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12th International Congress of Protozoology

作者： Ankri Serge Ohad Fisher Hala Harony Mona Abed sabina Bernes Rama Siman-Tov. Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel Department of Molecular Microbiology The Bruce Rappaport Faculty of Medicine TechnionP.O.B 9649 Haifa 31096 Israel

＜正＞DNA methylation is an epigenetic modification that occurs in a wide range of prokaryotic and eukaryotic organisms. DNA methylation is an important mechanism of regulation of genomic functions such as differential control of gene expression. Our knowledge about the relevance of DNA methylation in the biology of protozoan organisms is scanty. We identified by immunodetection the presence of 5-methylated cytosine （m5C） in the parasite Entamoeba histolytica. The synthesis of m5C is catalyzed by a cytosine-5 DNA methyltransferase （Ehmeth） that belongs to the Dnmt2 proteins family. The biological

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巴伐利亚州高等教育的乡村化发展战略——以因河畔米尔多夫校区为例

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应用型高等教育研究 2019年第1期4卷 15-19页

作者： sabina Schutter 陈颖(翻译) 罗森海姆应用科学大学德国罗森海姆83024 奥斯纳布吕克应用科学大学

出生率下降、老年人口群体增加以及各种地缘因素都对高校的区域设置产生重要影响。乡村地区需要受过良好教育的年轻专业人才,从而满足区域发展对专业人才的需求。要实现这一目标,必须注意到异质学生群体代表的各种不同利益。以因河畔米... 详细信息

出生率下降、老年人口群体增加以及各种地缘因素都对高校的区域设置产生重要影响。乡村地区需要受过良好教育的年轻专业人才,从而满足区域发展对专业人才的需求。要实现这一目标,必须注意到异质学生群体代表的各种不同利益。以因河畔米尔多夫校区为例,探讨了高校乡村化建设与发展。

关键词：乡村地区高等教育地方化战略人口变化

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Asthma-associated genetic variants in 17q21 influence ORMDL3 and GSDMA gene expression and IL-17 secretion in cord blood

Asthma-associated genetic variants in 17q21 influence ORMDL3...

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中华医学会呼吸病学年会——2011（第十二次全国呼吸病学学术会议）

作者： Anna Lluis Michaela Schedel sabina llli Martin Depner Erika von Mutius Michael Kabesch Bianca Schaub University Childrens Hospital LMU MunichGermany Department of Pneumology Allergology and NeonatologyMedical School HannoverGermany

Objectives In a genome-wide association study genetic variants on chromosome 17q21 were shown to be strongly associated with childhood asthma and ORMDL3 gene expression. Regulation of the 17q21 locus and its immunological relevance early in life has not been well *** investigated the effect of previously asthma-associated SNPs(single

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Study on the Protection of Digital Copyright:the International Framework

Study on the Protection of Digital Copyright:the Internation...

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作者：斯蒂娜（Estefania sabina Abem Abia Angue）大连海事大学

学位级别：硕士

近年来,随着知识社会和现代法律的发展,互联数字著作权的保护成为人们关心的至关重要的问题。由于公众通过互联网可以获取各种信息和文化作品,所以就产生了许多与侵犯知识产权有关的问题,创作者本应该享受其出版的思想背后的权利,即使... 详细信息

近年来,随着知识社会和现代法律的发展,互联数字著作权的保护成为人们关心的至关重要的问题。由于公众通过互联网可以获取各种信息和文化作品,所以就产生了许多与侵犯知识产权有关的问题,创作者本应该享受其出版的思想背后的权利,即使它在通过因特网进行传播时仍然没有足够的保证。现在我们都知道,生产创造信息通常需要大量的投资,例如需要开发新的计算机程序、数据库、多媒体、音乐或胶片录制。因此,产生了一个问题,如果生产创造信息昂贵且困难,而复制它廉价且容易那么为什么公司还进行投资,例如投资计算机程序以生产新的软件。相当比例的用户都不遵守规则,因为他们知道对违反规则的处罚是极小的,甚至有时显得无关紧要。正如在一些国家所出现的情形,在大多数立法中规定的刑罚不适用。这里让人感到不解的是:为什么复制信息非常容易且廉价?比如高比例的非法复制音乐、书籍、软件或视频。答案多种多样,众所周知,世界各地的立法者一直在努力平衡建立更好的机制,以帮助在这个新的全球环境中维护版权保护,并依赖于新技术。但即便如此,由于互联网和社交媒体等相关平台的使用大幅度增加,版权保护也变得非常困难。事实上出于同样的原因,它仍然需要建立更多的版权和各自的保护与他们的创造者之间的联系,证明是一项工作不仅必要而且紧迫。在本论文的第一章中,我从数字版权的概念研究出发,从定义、数字版权概念到保护及其目的进行论述。也论述了相关国际公约对其的保护以及一些相关的权利。第二章讨论互联网作为数字版权保护侵权问题的关键利益相关者,认为互联网是问题的根源,分析了侵权行为类型,讨论版权所有者和用户之间权利平衡的困难。第三章系统地论述包括WIPO互联网条约(WCT、WPPT)在内的国际公约对版权保护的新趋势和国际解决方案,以及分析其主要条款(WCT第11条和WPPT第18条),论述WIPO执行立法,如EC指令、DMCA和FTA协议,还分析了有效的补救措施,如TPM和DRM。第四章重点关注国际协调的必要性。第五章介绍了笔者对数字技术国际版权保护研究的反思和建议,并提出建议。希望我的研究结果可以为未来的法律文章提供一个更加清晰的方向。

关键词：数字技术著作权保护国际框架

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Allelopathy of Medicinal Plants: Current Status and Future Prospects in Weed Management

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Agricultural Sciences 2018年第12期9卷 1569-1588页

作者： A. K. M. Mominul Islam sabina Yeasmin Jamal Ragheb Said Qasem Abdul Shukor Juraimi Md. Parvez Anwar Weed Management Laboratory Department of Agronomy Bangladesh Agricultural University Mymensingh Bangladesh Department of Agronomy Bangladesh Agricultural University Mymensingh Bangladesh Department of Plant Protection Faculty of Agriculture University of Jordan Amman Jordan Department of Crop Science University of Putra Malaysia Serdang Malaysia

An attempt has been made in this article to accumulate and elucidate the literatures about the allelopathic potentiality of medicinal plants, and its role on the development of bio-herbicides for eco-friendly weed management strategies to conserve bio-diversity and ecological balance. This review paper has been prepared by comprehensive studies of various published research articles, books and proceedings available in the world literature. The farmers of different countries use several weed management techniques in order to minimize the deleterious effect of weeds. Among them most commonly used practice is application of herbicides due to its high efficacy and cost effectiveness, less time-consuming nature, flexibility and easy accessibility, and more rapid out return. Although use of synthetic herbicides in the crop fields has increased the crop production as well as the productivity by reducing the weed infestation, over time it causes a number of environmental hazards. Hence, to avoid these detrimental effects of synthetic herbicide, a lot of efforts have been dedicated by the researchers to search the novel natural plant products mainly allelochemicals and try to apply them as a tool for the development of bio-degradable natural herbicides. This paper intended to reflect the current state of allelopathic medicinal plants and their potentiality to develop eco-friendly and natural product-based herbicides for sustainable agriculture, and to invite further debate on this issue.

关键词： Allelochemicals Medicinal Plants Natural Products Bio-Herbicides Sustainable Weed Management

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Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma:an exploratory study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第6期22卷 512-520页

作者： Huiyuan ZHU Shaochun YAN Jingshuo WU Zhong ZHANG Xiaolin LI Zheng LIU Xing MA Lina ZHOU Lin ZHANG Mingming FENG Yiwei GENG Aixin ZHANG sabina JANCIAUSKIENE Aiguo XU Department of Pulmonary and Critical Care Medicine Zhengzhou Second People's HospitalZhengzhou Affiliated Hospital of Jinan UniversityZhengzhou 450006China Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Cell Biology School of Basic and Forensic MedicineBaotou Medical CollegeBaotou 014040China Department of Hematology First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Respiratory Medicine German Center for Lung ResearchHannover Medical SchoolHannover 30625Germany

Background:Previous studies have shown that macrophage migration inhibitory factor(MIF)is involved in the pathogenesis of *** study aimed to investigate whether serum MIF reflects a therapeutic response in allergic ***:We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls,analyzing the parameter levels of serum MIF,serum total immunoglobulin E(tIgE),peripheral blood eosinophil percentage(EOS%),and fractional exhaled nitric oxide(FeNO).Lung function indices were used to identify disease severity and therapeutic ***:Our study showed that all measured parameters in patients were at higher levels than those of *** one week of treatment,most parameter levels decreased significantly except for serum ***,we found that serum MIF positively correlated with EOS%as well as FeNO,but negatively correlated with lung function *** operator characteristic(ROC)curve analysis indicated that among the parameters,serum MIF exhibited a higher capacity to evaluate therapeutic *** area under the curve(AUC)of MIF was 0.931,with a sensitivity of 0.967 and a specificity of ***:Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.

关键词： Macrophage migration inhibitory factor(MIF) Allergic asthma Eosinophilic inflammation Fractional exhaled nitric oxide Immunoglobulin E(IgE)

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Efficacy and Economics of Different Need Based Nitrogen Management Approaches in Winter Rice

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American Journal of Plant Sciences 2018年第13期9卷 2601-2611页

作者： Nilufar akhtar Jahan sabina Yeasmin Md. Parvez Anwar Md. Ariful Islam Hamidur Rahman A. K. M. Mominul Islam Department of Agronomy Bangladesh Agricultural University Mymensingh Bangladesh Weed Management Laboratory Department of Agronomy Bangladesh Agricultural University Mymensingh Bangladesh

This experiment aimed to study the efficacy of different nitrogen (N) management approaches in winter rice. The experiment consisted of two rice varieties: 1) BRRI (Bangladesh Rice Research Institute) dhan29-an inbred and 2) Dhanigold-a hybrid, and eight N management approaches: 1) BRRI recommended N (control), 2) Soil analysis based N management, 3) N application based on Agro-ecological zone, 4) 20 kg·N·ha-1 at ≤35 SPAD (Silicon photon activate diode) value, 5) 30 kg·N·ha-1 at ≤35 SPAD value, 6) 20 kg·N·ha-1 at ≤3.0 LCC (leaf colour chart) value, 7) 30 kg·N·ha-1 at ≤3.0 LCC value and 8) Urea Super Granule. Between two varieties, hybrid Dhani gold produced higher grain yield (6.67 t·ha-1) than the inbred BRRI dhan29. Application of 20 kg·N·ha-1 at ≤3.0 LCC value gave the highest grain yield (7.10 t·ha-1), whereas the lowest grain yield (5.92 t·ha-1) was found from the SPAD approach with 20 kg·N·ha-1 at ≤35 SPAD value. In case of treatment interaction highest grain yield (7.34 t·ha-1) was found in BRRI dhan29 coupled with 20 kg·N·ha-1 at ≤3.0 LCC value with 18 kg·N·savings·ha-1 over control, maximum gross income (146,800 BDT·ha-1) and net benefit (142,120 BDT·ha-1), which was statistically identical with the grain yield from the interaction of Dhani gold and 30 kg·N·ha-1 at ≤3.0 LCC value but required 42 kg·extra·N·ha-1 (over control). The lowest grain yield (5.19 t·ha-1) was found when Dhanigold was coupled with 30 kg·N·ha-1 at ≤35 SPAD value, while the 20 kg·N·application·ha-1 at ≤35 SPAD value gave moderate yield (6.87 t·ha-1) with considerable higher gross (139,600 BDT·ha-1) and net (136,090 BDT·ha-1) incomes than the control (gross: 121,000 and net: 115,600 BDT·ha-1). The results reveal that 20 kg·N·ha-1 at ≤3.0 LCC value appeared as the promising practice for inbred BRRI dhan29, and 30 kg·N·ha-1 at ≤35 SPAD value for hybrid Dhanigold in terms of yield, N use efficiency and economic benefit of winter rice.

关键词： Rice Nitrogen Demand Leaf Color Chart SPAD Meter Nitrogen Use Efficiency Nitrogen Economics

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含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方改善轻、中度痤疮症状的临床观察

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临床皮肤科杂志 2022年第3期51卷 175-179页

作者：李舒婷何晓峰张中兴 Julie CRIBIER sabina MERALLI-BALLOU Andrew STEEL 鞠强牛悦青欧莱雅中国研发和创新中心上海201206 欧莱雅中国活性健康化妆品部上海200040 欧莱雅法国研发和创新中心舍维伊拉吕94550 上海交通大学医学院附属仁济医院皮肤科上海200120

目的:评价含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方改善轻、中度痤疮临床症状的有效性和安全性。方法:招募66例轻、中度女性痤疮患者,按要求使用测试产品28 d后停用14 d,分别在使用前、使用7 d和28 d以及停用7 d和14 d后由皮肤... 详细信息

目的:评价含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方改善轻、中度痤疮临床症状的有效性和安全性。方法:招募66例轻、中度女性痤疮患者,按要求使用测试产品28 d后停用14 d,分别在使用前、使用7 d和28 d以及停用7 d和14 d后由皮肤科医生进行痤疮皮损计数、痤疮炎症后红斑和色素沉着计数、毛孔可见度和肤色均匀度评级,拍摄面部标准照片并进行图像分析,并由患者完成自我评价问卷。结果:共有42例患者完成全部试验。与使用前相比,测试产品在使用后7 d和28 d能显著减少非炎性和炎性皮损数量,改善毛孔可见度和肤色均匀度,并且在停用后14 d内仍能维持效果。此外,测试产品对于肤色、红斑程度/面积及血流灌注等图像分析指标也有显著的改善作用。患者对测试产品耐受良好,表现出了较高的满意度和持续使用的意愿。结论:含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方对于改善轻、中度痤疮临床症状具有较好的有效性和安全性,减少皮损同时能减轻痤疮炎症后红斑和色素沉着并改善肤质和肤色。

关键词：痤疮

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你知道小婴儿在想什么吗？

你知道小婴儿在想什么吗？

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2020年

作者： (德)萨宾娜·鲍恩(sabina Pauen)

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Case Report: Caseous Calcification of the Mitral Annulus in an 88-Year-Old Woman

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Open Journal of Internal Medicine 2020年第4期10卷 337-341页

作者： Giuseppe Fede Giuseppe Abate Paola Belluardo Carmelo Di Tommasi Maria Luisa Guarrella Nicoletta Guccione Guglielmo Piccione Salvatore Solarino Giuseppe Sulsenti Giovanni Tasca sabina Ficili Department of Cardiovascular Disease Maggiore Hospital Modica Italy

The caseous calcification of the mitral annulus (CCMA) is a rare variant of the mitral annulus calcification (MAC), with prevalence of 0.067% in general population. It is usually an asymptomatic condition but rarely it can cause severe mitral valve dysfunction, embolization, and conduction abnormalities. Transthoracic echocardiography (TTE) is a useful diagnostic tool. However, it can be necessary a multi-modality imaging approach for a differential diagnosis among other intra-cardiac masses. We are presenting a case of CCMA in an 88-year-old woman admitted to our department for acute decompensation of chronic heart failure. TTE has shown pathognomonic findings of CCMA. Tridimensional trans-esophageal echocardiography (3D TEE) gave a better characterization of the CCMA, avoiding further diagnostic procedures.

关键词： Mitral Valve Caseous Calcification Tridimensional Echocardiography

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