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Genetic reporter analysis reveals an expandable reservoir of OCT4+cells in adult skin

Cell Regeneration 2014年第1期3卷 63-68页

作者： Anne Limbourg sabine schnabel Vladimir J Lozanovski L Christian Napp Teng-Cheong Ha Tobias Maetzig Johann Bauersachs Hassan Y Naim Axel Schambach Florian P Limbourg Research Group Regenerative Agents HannoverGermany REBIRTH Cluster of Excellence HannoverGermany Integrated Research Center Transplantation(IFB-Tx) HannoverGermany Current affiliation:Department of Plastic Hand and Reconstructive SurgeryHannoverGermany Department of Cardiology and Angiology HannoverGermany Institute of Experimental Hematology OE6960 Hannover Medical SchoolCarl-Neuberg-Str.1D-30625 HannoverGermany Department of Physiological Chemistry Hannover Veterinary SchoolHannoverGermany Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolHarvardUSA Department of Nephrology and Hypertension Hannover Medical SchoolHannoverGermany Department of General and Transplant Surgery University Hospital HeidelbergHeidelbergGermany Vascular Medicine and Transplantation Research Dept.of Nephrology and HypertensionOE 6841Hannover Medical SchoolCarl-Neuberg-Str.1D-30625 HannoverGermany

The transcription factor Oct4(Pou5f1)is a critical regulator of pluripotency in embryonic and induced pluripotent stem ***,Oct4 expression might identify somatic stem cell populations with inherent multipotent potential or a propensity for facilitated ***,analysis of Oct4 expression is confounded by Oct4 pseudogenes or non-pluripotency-related *** analysis of a transgenic Oct4-EGFP reporter mouse identified testis and skin as two principle sources of Oct4^(+)cells in postnatal *** the prevalence of GFP^(+)cells in testis rapidly declined with age,the skin-resident GFP^(+)population expanded in a cyclical *** cells were identified as epidermal stem cells dwelling in the stem cell niche of the hair follicle,which endogenously expressed all principle reprogramming factors at low ***,skin wounding or non-traumatic hair removal robustly expanded the GFP^(+)epidermal cell pool not only locally,but also in uninjured skin areas,demonstrating the existence of a systemic ***,the epithelial stem cell niche of the hair follicle harbors an expandable pool of Oct4^(+)stem cells,which might be useful for therapeutic cell transfer or facilitated reprogramming.

关键词： Oct4 Epidermal stem cells Skin Transgenic reporter mice

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Categories and Weak Equivalences of Graded Algebras

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Algebra Colloquium 2019年第4期26卷 643-664页

作者： Alexey Gordienko Ofir schnabel James Zhang Department of Higher Mathematics Moscow State Technical University of Civil Aviation Kronshtadtsky Boulevardd.20125993 MoscowRussia Department of Mathematics ORT Braude College2161002 KarmiclIsrael 不详

In the study of the structure of graded algebras(such as graded ideals,graded subspaces,and radicals)or graded polynomial identities,the grading group can be replaced by any other group that realizes the same *** we come to the notion of weak equivalence of gradings:two gradings are weakly equivalent if there exists an isomorphism between the graded algebras that maps each graded component onto a graded *** group grading on an algebra can be weakly equivalent to G-gradings for many different groups G;however,it turns out that there is one distinguished group among them,called the universal group of the *** this paper we study categories and functors related to the notion of weak equivalence of *** particular,we introduce an oplax 2-functor that assigns to each grading its support,and show that the universal grading group functor has neither left nor right adjoint.

关键词： algebra grading adjoint functor oplax 2-functor (co)limit

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Crustal Structure across the Northwestern Margin of South China Sea:Evidence for Magma-poor Rifting from a Wide-angle Seismic Profile

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Acta Geologica Sinica(English Edition) 2012年第4期86卷 854-866页

作者： DING Weiwei Michael schnabel Dieter FRANKE RUAN Aiguo WU Zhenli The Second Institute of Oceanography State Oceanic Administration Federal Institute for Geoscience and Natural Resource(BGR)

We present results from a 484 km wide-angle seismic profilie acquired in the northwest part of the South China Sea （SCS） during OBS2006 cruise. The line that runs along a previously acquired multi-channel seismic line （SO49-18） crosses the continental slope of the northern margin, the Northwest Subbasin （NWSB） of the South China Sea, the Zhongsha Massif and partly the oceanic basin of the South China Sea. Seismic sections recorded on 13 ocean-bottom seismometers were used to identify refracted phases from the crustal layer and also reflected phases from the crust-mantle boundary （Moho）. Inversion of the traveltimes using a simple start model reveals crustal images in the study area. The velocity model shows that crustal thickness below the continental slope is between 14 and 23 kin. The continental part of the line is characterized by gentle landward mantle uplift and an abrupt oeeanward one. The velocities in the lower crust do not exceed 6.9 km/s. With the new data we can exclude a high-velocity lower crustal body （velocities above 7.0 kin/s） at the location of the line. We conclude that this part of the South China Sea margin developed by a magma-poor rifting. Both, the NWSB and the Southwest Sub-basin （SWSB） reveal velocities typical for oceanic crust with crustal thickness between 5 and 7 kin. The Zhongsha Massif in between is extremely stretched with only 6-10 km continental crust left. Crustal velocity is below 6.5 kin/s; possibly indicating the absence of the lower crust. Multi-channel seismic profile shows that the Yitongansha Uplift in the slope area and the Zhongsha Massif are only mildly deformed. We considered them as rigid continent blocks which acted as rift shoulders of the main rift subsequently resulting in the formation of the Northwest Sub-basin. The extension was mainly accommodated by a ductile lower crustal flows, which might have been extremely attenuated and flow into the oceanic basin during the spreading stage. We compared the crustal stru

关键词： P-wave velocity model magma-poor rifting lower crust flow South China Sea

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Spinel Castables for Steel Ladle Lining:In-Situ Versus Preformed

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China's Refractories 2012年第3期21卷 7-15页

作者： Andreas BUHR Marion schnabel LONG Bin Reinhard EXENBERGER Christian RAMPITSCH Jerry DUTTON Almatis GmbH Frankfurt Germany Qingdao Almatis Co. Ltd. Qingdao 266071 China Voestalpine Stahl GmbH Linz Austria Stourbridge United Kingdom

The paper discusses the difference in the formulation concepts of alumina - spinel （spinel containing ） and alumina - magnesia （ spin, el forming） castables and the influence on their physical properties. The individual property profile is discussed with respect to the requirements of refactory lining materials for the different zones of a steel ladle.

关键词： in-situ spinel preformed spinel steel ladle lining

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Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 235-243页

作者： Francisco M. Ojeda Christian Miiller Daniela Bornigen David-Alexandre Tregouet Arne Schillert Matthias Heinig Tanja Zeller Renate B. schnabel Department of General and Interventional Cardiology University Heart Center Hamburg-Eppendorf 20246 Hamburg Germany German Center for Cardiovascular Research (DZHK) Hamburg |Kiel| Luebeck Germany Sorbonne Universites University Pierre et Marie Curie Paris 06 Institut National pour la Sante et la Recherche Medicale (INSERM) Unite Mixte de Recherche en Sante (UMR_S) 1166 F-75013 Paris France Institute for Cardiometaholism and Nutrition (ICAN) F-75013 Paris France Institut fur Medizinische Biometrie und Statistik Universitat zu Lubeck Universitatsklinikum Schleswig-Holstein Campus Lubeck 23562 Lubeck Germany Institute of Computational Biology German Research Center for Environmental Health Helmholtz Zentrum Munchen 85764 Neuherberg Germany

Prognostic models based on survival data frequently make use of the Cox proportional hazards model. Developing reliable Cox models with few events relative to the number of predictors can be challenging, even in low-dimensional datasets, with a much larger number of observations than variables. In such a setting we examined the performance of methods used to estimate a Cox model, including （i） full model using all available predictors and estimated by standard techniques, （ii） backward elimination （BE）, （iii） ridge regression, （iv） least absolute shrinkage and selection operator （lasso）, and （v） elastic net. Based on a prospective cohort of patients with manifest coronary artery disease （CAD）, we performed a simulation study to compare the predictive accuracy, calibration, and discrimination of these approaches, Candidate predictors for incident cardiovascular events we used included clinical variables, biomarkers, and a selection of genetic variants associated with CAD. The penalized methods, i.e., ridge, lasso, and elastic net, showed a comparable performance, in terms of predictive accuracy, calibration, and discrimination, and outperformed BE and the full model. Excessive shrinkage was observed in some cases for the penalized methods, mostly on the simulation scenarios having the lowest ratio of a number of events to the number of variables. We conclude that in similar settings, these three penalized methods can be used interchangeably. The full model and backward elimination are not recommended in rare event scenarios.

关键词： Proportional hazards regression Penalized regression Events per variable Coronary artery disease

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Quantum expander for gravitational-wave observatories

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Light(Science & Applications) 2019年第1期8卷 62-69页

作者： Mikhail Korobko Yiqiu Ma Yanbei Chen Roman schnabel Institut für Laserphysik und Zentrum fur Optische Quantentechnologien Universitat HamburgLuruper Chaussee 14922761 HamburgGermany Theoretical Astrophysics 350-17 California Institute of TechnologyPasadenaCA 91125USA

The quantum uncertainty of laser light limits the sensitivity of gravitational-wave *** the past 30 years,techniques for squeezing the quantum uncertainty,as well as for enhancing gravitational-wave signals with optical resonators have been ***,however,have finite linewidths,and the high signal frequencies that are produced during the highly scientifically interesting ring-down of astrophysical compact-binary mergers still cannot be ***,we propose a purely optical approach for expanding the detection *** uses quantum uncertainty squeezing inside one of the optical resonators,compensating for the finite resonators’linewidths while keeping the low-frequency sensitivity *** quantum expander is intended to enhance the sensitivity of future gravitational-wave detectors,and we suggest the use of this new tool in other cavity-enhanced metrological experiments.

关键词： wave quantum unchanged

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Analysis of a Simple Probe for <i>In-Situ</i>Resistivity Measurements

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Journal of Water Resource and Protection 2017年第1期9卷 1-10页

作者： Jens Munk Todd Petersen Matt Cullin William schnabel Department of Electrical Engineering University of Alaska Anchorage Anchorage AK USA Department of Mechanical Engineering University of Alaska Anchorage Anchorage AK USA University of Alaska Fairbanks Fairbanks AK USA

We present a probe factor for a simple measurement device, which can be used to determine in-situ electrical resistivity in soils or other penetrable bodies. The probe is primarily sensitive to the material immediately surrounding it and therefore is ideal for determining localized conductivities. The geometry of the probe can be scaled to effectively adjust the region of interest. The calibration, or “probe factor” is a function of the geometry, as well as the electrode configuration. Results are presented assuming a Wenner array configuration, however they can easily be extended to other geometries, such as the Schlumberger or dipole-dipole array.

关键词： Electrical Resistivity Measurements Soil Moisture Electrical Conductivity Geophysical Measurement

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Models for the estimation of probable intake of flavouring substances

Models for the estimation of probable intake of flavouring s...

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第三届中国香料香精高层论坛

作者： Dr. Jürgen schnabel Head Global Regulatory and Scientific Affairs Givaudan Flavours

＜正＞～～

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桃褐腐病菌抗药性分子机理研究进展

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植物保护 2010年第5期36卷 28-32页

作者：尹良芬胡勐郡金鑫 Guido schnabel 罗朝喜华中农业大学植物科技学院武汉430070 湖北省作物病害监测和安全控制重点实验室武汉430070 Clemson University Dept. of ESPS Clemson 29634 USA

桃褐腐病是严重危害桃生产的重要病害之一。在实际生产中,该病害的控制主要以化学防治为主。由于杀菌剂的大量使用,桃褐腐病菌已对几类常用的杀菌剂产生了不同程度的抗药性。本文就桃褐腐病菌(Moniliniaspp.)对生产上使用的几大类杀菌... 详细信息

桃褐腐病是严重危害桃生产的重要病害之一。在实际生产中,该病害的控制主要以化学防治为主。由于杀菌剂的大量使用,桃褐腐病菌已对几类常用的杀菌剂产生了不同程度的抗药性。本文就桃褐腐病菌(Moniliniaspp.)对生产上使用的几大类杀菌剂的抗药性情况及抗药性分子机制研究进展进行简单概述和分析,以供国内同行借鉴与参考。

关键词：桃褐腐病杀菌剂抗药性分子机理

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贵州喀斯特地区碳酸盐岩的宇宙成因核素^(36)Cl侵蚀速率

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科学通报 2013年第20期58卷 1884-1885页

作者：徐胜刘丛强 FREEMAN Stewart 郎赟超 schnabel Christoph 涂成龙 WILCKEN Klaus 赵志琦中国科学院地球化学研究所环境地球化学国家重点实验室贵阳550002 Scottish Universities Environmental Research Center East KilbrideG75 0QFUK

喀斯特地区侵蚀速率是理解全球碳循环、喀斯特地貌演化以及土地利用等学科的最基本问题之一.侵蚀速率估算方法主要包括：（1）流域河水化学溶解物平衡的计算;（2）置于不同环境下的大理岩片重量损失的观测;（3）显微侵蚀测量仪对暴露地... 详细信息

喀斯特地区侵蚀速率是理解全球碳循环、喀斯特地貌演化以及土地利用等学科的最基本问题之一.侵蚀速率估算方法主要包括：（1）流域河水化学溶解物平衡的计算;（2）置于不同环境下的大理岩片重量损失的观测;（3）显微侵蚀测量仪对暴露地表的直接测量;（4）碳酸盐岩中石英脉的长期观测;（5）地表岩石中宇宙成因核素36Cl（半衰期3万年）的测定.与其他方法相比,地表岩石中36Cl含量反映了104-105年尺度内的岩石暴露和侵蚀历史.

关键词：宇宙成因核素喀斯特地区侵蚀速率碳酸盐岩贵州长期观测全球碳循环土地利用

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