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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 148-150页

作者： sabine lieb Sebastian Ebel Daniel Seehofer Thomas Berg Florian van Bommel Division of Hepatology Department of Medicine IILeipzig University Medical CenterLeipzigGermany Department of Diagnostic and Interventional Radiology Leipzig University Medical CenterLeipzigGermany Department of Visceral VascularThoracic and Transplant SurgeryLeipzig University Medical CenterLeipzigGermany

With great interest we have read the comment of *** on the recently published CRAFITY score for the prediction of response to anti-programmed death(ligand)1[PD-(L)1]-based immunotherapy in patients with unresectable h... 详细信息

关键词： patients hepatocellular carcinoma

Replacement of annular domain with trapezoidal domain in computational modeling of nonaqueous-phase-liquid dissolution-front propagation problems

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Journal of Central South University 2015年第5期22卷 1841-1846页

作者：赵崇斌 Thomas POULET Klaus REGENAUER-lieb Computational Geosciences Research Centre Central South University CSIRO Division of Earth Science and Resource Engineering P.O.Box 1130 Bentley WA 6102 Australia School of Earth and Environment The University of Western Australia

In order to simulate the instability phenomenon of a nonaqueous phase liquid(NAPL) dissolution front in a computational model, the intrinsic characteristic length is commonly used to determine the length scale at which the instability of the NAPL dissolution front can be initiated. This will require a huge number of finite elements if a whole NAPL dissolution system is simulated in the computational model. Even though modern supercomputers might be used to tackle this kind of NAPL dissolution problem, it can become prohibitive for commonly-used personal computers to do so. The main purpose of this work is to investigate whether or not the whole NAPL dissolution system of an annular domain can be replaced by a trapezoidal domain, so as to greatly reduce the requirements for computer efforts. The related simulation results have demonstrated that when the NAPL dissolution system under consideration is in a subcritical state, if the dissolution pattern around the entrance of an annulus domain is of interest, then a trapezoidal domain cannot be used to replace an annular domain in the computational simulation of the NAPL dissolution ***, if the dissolution pattern away from the vicinity of the entrance of an annulus domain is of interest, then a trapezoidal domain can be used to replace an annular domain in the computational simulation of the NAPL dissolution system. When the NAPL dissolution system under consideration is in a supercritical state, a trapezoidal domain cannot be used to replace an annular domain in the computational simulation of the NAPL dissolution system.

关键词： nonaqueous phase liquid(NAPL) trapezoidal domain computational simulation dissolution front instability

Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2007年第26期13卷 3567-3574页

作者： John G lieb II Peter V Draganov Gastroenterology Fellow Division of GastroenterologyDepartment of Internal MedicineUniversity of Florida FL 32610-0214United States Associate Professor of Medicine Division of GastroenterologyUniversity of Florida FL 32610-0214United States

Acute pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The only way to prevent this complication is to avoid an ERCP all together. Because of the risks involved, a careful consideration should be given to the indication for ERCP and the potential risk/benefit ratio of the test. Once a decision to perform an ERCP is made, the procedure should be carried out with meticulous care by an experienced endoscopist, and with a minimum of pancreatic duct opacification. Several pharmacologic agents have been tested, but to date the most important method of reducing post ERCP pancreatitis is the placement of pancreatic stent. Pancreatic stents should be placed in all patients at high risk of this complication such as those undergoing pancreatic sphincterotomy, pancreatic duct manipulation and intervention, and patients with suspected sphincter of Oddi dysfunction. Pancreatic stents should be also considered in patients requiring precut sphincterotomy to gain biliary access.

关键词： Post endoscopic retrograde cholangiopancre-atography pancreatitits Somatostatin Gabexate IL-10 Pancreatic stents Aspirating catheter Sphincter of Oddidysfunction

Pancreatic function testing: Here to stay for the 21st century

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World Journal of Gastroenterology 2008年第20期14卷 3149-3158页

作者： John G lieb II Peter V Draganov University of Florida

The diagnosis of Chronic Pancreatitis （CP） is based on the detection of abnormal structure or function of the diseased pancreas. The pancreatic function tests more accurately determine the presence of CP than tests of structure, especially for early stage disease. The function tests can be divided into two categories： non- invasive and invasive. The invasive ＂tube＂ tests can reliably detect mild, early CP, but are only available at a few referral centers and tend to be poorly tolerated by patients. The non-invasive tests are easy to obtain, but tend to perform poorly in patients with early, mild disease. Therefore, no one test is useful in all clinical situations, and a detailed understanding of the rational, pathophysiologic basis, strengths, and limitations of various tests is needed. This review highlights the role of various pancreatic function tests in the diagnosis of CP including fecal fat analysis, fecal elastase, fecal chymotrypsin, serum trypsin, the secretin stimulation test, the cholecystokinin （CCK） stimulation test, the combined secretin-CCK stimulation test, the intraductal and endoscopic secretin stimulation tests, and the functional magnetic resonance imaging of the pancreas after secretin stimulation.

关键词： Pancreatic function testing Secretinstimulation test CCK stimulation test Fecal elastase Endsocopic secretin stimulation test Chronic pancreatitis

Rock Plasticity from Microtomography and Upscaling

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Journal of Earth Science 2015年第1期26卷 53-59页

作者： Jie Liu Reem Freij-Ayoub Klaus Regenauer-lieb School of Earth Science and Geological Engineering Sun Yat-Sen University School of Earth and Environment the University of Western AustraliaPerth WA 6000Australia Earth Science and Resource Engineering CSIROKensington WA 6151Australia School of Petroleum Engineering University of New South WalesSydney NSW 2052Australia

We present a workflow for upscaling of rock properties using microtomography and percolation theory. In this paper we focus on a pilot study for assessing the plastic strength of rocks from a digital rock image. Firstly, we determine the size of mechanical representative volume ele- ment （RVE） by using upper/lower bound dissipation computations in accordance with thermody- namics. Then the mechanical RVE is used to simulate the rock failure at micro-scale using FEM. Two cases of different pressures of linear Drucker-Prager plasticity of rocks are computed to compute the macroscopic cohesion and the angle of internal friction of the rock. We also detect the critical exponents of yield stress for sealing laws from a series of derivative models that are created by a shrinking/expanding algorithm. We use microtomographic data sets of two carbonate samples and compare the results with previous results. The results show that natural rock samples with irregular structures may have the critical exponent of yield stress different from random models. This unexpected result could have significant ramifications for assessing the stability of solid materials with internal structure. Therefore our pilot study needs to be extended to investigate the scaling laws of strength of many more natural rocks with irregular microstructure.

关键词： plastic strength rock mierotomography percolation theory upscaling.

Borehole deformation based in situ stress estimation using televiewer data

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2475-2481页

作者： Hamid Roshan Danqi Li Ismet Canbulat Klaus Regenauer-lieb School of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW2052Australia WA School of Mines MineralsEnergy and Chemical EngineeringCurtin UniversityPerthWA6102Australia

The knowledge of in situ stress is critical in safe and optimised extraction of minerals and energy *** situ stresses are either measured directly(***)or estimated indirectly(*** breakouts).Borehole breakout analysis for in situ stress estimation is considered a relatively simple and cost-efficient *** technique,however,poses certain limitations such as complexities with progressive formation of breakouts and it requires inputs such as rock failure parameters that are not often *** a result,significant effort has been made to develop new indirect methods for in situ stress *** deformation analysis using four-arm caliper has been recently proposed for in situ stress estimation and has shown promising *** this study,we demonstrate a new methodology that analyses the borehole televiewer data with the technique of borehole deformation analysis to estimate the in situ stresses through a field case *** advantages and challenges of using borehole televiewer data for stress estimation based on borehole deformation analysis are discussed and the best practice to obtain the reliable results is *** limitations of using fourarm caliper and borehole deformation analysis for in situ stress estimation are also discussed and it is shown how televiewer data can overcome such ***,the in situ stress results obtained from televiewer data and borehole deformation analysis are compared with independent in situ stress measurements to show the robustness and reliability of the proposed methodology.

关键词： In situ stress Borehole deformation Televiewer Elastic properties Downhole logging

Coupling of Thermal-Hydraulic-Mechanical Processes for Geothermal Reservoir Modelling

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Journal of Earth Science 2015年第1期26卷 47-52页

作者： Ali Karrechl Oussama Beltaief Ruyan Vincec Thomas Poulet Klaus Regenauer-lieb School of Civil and Resource Engineering The University of Western AustraliaCrawley WA 6009Australia Tunisia Polytechnic School Rue AlkhawarizmiLa MarsaTunisia Earth Science and Resource Engineering CSIROKensington WA 6151Australia School of Petroleum Engineering University of New South WalesSydney NSW 2052Australia School of Earth and Environment The University of Western AustraliaPerth WA 6000Australia

This paper uses a fully coupled framework of thermal-hydraulic-mechanical processes to investigate how the injection and extraction of fluid within a geothermal reservoir impacts on the distributions of temperature, pore pressure, and deformation within the rock formations. Based on this formulation, a numerical model is developed in light of the thermodynamics of porous materials. The proposed procedure relies on the derivation of dissipative flow rules by postulating proper storage and dissipation functions. This approach opens new horizons for several resource engineering applications. Since it allows for full coupling, this formulation can play a key role in predicting risks when used for reservoir simulation. The results indicate that the injection-extraction process and temperature change have a definite impact on altering the in-situ properties of the reservoir.

关键词： poro-mechanics resource engineering fluid injection and extraction temperaturechange pore pressure stress deformation uplift subsidence.

Limit analysis for the seismic stability of three-dimensional rock slopes using the generalized Hoek-Brown criterion

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International Journal of Mining Science and Technology 2022年第2期32卷 237-245页

作者： A.Karrech X.Dong M.Elchalakani H.Basarir M.A.Shahin K.Regenauer-lieb School of Engineering University of Western AustraliaCrawleyWA 6009Australia Department of Geoscience and Petroleum Norwegian University of Science and TechnologyTrondheim 7031Norway School of Civil and Mechanical Engineering Curtin UniversityPerth 6102Australia School of Minerals and Energy Resources Engineering UNSWSydneyNSW 2052Australia

The parameters that influence slope stability and their criteria of failure are fairly understood but over-conservative design approaches are often preferred,which can result in excessive overburden removal that may jeopardize profitability in the context of open pit *** methods such as finite element and discrete element modelling are instrumental to identify specific zones of stability,but they remain approximate and do not pinpoint the critical factors that influence stability without extensive parametric studies.A large number of degrees of freedom and input parameters may make the outcome of numerical modelling insufficient compared to analytical *** analytical approaches have not tackled the stability of slopes using non-linear plasticity criteria and threedimensional failure *** paper bridges this gap by using the yield design theory and the Hoek-Brown ***,the proposed model includes the effect of seismic forces,which are not always taken into account in slope stability *** results are presented in the form of rigorous mathematical expressions and stability charts involving the loading conditions and the rock mass properties emanating from the plasticity criterion.

关键词： Three-dimensional slope Seismic stability Generalized Hoek-Brown criterion Open pit

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瑞典金融市场剖析

城市金融 1995年第8期 36-37页

作者： lieb,A 朱景彬

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