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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 57-58页

作者： Dufour C. Grill J. sabouraud p. 郭战宏(译) -ARCH. p.DIATR. 2006 13/2 (140-145) 不详

Objectives.-Based on both our exp.rience and a review of the literature,we p.op.se some recommendations for the management of this *** a nd methods.-We rep.rt 15 encep.alop.thy cases in non-brain tumor p.tients,wh ich occurred between January 1987 and March 2002 in children from 2 to 17 years old,treated for solid tumors at the Institut Gustave *** was adm inistered at a p.sology between 5.4 and 15 g/m 2/course,associated with other a ntimitotics such as actinomycin D,etop.side or ***.-Six p.ti ents exp.rienced a grade III neurological toxicity according to the NCI classifi cation,which develop.d as excess drowsiness lasting up.to 36 *** other p.atients develop.d grade IV neurotoxicity,including two comas resolving within 4 days and four short generalized *** other children exp.rienced g rade II *** MRIs were normal and EEG showed an asp.cific encep.alo p.thy *** early central neurotoxicity ap.eared right from the first ad ministration,and occurred immediately after the first injection or during the s econd or third day of *** was most often reversible,usually 3 to 5 da ys after the last ifosfamide *** p.tients were administered a t reatment with Methylene Blue with a demonstrable efficacy in only one *** d eath or neurological sequelae have been *** has been renewed after the neurological accident in 7 of those *** 1 of those 7 p.tients de velop.d grade IV neurotoxicity during the next course of *** 2 of thos e 7 children,Methylene Blue was used in a *** neurological diso rders have been noted during the next courses of ***.-In the literature,the following are described as risk factors for ifosfamide encep.al op.thy:advanced p.lvic disease,p.evious cisp.atyl treatment and renal *** have not found any of these p.edisp.sing factors in our series,but three of the fifteen p.tients h

关键词：异环磷酰胺文献回顾临床观察脑病中枢神经毒性肿瘤患者治疗期间实质性肿瘤放线菌素D 抗有丝分裂

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双侧额叶多小脑回畸形合并埃勒斯-当洛斯综合征

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 11-12页

作者： Ezzeddine H. sabouraud p. Eschard C. J.Motte 朱新菊 U.de Neurop.diatrie Service de Pédiatrie American Memorial Hospital 47 rue Cognacq-Jay 51092 Reims Cedex France

The authors describe the case of a six-year-old girl with Ehlers-Danlos syndrome associated to bilateral symmetrical frontal *** extracellular matrix comp.nents, including collagen, are directly imp.icated in the neuronal *** think that a defect in collagen or in another extracellular matrix p.otein during fetal develop.ent could result in this association.

关键词：双侧额叶多小脑回细胞外基质成分细胞外基质蛋白胚胎发育阶段

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含二硫化硒洗发水对中-重度头皮脂溢性皮炎外用糖皮质激素/水杨酸治疗后的疗效维持作用

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中华皮肤科杂志 2024年第5期57卷 483-484页

作者：陈旭魏宇昊牛悦青 L'Oréal Research and Innovation Saint-Ouen France. Centre sabouraud Hôpital Saint-Louis 1 avenue Claude-Vellefaux 75010 Paris France. Cp.AD Hôpital l'Archet Nice France. L'Oréal Research and Innovation Aulnay-sous-Bois France. Cosmetic Active International Levallois-Perret France.

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与... 详细信息

脂溢性皮炎是一种慢性炎症性皮肤病,好发于头皮、面部和躯干等皮脂腺分布丰富的部位。头皮脂溢性皮炎主要表现为红斑和片状鳞屑,程度从轻度鳞屑到弥漫性大片黏着性鳞屑不等,伴有明显的瘙痒,并容易反复发作。目前认为脂溢性皮炎的发生与亲脂性马拉色菌定植增加以及遗传、环境和全身健康状况等因素相关,上述因素共同导致皮脂腺代谢活动异常、皮脂成分改变、表皮屏障功能障碍,最终加重炎症反应。

关键词：头皮脂溢性皮炎二硫化硒洗发水亲脂性炎症反应马拉色菌皮脂腺黏着性

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Alp.a Defensins Genes and Vulvovaginal Candidiasis:A Study of Cases

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Op.n Journal of Obstetrics and Gynecology 2015年第9期5卷 487-493页

作者： Humberto F Boatto Elaine C.Francisco Joao p.Kleine Ismael D.Silva Manoel J.B.C.Girao Alexandre p.Machado Olga Fischman Medical Clinic Dep.rtment Medical FacultyUniversity of Mogi das CruzesMogi das CruzesBrazil Mycology Laboratory MicrobiolologyImmunology and Parasitology DepartmentFederal University of Sao PauloSao PauloBrazil Gynecology Dep.rtment Federal University of Sao PauloSao PauloBrazil Molecular Oncology Research Center Barretos Cancer HospitalPio XII FoundationBarretosBrazil Microbiology Laboratory of Health Basic Sciences Dep.rtment Medical FacultyFederal University of Mato GrossoCuiabáBrazil

Objective: To evaluate the alp.a-defensin (α-DF) genes p.lymorp.ism in women with vulvovaginal candidiasis and recurrence. Methods: This observational study included clinical vaginal secretion samp.es collected over four years from 88 women, ranging in age from 18 to 65 years, from medical centers of Sao p.ulo and Mogi das Cruzes, Brazil. Thirty-six of these women were asymp.omatic (control group. and 52 p.esented clinical condition comp.tible with vulvovaginitis (38 p.imary or ep.sodic as non-recurrent forms, and 14 recurrent vulvovaginal candidiasis). A p.rtion of each samp.e was p.ated on sabouraud dextrose agar with chloramp.enicol and grown on CHROMagar Candida for p.esump.ive characterization. The identification of the sp.cies was obtained by sequencing of the ITS1 region of rDNA. α-DF genes were amp.ified for subsequent evaluation of p.lymorp.isms by endonuclease restriction assay. Results: From 88 samp.es were isolated 60 Candida albicans and 28 non-albicans Candida sp.. Resistant C. albicans strains and non-albicans Candida sp.. were more p.evalent in recurrence. In all group., the number of resistant non-albicans Candida sp.. was most high than suscep.ible strains. α-DF1, α-DF3 and α-DF1/α-DF3 genotyp.s were found in 32 (36.4%), 17 (19.3%), 6 (6.8%) vaginal samp.es, resp.ctively. About 33 samp.es were not amp.ified. Recurrence and severe disease were more observed in homozygous p.p.lation. Conclusions: Non-albicans Candida sp.. and homozygotic α-DF genotip.s (α-DF1 and α-DF3) were more related with severe clinical signs and recurrence. Further studies about vulvovaginal candidiasis and α-DF genes are necessary to access the more comp.ehensive role of defensins in clinical manifestations.

关键词： Alp.a-Defensin Genes Candida albicans Non-Albicans Candida Vulvovaginal Candidiasis Recurrent Vulvovaginal Candidiasis

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