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Phenotypical Aspects of a Familial Syndromic Retinitis Pigmentosa

Open Journal of Ophthalmology 2024年第2期14卷 168-173页

作者： Irma Eneida Dos Santos Joseph Matar Mass ndiaye Mariama Diambone Badji Alioune Abdoulaye Ndongo Gerauld Akpo Jean Pierre Diagne Gabriel Karold Mendy Mouhamed Attye Aboubacry Sadikh Sow Elhadji Amadou Ba Paule Aida Ndoye Roth Ophthalmology Department of Aristide Le Dantec Hospital Dakar Senegal Pediatric Department of Aristide Le Dantec Hospital Dakar Senegal Radiological Imaging Department of Aristide Le Dantec Hospital Dakar Senegal Ophthalmology Department of Abass Ndao Hospital Dakar Senegal

Aim: To report a familial case of syndromic retinitis pigmentosa identified at Aristide Le Dantec Hospital in Dakar and to describe their clinical characteristics ophthalmic. Observation: We report a sibling group of nine children, four died at a young age from unknown causes. Three children were affected by retinitis pigmentosa, two cases were syndromic. A history of nyctalopia was found in all three affected children. The mean age of onset of decreased visual acuity was 6.6 years. Patient 1 affected by syndromic retinitis pigmentosa had an extraocular sign of cystic dilation of the main bile duct. Patient 2 had myoclonic epilepsy, psychomotor retardation, and the molar tooth sign on cerebral MRI (highly suggestive of Joubert syndrome). The third child had isolated retinitis pigmentosa. Ophthalmological examinations (fundus examination, electroretinogram, and visual evoked potentials) and pediatric examinations in the remaining two children were normal. Discussion and Conclusion: Retinitis pigmentosa is a rare degenerative disease that can be associated with several other malformations, highlighting the importance of screening for associated conditions. It presents a grim functional prognosis and a life prognosis dependent on extraocular manifestations. Molecular biology (karyotyping, next-generation sequencing) could have identified the implicated genes and allowed for a formal diagnosis and genetic counseling.

关键词： Retinitis Pigmentosa Syndromic Heredity Ciliopathy

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Epidemiological Aspects of Obesity, Overweight and Cardiovascular Risk Factors at Associes in Semi-Urban Areas (Case of Sébikotane)

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Food and Nutrition Sciences 2024年第5期15卷 390-400页

作者： Djiby Sow Nafy ndiaye Mouhamed Yakham Leye Maty Diagne Camara Michel Assane Ndour Mouhamed Dieng Houleye Saou Ndiouga Fall Boundia Djiba Demba Diédhiou Im Diallo Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye Clinique Mé dicale II Centre Hospitalier Abass Ndao Universit&#233 Cheikh Anta Diop de Dakar Dakar Senegal Pikine Department of Internal Medicine and Endocrinology Cheikh Anta Diop University Dakar Senegal Department of Public Health Cheikh Anta Diop University Dakar Senegal

Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Patients and Methods: This was a cross-sectional, descriptive study conducted on November 28 and 29, 2023 in Sébikotane. It focused on volunteers for screening for chronic non-communicable diseases. Epidemiological and clinical data were evaluated. Results: One hundred and twenty-nine cases of obesity were recorded (28%). Two hundred and eighty-two cases were overweight or obese (61.3%). The mean age was 49.55 years, with a standard deviation of 12.41 years. The age group [40 - 49 years] was the most representative, with 85 cases (30.1%), and the majority were female, with 264 cases (93.6%). Primary education was the most common, with 75 cases (46.3%). Grade 1 obesity concerned ninety-seven cases (75.2%), and diabetes was present in thirty cases (23%). Hypertension was present in ninety-five cases (33.7%). Obesity was more marked in the age group [40 - 49 years] with 45 cases (36%). Conclusion: Obesity and overweight are a major cause of morbidity and mortality. The development and implementation of a prevention and management program is essential.

关键词： Obesity Overweight Risk Factors Sébikotane Senegal

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Survey on Knowledge of Cardiovascular Disease Risk Factors in the Dakar Region

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Journal of Diabetes Mellitus 2024年第2期14卷 122-132页

作者： Djiby Sow Nafy ndiaye Mouhamed Yakham Leye Fulgence A. Faye Michel Assane Ndour Marie Joseph Gomis Fall Ndiouga Mouhamed Dieng Boundia Djiba Houleye Saou Ibrahima M. Diallo Demba Diédhiou Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye Clinique Mé dicale II Centre Hospitalier Abass Ndao UCAD Dakar Senegal Department of Internal Medicine and Endocrinology Centre Hospitalier Pikine Dakar Senegal Department of Medicine Faculty of Health and Sustainable Development Alioune Diop University of Bambey Bambey Senegal

Introduction: Non-communicable diseases constitute a major public health problem, due to their morbi-mortality. The aim was to study knowledge of cardiovascular risk factors among residents of Dakar. Patients and Methods: This was a descriptive cross-sectional study. Our investigations were recruited over a six-month period (October 17, 2021 to March 21, 2022). Results: Two hundred and twenty-six (226) patients were enrolled. The mean age was 45.9 years. The under-40 age group was the most represented with 37.2%. There were 129 men (57.1%), giving a male/female sex ratio of 1.33. The highest level was represented by 159 people (70.4%). Those who responded (heart disease) were in the majority (38.1%). Hypertension was the most common CVD for 101 people (44.7%). One hundred and ninety (190) people (84%) knew the risk factors for CVD. Good knowledge of risk factors concerned 103 people (54.2%). Obesity was the best-known risk factor in 156 cases (69%). The media was the most important source of information for 121 people (53.5%). Hypertensives were the most represented with 8.4%. One hundred and thirty (130) people (57.5%) had previously paid attention to these FDRCVs. Awareness campaigns were the most effective means of communication for 170 cases (75.2%). Sixteen (16) people (35.6%) were taking antihypertensive medication. Walking was the most popular physical activity for 102 people (45%). People with a balanced diet were in the majority, with 174 respondents (77.0%). Conclusion: NCDs are a major cause of morbidity and mortality. It is essential to develop and implement a prevention and management program.

关键词： Hypertension Diabetes Risk Factors Senegal

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Prognosis Factors of Urinary Quality of Life in Parkinson Disease

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Open Journal of Therapy and Rehabilitation 2024年第1期12卷 10-17页

作者： Ngor Side Diagne Sakhi Othman Ababacar Mamadou Gueye Marie Jeanne Sakho Fatou Dialo Mboup Amélie Ndeye Makarame Sy Papa Ndiouga Lo Ba Seydina Ousmane Anna Modji Basse Maouly Fall Adjaratou Dieynaba Sow Moustapha ndiaye Amadou Gallo Diop Physical Médicine and Rehabilitation Department Fann Teaching Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal Physical Médicine and Rehabilitation Department Ibn Rochd Teaching Hospital Casablanca Morocco Physical Médicine and Rehabilitation Department Military Hospital Dakar Senegal Neurology Department Fann Teaching Hospital Dakar Senegal

Introduction: Quality of life in Parkinson disease is not necessary linked to motor symptoms. It’s correlated of overactive bladders and prostatic symptoms. Prognosis factors of urinary quality of life are unknown. Objectives: Our study aims to find prognosis factors of quality of life associated specifically of urinary disorders in PD. Patients and methods: We conducted a transversal, analytic and descriptive study in Physical Medicine, and Neurology departments, Fann Teaching Hospital, Dakar and included patients followed for treatment of PD. Urinary disorders, quality of life and functional autonomy were assessed respectively by Urinary Symptoms Profile (USP), Qualiven Short Form, Schwab and England Scale. Results: 38 patients presented PD, with a mean age of 60.89 ± 13.6 years and sex-ratio of 2.45. Mean duration of PD was 3.1 ± 2.9 years. Urinary disorders were found in 47.36% and dominated by incontinence (88.88%) and overactive bladders (88.88%) which were minor in more than 55%. Quality of life was impaired in 88.88% of cases. Minor forms (43.75%) were predominant and constraint dimension (50%) was the most severely altered. Prognosis factors for quality of life of urinary disorders were PD stages (0.046) and functional autonomy (0.042). Discussion and conclusion: Urinary disorders in PD are common, impaired quality of life, especially the constraint dimension, depends on stage of evolution of PD and functional autonomy of patients.

关键词： Urinary Quality of Life Parkinson Disease Dakar

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Profile of Autoimmune Polyendocrinopathies at the Medical Clinic II of the Abass Ndao Hospital: About 40 Cases

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Open Journal of Internal Medicine 2024年第1期14卷 74-82页

作者： Michel Assane Ndour Djiby Sow Mouhamed Dieng Ibrahima Mané Diallo Boundia Djiba Mélaine Honorine Olympio Julie Borges Preira Muriel Diembou Fatou Kiné Gadji Fama ndiaye El Hadj Mamadou Moussa Thioye Charles Halim Demba Diédhiou Anna Sarr Maïmouna Ndour Mbaye Abass Ndao Hospital Internal Medicine Department Cheikh Anta Diop University Dakar Senegal Aristide Le Dantec Hospital Internal Medicine Department Cheikh Anta Diop University Dakar Senegal

Introduction: Autoimmune polyendocrinopathies (AP) represent a group of rare concomitant pathologies, making them underdiagnosed. The objective was to study their profile at the Medical Clinic II of the Abass Ndao Hospital. Patients and Methods: This was an observational, descriptive and analytical study, lasting 24 months, from January 1, 2020 to December 31, 2022. We assessed the epidemiological, clinical and paraclinical characteristics of the patients and classified the APs found. Results: We included 40 patients divided into type III (38 cases) and IV (2 cases). A female predominance was noted with a sex ratio of 0.21. The mean age was 38.6 years. A family history of component diseases of autoimmune polyendocrine syndrome (APS) was found in 62.5%. Goiter (80%) was the main clinical sign present. All 38 patients with ISAP-3 had autoimmune thyroiditis, including 29 cases of Graves’ disease (72.5%) and 9 cases of Hashimoto’s thyroiditis (22.5%). They were associated with either type 1 diabetes (57.9%), Biermer’s disease (21.1%), vitiligo + alopecia (18.4%), lupus (2.6%). The 2 patients with AP-4 had Biermer’s disease associated with either Addison’s disease or type 1 diabetes. Management depended on the pathologies present and their possible complications. The immunological phenomena were also controlled. Conclusion: This series is globally similar to the literature. The polymorphous character of the clinical pictures requires a better collaboration between specialists leading to a clinical and holistic synthesis.

关键词： APS Biermer Graves’ Disease Hashimoto’s Addison’s Vitiligo Senegal

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Rib Osteosynthesis for Sub-Acute Management of a Flail Chest in a Tertiary Centre in a Low-Middle Income Country of Sub-Saharan Africa: Case Report at Douala Laquintinie Hospital

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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue Mebouinz Ferdinand Guy Aristide Bang Kobe Folkabo Zephany Banga Nkomo Douglas Moussa Seck Diop Abdoul Lahad Mbeng Marcella Derboise Christelle Biyouma Noel Essomba Souleyman Diatta Handy Eone Daniel Arthur Essomba Hassan ndiaye Maurice Aurelien Sosso Department of Surgery and Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon Department of Surgery and Affiliated Disciplines Douala Laquintinie Hospital Douala Cameroon Department of Surgery and Specialties Yaoundé General Hospital Yaoundé Cameroon Department of Surgery and Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service de Chirurgie Thoracique et Cardiovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR des Sciences de la Santé Ziguinchor Sénégal

Background: Costal fracture surgical is still a debate, therefore we shall select between early and delay surgical management. Case Report: We are reporting two cases of post road traffic clash delay ribs fractures osteosynthesis involving a 63-year-old man with multistage fractures on the left and pulmonary pinning of one of the costal arches, complicated by a homolateral haemothorax and a 41-year-old man with a bilateral flail chest. Conclusion: The simple postoperative course and the immediate postoperative improvement in the patient’s clinical respiratory condition enabled us to discuss the time frame for management, in this case the indication for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

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Early Prosthetic Valve Endocarditis with Mycobacterium Tuberculosis after Mitral Valve Replacement: A Case Report

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World Journal of Cardiovascular Surgery 2024年第3期14卷 33-40页

作者： Papa Amath Diagne Mory Camara Papa Ousmane Ba Momar Sokhna Diop Moussa Samba Abdou Lahad Mbengue Jean Claude Ndiogou Dione Myriam Bizrane Marième Soda Mbaye Moussa Seck Diop Toudiani Malam Kaka Papa Salmane Ba Papa Adama Dieng Amadou Gabriel Ciss Assane ndiaye Cardiovascular and Thoracic Surgery Department FANN National University Hospital Dakar Senegal

Background: Tuberculous endocarditis is a rare but serious complication of heart valve replacement surgery. We report the case of a 24-year-old patient, who presented with tuberculous endocarditis after mechanical mitral valve replacement, with a favorable clinical course following anti-tuberculosis treatment. Case Presentation: We report a 24-year-old male patient, admitted to the cardiac surgery department of the Fann Hospital (Dakar, Senegal), for the management of severe mixed (rheumatic and endocarditic) mitral insufficiency with associated tricuspid insufficiency. He had a history of recurrent angina and polyarthralgia in childhood, was hospitalized several times for refractory global cardiac decompensation, and for a suspected infective endocarditis a month before his admission. On admission, the clinical examination revealed signs suggestive of mitral and tricuspid insufficiency. Transthoracic echocardiography revealed severe post-endocarditic mitral insufficiency with A3 amputation, highly mobile 15 mm vegetations on the free edge of the large valve, moderate tricuspid insufficiency, and severe pulmonary artery hypertension. Mechanical mitral valve replacement and tricuspid valve annuloplasty using autologous pericardial strip were performed via median sternotomy. After ten days, the patient presented with global cardiac decompensation associated with a clinico-biological infectious syndrome, and tans-oesophageal echography revealed an abscess at the sinotubular junction, communicating with the aorta. A thoraco-abdomino-pelvic CT scan was done, which revealed a bilateral alveolar-interstitial syndrome with mediastinal lymphadenopathy. Anti-tuberculosis treatment with RHZE was initiated for 06 months. The clinical course was favorable. Conclusion: Tuberculous endocarditis in prostheses is a serious complication of heart valve replacement surgery, which may evolve favorably under medical treatment.

关键词： Tuberculous Endocarditis Prosthetic Valve Endocarditis Mycobacterium Tuberculosis

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Numerical Approach of Network Problems in Optimal Mass Transportation

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Applied Mathematics 2012年第5期3卷 457-466页

作者： Lamine ndiaye Babacar Mbaye ndiaye Pierre Mendy Diaraf Seck Laboratory of Mathematics of Decision and Numerical Analysis (LMDAN) FASEG University of Cheikh Anta Diop Dakar Senegal Unité Mixte Internationale UMMISCO Institut de Recherche pour le Développement Bondy France

In this paper, we focus on the theoretical and numerical aspects of network problems. For an illustration, we consider the urban traffic problems. And our effort is concentrated on the numerical questions to locate the optimal network in a given domain (for example a town). Mainly, our aim is to find the network so as the distance between the population position and the network is minimized. Another problem that we are interested is to give an numerical approach of the Monge and Kantorovitch problems. In the literature, many formulations (see for example [1-4]) have not yet practical applications which deal with the permutation of points. Let us mention interesting numerical works due to E. Oudet begun since at least in 2002. He used genetic algorithms to identify optimal network (see [5]). In this paper we introduce a new reformulation of the problem by introducing permutations . And some examples, based on realistic scenarios, are solved.

关键词： Optimal Mass Transportation Network Urban Traffic Monge-Kantorovich Problem Global Optimization

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Impact of Foreign Direct Investment (FDI) on Economic Growth of WAEMU from1980to2005

Impact of Foreign Direct Investment (FDI) on Economic Growth...

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作者： ndiaye Galaye 湖南大学

学位级别：硕士

近年来，发展中国家尤其是非洲的发展中国家的FDI (外商直接投资)对经济增长的影响正在逐渐增加。为吸引外商投资，大部分非洲国家比如WAEMU (西非经济货币联盟)国家在最近几十年已经启动贸易自由化进程并试图创造有利环境来保证它的实... 详细信息

近年来，发展中国家尤其是非洲的发展中国家的FDI (外商直接投资)对经济增长的影响正在逐渐增加。为吸引外商投资，大部分非洲国家比如WAEMU (西非经济货币联盟)国家在最近几十年已经启动贸易自由化进程并试图创造有利环境来保证它的实施。WAEMU国家对贸易自由化和宏观经济制度环境引入了具体的措施，旨在改善FDI的监管框架。这表明外商直接投资对经济增长具有积极的影响。本文将探讨WAEMU国家的FDI对经济增长的影响。本文对过去论文中用于期货扩展性研究的基本模型进行改进，来探讨发展中国家的FDI流入问题。本文估计了若干个从1980到2005年的固定效应，随机效应以及动态面板模型，模型中的数据来源于七个WAEMU中的发展中国家。研究发现，WAEMU国家的FDI正有力的促进其贸易的发展、FDI自由化和经济合作，并改善其商业环境和提高劳动成本。研究结果表明：FDI对经济增长和以经济增长为目的的匮乏的国内资本有重大影响，这使得WAEMU国家能够吸引更多的外国资本，创造更多的就业机会和财富。

关键词：国内生产总值外商直接投资经济增长通货膨胀资本 WAEMU

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Grazing effects on vegetation dynamics in the savannah ecosystems of the Sahel

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Ecological Processes 2023年第1期12卷 752-763页

作者： Haftay Hailu Gebremedhn Ousmane ndiaye Sylvanus Mensah Cofélas Fassinou Simon Taugourdeau Torbern Tagesson Paulo Salgado African Center of Excellence for Climate-Smart Agriculture and Biodiversity Conservation Haramaya UniversityP.O.Box 138Dire DawaEthiopia Dispositif en Partenariat«Pôle Pastoralisme Et Zones Sèches» Route du Front de Terre BP 2057Pôle de Recherche de HannISRADakarSenegal Centre de Recherches Zootechniques de Dahra Institut Sénégalais de Recherches AgricolesDakarSenegal Laboratoire de Biomathématiques et d’Estimations Forestières Facultédes Sciences AgronomiquesUniversitéd’Abomey-CalaviCotonouBenin Chair of Forest Growth and Dendroecology Albert-Ludwigs-Universität FreiburgFreiburg Im BreisgauGermany Facultédes Sciences et Techniques Département BVUniversitéCheikh-Anta-DiopDakarSenegal UMR SELMET CIRADINRAEInstitut Agro Univ MontpellierMontpellierFrance Department of Physical Geography and Ecosystem Science Lund UniversitySölvegatan 1222362 LundSweden Department of Geosciences and Natural Resource Management University of CopenhagenØster Voldgade 101350 CopenhagenDenmark

Background The savannah ecosystems of Sahel have experienced continuous and heavy grazing of livestock for centuries but still,their vegetation response to grazing pressure remains poorly *** this study,we analysed the herbaceous plant dynamics,measured by species diversity,composition,cover,and biomass in response to grazing pressure in the savannah ecosystems of *** Senegal,we selected four savannah sites represented with high,moderate,light and no grazing intensity *** survey methods were used for sampling the vegetation data within each of the *** richness and composition were analysed using species accumulation curve and multivariate ***,we used General Linear Models and a piecewise Structural Equation Model(pSEM)to examine the relationships between grazing intensity,vegetation cover,diversity and *** The herbaceous species diversity and composition varied significantly among the different grazing intensity levels(p<0.001).The plant species composition shifted from the dominance of grass cover to the dominance of forb cover with increasing grazing ***,the attributes of species diversity,herbaceous biomass,and ground cover were higher on sites with low grazing than sites with high and moderate grazing *** all sites,species diversity was positively related to total *** pSEM explained 37%of the variance in total biomass and revealed that grazing intensity negatively influenced total biomass both directly and indirectly through its negative influence on species *** Managing grazing intensity may lead to higher plant production and higher mixed forage establishment in the dryland savannah *** information can be used to support land management strategies and promote sustainable grazing practices that balance the needs of livestock with the conservation of ecosystem health and biodiversity.

关键词： Biomass Biodiversity Diodella sarmentosa Forb Grazing intensity Invasive species Pastoral ecosystem Senegal West Africa

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