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Promising drug targets and associated therapeutic interventions in Parkinson's disease

Neural Regeneration Research 2021年第9期16卷 1730-1739页

作者： sachchida nand rai Payal Singh Ritu Varshney Vivek K.Chaturvedi Emanuel Vamanu M.P.Singh Brijesh Kumar Singh Centre of Biotechnology University of AllahabadPrayagrajIndia Department of Zoology Institute of ScienceBanaras Hindu UniversityVaranasiIndia Department of Bioengineering and Chemistry Indian Institute of Technology GandhinagarPalajGujaratIndia Faculty of Biotechnology University of Agronomic Science and Veterinary MedicineBucharestRomania Department of Pathology and Cell Biology Columbia University Medical CenterNew YorkNYUSA

Parkinson's disease(PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.

关键词： dopamine epigenetics gene therapies glutamate receptor levodopa molecular chaperones monoamine oxidase B mucuna alpha-synuclein Parkinson's disease striatum substantia nigra

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Unsupervised machine learning-based clustering identifies unique molecular signatures of colorectal cancer with distinct clinical outcomes

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Genes & Diseases 2023年第6期10卷 2270-2273页

作者： Manish Pratap Singh Sandhya rai Sarvesh K.Gupta nand K.Singh Sameer Srivastava Motilal Nehru National Institute of Technology Allahabad Prayagraj 211004India Deen Dayal Upadhyay Gorakhpur University Gorakhpur 273001India

Colorectal cancer(CRC)is known to harbor considerable heterogeneity.1 Consequently,it could be hypothesized that similar-appearing tumors might exhibit substantial genetic differences while diverse-appearing tumors may have a similar genetic landscape.2 Due to these differences at the molecular level,they behave or respond differently to therapies as *** progression is a multistep process and involves the accumulation of substantial genetic and epigenetic events in a stage-dependent manner.

关键词： cancer colorectal signature

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Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine

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Genes & Diseases 2021年第2期8卷 133-145页

作者： Manish Pratap Singh Sandhya rai Ashutosh Pandey nand K.Singh Sameer Srivastava Department of Biotechnology Motilal Nehru National Institute of TechnologyAllahabadUP211004India

Molecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical *** treatment strategies in colorectal cancer are largely‘one drug fit all’model for patients that display same pathological ***,CRC is a very heterogenous set ofmalignancy that does not support for above *** subtype displays different pathological and genetic *** on these features,therapeutic stratification for individual patients may be designed,which may ultimately lead to improved therapeutic *** this comprehensive review,we have attempted to briefly outline major CRC pathways.A detailed overview of molecular subtypes and their clinical significance has been *** and futuremethods,governing CRC subtyping in the era of personalized therapywith a special emphasis on CMS subtypes of CRC has been ***,discovery and validation of new CRC patient stratification methods,screening for novel therapeutic targets,and enhanced diagnosis of CRC may improve the treatment outcome.

关键词： Biomarkers CMS subtypes Immunotherapy Molecular screening Personalized medicine

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Some Physicochemical and Thermal Studies on Organic Analog of a Nonmetal-Nonmetal Monotectic Alloy;2-Cyanoacetamide–4-chloronitrobenzene System

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American Journal of Analytical Chemistry 2011年第8期2卷 953-961页

作者： Manjeet Singh Rama nand rai Uma Shankar rai 不详

The phase equilibrium data on organic analog of the nonmetal-nonmetal system, involving 2-cyanoacetamide (CA)―4-chloronitrobenzene (CNB), show the formation of a monotectic (0.10 mole fraction of CNB) and a eutectic (0.98 mole fraction of CNB) with a large miscibility gap starting from 0.10 mole fraction of CNB of monotectic (M) and ending at 0.92 mole fraction of CNB of monotectic horizontal (Mh);the upper consolute temperature Tc being 63?C above the monotectic horizontal at 118?C and eutectic temperature is at 85?C. The values of enthalpy of fusion of the pure components, the eutectic and the monotectic were determined by the differential scanning calorimetry (Mettler DSC-4000 system). Using these data, the size of the critical radius, interfacial energy, excess thermodynamic functions, entropy of fusion, and enthalpy of mixing were calcu-lated. The solid-liquid interfacial energy data confirm the applicability of the Cahn wetting condition. While growth data obey the Hillig-Turnbull equation, the microstructural investigations give typical characteristic features of the eutectic and the monotectic of the system.

关键词： Phase Diagram Thermal Properties Eutectic Composite Monotectic Alloys Interfacial Energy Microstructure Solvent Free Synthesis

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