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Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin

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Cellular & Molecular Immunology 2020年第4期17卷 380-394页

作者： Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag Institute of Immunology Section Molecular ImmunologyHeidelberg UniversityIm Neuenheimer Feld 30569120 HeidelbergGermany Institute of Human Genetics Department of Human Molecular Geneticsand nCounter Core FacilityHeidelberg UniversityIm Neuenheimer Feld 36669120 HeidelbergGermany Department of Dermatology Heidelberg UniversityIm Neuenheimer Feld 44069120 HeidelbergGermany

The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin *** psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal ***,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the ***,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains ***,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T *** activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/*** T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 *** particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/*** latter molecule initiated STAT1 signaling and IFN γproduction in T *** of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin ***,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases.

关键词： keratinocytes inflammatory skin diseases psoriasis human T cells costimulation CD2 LFA-1 nonprofessional antigenpresenting cells Th1 cells Th17 cells

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阿尔茨海默病发病与淀粉样β蛋白1～42/α1-抗糜蛋白酶复合物及脂质代谢紊乱的关系

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中国临床康复 2005年第9期9卷 42-45,i002页

作者：孙永馨贾建平 sabina Janciauskiene 首都医科大学宣武医院神经内科 Wallenberg Lab Plan2University HospitalUMAS MalmSweden S-20502

目的:研究淀粉样β蛋白(Aβ)1～42与α1-抗糜蛋白酶(antichymotrypsin,ACT)形成的复合物对神经胶质瘤细胞(DK-MG)脂质代谢的影响,探索脂质代谢紊乱与阿尔茨海默病(Alzheimerdisease,AD)发病机制的相关性。方法:实验于2001-01/2002-03在... 详细信息

目的:研究淀粉样β蛋白(Aβ)1～42与α1-抗糜蛋白酶(antichymotrypsin,ACT)形成的复合物对神经胶质瘤细胞(DK-MG)脂质代谢的影响,探索脂质代谢紊乱与阿尔茨海默病(Alzheimerdisease,AD)发病机制的相关性。方法:实验于2001-01/2002-03在瑞典隆德大学附属马尔默医院Wallenberg实验室和首都医科大学宣武医院神经内科实验室完成,Aβ1～42与ACT溶液室温下以10∶1摩尔比混合孵育2h,琼脂糖凝胶电泳和Western-blot检测反应产物Aβ1～42/ACT。观察在Aβ1～42/ACT存在的条件下,细胞对低密度脂蛋白(low-densitylipoprotein,LDL)的摄取、降解和细胞内胆固醇的合成;红油O染色观察细胞内脂质的含量;RT-PCR检测LDL受体(LDLr)的mRNA表达水平。结果:Aβ1～42,ACT单克隆抗体染色证实Aβ1～42/ACT复合物的存在。与对照组细胞相比,Aβ1～42/ACT使细胞摄取LDL增加50%(t=10.30,P<0.01),胞内脂质颗粒增加20倍(t=6.84,P<0.05),LDLr的mR-NA水平增加48%(t=20.79,P<0.01)。相反,Aβ1～42,ACT单分子对上述脂质代谢过程没有显著影响。Aβ1～42,ACT,Aβ1～42/ACT对LDL降解、细胞内胆固醇的合成都没有影响。结论:Aβ1～42/ACT复合物使神经胶质细胞内的脂质累积增加,可能是LDLr表达上调增加LDL摄取的结果。脂质代谢紊乱是AD发病的假说之?

关键词：阿尔茨海默病淀粉样β蛋白 α1-抗糜蛋白酶脂蛋白类,LDL 脂类/代谢

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Water Service Provision in Owerri City, Nigeria

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Journal of Water Resource and Protection 2012年第7期4卷 497-506页

作者： Emmanuella C. Onyenechere sabina C. Osuji Department of Geography & Environmental Management Imo State University Owerri Nigeria Department of Urban & Regional Planning Imo State University Owerri Nigeria

The study investigates water service provision in Owerri-a Nigerian city. For the study both primary and secondary data were obtained and analysed. Secondary data were obtained from Imo State Water Corporation (ISWC) and the Works Department of Owerri Municipal Council. While, primary data were obtained from all the 17 wards that constitute Owerri city, i.e. the municipal area. Key informants were identified and interviewed using a structured interview schedule. The analysis of variance employed showed that there are significant differences in the water service provision pattern in the seventeen wards in Owerri city. The study found that though most residents of Owerri city rely heavily on commercial borehole owners and water tanker drivers/water peddlers for their daily supplies, the government through its SWA is in control, and there is an absence of a popularly acceptable regulatory framework/water policy. It recommends that Water decree 101 from 1993 (water legislation) be reviewed to address growing challenges. In order to enhance regular water supply at less cost, the study recommends that government should collaborate with the private sector and other community based organizations in a tripartite partnership. A new regulatory framework that will carry out government ownership and control of water resources and participatory aspects of water management should be produced by ISWC.

关键词： Boreholes Regulation State Water Agency Water Peddlers Water Policy

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Ascites as a Symptom of a Rotavirus Infection—Case Report

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Advances in Infectious Diseases 2014年第2期4卷 73-76页

作者： sabina Wiecek Urszula Grzybowska-Chlebowczyk Halina Wos Department of Paediatrics Medical University of Silesia Katowice Poland

Rotaviruses (RV) are the most common cause of acute diarrhoea in children. The course of RV in-fections may vary from a mild to a serious course of diarrhoea with significant disturbances to the water-electrolyte and acid-base homeostasis and complications requiring hospitalisation. There are known cases of postinfectious enteropathy and severe cases may involve a complete villous atrophy and temporary intolerance to lactose in the course of rotavirus infection. Opinions on the changes in the permeability of the mucous of the small intestine in the result of ongoing inflammation are largely diverse. This study presents a very rare complication of a rotavirus infection which is ascites in a 3-month infant. It seems that the pathomechanism of ascites in presented patient is very complex and affected by other factors such as nutritional disorders, including hypoproteinemia and hypoalbuminemia and immunological factors.

关键词： Rotavirus Infection Ascites Children

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Green–Nature

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装饰 2020年第3期 2-2页

作者： sabina Oberholzer Renato Tagli

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New Software for the Identification and Characterization of Peptides Generated during Fontina Cheese Ripening Using Mass Spectrometry Data

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Journal of Chemistry and Chemical Engineering 2012年第4期6卷 323-326页

作者： sabina Valentni Massimo Natale Elisa Ficarra Andrea Barmaz Institut Agricole Rdgional Rdg. La Rochbre 1/A Aosta 11100 Italy BioDigitalValley S.rl. via Carlo Viola 78 Pont Saint Martin （AO） 11026 Italy Department of Control and Computer Engineering Politecnico di Torino Torino 11029 Italy

The aim of this work was to design and implement a new bioinformatics software which is able to identify the protein peptides from the peaks which arise from in-source or MS/MS fragmentation. The oligopeptide fraction was extracted from Fontina cheese at different ages of ripening and subsequently analyzed by LC/MS/MS. On the resulting total ion chromatograms, the peptides were identified by a method based both on the in-source fragmentation detectable with a single-quadrupole mass analyzer and by a new software which was developed. This software performs an in-silieo digestion of the major milk proteins, it calculates all the possible peptide fragments which are generated by the loss of the first N- or C-terminal amino acids, and finally, it matches the experimental ion chromatogram with the in-silico which generated theoretical spectrum to identify the exact amino-acid protein sequence of the unknown oligopeptide. With this tool, the useful insights into the proteolytic processes which occur during Fontina cheese aging are obtained, which leads to a better knowledge about the functional features of the proteolysis end product.

关键词： Fontina PDO cheese ripening LC-MS/MS new bioinformatics software.

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Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients

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Cancer Communications 2022年第6期42卷 517-535页

作者： Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger sabina Berezowska Axel Walch Research Unit Analytical Pathology Helmholtz Zentrum Munchen-German Research Center for Environmental HealthNeuherberg 85764Germany Institute of Pathology University of BernBern 3008Switzerland Graduate School for Health Sciences University of BernMittelstrasse 43Bern 3012Switzerland Center for Excellence in Molecular Cell Science Chinese Academy of SciencesShanghai 200031P.R.China Department of Laboratory Medicine and Pathology Institute of PathologyLausanne University Hospital and University of LausanneLausanne 1011Switzerland

Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC *** spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with *** evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine ***:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with *** specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%*** contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,*** combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic *** multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic *** Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non

关键词： cancer metabolism machine learning mass spectrometry imaging metabolic classifier Nonsmall cell lung cancer prognosis spatial metabolomics treatment response

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淀粉样蛋白Aβ_(1-42)与α_1-抗糜蛋白酶反应的体外研究

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中国神经精神疾病杂志 2010年第4期36卷 220-224页

作者：孙永馨贾建平 sabina Janciauskiene 首都医科大学宣武医院北京100053 Department of Medicne Wallenberg LaboratoryMalm University Hospital

目的研究淀粉样蛋白Aβ1-42与α1-抗糜蛋白酶(α1-antichymotrypsin,ACT)在体外动态反应的性质,为阿尔茨海默病(Alzheimer's disease,AD)发病机制的研究探索新的领域。方法Aβ1-42、ACT以10:1的摩尔比溶解于Tris缓冲液中,37℃下孵育7h... 详细信息

目的研究淀粉样蛋白Aβ1-42与α1-抗糜蛋白酶(α1-antichymotrypsin,ACT)在体外动态反应的性质,为阿尔茨海默病(Alzheimer's disease,AD)发病机制的研究探索新的领域。方法Aβ1-42、ACT以10:1的摩尔比溶解于Tris缓冲液中,37℃下孵育7h形成复合物。SDS-PAGE及糜蛋白酶(chymotrypsin,CHY)干扰实验探索Aβ1-42/ACT复合物的性质;采用ACT蛋白酶抑制剂活性的化学计量法研究和荧光标记Aβ1-42的解离追踪计算Aβ1-42与ACT的结合速率和解离速率;定量分析Aβ1-42浓度对ACT活性的影响。结果Aβ1-42与ACT反应7h形成的复合物在SDS-PAGE电泳条件下不稳定,ACT仍具有蛋白酶抑制剂活性。Aβ1-42与ACT结合后,后者的蛋白酶抑制剂活性减弱约10倍(SI=1.1vsSI=10.5),并且在一定范围内ACT的活性随Aβ1-42浓度的增高而减弱。Aβ1-42/ACT的结合速率常数为1.7(M.s)-1,解离速率常数为1.4×10-5s-1,即37℃、PH值7.4条件下Aβ1-42与ACT的结合速率远远高于解离速率。结论体外定量实验证实Aβ1-42、ACT之间的动态反应可形成稳定复合物并最终使ACT丧失蛋白酶抑制剂活性,提示ACT在AD的发病中可能发挥着与Aβ1-42相关的重要作用。

关键词：淀粉样蛋白Aβ1-42 阿尔茨海默病 α1-抗糜蛋白酶蛋白酶

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Traditional Chinese medicine in psychiatry： the fruit-basket-problem

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Journal of Integrative Medicine 2016年第4期14卷 239-240页

作者： Peggy Bosch Peter de Rover Sujung Yeo Sook-Hyun Lee sabina Lim Maurits van den Noort Donders Center for Cognition Radboud University Nijmegen 6525 HR Nijmegen The Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau 47551 Bedburg-Hau Germany Division of Acupuncture & Meridian WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute and School of Korean Medicine Kyung Hee University Seoul 130-701Korea Karel de Grote Hoge School 2018 Antwerp Belgium Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University Wonju 26339 Korea Brussels Institute for Applied Linguistics Free University of Brussels 1050 Brussels Belgium

Traditional Chinese medicine （TCM） is gaining popularity in the treatment of psychiatric disorders that can be described and treated from either an Eastern or a Western perspective. In Eastern medicine, the disorders are described according to five diagnostic methods that are used in TCM： inspection, auscultation, olfaction, inquiry, and palpation, including tongue and pulse diagnosis.

关键词： medicine Chinese traditional diagnostic methods psychiatry

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Using Fuzzy Decision Support Systems in Human Resource Management

Using Fuzzy Decision Support Systems in Human Resource Manag...

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2012 International Conference on Innovation and Information Management(ICIIM 2012)

作者： sabina Nobari Zarifa Jabrailova Azita Nobari Institute of Information Technologies of ANAS BakuAzerbaijan Education Administration Institute of management of Islamic Azad UniversityGarmsarIran

Today,the importance and unique roles of human resources have more importance and position than past,so in advanced organizational thought,human is mentioned the main source and property or a main interpretation source of any *** human resources are the Key of organizational success or *** of the fundamental concerns of human resource managers is hiring *** of the right choice in selecting people,will damage to the organization a *** the past,Organizations tested people based on employment tests to hire a special emphasis such as character test,intelligence test,skills test,*** the major problem of this test was the definitive vision on *** you know many of the traits are qualitative,not measured traits for the selection and *** to this,using fuzzy logic approach in human resources management has found a special *** in today’s competitive environment,decisions using of applying information technology are the irrefutable principles of organizations and help to managers in making decisions meaningfully.

关键词： Fuzzy Decision Support Systems Human Resource Management TOPSYS method Fuzzy logic.

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