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data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère sabine dölle-bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 367-376页

作者： sabine Gerum Alexandra d Jensen Falk Roeder department of Radiation Oncology University Hospital LMU Munich department of Radiation Oncology University Hospital Gie?en and Marburg CCU Molecular Radiation Oncology German Cancer Research Center department of Radiotherapy and Radiation Oncology Paracelsus Medical University

Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches.

关键词： Hepatocellular carcinoma Stereotactic body radiation therapy Local-ablative treatment Combination approaches Mini-review

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High temperature characteristic of hydroxyapatite-titania

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中国有色金属学会会刊：英文版 2005年第S3期15卷 443-446页

作者：汪涛张文彦 d.R.Annett S.sabine College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Institute of Ceramic Materials Technische Universitt Bergakademie Freiberg Freiberg 09596 Germany Institute of Analytical Chemistry Technische Universitt Bergakademie Freiberg Freiberg 09596 Germany

In order to provide the kinetic mechanism for optimizing the quality of the hydroxyapatite （Ca 10（PO4）6-（OH）2, HA） coating on Ti-alloy orthopedic devices, the high temperature behavior of HA-titania （TiO2） composite specimen was investigated using XRd, FTIR and 31P MAS NMR methods. Thermal treatment of HA-TiO2 mixture powders leads to dehydroxylate and decompound of HA as well as chemical reaction between the two materials. Evidence for the initiation of the dehydroxylation of hydroxyapatite was found at 700℃ in air. The decomposition product of β-tricalcium phosphate was proven at 900℃ in air. Additionally, the formation of CaTiO3, derived from the chemical reaction between HA and titania at 900℃, was confirmed.

关键词： hydroxyapatite FT-IR spectroscopy NMR spectroscopy titania XRd

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Effects of solvents and temperature on spherulites of self-assembled phloroglucinol tristearate

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 389-396页

作者： Yawen Yao sabine Rosenfeldt Kai Zhang Wood Technology and Wood Chemistry Georg-August-University of Goettingen37077 GottingenGermany department of Chemistry and Bavarian Polymer Institute University of Bayreuth95447 BayreuthGermany

Herein,phloroglucinol tristearate(PhgTS)was used to study the crystallization process due to its unique symmetric structure containing a benzene ring and three aliphatic *** of crystallized PhgTS from four solvents under diverse conditions were analyzed in detail and their formation process was *** cross is shown by PhgTS spherulites obtained from aprotic solvents via polarized optical *** comparison,no Maltese cross can be observed from branch-like crystals formed from protic *** on the micro-scaled morphology,lamellae were found to be the basic blocks constructing both PhgTS spherulites and branch-like crystals,which were formed predominantly by stacked PhgTS *** differential characters of the solvents did not affect the formation of lamellas,the solvents played a crucial role in the formation of self-assembled microscaled *** particular,the morphologies of spherulites were strongly affected by the concentration of PhgTS solutions,surrounding tempera-ture and evaporation rate of ***,a higher concentration of PhgTS led to more homogeneous spherulites,a lower evaporation rate resulted in more compact spherulites,and a higher surounding temperature generated preferentially more ring-banded spherulites of PhgTS.

关键词： phloroglucinol tristearate aprotic and protic solvent self-assembly spherulites

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Review on dating Methods:Numerical dating in the Quaternary Geology of High Asia

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Journal of Mountain Science 2010年第2期7卷 105-122页

作者： Matthias Kuhle sabine Kuhle Georg-August-University of Goettingen Department of Geography and High Mountain Geomorphology

Over the past few years, OSL and TCN datings of glacial material from High Asia have come into fashion. To this day, however, these techniques do not permit safe calibration. The intensity of the cosmic ray flux is being modulated by the solar and terrestrial magnetic fields and their secular fluctuations in the past. So far, these variations cannot be converted into the respective local TCN production rates for High Asia. We have reason to believe that the ages that are being calculated despite these uneertainties are generally overestimated. This assessment is supported by eonventional radiocarbon dates and above＂ all by the glacial chronology developed independently on the basis of the Quaternary geological method. The strongly emerging evidence for a much more extensive LGM glaciation of High Asia is, however, either being ignored or rejected by many authors, solely on the basis of the above-mentioned uncalibrated datings. This self-conceit based on the ＂dating fallacy＂, as we call it, should be avoided since it goes decidedly against the standards of the scientific method established in Quaternary geology and makes a fundamental scientific discussion impossible.

关键词： Calibration of numerical dating Geomagnetic field excursions Solar activity Interface problem Tibetan ice sheet dating fallacy

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Spatial/temporal indexing and information visualization genre for environmental digital libraries

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第11期6卷 1235-1248页

作者： CHEN Su-shing GRUNWALd sabine department of Computer ＆ Information Science ＆ Engineering University of Florida Gainesville Florida 32611 USA department of Soil and Water Science University of Florida Gainesville Florida 32611 USA

Protecting and preserving our environmental systems require the ability to understand the spatio-temporal distri- bution of soils, parent material, topography, and land cover as well as the effects of human activities on ecosystems. Space-time modelling of ecosystems in an environmental digital library is essential for visualizing past, present, and future impacts of changes occurring within such landscapes (e.g., shift in land use practices). In this paper, we describe three novel features, spa- tio-temporal indexing, visualization, and geostatistical genre, for the environmental digital library, Environmental Visualization and Geographic Enterprise System (ENVISAGE), currently in progress at the University of Florida.

关键词： Spatio-temporal indexing Geostatistics GIS (Geographic Information System) Visualization Environmentaldigital library Spatio-temporal search

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Promoting Health democracy

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Psycho-Oncologie 2024年第1期18卷 5-7页

作者： sabine dutheil Marie-Frédérique Bacqué Kristopher Lamore Clinique Tivoli LISAL’Institut du Sein d’AquitaineBordeaux33300France UR3071 Universitéde StrasbourgStrasbourg67000France University.Lille CNRSUMR 9193—SCALab—Sciences Cognitives et AffectivesLilleF-59000France

Introduction,L’histoire de la démocratie sanitaire-devenue par un glissement sémantique la démocratie en santé-est un long processus encore et toujours en marche de la relation entre les citoyens et leur système de santé[1,2].Cette relation aétéet continue d’être influencée par des changements sociétaux majeurs au cours des dernières décennies.

关键词： des continue relation

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Transferability and Scalability of Soil Total Carbon Prediction Models in Florida, USA

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Pedosphere 2018年第6期28卷 856-872页

作者： sabine GRUNWALd Congrong YU Xiong XIONG department of Soil and Water Sciences University of Florida State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University College of Hydrology and Water Resource Hohai University Agricultural and Biological Engineering department University of Florida

The applicability, transferability, and scalability of visible/near-infrared(VNIR)-derived soil total carbon(TC) models are still poorly understood. The objectives of this study were to: i) compare models of three multivariate statistical methods, partial least squares regression(PLSR), support vector machine(SVM), and random forest methods, to predict soil logarithm-transformed TC(logTC) using five fields(local scale) and a pooled(regional-scale) VNIR spectral dataset(a total of 560 TC spectral datasets), ii)assess the model transferability among fields, and iii) evaluate their up-and downscaling behaviors in Florida, USA. The transferability and up-and downscaling of the models were limited by the following factors: i) the spectral data domain, ii) soil attribute domain,iii) methods that describe the internal model structure of VNIR-TC relationships, and iv) environmental domain space of attributes that control soil carbon dynamics. All soil logTC models showed excellent performance based on all three methods with R^2> 0.86,bias d error(RMSE) = 0.09%, residual predication deviation(RPd) > 2.70%, and ratio of prediction error to interquartile range(RPIQ) > 4.54. The PLSR method performed substantially better than the SVM method to scale and transfer the TC models. This could be attributed to the tendency of SVM to overfit models, while the asset of the PLSR method was its robustness when the models were validated with independent datasets, transferred, and/or scaled. The upscaled soil TC models performed somewhat better in terms of model fit(R2), RPd, and RPIQ, whereas the downscaled models showed less bias and smaller RMSE based on PLSR. We found no universal trend indicating which of the four limiting factors mentioned above had the most impact that constrained the transferability and scalability of the models. Given that several factors can impinge on the empirically derived soil spectral prediction models, as demonstrated by this study,

关键词： attribute domain multivariate statistical methods partial least squares regression random forest support vector machine soil carbon dynamics visible-near infrared spectroscopy

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When invasive ants meet: effects of outbreeding on queen performance in the tramp ant Cardiocondyla itsukii

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Insect Science 2019年第2期26卷 333-340页

作者： Jurgen Heinze sabine Frohschammer Abel Bernadou LS Zoologie/Evolutionsbiologie Universitat Regensburg Regensburg Germany

Most disturbed habitats in the tropics and subtropics harbor numerous species of invasive ants, and occasionally the same species has been introduced repeatedly from multiple geographical sources. We examined how experimental crossbreeding between sexuals from different populations affects the fitness of queens of the tramp ant Cardiocondyla itsukii, which is widely distributed in Asia and the Pacific Islands. Eggs laid by queens that mated with nestmate males had a higher hatchi ng rate than eggs laid by queens mated to males from neighboring (Hawaii x Kauai) or distant introduced populations (Hawaii/Kauai x Okinawa). Furthermore, inbreeding queens had a Ion ger lifespan and produced a less female-biased offspring sex ratio than queens from allopatric mating. This suggests that the genetic divergence between different source populations may already be so large that in case of multiple invasions eventual crossbreeding might negatively affect the fitness of tramp ants.

关键词： Cardiocondyla longevity outbreeding depression reproductive success tramp ants

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Pentacene-based nanorods on Au（111） single crystals： Charge transfer, diffusion, and step-edge barriers

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Nano Research 2013年第6期6卷 449-459页

作者： sabine-Antonia Savu sabine Abb Simon Schundelmeier Jonathan d. Saathoff James M. Stevenson Christina Tonshoff Holger F. Bettinger Paulette Clancy M. Benedetta Casu Thomas Chasse Institute of Physical and Theoretical Chemistry University of Tuebingen Aufder Morgenstelle 18 72076 Tuebingen Germany School of Chemical and Biomolecular Engineering Cornel/University Ithaca New York 14853 USA Institute of Organic Chemistry University of Tuebingen Auf der Morgenstelle 18 72076 Tuebingen Germany

We investigate nanorod assemblies of two 64-substituted pentacenes, namely （2,3-X2-9,10-Y2）-substituted pentacenes with X -- Y = OCH3 （MOP） and with X = F, Y-- OCH3 （MOPF）, grown on Au（111） single crystals. By using a multi-technique approach based on ultraviolet photoelectron spectroscopy X-ray photoelectron spectroscopy; and X-ray absorption, we find evidence for charge transfer screening at the interface with gold. Furthermore, the MOP and MOPF nanorods show a rough surface morphology, which was investigated with atomic force microscopy. We use molecular simulation techniques to investigate the energetic barriers to diffusion and to traverse step-edges to estimate their influence on the nanorod roughness. We find that barriers to surface diffusion on a terrace are anisotropic and that their direction favors the formation of nanorods in these materials.

关键词： nanorod assembly substituted pentacene electronic structures/ processes/mechanisms organic electronics charge transfer diffusion and step-edge barrier

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