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Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients

Cancer Communications 2022年第6期42卷 517-535页

作者： Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger sabina Berezowska Axel Walch Research Unit Analytical Pathology Helmholtz Zentrum Munchen-German Research Center for Environmental HealthNeuherberg 85764Germany Institute of Pathology University of BernBern 3008Switzerland Graduate School for Health Sciences University of BernMittelstrasse 43Bern 3012Switzerland Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031P.R.China Department of Laboratory Medicine and Pathology Institute of PathologyLausanne University Hospital and University of LausanneLausanne 1011Switzerland

Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC *** spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with *** evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine ***:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with *** specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%*** contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,*** combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic *** multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic *** Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non

关键词： cancer metabolism machine learning mass spectrometry imaging metabolic classifier Nonsmall cell lung cancer prognosis spatial metabolomics treatment response

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New Software for the Identification and Characterization of Peptides Generated during Fontina Cheese Ripening Using Mass Spectrometry Data

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Journal of Chemistry and Chemical Engineering 2012年第4期6卷 323-326页

作者： sabina Valentni Massimo Natale Elisa Ficarra Andrea Barmaz Institut Agricole Rdgional Rdg. La Rochbre 1/A Aosta 11100 Italy BioDigitalValley S.rl. via Carlo Viola 78 Pont Saint Martin （AO） 11026 Italy Department of Control and Computer Engineering Politecnico di Torino Torino 11029 Italy

The aim of this work was to design and implement a new bioinformatics software which is able to identify the protein peptides from the peaks which arise from in-source or MS/MS fragmentation. The oligopeptide fraction was extracted from Fontina cheese at different ages of ripening and subsequently analyzed by LC/MS/MS. On the resulting total ion chromatograms, the peptides were identified by a method based both on the in-source fragmentation detectable with a single-quadrupole mass analyzer and by a new software which was developed. This software performs an in-silieo digestion of the major milk proteins, it calculates all the possible peptide fragments which are generated by the loss of the first N- or C-terminal amino acids, and finally, it matches the experimental ion chromatogram with the in-silico which generated theoretical spectrum to identify the exact amino-acid protein sequence of the unknown oligopeptide. With this tool, the useful insights into the proteolytic processes which occur during Fontina cheese aging are obtained, which leads to a better knowledge about the functional features of the proteolysis end product.

关键词： Fontina PDO cheese ripening LC-MS/MS new bioinformatics software.

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淀粉样蛋白Aβ_(1-42)与α_1-抗糜蛋白酶反应的体外研究

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中国神经精神疾病杂志 2010年第4期36卷 220-224页

作者：孙永馨贾建平 sabina Janciauskiene 首都医科大学宣武医院北京100053 Department of Medicne Wallenberg LaboratoryMalm University Hospital

目的研究淀粉样蛋白Aβ1-42与α1-抗糜蛋白酶(α1-antichymotrypsin,ACT)在体外动态反应的性质,为阿尔茨海默病(Alzheimer's disease,AD)发病机制的研究探索新的领域。方法Aβ1-42、ACT以10:1的摩尔比溶解于Tris缓冲液中,37℃下孵育7h... 详细信息

目的研究淀粉样蛋白Aβ1-42与α1-抗糜蛋白酶(α1-antichymotrypsin,ACT)在体外动态反应的性质,为阿尔茨海默病(Alzheimer's disease,AD)发病机制的研究探索新的领域。方法Aβ1-42、ACT以10:1的摩尔比溶解于Tris缓冲液中,37℃下孵育7h形成复合物。SDS-PAGE及糜蛋白酶(chymotrypsin,CHY)干扰实验探索Aβ1-42/ACT复合物的性质;采用ACT蛋白酶抑制剂活性的化学计量法研究和荧光标记Aβ1-42的解离追踪计算Aβ1-42与ACT的结合速率和解离速率;定量分析Aβ1-42浓度对ACT活性的影响。结果Aβ1-42与ACT反应7h形成的复合物在SDS-PAGE电泳条件下不稳定,ACT仍具有蛋白酶抑制剂活性。Aβ1-42与ACT结合后,后者的蛋白酶抑制剂活性减弱约10倍(SI=1.1vsSI=10.5),并且在一定范围内ACT的活性随Aβ1-42浓度的增高而减弱。Aβ1-42/ACT的结合速率常数为1.7(M.s)-1,解离速率常数为1.4×10-5s-1,即37℃、PH值7.4条件下Aβ1-42与ACT的结合速率远远高于解离速率。结论体外定量实验证实Aβ1-42、ACT之间的动态反应可形成稳定复合物并最终使ACT丧失蛋白酶抑制剂活性,提示ACT在AD的发病中可能发挥着与Aβ1-42相关的重要作用。

关键词：淀粉样蛋白Aβ1-42 阿尔茨海默病 α1-抗糜蛋白酶蛋白酶

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Traditional Chinese medicine in psychiatry： the fruit-basket-problem

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Journal of Integrative Medicine 2016年第4期14卷 239-240页

作者： Peggy Bosch Peter de Rover Sujung Yeo Sook-Hyun Lee sabina Lim Maurits van den Noort Donders Center for Cognition Radboud University Nijmegen 6525 HR Nijmegen The Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau 47551 Bedburg-Hau Germany Division of Acupuncture & Meridian WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute and School of Korean Medicine Kyung Hee University Seoul 130-701Korea Karel de Grote Hoge School 2018 Antwerp Belgium Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University Wonju 26339 Korea Brussels Institute for Applied Linguistics Free University of Brussels 1050 Brussels Belgium

Traditional Chinese medicine （TCM） is gaining popularity in the treatment of psychiatric disorders that can be described and treated from either an Eastern or a Western perspective. In Eastern medicine, the disorders are described according to five diagnostic methods that are used in TCM： inspection, auscultation, olfaction, inquiry, and palpation, including tongue and pulse diagnosis.

关键词： medicine Chinese traditional diagnostic methods psychiatry

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Using Fuzzy Decision Support Systems in Human Resource Management

Using Fuzzy Decision Support Systems in Human Resource Manag...

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2012 International Conference on Innovation and Information Management(ICIIM 2012)

作者： sabina Nobari Zarifa Jabrailova Azita Nobari Institute of Information Technologies of ANAS BakuAzerbaijan Education Administration Institute of management of Islamic Azad UniversityGarmsarIran

Today,the importance and unique roles of human resources have more importance and position than past,so in advanced organizational thought,human is mentioned the main source and property or a main interpretation source of any *** human resources are the Key of organizational success or *** of the fundamental concerns of human resource managers is hiring *** of the right choice in selecting people,will damage to the organization a *** the past,Organizations tested people based on employment tests to hire a special emphasis such as character test,intelligence test,skills test,*** the major problem of this test was the definitive vision on *** you know many of the traits are qualitative,not measured traits for the selection and *** to this,using fuzzy logic approach in human resources management has found a special *** in today’s competitive environment,decisions using of applying information technology are the irrefutable principles of organizations and help to managers in making decisions meaningfully.

关键词： Fuzzy Decision Support Systems Human Resource Management TOPSYS method Fuzzy logic.

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Determination of Anodized Aluminum Material Characteristics by Means of Nano-Indentation Measurements

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Materials Sciences and Applications 2011年第10期2卷 1452-1464页

作者： Maria Datcheva sabina Cherneva Maria Stoycheva Roumen Iankov Dimitar Stoychev 不详

An aluminium AD-3 has been anodized under four different conditions, namely at low temperature (?5℃), room temperature (25℃), with and without sealing the anodized coating in boiling distilled water. The solution used for formation of alumina layer in all cases was an electrolyte containing 180 g/l sulphuric acid at a constant forming voltage (voltastatic anodizing). In order to assess the mechanical properties of the obtained anodic alumina layers a series of nanoindentation tests was performed employing different indentation procedures. The two mechanical characteristics of the alumina films, the indentation hardness (HIT) and the indentation modulus (EIT), were determined by means of the instrumented indentation and the Oliver & Pharr approximation method. All measurements were done on Agilent G200 Nanoindenter fitted with a diamond Berkovich type tip. Time dependent effects were investigated by tests with different peak hold time and different loading rate. The change of the mechanical properties with indentation depth was also examined. The effect of the working temperature during the growth of the alumina layers and the influence of the pore sealing on the mechanical properties are evaluated via comparison of the average load-displacement curves. The role of the temperature of the electrolyte and the sealing process during the formation of the alumina films, with respect to possible changes of their chemical composition and structure, are discussed in order to explain the observed differences in the measured load-displacement curves and the determined HIT and EIT.

关键词： Thin Films Alumina Mechanical Properties Nanoindentation

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The effects of climate and land use change on the potential distribution and nesting habitat of the Lesser Adjutant in Nepal

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Avian Research 2023年第3期14卷 326-335页

作者： Hem Bahadur Katuwal Hari Prasad Sharma Prashant Rokka Krishna Prasad Bhusal Bishnu Prasad Bhattarai sabina Koirala Sandeep Chhetri Luitel Shailendra Yadav Ganesh Sah Hem Sagar Baral Laxman Prasad Poudyal Lin Wang Rui-Chang Quan Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan666303China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw05282Myanmar Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation MenglaYunnan666303China Nepal Zoological Society Kathmandu44600Nepal Central Department of Zoology Institute of Science and TechnologyTribhuvan UniversityKathmandu44600Nepal Faculty of Forestry Agriculture and Forestry UniversityHetaudaMakwanpur44107Nepal IUCN SSC Bird Red List Authority Rue Mauverney1196GlandSwitzerland Mithila Wildlife Trust JanakpurdhamDhanusa45600Nepal Zoological Society of London-Nepal Office Kathmandu44600Nepal Institute of Land Water and SocietySchool of Environmental SciencesCharles Sturt UniversityAlbury-WodongaAustralia Shivapuri-Nagarjun National Park Department of National Parks and Wildlife ConservationKathmanduNepal

Climate change and land use change pose a threat to the world’s biodiversity and have significant impacts on the geographic distribution and composition of many bird species,but little is known about how they affect threatened large-sized waterbird species that rely on agricultural *** address this gap,we investigated how climate and land use changes influence the distribution and nesting habitats of the globally vulnerable Lesser Adjutant(Leptoptilos javanicus) in *** 2012 and 2023,we collected distribution data from 24 districts and nesting site information from 18 *** a nation-wide breeding survey conducted in 2020,we documented a total of 581 fledglings from 346 nests in 109 *** ensemble model predicted a current potential distribution of 15%(21,637 km2) and a potential nesting habitat of 13%(19,651 km2) for the species in *** highest predicted current suitable distribution and nesting habitat was in Madhesh Province,while none was predicted in Karnali *** majority of this predicted distributional and nesting habitat falls on agricultural landscapes(>70%).Our model showed a likely range expansion of up to 15%(21,573 km2) for the distribution and up to 12%(17,482 km2) for the nesting habitat under SSP5-8.5 scenarios for the *** range expansion is expected to occur mainly within the current distribution and breeding range(Tarai and some regions of Siwalk),particularly in Lumbini and Sudurpashchim provinces,and extend to the northern portions(Siwalik and Mid-hill regions) in other ***,the current Protected Areas and Important Bird and Biodiversity Areas are inadequate for providing optimal habitats for the *** the model suggests range expansion,the use of such novel habitats is primarily contingent on the availability and protection of large-sized trees(particularly Bombax ceiba,observed in 65% of colonies) in agricultural regions where nesting ***,our research sugges

关键词： Agricultural landscapes Bombax ceiba Ensemble modeling Farmland bird IBA Nest site

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Potentiality of Different Seed Priming Agents to Mitigate Cold Stress of Winter Rice Seedling

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1491-1506页

作者： Md.Parvez Anwar Md.Ariful Islam Khalid A.K.M.Mominul Islam sabina Yeasmin Sharif Ahmed Adel Hadifa Ismail A.Ismail Akbar Hossain Ayman EL Sabagh Agro Innovation Laboratory Department of AgronomyBangladesh Agricultural UniversityMymensingh2202Bangladesh International Rice Research Institute Bangladesh OfficeDhaka1213Bangladesh Rice Research and Training Center Field Crops Research InstituteAgricultural Research CenterSakha33717Egypt Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Bangladesh Wheat and Maize Research Institute Dinajpur5200Bangladesh Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafr Elsheikh33516Egypt

Seed priming has proved to be an effective pre-germination seed invigoration technique for different crops to improve seed and seedling performance under different abiotic *** Bangladesh,winter rice is very often exposed to cold waves just after sowing in the nursery bed resulting in poor seed germination and seedling emergence,yellowish and thin seedlings production,and a very low survival *** priming may mitigate the cold stress during seed germination and seedling emergence and helps in the quality seedling production of winter *** evaluate the efficacy of different seed priming techniques in increasing seedling emergence,growth,vigor and survivability of winter rice cultivars under cold stress,a pot experiment was conducted at the Department of Agronomy,Bangladesh Agricultural University during December 2018 to January *** experiment comprised two factors,(A)Winter rice variety namely,(i)BRRI dhan29 and (ii)BRRI dhan36;(B)Seed priming agent namely (i)Control(no priming),(ii)20000 ppm NaCl,(iii)30000 ppm NaCl,(iv)20000 ppm KCl,(v)30000 ppm KCl,(vi)20000 ppm CaCl2,(vii)30000 ppm CaCl2,(viii)50 ppm CuSO4,(ix)75 ppm CuSO_(4),(x)10000 ppm ZnSO4,(xi)15000 ppm ZnSO4,(xii)2 ppm Na2MoO4,(xiii)3 ppm Na2MoO4,(xiv)100 ppm PEG(Polyethylene glycol 4000)and (xv)150 ppm *** were sown on two different dates viz.,1st December and 1st January so that seedlings are exposed to cold stress at different *** experiment was laid out in a completely randomized design(CRD)with three *** indicated that(in most of the cases)seed priming has a positive impact on seedling emergence rate(%),root length,shoot length,root shoot ratio,root dry weight,shoot dry weight,seedling dry weight and survival rate(%).Among the priming agents,KCl and CaCl2 performed best;while priming with NaCl and PEG showed no advantages over no priming for both the sowing *** general,BRRI dhan36 performed better than BRRI dhan29 in terms of seedling growth because

关键词： Seed invigoration seedling emergence seedling mortality seedling growth low temperature stress

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Prevalence and Factors Associated with Anaemia among Pregnant Women Attending Antenatal Clinic in the Second and Third Trimesters at Pumwani Maternity Hospital, Kenya

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Open Journal of Obstetrics and Gynecology 2016年第1期6卷 16-27页

作者： Okubatsion Tekeste Okube Waithira Mirie Eunice Odhiambo Wakasiaka sabina Michael Habtu School of Nursing Sciences College of Health Sciences University of Nairobi Nairobi Kenya Institute of Tropical Medicine and Infectious Diseases Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

Background: Anaemia is one of the most common nutritional deficiency diseases observed globally and affects more than a quarter of the world’s population. Globally, 41.8% pregnant women and close to one third of non-pregnant women (30.2%) are anaemic. Anaemia during pregnancy contributes to 20% of all maternal deaths and it increases the risks of foetal, neonatal and overall infant mortality. In Kenya, according to the Ministry of Health, the prevalence of anaemia among pregnant women is 55.1%. Objective: To determine the prevalence and associated factors of anaemia among pregnant women attending antenatal clinic (ANC) at Pumwani Maternity Hospital (PMH). Methodology: A hospital based cross-sectional study design was conducted from 8th June to 18th August, 2015. Systematic random sampling method was used to select 258 pregnant women. Mothers who attended ANC during the study period and who met the inclusion criteria were interviewed and a capillary blood sample was taken. Hemoglobin level was determined by using HemoCue photometer. Data were cleaned, coded and fed into SPSS Version 20.0 for analysis. Descriptive statistics such as frequency, percentage, mean and standard deviation were used to describe selected variables. Pearson’s chi-square test and odds ratio (OR) with corresponding 95% confidence intervals (CI) computed to find association between independent and dependent variables. Multivariate analysis was done to determine factors significantly and independently predicting anaemia during pregnancy. Results: The present study revealed that the prevalence of anaemia among the pregnant women was 57%. Advanced maternal age (>31 years) (AOR = 2.71;95% CI = 1.25 - 5.88;P = 0.012) more than 18 - 24 years, government/private employed women (AOR = 2.94;95% CI = 1.47 - 5.88;P = 0.002) and self-employed women (AOR = 1.91;95% CI = 1.03 - 3.53;P = 0.039) compared to housewives, not taking iron/folic acid supplementation (IFAS) (AOR = 2.04; 95% CI =

关键词： Anaemia Associated Factors Pregnant Women Prevalence

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Occupational Health and Safety Hazards Experienced by Healthcare Workers at Two Hospitals in Suyani, Bono Region, Ghana

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Occupational Diseases and Environmental Medicine 2023年第2期11卷 122-136页

作者： Samuel Yaw Opoku Carlos Yeboah sabina Ampon-Wireko Richard Kwasi Hinneh School of Public Health and Allied Sciences Catholic University of Ghana Sunyani Ghana School of Nursing and Midwifery Catholic University of Ghana Sunyani Ghana

INTRODUCTION Occupational safety and health (OSH) is generally the anticipation, recognition, evaluation, and control of hazards arising in or from the workplace. The study sought to assess and evaluate occupational health and safety hazards experienced among health workers in the Bono region of Ghana. METHODOLOGY The study was descriptive cross-sectional quantitative study. Data was from two hundred (200) health workers and was analyzed using the binary logistic regression analysis. RESULTS The findings from the study show that risk factors associated with biological hazards were clinical staff [OR = 2.487 (1.146 - 5.397), p = 0.021], poor maintenance of hospital items [OR = 0.446 (0.240 - 0.831), p = 0.011], assault (verbal) abuse [OR = 2.581 (1.317 - 5.059), p = 0.006] and extreme pressure from work [OR = 2.975 (1.519 - 5.829), p = 0.001]. Non-biological hazards were associated with being single [OR = 0.499 (0.263 - 0.947), p = 0.034], being verbally assaulted [OR = 3.581 (1.865 - 6.876), p CONCLUSION Risk factors related with biological hazards include poor maintenance of hospital items and extreme pressure from work whereas non-biological hazards were associated with being single, being verbally assaulted. Clinical healthcare providers are more vulnerable to occupational health and safety hazards. The study recommends the provision of strategic policies to promote and protect the workers’ health based on the development of the epidemiological profile of health, needs to be readjusted and strengthened.

关键词： Occupational Health and Safety Healthcare Hazards Biological Hazards Non-Biological Hazards Nurses Safety Hospital Hazards

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