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Feasibility of Improved Attenuation Correction for SPECT Reconstruction in the Presence of Dense Materials Using Dual-Energy Virtual Monochromatic CT: A Phantom Study

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Open Journal of Medical Imaging 2015年第4期5卷 183-193页

作者： sachiko Yamada Takashi Ueguchi Eku Shimosegawa Koichi Fujino Takeshi Shimazu Kenya Murase Jun Hatazawa Department of Radiology Osaka University Hospital Osaka Japan Department of Medical Physics and Engineering Osaka University Graduate School of Medicine Osaka Japan Center for Information and Neural Networks National Institute of Information and Communications Technology Osaka Japan Graduate School of Frontier Biosciences Osaka University Osaka Japan Department of Molecular Imaging in Medicine Osaka University Graduate School of Medicine Osaka Japan Department of Traumatology and Acute Critical Medicine Osaka University Graduate School of Medicine Osaka Japan Department of Nuclear Medicine and Tracer Kinetics Osaka University Graduate School of Medicine Osaka Japan

Objective: Computed tomography (CT)-based attenuation correction (CTAC) offers the clear benefit of reliable reconstruction of single-photon emission computed tomography (SPECT) images through its ability to achieve object-specific attenuation maps, but artifacts from dense materials often deteriorate CTAC performance. Therefore, we investigate the feasibility of CTAC in the presence of dense materials using dual-energy virtual monochromatic CT data. Methods: A sodium pertechnetate-filled cylindrical uniform phantom, with a pair of undiluted iodine syringes attached, is scanned with a dual-source CT scanner to obtain both single-energy (120 kVp) polychromatic and dual-energy (80 kVp/140 kVp with tin filtering) virtual monochromatic CT images. The single-energy and the dual-energy CT images are then converted to attenuation maps at 141 keV. SPECT images are reconstructed from 99mTc emission data of the phantom using each single-energy and dual-energy attenuation map and incorporating CTAC procedure. A region-of-in- terest analysis is performed to quantitatively compare the attenuation maps between the single-energy and the dual-energy techniques, each at an iodine-free position and a position adjacent to the iodine solutions. Results: At the iodine-free position, the phantom provides a uniform distribution of attenuation maps in both the single-energy and the dual-energy techniques. In the presence of adjacent iodine solutions, however, severe artifacts appeare in the single-energy CT images. These artifacts make attenuation values fluctuate, resulting in erroneous pixel values in the CTAC SPECT images. In contrast, dual-energy CT strongly suppresses the artifacts and hence improves the uniformity of the attenuation maps and the resultant SPECT images. Conclusions: Dual-energy CT with virtual monochromatic reconstruction has the potential to substantially reduce artifacts arising from dense materials. It has the potential to improve the accuracy of attenuation maps a

关键词： SPECT Attenuation Correction Dual-Energy CT Virtual Monochromatic Imaging Artifact Reduction

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Cembrane-Type Diterpenoids and a Phenolic Compound from the Leaves of a Thai Medicinal Plant, <i>Croton sublyratus</i>Kurz

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American Journal of Plant Sciences 2014年第9期5卷 1370-1377页

作者： Yasue Oka Susumu Kawakami sachiko Sugimoto Katsuyoshi Matsunami Hideaki Otsuka Duanporn Lhieochaiphant Sorasak Lhieochaiphant Department of Pharmaceutical Sciences Faculty of Pharmacy Chiang Mai University Chiang Mai Thailand Department of Pharmacognosy Graduate School of Bio-medical and Health Sciences Hiroshima University Hiroshima Japan Faculty of Pharmacy Payap University Chiang Mai Thailand

From the leaves of a Thai medicinal plant, Croton sublyratus, collected in Thailand, two new cembrane-type diterpenoids, named sublylactones A and B, and a phenolic compound were isolated from the EtOAc-soluble fracti... 详细信息

关键词： Croton Sublyratus Euphorbiaceae Diterpene Cembrane

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稀有类型的SiC的同位素特征

稀有类型的SiC的同位素特征

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中国矿物岩石地球化学学会第14届学术年会

作者：徐于晨 sachiko Amari Frank Gyngard Ernst Zinner 林杨挺月球与行星科学研究中心中国科学院地球化学研究所空间科学和物理系实验室圣路易斯华盛顿大学地球深部研究重点实验室中国科学院地质与地球物理研究所

＜正＞陨石中的太阳系外颗粒是超新星、新星、AGB星等各种恒星在演化晚期由喷出物凝聚而形成的尘埃。46亿年前,太阳系外颗粒加入到了原始太阳星云中,并在太阳系的所有形成演化过程中残留,1987年,前人首次成功分离出了太阳系外成因的矿... 详细信息

＜正＞陨石中的太阳系外颗粒是超新星、新星、AGB星等各种恒星在演化晚期由喷出物凝聚而形成的尘埃。46亿年前,太阳系外颗粒加入到了原始太阳星云中,并在太阳系的所有形成演化过程中残留,1987年,前人首次成功分离出了太阳系外成因的矿物相之一—金刚石。太阳系外颗粒存在于陨石、星际尘埃颗粒和宇宙物质中（Zinner,2007）,是人们认识不同恒星的核合成和太阳星云初始状态,了解恒星内部核反应过程和恒星演化

关键词：超新星碳化硅同位素纳米离子探针

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Latent Autoimmune Diabetes in Adults Complicated by Persistent Isolated Glucosuria in the Absence of Hyperglycemia

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Case Reports in Clinical Medicine 2017年第5期6卷 133-136页

作者： Kosuke Inoue Yuya Tsurutani Chiho Sugisawa sachiko Suematsu Jun Saito Masao Omura Tetsuo Nishikawa Endocrinology and Diabetes Center Yokohama Rosai Hospital Yokohama Japan

Latent autoimmune diabetes in adults (LADA) is an autoimmune diabetes of adult-onset with the presence of diabetes associated autoantibodies. Familial renal glucosuria (FRG) is an inherited renal tubular disorder that causes persistent isolated glucosuria in the absence of hyperglycemia. We report a novel case of LADA and certain FRG. A 44-year-old man was admitted to our hospital for uncontrolled diabetes. Before admission, he had never suffered from diabetic coma and showed an improvement in HbA1c only with diet therapy. His HbA1c was 11.9% (107 mmol/mol), and anti-glutamic acid decarboxylase antibody was 13.0 U/mL. A glucagon stimulation test showed the decrease of insulin secretion: plasma C-peptide (CPR) 0 min, 0.69 ng/mL;CPR 6 min, 0.90 ng/mL. Analysis of genomic DNA revealed a novel heterozygous mutation in the SGLT2 coding gene, SLC5A2 (c.875G >A, ***292Tyr), which was assessed as probably damaging with a score of 0.998 (sensitivity: 0.27;specificity: 0.99) by an in silico analysis. Therefore, he was diagnosed with LADA and certain FRG. He has not shown any symptoms and his HbA1c improved to 6.4% (46 mmol/mol) three months after the introduction of insulin therapy. Our case clearly implies the clinical effectiveness of SGLT2 inhibition in patients with LADA.

关键词： Latent Autoimmune Diabetes in Adults (LADA) Familial Renal Glucosuria (FRG) SLC5A2 Mutation Sodium-Glucose Cotransporter 2 (SGLT2) Insulin Therapy

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Murchison中亚微米级碳化硅颗粒的同位素特征

Murchison中亚微米级碳化硅颗粒的同位素特征

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第十届全国月球科学与比较行星学陨石学与天体化学学术研讨会

太阳系外颗粒在原始陨石中以微量组分的形式存在,因其同位素特征明显偏离太阳系物质组分被发现。其同位素比值变化可跨越数个数量级,大至无法以物理或化学分馏理论及放射性元素衰变来解释,只可能形成于星体内部的核反应。陨石中的太阳...

太阳系外颗粒在原始陨石中以微量组分的形式存在,因其同位素特征明显偏离太阳系物质组分被发现。其同位素比值变化可跨越数个数量级,大至无法以物理或化学分馏理论及放射性元素衰变来解释,只可能形成于星体内部的核反应。陨石中的太阳系外颗粒作为超新星、新星、AGB星等各种恒星在演化晚期由喷出物凝聚形成的尘埃,为人类提供了了解其他恒星的物质样本。

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The Relationship between Gait Asymmetry and Respiratory Function in Stroke Patients: A Pilot Study

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Open Journal of Therapy and Rehabilitation 2021年第4期9卷 111-122页

作者： Yoshino Terui Satomi Iwasawa Kazuto Kikuchi Yutaka Furukawa Eriko Suto sachiko Uemura Masahiro Satake Takanobu Shioya Department of Rehabilitation Akita University Graduate School of Health Sciences Akita City Akita Japan Department of Rehabilitation Akita Prefectural Center for Rehabilitation and Psychiatric Medicine Daisen City Akita Japan Department of Physical Therapy Akita Rehabilitation College Akita City Akita Japan Department of Rehabilitation Medicine Akita City Hospital Akita City Akita Japan Geriatric Health Services Facility Nikoniko-en Akita City Akita Japan

INTRODUCTION: Gait asymmetry can become very pronounced in patients who have suffered a stroke. The impairment of trunk function in some stroke patients can restrict thorax mobility and cause respiratory muscle weakness. Trunk and neck dysfunction are believed to affect the gait in stroke patients. OBJECTIVE: This study aimed to investigate the relationship between gait asymmetry and respiratory function in stroke patients by measuring the step time and trunk acceleration. METHODS: This study employed a cross-sec- tional design. Thirty stroke patients participated in this study. The symmetry index (SI) and Lissajous index (LI) were used to evaluate asymmetry during walking. The respiratory function and respiratory muscle strength were evaluated by spirometry. We examined the relation between SI or LI and the respiratory function/respiratory muscle strength in patients with stroke. RE-

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Phytoremediation Potential of Sorghum as a Biofuel Crop and the Enhancement Effects with Microbe Inoculation in Heavy Metal Contaminated Soil

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Journal of Biosciences and Medicines 2015年第6期3卷 9-14页

作者： Kokyo Oh Tiehua Cao Hongyan Cheng Xuanhe Liang Xuefeng Hu Lijun Yan Shinichi Yonemochi sachiko Takahi Center for Environmental Science in Saitama Kazo Japan Center of Resource and Environmental Science Jilin Academy of Agricultural Sciences Changchun China College of Resources and Environment Shanxi Agricultural University Taigu Shanxi China School of Environmental and Chemical Engineering Shanghai University Shanghai China Faculty of Education and Human Studies Akita University Akita Japan

Phytoremediation is an eco-friendly and low-cost biotechnology using plants to extract, contain, degrade, or immobilize pollutants from the contaminated environment. Selection of the ideal plant species and suitable enhancing measures to obtain high remediation efficiency and large valuable biomass are essential requirement for a successful phytoremdaition. Sorghum (Sorghum bicolor L.) is one of the most attractive bioenergy crops for producing biofuels with high biomass production. In this study, the phytoremediation potential of sorghum to heavy metals and the promotion effects by a lead-tolerant fungus (LTF) were investigated using a multiple heavy metal contaminated soil with Pb, Ni, and Cu. The results showed that the sorghum survived the heavy contamination, and LTF inoculation promoted the plant growth and increased the phytoextraction yields of Pb, Ni, and Cu. The phytoextraction potential (μg/plant) of the whole sorghum for Sorghum were 410 (Pb), 74 (Ni), and 73 (Cu), and for Sorghum with LTF inoculation were 590 (Pb), 120 (Ni), and 93 (Cu), respectively. The results suggested that sorghum would be one of the ideal candidates for phytoremediation of contaminated soil because of its high phytoremediation potential, large biomass production, and utilization in biofuel production.

关键词： Sorghum Phytoremediation Contaminated Soil Heavy Metals Biofuel Plants

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Gastrointestinal symptoms in a Japanese population:A health diary study

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World Journal of Gastroenterology 2007年第4期13卷 572-578页

作者： Yasuharu Tokuda Osamu Takahashi sachiko Ohde Masaaki Shakudo Haruo Yanai Takuro Shimbo Shunichi Fukuhara Shigeaki Hinohara Tsuguya Fukui Clinical Practice Evaluation and Research Center St. Luke's Life Science Institute St. Luke's International Hospital Japan Intermedica Co Japan St. Luke's Graduate School of Nursing Japan Research Institute International Medical Center Japan Department of Epidemiology and Healthcare Research Kyoto University Graduate School of Medicine and Public Health Japan Clinical Practice Evaluation and Research Center St. Luke’s Life Science Institute St. Luke’s International Hospital Japan

AIM: To investigate the incidence of gastrointestina symptoms and the nature of consequent utilization o health care services in a Japanese population. METHODS: Using self-report, we conducted a prospective cohort study of a nationally representative sample of the Japanese population over a one-month period to determine the incidence of gastrointestina symptoms of all kinds and resultant health care utilization. Both information on visits to physicians and use of complementary and alternative medicine therapies were collected. RESULTS: From a total of 3568 in the recruitmen sample, 3477 participants completed a health diary (response rate 97%). The data of 112 participants with baseline active gastrointestinal diseases were excluded from the analysis, leaving 3365 participants in the study The incidence of gastrointestinal symptoms was 25% and the mean number of symptomatic episodes was 0.66 in a month. Abdominal pain, diarrhea, nausea, constipation and dyspepsia were the most frequent symptoms Female gender, younger age, and low baseline quality o life were risk factors for developing these symptoms. The participants were more likely to treat themselves, using dietary, complementary or alternative medicines, than to visit physicians, except in the case of ***: Gastrointestinal symptoms are common in the Japanese population, with an incidence of 25%. Abdominal pain, diarrhea, nausea, constipation and dyspepsia are the most frequent symptoms. Risk factors for developing these symptoms include female gender, younger age, and low baseline quality of life.

关键词：日本胃病肠病日常检查健康检查消化系统

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Genetic diagnosis of lymph-node metastasis in colorectal cancer

Genetic diagnosis of lymph-node metastasis in colorectal can...

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第六次全国大肠癌会议暨中日韩大肠癌会议

作者： sachiko Sugai Yoshio Miki Hirotoshi Ohta Masashi Ueno Makoto Seki Takashi Takahashi Dept. of Clinical Laboratory The Cancer Institutehospital Surgery The Cancer Institutehospital Dept. of Clinical Laboratory The Cancer Institutehospital

The presence of metatatic tumor in regional lymph nodes at the time of colorectal surgery is of major significance for tumor recurrence and prognosis in patients with colorectal cancer. However, conventional staining may not be sensitive enough. Mutant allele-specific amplification(MASA) is a method to be able to detect micrometastasis to lymph nodes that are histologically diagnosed as negative.

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Short-Term Drug-Drug Interaction between Sildenafil and Bosentan under Long-Term Use in Patients with Pulmonary Arterial Hypertension

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Pharmacology & Pharmacy 2013年第7期4卷 542-548页

作者： sachiko Miyakawa Keiichi Odagiri Naoki Inui Akio Hakamata Takahiro Goto Shimako Tanaka Shinya Uchida Noriyuki Namiki Hiroshi Watanabe Department of Clinical Pharmacology and Therapeutics Hamamatsu University School of Medicine Hamamatsu Japan Department of Clinical Pharmacology and Therapeutics Hamamatsu University School of Medicine Hamamatsu Japan Department of Drug Evaluation and Informatics School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan Department of Pharmacy Practice and Science School of Pharmaceutical Science University of Shizuoka Shizuoka Japan.

Sildenafil and bosentan are often co-administered for pulmonary arterial hypertension (PAH) treatment. The plasma concentration of sildenafil can be decreased by half if co-administered with bosentan. Many patients take these agents simultaneously in the morning and the evening. The aim of this study was to examine the pharmacokinetics of sildenafil which was interfered with bosentan administration to ascertain whether these agents should be given concomitantly or separately. A two-way crossover study was conducted in 6 PAH patients with combination therapy of sildenafil and bosentan. Participants underwent the sequence of treatment phases: phase S (sildenafil administered 3 h before bosen-tan);phase B (bosentan administered 3 h before sildenafil);and phase C (administered concomitantly). Blood samples were collected on the last day of each phase. There was no significant difference in maximum plasma concentration or area under the plasma concentration-time curve (AUC0-8) between phase C and phase S (95.5 ± 24.8 vs. 72.9 ± 40.9 (p = 0.07), 209.7 ± 81.8 vs. 180.2 ± 126.4 (p = 0.24), respectively) or between phases C and B (87.8 ± 42.0 vs. 99.6 ± 33.9 (p = 0.59), 197.2 ± 88.2 vs. 240.7 ± 121.8 (p = 0.19), respectively) (ng/mL, mean ± standard deviation). Large intra-and inter-individual variability in sildenafil concentration was noted. The timing of administration of sildenafil and bosentan does not significantly influence the plasma concentration of sildenafil. Physicians do not need to be overly concerned about the timing of administration of these drugs to maximize the sildenafil concentration.

关键词： Drug-Drug Interaction Pulmonary Arterial Hypertension Sildenafil Bosentan Pharmacokinetics

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