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Chimeric Antigen Receptors and Regulatory T Cells:The Potential for HLA-Specific Immunosuppression in Transplantation

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Engineering 2022年第3期8卷 30-43页

作者： sabrina Wright Conor Hennessy Joanna Hester Fadi Issa Nuffield Department of Surgical Sciences University of OxfordOxford OX39DUUK

Chimeric antigen receptors(CARs)are a breakthrough in genetic engineering that have revolutio nized the field of adoptive cellular therapy(ACT).Cells expressing these receptors are rerouted to a predefined target by the inclusion of an antigen-specific binding region within the synthetic CAR *** advantage of cells with programmed specificity has been demonstrated clinically in the field of oncology,and it is clear that such cells have greater accuracy,potency,and reduced off-target therapeutic effects compared with their unmodified *** contrast to conventional T cells(Tconvs),regulatory T cells(Tregs)play a major role in suppressing immune activation and regulating the host immune *** expression within Tregs has been proposed as a therapy for autoimmune and inflammatory diseases,graft-versus-host disease(GVHD),and organ transplant rejectio *** the latter,they hold immense potential as mediators of immune tolerance for recipients of ***,current research into CAR-Treg engineering is extremely limited,and there is uncertainty regarding optimal design for therapeutic *** review examines the rationale behind the development of CAR-Tregs,their significance for human transplantation,potential designs,safety considerations,and comparisons of CAR-Tregs in transplantation models to date.

关键词： Chimeric antigen receptors T cell Treg Alloimmunity Bioengineering Transplant Autoimmunity

Optimization method for a radar situation interface from error-cognition to information feature mapping

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Journal of Systems Engineering and Electronics 2022年第4期33卷 924-937页

作者： WU Xiaoli WEI Wentao CALDWELL sabrina XUE Chengqi WANG Linlin School of Design Art&Media Nanjing University of Science&TechnologyNanjing 210094China School of Mechanical Engineering Southeast UniversityNanjing 211189China College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 211100China School of Computer Science Australian National UniversityCanberra 2600Australia

With the rapid development of digital and intelligent information systems, display of radar situation interface has become an important challenge in the field of human-computer interaction. We propose a method for the optimization of radar situation interface from error-cognition through the mapping of information characteristics. A mapping method of matrix description is adopted to analyze the association properties between error-cognition sets and design information sets. Based on the mapping relationship between the domain of error-cognition and the domain of design information, a cross-correlational analysis is carried out between error-cognition and design *** obtain the relationship matrix between the error-cognition of correlation between design information and the degree of importance among design information. Taking the task interface of a warfare navigation display as an example, error factors and the features of design information are extracted. Based on the results, we also propose an optimization design scheme for the radar situation interface.

关键词： radar situation interface error-cognition information feature mapping visual information display

An Interpretable Artificial Intelligence Based Smart Agriculture System

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Computers, Materials & Continua 2022年第8期72卷 3777-3797页

作者： Fariza sabrina Shaleeza Sohail Farnaz Farid Sayka Jahan Farhad Ahamed Steven Gordon School of Engineering and Technology Central Queensland UniversitySydneyAustralia College of Engineering Science and EnvironmentThe University of NewcastleSydneyAustralia School of Social Sciences Western Sydney UniversitySydneyAustralia Department of Environmental Sciences Macquarie UniversitySydneyAustralia School of Computing Data and MathematicalSciencesWestern Sydney UniversitySydneyAustralia School of Engineering and Technology Central Queensland UniversityCairnsAustralia

With increasing world population the demand of food production has increased *** of Things(IoT)based smart agriculture system can play a vital role in optimising crop yield by managing crop requirements in *** can be an important factor to make such systems trusted and easily adopted by *** this paper,we propose a novel artificial intelligence-based agriculture system that uses IoT data to monitor the environment and alerts farmers to take the required actions for maintaining ideal conditions for crop *** strength of the proposed system is in its interpretability which makes it easy for farmers to understand,trust and use *** use of fuzzy logic makes the system customisable in terms of types/number of sensors,type of crop,and adaptable for any soil types and weather *** proposed system can identify anomalous data due to security breaches or hardware malfunction using machine learning *** ensure the viability of the system we have conducted thorough research related to agricultural factors such as soil type,soil moisture,soil temperature,plant life cycle,irrigation requirement and water application timing for Maize as our target *** experimental results show that our proposed system is interpretable,can detect anomalous data,and triggers actions accurately based on crop requirements.

关键词： Explainable artificial intelligence fuzzy logic internet of things machine learning sensors smart agriculture

First report of polymicrobial necrotizing fasciitis caused by Eggerthia catenaformis and Finegoldia magna

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World Journal of Emergency Medicine 2022年第4期13卷 326-329页

作者： Claudius Illg Jonas Kolbenschlag Ruth Christine Schäfer Adrien Daigeler sabrina Krauss Department of Hand Plastic and Reconstructive SurgeryBG Unfallklinik TuebingenEberhard Karls UniversityTuebingen 72076Germany

Dear editor,Necrotizing fasciitis is a relatively rare,rapidly advancing,infectious disease with high lethality.[1]It is characterized by subcutaneous and fascial tissue necrosis and can even extend to involve skin and muscle.[2]The initial spread along fascial planes with little visual evidence impedes the crucial early *** often report minor or major trauma preceding the infection,yet in some cases,the disease develops idiopathically.[3]Risk factors,including older age,diabetes,chronic renal failure,and obesity,predispose to impaired immunity and loss of physiological barriers.[2]

关键词： impaired immunity fas

Effective transport width——A methodology to describe the spatial variability of bedload transport

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International Journal of Sediment Research 2023年第2期38卷 294-301页

作者： Rolf Rindler sabrina Schwarz Marcel Liedermann Dorian Shire-Peterlechner Andrea Kreisler Johann Aigner Michael Tritthart Helmut Habersack Institute of Hydraulic Engineering and River Research Department of Water Atmosphere and Environment University of Natural Resources and Life Sciences

The monitoring of bedload transport processes in rivers is a still challenging task in research and the parameter effective transport width(ETW) allows, for the first time, a process description of the local variability of the bedload transport. In this paper, the distribution of bedload transport over a river crosssection was studied by statistically analyzing long-term monitoring data. Using an innovative integrated measurement system, combining geophones distributed over the river width with bedload traps and basket sampling, allows for continuous, high-resolution, long-term monitoring data of bedload transport characteristics to be generated. Geophone data can be used to record and describe bedload transport processes such as intensity, temporal variability, and local variability. One parameter observed was the ETW, which describes the width where bedload transport is taking place for different discharge classes in gravel bed rivers. With the help of a data series recorded over more than a decade, it is now possible, for the first time, to statistically describe the continuously and directly measured ETW. Hence, it became evident that the effective bedload transport width depends on the discharge rate and local transport capacity, and that bedload transport over the entire river width only occurs at high flows that prevail a few days a year.

关键词： Bedload transport Spatial distribution Effective transport width Plate geophones

Acid-mediated decarboxylative C–H coupling between arenes and O-allyl carbamates

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Organic Chemistry Frontiers 2022年第6期9卷 1711-1718页

作者： Camilla Loro Julie Oble Francesca Foschi Marta Papis Egle MBeccalli sabrina Giofrè Giovanni Poli Gianluigi Broggini Dipartimento di Scienza e Alta Tecnologia Universitàdegli Studi dell’Insubriavia Valleggio 922100 ComoItaly Sorbonne Université Facultédes Sciences et IngénierieCNRSInstitut Parisien de Chimie MoléculaireIPCM4 place Jussieu75005 ParisFrance DISFARM Sezione di Chimica Generale e Organica“A.Marchesini”Universitàdegli Studi di Milanovia Venezian 2120133 MilanoItaly

Treatment of O-allyl N-tosyl carbamates with aromatic compounds in the presence of Cu(OTf)_(2) or TMSOTf as promoters affords N-substituted 1-arylpropan-2-amines,1,2-diarylpropanes,1,1-diarylpropanes,or indanes,depending on the nature of the promoter and of the aryl substrates.A full mechanistic rational allowing appreciation of the outcome of these novel C–H based cascades is *** initial acid promoted decarboxylative/deamidative Friedel–Crafts allylation takes *** protonation of the allylated arene,evolution of the resulting cation may follow different paths depending on the nature of the arene partner and of the allyl moiety in the carbamate.

关键词： allyl moiety coupling

Spatially resolved transcriptomics in immersive environments

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 12-24页

作者： Denis Bienroth Hieu TNim Dimitar Garkov Karsten Klein sabrina Jaeger-Honz Mirana Ramialison Falk Schreiber Department of Computer and Information Science University of KonstanzKonstanzGermany Cell Biology Murdoch Children’s Research InstituteParkvilleMelbourneVICAustralia Australian Regenerative Medicine Institute Monash UniversityClaytonMelbourneVICAustralia Systems Biology Institute Australia ClaytonMelbourneVICAustralia Faculty of Information Technologies Monash UniversityMelbourneAustralia

Spatially resolved transcriptomics is an emerging class of high-throughput technologies that enable biologists to systematically investigate the expression of genes along with spatial *** data acquisition,one major hurdle is the subsequent interpretation and visualization of the datasets *** address this challenge,VR-Cardiomics is presented,which is a novel data visualization system with interactive functionalities designed to help biologists interpret spatially resolved transcriptomic *** implementing the system in two separate immersive environments,fish tank virtual reality(FTVR)and head-mounted display virtual reality(HMD-VR),biologists can interact with the data in novel ways not previously possible,such as visually exploring the gene expression patterns of an organ,and comparing genes based on their 3D expression ***,a biologist-driven use-case is presented,in which immersive environments facilitate biologists to explore and compare the heart expression profiles of different genes.

关键词： Spatially-resolved transcriptomics Spatial transcriptomics Virtual reality Fish tank virtual reality Head-mounted display Immersive analytics Immersive environment

巴西“走出去”:四座世博会国家馆的故事,2020/1970/1958/1939

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时代建筑 2024年第1期 76-83页

作者： [巴西]卡洛斯·爱德华多·科马斯于云龙(译) [巴西]潘思如(校) 同济大学建筑与城市规划学院

在巴西近期的建筑作品中,2020年迪拜世博会的巴西馆尤为出色。包括保罗·门德斯·达洛查生前的合作伙伴―MMBB建筑事务所在内的联合团队设计了这一建筑。达洛查设计了声誉颇佳的1970年大阪世博会巴西馆,呼应了卢西奥·科斯塔在20世纪30... 详细信息

在巴西近期的建筑作品中,2020年迪拜世博会的巴西馆尤为出色。包括保罗·门德斯·达洛查生前的合作伙伴―MMBB建筑事务所在内的联合团队设计了这一建筑。达洛查设计了声誉颇佳的1970年大阪世博会巴西馆,呼应了卢西奥·科斯塔在20世纪30年代所发出的倡议:设计一座展现包容和多元现代建筑的里程碑。作为圣保罗粗野主义的巅峰之作,大阪展馆可与之前的两座经典之作相媲美,即1958年塞尔吉奥·伯纳德斯设计的布鲁塞尔世博会巴西馆,和1939年卢西奥·科斯塔和奥斯卡·尼迈耶合作设计的纽约世界博览会巴西馆。这两座里约派现代建筑的典范之作,突破了20世纪20年代柯布西耶式纯粹主义的藩篱。上述四个座国家馆虽是临时性的纪念建筑,但却彰显了国家与民族特征,同时融合了政治、宣传、商业和娱乐的功能。对这些世博馆的比较分析显示,尽管它们分别建于不同的年代,但在设计策略和元素上存在着明显的共同点。首先它们都是传统开放式广场或覆顶集会空间的变体。其次,这些设计与周边环境都形成了鲜明对比,以增强建筑的记忆点和纪念性。例如,迪拜巴西馆的流动广场与周遭的沙漠形成鲜明对比;大阪巴西馆的人造山丘和山谷与城市中的众多运河相映成趣;布鲁塞尔和纽约的巴西馆则分别以池塘作为冬季花园和庭院的焦点。这些建筑都具有鲜明的工程学意识,景观设计丰富,同时巧妙地融入对原型、典型和用典的隐喻,创造出既能陈列各种展览又能容纳各类活动的空间。这些展馆氛围的恰当营造,使其更接近供公众休闲娱乐的公共空间,而有别于大使馆或国家博物馆。文章强调了现代建筑作为一种形式系统的持久性,同时指出所有五感与智识的结合对于塑造能够激发思考和行动的纪念性建筑至关重要。

关键词：巴西国家馆现代建筑形式体系设计策略

The role of general anesthetics and the mechanisms of hippocampal and extra-hippocampal dysfunctions in the genesis of postoperative cognitive dysfunction

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Neural Regeneration Research 2017年第11期12卷 1780-1785页

作者： Marco Cascella sabrina Bimonte Division of Anesthesia and Pain Medicine Istituto Nazionale Tumori-IRCCS-Fondazione G.Pascale Via Mariano SemmolaNaplesItaly

Postoperative cognitive dysfunction （POCD） is a multifactorial process with a huge number of predisposing, causal, and precipitating factors. In this scenario, the neuroinflammation and the microglial activation play a pivotal role by triggering and amplifying a complex cascade involving the immuno-hormonal acti- vation, the micro circle alterations, the hippocampal oxidative stress activation and, finally, an increased blood-brain barrier＇s permeability. While the role of anesthetics in the POCD＇s genesis in humans is debated, a huge number of preclinical studies have been conducted on the topic and many mechanisms have been proposed to explain the potential neurodegenerative effects of general anesthetics. Probably, the problem concerns on what we are searching for and how we are searching and, surprisingly, preclinical studies showed that anesthetics may also manifest neuroprotective properties. The aim of this paper is to offer an overview on the potential impact of general anesthetics on POCD. Mechanisms of hippocampal and extra-hippocampal dysfunction due to neuroinflammation are discussed, whereas further research perspectives are also given.

关键词： neuroinflammation microglial activation dementia anesthesia neurodegeneration neuroprotection