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molecular phylogeny of Trametes and related genera,and description of a new genus Leiotrametes

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Fungal Diversity 2012年第4期55卷 47-64页

作者： Stéphane Welti Pierre-Arthur moreau Anne Favel Régis Courtecuisse mireille Haon David Navarro sabine Taussac Laurence Lesage-meessen INRA Aix-Marseille Univ.UMR1163 de Biotechnologie des Champignons Filamenteux ESIL163 avenue de LuminyCP 92513288 MarseilleCedex 09France Facultédes sciences pharmaceutiques et biologiques Laboratoire des sciences végétales et fongiquesUniversitéLille 2.3 rue du Professeur LaguesseB.P.83F-59006 LilleCedexFrance A.Favel:m.Haon:D.Navarro:S.Taussac:L.Lesage-meessen CIRm-CF UMR 1163 BCF13009 MarseilleFrance

A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical *** sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by maximum Likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium *** results were obtained from analyses of ribosomal LSU sequences downloaded from *** Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(***,***,***,***)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and *** presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these *** the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:Leiotrametes Welti&***..Two new combinations:Leiotrametes lactinea(Berk.)Welti&*** ***(Berk.)Welti&*** proposed.

关键词： Basidiomycota Polyporales Artolenzites Coriolopsis Lenzites Pycnoporus morphology Biogeography

Intra-arterial thrombolytics during endovascular thrombectomy for acute ischaemic stroke in the mR CLEAN Registry

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Stroke & Vascular Neurology 2023年第1期8卷 17-25页

作者： sabine L Collette Reinoud P H Bokkers Aryan mazuri Geert J LycklamaàNijeholt Robert J van Oostenbrugge Natalie E LeCouffe Faysal Benali Charles B L m majoie Jan Cees de Groot Gert Jan R Luijckx maarten Uyttenboogaart 无 Department of Radiology Medical Imaging CentreUniversity Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands Department of Radiology Haaglanden Medical CentreThe Haguethe Netherlands Department of Neurology Cardiovascular Research Institute Maastricht(CARIM)Maastricht University Medical CentreMaastrichtthe Netherlands Department of Neurology Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Radiology Maastricht University Medical CentreMaastrichtthe Netherlands Department of Radiology and Nuclear medicine Amsterdam UMCUniversity of AmsterdamAmsterdam NeuroscienceAmsterdamthe Netherlands Department of Neurology University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands On behalf of the mR CLEAN Registry investigators

Introduction The efficacy and safety of local intra-arterial(IA)thrombolytics during endovascular thrombectomy(EVT)for large-vessel occlusions is *** analysed how often IA thrombolytics were administered in the multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(mR CLEAN)Registry,whether it was associated with improved functional outcome and assessed technical and safety outcomes compared with EVT without IA *** In this observational study,we included patients undergoing EVT for an acute ischaemic stroke in the anterior circulation from the mR CLEAN Registry(march 2014-November 2017).The primary endpoint was favourable functional outcome,defined as an modified Rankin Scale score≤2 at 90 *** endpoints were reperfusion status,early neurological recovery and symptomatic intracranial haemorrhage(sICH).Subgroup analyses for IA thrombolytics as primary versus adjuvant revascularisation attempt were *** Of the 2263 included patients,95(4.2%)received IA thrombolytics during *** IA thrombolytics administered were urokinase(median dose,250000 IU(IQR,193750-250000))or alteplase(median dose,20 mg(IQR,12-20)).No association was found between IA thrombolytics and favourable functional outcome(adjusted OR(aOR),1.16;95%CI 0.71 to 1.90).Successful reperfusion was less often observed in those patients treated with IA thrombolytics(aOR,0.57;95%CI 0.36 to 0.90).The odds of sICH(aOR,0.82;95%CI 0.32 to 2.10)and early neurological recovery were comparable between patients treated with and without IA *** primary and adjuvant revascularisation attempts,IA thrombolytics were more often administered for proximal than for distal *** outcomes were comparable for patients receiving IA thrombolytics as a primary versus adjuvant revascularisation *** Local IA thrombolytics were rarely used in the mR CLEAN *** the relatively small st

关键词： arterial throm acute

management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the mR CLEAN Registry

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Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： sabine L Collette michael P Rodgers marianne A A van Walderveen Kars C J Compagne Paul J Nederkoorn Jeannette Hofmeijer Jasper m martens Gert J de Borst Gert Jan R Luijckx Charles B L m majoie Aad van der Lugt Reinoud P H Bokkers maarten Uyttenboogaart University medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University medical Centre LeidenThe Netherlands Erasmus mC University Medical CentreRotterdamThe Netherlands Amsterdam University medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hospital ArnhemThe Netherlands University medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(mR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included patients,169(39%)underwent EVT with *** 123/168(73%)patients,CAS was performed before intracranial *** 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without *** during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.

关键词： stenosis carotid treatment

无线技术的新起点——实用的WireleSS无线技术赢得优势

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流程工业 2009年第7期 19-24页

作者： sabine mühlenkamp PROCESS德文版编辑

2008年9月19日WirelessHART通信规范正式获得国际电工标准委员会（IEC）的认可，成为一种公共可用的规范。这一标准的获批，成为过程自动化领域发展无线技术的新起点，不仅使得流程工业企业对无线新产品．新技术有了更高的期望，无线产... 详细信息

2008年9月19日WirelessHART通信规范正式获得国际电工标准委员会（IEC）的认可，成为一种公共可用的规范。这一标准的获批，成为过程自动化领域发展无线技术的新起点，不仅使得流程工业企业对无线新产品．新技术有了更高的期望，无线产品的设备供应商也看到了新的商机，纷纷推出了自己的无线新品。

关键词：无线技术 WireleSS 国际电工标准优势流程工业企业无线产品过程自动化设备供应商

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

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World Journal of Gastroenterology 2021年第24期27卷 3630-3642页

作者： Ulrike Bauer sabine Gerum Falk Roeder Stefan münch Stephanie E Combs Alexander B Philipp Enrico N De Toni martha m Kirstein Arndt Vogel Carolin mogler Bernhard Haller Jens Neumann Rickmer F Braren marcus R makowski Philipp Paprottka markus Guba Fabian Geisler Roland m Schmid Andreas Umgelter Ursula Ehmer Internal medicine Ⅱ Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of Radiotherapy and Radiation Oncology University of SalzburgSalzburg 5020Austria Department of Radiation Oncology University Hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Department of Radiation Oncology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of medicine II Liver CentreUniversity HospitalLMU MunichMunich 81377Germany Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany Institute of Pathology Technical University of MunichMunich 81675Germany Institute of medical Informatics Statistics and EpidemiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Pathology Faculty of MedicineUniversity Hospital of MunichMunich 81377Germany Institute of Diagnostic and Interventional Radiology Klinikum rechts der IsarTechnical University of MunichMunich 81675Germany Institute of Diagnostic and Interventional Radiology Section for Interventional RadiologyKlinikum rechts der IsarTechnical University of MunichMunich 81675Germany Department of General- Visceral-Vascular-and Transplant-SurgeryUniversity hospital of MunichCampus GroßhadernLMU MunichMunich 81377Germany Emergency Department Vivantes hospital groupHumboldt hospitalBerlin 13509Germany

BACKGROUND Liver transplantation(LT)presents a curative treatment option in patients with early stage hepatocellular carcinoma(HCC)who are not eligible for resection or ablation *** to a risk of up 30%for waitlist drop-out upon tumor progression,bridging therapies are used to halt tumor *** chemoembolization(TACE)and less commonly stereotactic body radiation therapy(SBRT)or a combination of TACE and SBRT,are used as bridging therapies in ***,it remains unclear if one of those treatment options is *** analysis of explant livers after transplantation provides the unique opportunity to investigate treatment response by *** To analyze histopathological response to a combination of TACE and SBRT in HCC in comparison to TACE or SBRT *** In this multicenter retrospective study,27 patients who received liver transplantation for HCC were *** received either TACE or SBRT alone,or a combination of TACE and SBRT as bridging therapy to liver *** explants of all patients who received at least one TACE and/or SBRT were analyzed for the presence of residual vital tumor tissue by histopathology to assess differences in treatment response to bridging *** analysis was performed using Fisher-Freeman-Halton exact test,Kruskal-Wallis and mann-Whitney-U *** Fourteen patients received TACE only,four patients SBRT only,and nine patients a combination therapy of TACE and *** were no significant differences between groups regarding age,sex,etiology of underlying liver disease or number and size of tumor ***,analysis of liver explants revealed that almost all patients in the TACE and SBRT combination group(8/9,89%)showed no residual vital tumor tissue by histopathology,whereas TACE or SBRT alone resulted in significantly lower rates of complete histopathological response(0/14,0%and 1/4,25%,respectively,P value<0.001).CONCLUSION Our data suggests th

关键词： Hepatocellular carcinoma Transarterial chemoembolization Stereotactic body radiation therapy Bridging therapy Liver transplantation