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Nanoparticle Exsolution on Perovskite Oxides:Insights into Mechanism,Characteristics and Novel Strategies

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Nano-Micro Letters 2024年第2期16卷 312-346页

作者： Yo Han Kim Hyeongwon Jeong Bo‑Ram Won Hyejin Jeon Chan‑ho Park Dayoung Park Yeeun Kim somi Lee Jae‑ha Myung Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

Supported nanoparticles have attracted considerable attention as a promising catalyst for achieving unique properties in numerous applications,including fuel cells,chemical conversion,and *** demonstrate high activity by expanding the number of active sites,but they also intensify deactivation issues,such as agglomeration and poisoning,*** for bottomup synthesis of supported nanoparticles has emerged as a breakthrough technique to overcome limitations associated with conventional *** are uniformly exsolved from perovskite oxide supports and socketed into the oxide support by a one-step reduction *** uniformity and stability,resulting from the socketed structure,play a crucial role in the development of novel ***,tremendous research efforts have been dedicated to further controlling exsolution *** effectively address exsolution at a more precise level,understanding the underlying mechanism is *** review presents a comprehensive overview of the exsolution mechanism,with a focus on its driving force,processes,properties,and synergetic strategies,as well as new pathways for optimizing nanocatalysts in diverse applications.

关键词： Supported nanoparticle Exsolution In situ growth Mechanism Perovskite oxide Catalyst

Control of Canine Endoparasites,Especially Isospora spp.,with Procox^(■) in Naturally Infected Puppies:Parasitological,Bacteriological and Health Parameters

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Open Journal of Veterinary Medicine 2013年第2期3卷 121-130页

作者： Barbara Anna Rauscher sabine schafer-somi Monika Ehling-Schulz Karin Mostl Stefanie Handl Barbara Hinney Joachim Spergser Roland Schaper Anja Joachim Institute of Parasitology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Centre for Artificial Insemination and Embryo Transfer Department for Small Animals and HorsesUniversity of Veterinary Medicine ViennaViennaAustria Functional Microbiology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Virology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Animal Nutrition Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaViennaAustria Clinical Microbiology and Infection Biology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Bayer Animal Health GmbH MonheimGermany

The effect of Procox? (Bayer, emodepside/toltrazuril suspension for dogs) against natural infections with Isospora spp. was investigated. Two groups were treated either with 0.5 ml suspension/kg of body weight (0.45 mg emodepside and 9 mg toltrazuril/kg of body weight) in the 3rd, 5th and 7th week of life (w.o.l.) (Procox? group;n = 28) or with a control anthelminthic (Dewormed Control group;n = 26). Animals were surveyed weekly from the 3rd w.o.l. by coproscopy and clinical examination. Faecal samples were examined microbiologically from the 4th to the 8th w.o.l. and faecal inflammatory markers canine calprotectin and canine S100A12 were measured in the 8th w.o.l. Specific antibody titres were evaluated in serum samples from five litters before and after vaccination against canine distemper virus and canine parvovirus 2. The prevalence of Isospora-positive animals increased to 67% in the Dewormed Control group (n = 15 puppies from four parasite-positive litters), while in the Procox? group (n = 15 puppies) it was less than 34% with significantly lower excretion (p ? was easily applied and effective;adverse effects did not occur. The level of seroconversion or titre increase upon vaccination was higher in parasite-free animals (91%) compared to Procox?-treated puppies (30%) and the Control animals (10%). Animals from parasite-free litters showed significantly different excretion patterns for haemolytic Escherichia coli and Clostridium perfringens, while there was no difference between Procox?-treated and Control animals. In some animals kept under poor hygienic conditions diarrhoea was noted in association with C. perfringens, E. coli or Salmonella. Concentrations of inflammatory markers in the faeces did not significantly differ between the Procox? and the Control group. Adequate control of parasitic and bacterial infections in suckling puppies requires both antiparasitic treatment and hygiene. Even when parasites do not cause overt effects treatment is recommended

关键词： Dog Emodepside Gut Health Isospora Toltrazuril Toxocara Vaccination

Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases

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Molecular Plant 2024年第5期17卷 824-837页

作者： Tom Schreiber Anja Prange Petra schafer Thomas Iwen Ramona Grutzner Sylvestre Marillonnet Aurelie Lepage Marie Javelle Wyatt Paul Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in *** this study,we identified two groups of exonucleases from the herpes virus and the bacteriophage T7 families that conferred an up to 38-fold increase in homology-directed repair frequencies when fused to Cas9/Cas12a in a tobacco mosaic virus-based transient assay in Nicotiana *** achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable transformation *** Arabidopsis thaliana,fusion of Cas9 to a herpes virus family exonuclease led to 10-fold higher frequencies of knock-ins in the first generation of *** addition,we demonstrated stable and heritable knock-ins in wheat in 1%of the primary *** together,our results open perspectives for the routine production of heritable knock-in and gene replacement events in plants.

关键词： homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease plants

Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Analysis of the Tragedy of Vila Socóin Cubatão (São Paulo, Brazil) Using the Haddon Matrix: A Comprehensive Examination of Socio-Environmental Factors and Risk Mitigation Strategies

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Journal of Environmental Protection 2024年第5期15卷 620-639页

作者： Rubens Martins Santos Nilce Ortiz sabine Neusatz Guilhen Nuclear and Energy Research Institute IPEN/SP S&#227o Paulo Brazil

The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an influx of migrants drawn by burgeoning industries, leading to unplanned urban growth and the emergence of vulnerable communities like Vila Socó. This article examines the interconnected factors—such as demographic shifts, inadequate planning, and regulatory oversight—that culminated in the devastating fire of 1984, claiming numerous lives and highlighting systemic failures. Utilizing the Haddon Matrix, this study dissects the Vila Socó incident, emphasizing the roles of human error, infrastructure integrity, and socio-economic disparities in disaster causation. By contextualizing the tragedy within Cubatão’s industrial trajectory, it underscores the urgent need for comprehensive risk assessment and proactive mitigation strategies in rapidly developing regions globally. Beyond its immediate focus, this work offers broader insights into the dynamics of industrial disasters and their socio-economic implications. As pipelines continue to play a vital role in global energy infrastructure, the lessons drawn from Vila Socó’s tragedy resonate deeply, emphasizing the imperative of robust safety protocols and accountable governance to prevent similar catastrophes in the future.

关键词： Haddon Matrix Vila Socó Accident Risk Analysis Cubatão

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隐藏世界——上海滴水湖洲际酒店

中国建筑装饰装修 2024年第5期 17-23+16页

作者： sabine Beck Hirsch Bedner Associates (HBA)

这座位于上海临港新城的豪华型湖滨度假酒店是独岛酒店,有着“一岛一酒店”的美称。酒店前身为滴水湖皇冠假日酒店,其建筑造型别致,宛若一朵在湖水上盛开的桃花临湖亲水,景致迷人。本次翻新设计以“隐藏世界”为概念,打造宛如一扇连接...

这座位于上海临港新城的豪华型湖滨度假酒店是独岛酒店,有着“一岛一酒店”的美称。酒店前身为滴水湖皇冠假日酒店,其建筑造型别致,宛若一朵在湖水上盛开的桃花临湖亲水,景致迷人。本次翻新设计以“隐藏世界”为概念,打造宛如一扇连接陆地和水域并通往海洋世界的门户,带给入住客人沉浸于想象和探索之境的体验。

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数字化赋能流程工业可持续发展

流程工业 2024年第3期 16-17页

作者： sabine Mühlenkamp 《PROCESS》编辑部

在保持流程工业竞争力的同时,如何不忽视可持续发展?整个流程行业都在寻找答案,尤其是目前正处于经济危机和能源转型双重压力下,自动化在其中正发挥着关键作用。

关键词：经济危机工业可持续发展能源转型流程工业流程行业数字化竞争力双重压力

Vanadium mineralization at Los Chihuidos sediment-hosted Cu-V deposit,Neuquén Basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.Rainoldi Daniel Beaufort Marta B.Franchini Adolfo Giusiano sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium mineralization at Los Chihuidos deposit of the Neuquén Basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the V ore with minor amounts of *** the implementation of the redox interface,abundant V-montmorillonite and V-hematite precipitated at the more oxidizing conditions and Cu-V-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with V-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including V-bearing montmorillonite,Cu-V-corrensite-type,V-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor V-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of V and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of V-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals V-chlorite Redox front Bleaching Hydrocarbons