidence of recurrent ACS in younger patients. However, LDL-C 〈 100 mg/dL might be sufficient as the target value of LDL-C-lowering therapy for secondary prevention of ischemic events in Japanese elderly patients.

关键词： Acute coronary syndrome Late coronary event Prevention

Enhanced bifunctional catalytic activities of N-doped graphene by Ni in a 3D trimodal nanoporous nanotubular network and its ultralong cycling performance in Zn-air batteries

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Journal of Energy Chemistry 2022年第3期31卷 466-473,I0013页

作者： Yanyi Zhang Xiang-Peng Kong Xiaorong Lin Kailong Hu Weiwei Zhao Guoqiang Xie Xi Lin Xingjun Liu Yoshikazu ito Hua-Jun Qiu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055GuangdongChina Shenzhen R&D Center for Al-based Hydrogen Hydrolysis Materials Shenzhen 518055GuangdongChina State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Blockchain Development and Research Institute Harbin Institute of TechnologyShenzhen 518055GuangdongChina Institute of Applied Physics Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukuba 305-8573Japan

Free-standing and fexible air electrodes with long-lasting bifunctional activities for both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)are crucial to the development of wearable Zn-air rechargeable *** this work,we synthesize a fexible air electrode consisting of 3D nanoporous N-doped graphene with trimodal shells and Ni particles through repeated chemical vapor deposition(CVD)and acidic etching *** results indicate that such trimodal graphene morphology significantly enhances the active N-dopant sites and graphene-coated Ni surface,which consequentially boosts both the ORR and OER activities,as well as catalytic ***-principles density functional theory(DFT)calculations reveal the synergetic effects between the Ni and the N-doped graphene;namely,the Ni nanoparticles boost the bifunctional activities of the coated N-doped graphene,and in turn the graphene-covering layers enhance the stability of *** to the better protection from the triple graphene shells,our trimodal N-doped graphene/Ni-based Zn-air battery can be stably discharged/recharged beyond 2500 h with low *** is reasonable to expect that such freestanding trimodal graphene/Ni would be promising in many fexible energy conversion/storage devices.

关键词： Triple shells Bifunctional Hierarchical Cycling durability ORR/OER

Pancreatic guidewire placement for achieving selective biliary cannulation during endoscopic retrograde cholangio-pancreatography

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World Journal of Gastroenterology 2008年第36期14卷 5595-5600页

作者： Kei ito Naotaka Fujita Yutaka Noda Go Kobayashi Takashi Obana Jun Horaguchi Osamu Takasawa Shinsuke Koshita Yoshihide Kanno Department of Gastroenterology Sendai City Medical Center 5-22-1 Tsurugaya Miyagino-ku Sendai Miyagi 983-0824 Japan

AIM: To investigate the frequency and risk factors for acute pancreatitis after pancreatic guidewire placement (P-GW) in achieving cannulation of the bile duct during endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: P-GW was performed in 113 patients in whom cannulation of the bile duct was difficult. The success rate of biliary cannulation, the frequency and risk factors of post-ERCP pancreatitis, and the frequency of spontaneous migration of the pancreatic duct stent were investigated. RESULTS: Selective biliary cannulation with P-GW was achieved in 73% of the patients. Post-ERCP pancreatitis occurred in 12% (14 patients: mild, 13; moderate, 1). Prophylactic pancreatic stenting was attempted in 59% of the patients. Of the 64 patients who successfully underwent stent placement, three developed mild pancreatitis (4.7%). Of the 49 patients without stent placement, 11 developed pancreatitis (22%: mild, 10; moderate, 1). Of the five patients in whom stent placement was unsuccessful, two developed mild pancreatitis. Univariate and multivariate analyses revealed no pancreatic stenting to be the only significant risk factor for pancreatitis. Spontaneous migration of the stent was observed within two weeks in 92% of the patients who had undergone pancreatic duct ***: P-GW is useful for achieving selective biliary cannulation. Pancreatic duct stenting after P-GW can reduce the incidence of post-ERCP pancreatitis, which requires evaluation by means of prospective randomized controlled trials.

关键词： Endoscopic retrograde cholangio-pancreatography Pancreatic duct stenting Acute pancreatitis Post-endoscopic retrograde cholangio-pancreatography pancreatitis Biliary cannulation

Immunological milieu in the peritoneal cavity at laparotomy for gastric cancer

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World Journal of Gastroenterology 2012年第13期18卷 1470-1478页

作者： Akira Yoneda Shinichiro ito Seiya Susumu Mitsutoshi Matsuo Ken Taniguchi Yoshitsugu Tajima Susumu Eguchi Takashi Kanematsu Yasuhiro Nagata Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasaki 852-8051Japan Department of Surgery Yamaguchi Prefectural Medical CenterYamaguchi 747-8511Japan Department of Surgery National Hospital Organization Nagasaki Medical CenterNagasaki 856-8562Japan

AIM： To investigate the immunological repertoire in the peritoneal cavity of gastric cancer patients. METHODS： The peritoneal cavity is a compartment in which immunological host-tumor interactions can occur. However, the role of lymphocytes in the peri- toneal cavity of gastric cancer patients is unclear. We observed 64 patients who underwent gastrectomy for gastric cancer and 11 patients who underwent lapa-roscopic cholecystectomy for gallstones and acted as controls. Lymphocytes isolated from both peripheral blood and peritoneal lavage were analyzed for surface markers of lymphocytes and their cytokine production by flow cytometry. CD4＋CD25h＋gh T cells isolated from the patient＇s peripheral blood were co-cultivated for 4 d with the intra-peritoneal lymphocytes, and a cytokine assay was performed. RESULTS： At gastrectomy, CCR7-CD45RA- CD8＋ effector memory T cells were observed in the peritoneal cavity. The frequency of CD4＋ CD25 h＋ghT ceils in both the peripheral blood and peritoneal cavity was elevated in patients at advanced stage [control vs stage IV in the peripheral blood： 6.89 （3.39-10.4） vs 15.34 （11.37-19.31）, P 〈 0.05, control vs stage IV in the peri- toneal cavity： 8.65 （5.28-12.0） vs 19.56 （14.81-24.32）, P 〈 0.05]. On the other hand, the suppression was restored with CD4＋ CD25h＋QhT cells from their own pe- ripheral blood. This study is the first to analyze lympho- cyte and cytokine production in the peritoneal cavity in patients with gastric cancer. Immune regulation at ad- vanced stage is reversible at the point of gastrectomy. CONCLUSION： The immunological milieu in the peri- toneal cavity of patients with advanced gastric cancer elicited a Th2 response even at gastrectomy, but this response was reversible.

关键词： Cytokines Gastric cancer Lymphocytes Peri-toneal cavity Regulatory T cell

Prognostic value of post-treatment ^(18)F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy

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Chinese Journal of Cancer Research 2014年第1期26卷 30-37页

作者： Kimiteru ito Keigo Shimoji Yoko Miyata Kouhei Kamiya Ryogo Minamimoto Kazuo Kubota Momoko Okasaki Miyako Morooka Jyunkichi Yokoyama Department of Radiology National Center of Neurology and Psychiatry Department of Radiology Juntendo University Graduate School of Medicine Division of nuclear Medicine International Medical Center of Global Health Department of Otolaryngology Head and Neck SurgeryJuntendo University Graduate School of Medicine

Objective：To clarify the prognostic value of post-treatment 18F-fluorodeoxyglucose （FDG） positron emission tomography （PET）/computed tomography （CT） in patients with advanced head and neck squamous cell carcinoma （HNSCC） after combined intra-arterial chemotherapy and radiotherapy （IACR）.Methods：Thirty-six patients with HNSCC who underwent IACR were *** period from the end of IACR to the last post-treatment 18F-FDG PET/CT examination was 8-12 *** patient-based and lesion-based analyses were used to evaluate the PET/CT *** lesion-based analysis,36 regions （12 lesions of recurrences and 24 scars at primary sites） were *** Kaplan-Meier method was used to assess the overall survival （OS） stratified by 18F-FDG uptake or visual interpretation ***：Twelve patients with recurrence were identified by six months after *** sensitivity and specificity in the patient-based analysis were 67％（8/12） and 88％（21/24）,*** mean OS was estimated to be 12.1 months （95％ CI,6.3-18.0 months） for the higher maximum standardized uptake value （SUVmax） group （n=7） and 44.6 months （95％ CI,39.9-49.3 months） for the lower SUVmax group （n=29）.OS in the higher SUVmax group （cut-off point,6.1） or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group （P＜0.001 and P＜0.05,respectively）.Conclusions：The SUVmax and visual interpretation of HNSCC on post-IACR 18F-FDG PET/CT can provide prognostic survival estimates.

关键词： 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) head and neck cancer recurrence survival time intra-arterial chemotherapy and radiotherapy (IACR)

Mesomorphic behavior of new azomethine liquid crystals having terminal iodo group

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Chinese Chemical Letters 2011年第3期22卷 260-263页

作者： Sie-Tiong Ha Teck-Leong Lee Guan-Yeow Yeap Masato M.ito Ayumu Saito Masaaki Watanabe Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Liquid Crystal Research Laboratory School of Chemical SciencesUniversiti Sains Malaysia11800 MindenPenangMalaysia Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan

A series of azomethine esters,3-hydroxy-4-{[（4-iodophenyl）imino]methyl}phenyl alkanoates possessing even number of carbon atoms at the terminal alkanoyloxy chain（C_（n-1）H_（2n-1）COO-,n = 4,6,8,10,12,14） was synthesized.n-Butanoyloxy was found non-mesogenic,whilst n-hexanoyloxy to n-tetradecanoyloxy exhibited enantiotropic smectic A phase with fan-shaped *** was found that the length of terminal alkanoyloxy chain influenced the mesomorphic properties.

关键词： Liquid crystals Azomethine ester Enantiotropic Smectic A

Inhalation properties of water-soluble drug loaded liposomes atomized by nebulizer

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 205-206页

作者： Shinshu Unida Yosuke ito Risako Onodera Kohei Tahara Hirofumi Takeuchi Gifu Pharmaceutical University

The pulmonary route presents several advantages in designing drug delivery systems in both systemic and topical *** use of particulate carriers is an attractive method for designing pulmonary drug delivery systems,because such carriers could control drug release and selective drug targeting when the carriers reach the target site in the *** prevention of local irritation,reduced drug toxicity,and improved drug stability are also preferable results of utilizing such carrier *** a number of particulate carriers,liposomes have an advantage in safety,because they consist of phospholipids,which are bio-components.

关键词： Liposome Nebulizer Inhalation property Pulmonary drug delivery