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Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

World Journal of Clinical Oncology 2023年第12期14卷 549-569页

作者： Hao-Ling Zhang Doblin Sandai Zhong-Wen Zhang Zhi-Jing Song Dinesh Babu Yasser Tabana sabbar saad dahham Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Rui Zhao Khaled Barakat Mohammad Syamsul Reza Harun Siti Nurfatimah Mohd Shapudin Bronwyn Lok Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia School of Public Health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Clinical College of Chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA 92182United States Pathology Center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Adenosine triphosphate(ATP)induced cell death(AICD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic *** comprehensive review unveils the intricate web of AICD mechanisms and their intricate connections with cancer *** review offers a comprehensive framework for comprehending the multifaceted role of AICD in the context of *** is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AICD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key ***,the exploration of AICD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

关键词： Adenosine triphosphate induced cell death Adenosine triphosphate homeostasis Mechanism Cancer signaling pathways Prognosis and clinical values Cancer treatment

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Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways

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Chinese Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat saad S dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid EMAN Testing and Research Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Research Universiti Sains Malaysia Penang 11800 Malaysia Institute for Research in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways.

关键词： Mesua ferrea a-Amyrin Apoptotic Antimetastatic Molecular pathways

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Practical Study for the Effect of Speed, Direction of Acceleration and Type of Machine on Vibrations Transferred to the Steering Wheel Horticulture Tractor Type (Goldoni)

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Engineering（科研） 2019年第1期11卷 48-58页

作者： Ghazwan Ahmed dahham saad Tawfik Muhamed Shamel Mohammed Saleh Department of Agricultural Machines and Equipment University of Mosul Mosul Iraq

Field an experiment was carried out in the farms of Agriculture and forestry academy at University in Nineveh. The research was conducted to investigate a practical study for the effect of four forward speeds (1.9, 2.6, 3.8 and 4.7 km/hr.) and three acceleration direction of axes lateral, longitudinal and vertical, and two types machines control (Mower and Rotovators) on the vibrations transferred to the steering wheel horticulture tractor type (Goldoni). The vibration points on the handgrip were calculated and tested. Root mean square acceleration (RMS), given in m/sec2, was calculated. Results showed increased acceleration vibration of the three directions (longitudinal, lateral and vertical) transferred to the steering wheel tractor by increased forward speed. The Mower score recorded the highest acceleration vibration for the three directions of Rotovators. The levels of vibration emitted from tractor to hand an operator during the experiment was high comparing with standard mechanical vibration. Handgrip vibration intensity in the vertical direction is bigger than the lateral and longitudinal direction. The total vibration evaluating was denoted as the square root mean of the three sum value (lateral, longitudinal and vertical) directions. The paper purpose was measuring and analyzing vibration level transferred to the steering wheel and reduces the machine vibration. This paper is helpful for design in order to increase the develop safety systems in easy and economical way.

关键词： Ergonomics Vibrations Hand-Transmitted Vibration Tractor

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