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Enhancing pharmaceutical potential and oral bioavailability of Allium cepa nanosuspension in male albino rats using response surface methodology

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Asian Pacific Journal of Tropical Biomedicine 2022年第1期12卷 26-38页

作者： Fatiqa Zafar Nazish Jahan Shaukat Ali saba jamil Riaz Hussain saba Aslam Department of Chemistry University of SahiwalSahiwalPakistan Department of Chemistry University of AgricultureFaisalabadPakistan Department of Chemistry University of OkaraOkaraPakistan Govt.Graduate College for Women Sargodha RoadFaisalabadPakistan

Objective:To enhance the pharmaceutical potential and oral bioavailability of quercetin contents of Allium cepa peel extract by novel nanosuspension ***:Nanoprecipitation approach was successfully used for the formulation of *** obtain pharmaceutical-grade nanosuspension with minimum particle size and polydispersity index,sodium lauryl sulphate was selected as a *** formulation parameters were statistically optimized by the response surface methodology *** optimized nanosuspension was subjected to stability and in vitro dissolution testing and characterized by scanning electron microscopy,atomic force microscopy,Fourier transform infrared spectroscopy,and zeta *** evaluate the preeminence of nanosuspension over coarse suspension,comparative bioavailability studies were carried out in male albino *** pharmaceutical potential of developed nanosuspension was evaluated by antioxidant,antimicrobial,and toxicity ***:The optimized nanosuspension showed an average particle size of 275.5 nm with a polydispersity index and zeta potential value of 0.415 and−48.8 mV,*** force microscopy revealed that the average particle size of nanosuspension was below 100 *** formulated nanosuspension showed better stability under refrigerated *** showed an improved dissolution rate and a 2.14-fold greater plasma concentration of quercetin than coarse ***,the formulated nanosuspension exhibited enhanced antioxidant and antimicrobial potential and was ***:Optimization of nanosuspension effectively improves the pharmaceutical potential and oral bioavailability of Allium cepa extract.

关键词： Allium cepa Nanoprecipitation Pharmaceutical potential Particle size Polydispersity index Stability Toxicity Quercetin

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层状双氢氧化物(LDHs)的合成及应用（英文）

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化学进展 2019年第2期31卷 394-412页

作者： saba jamil Afaaf Rahat Alvi Shanza Rauf Khan Muhammad Ramzan Saeed Ashraf Janjua Department of Chemistry University of Agriculture Department of Chemistry King Fahd University of Petroleum and Minerals

Layered double hydroxides, a class of anionic clays possessing sandwich like structure in which negative anions are sandwiched into positively charged metal layers in a repeating manner, have been studied extensively. Layered double hydroxides could be fabricated with combination of different divalent(Cd^(2+), Mn^(2+), Fe^(2+), Pb^(2+)) and trivalent(Al^(3+), Cr^(3+), Fe^(3+)) metals and layered arrangement imparts unique properties such as adsorption properties and catalytic properties in these compounds. Exciting feature of these compounds is the memory effect. There are a number of methods to synthesize these layered compounds, such as co-precipitation, hydrothermal, sol-gel, urea hydrolysis,?etc. The synthesized LDHs can be characterized morphologically and compositionally i.e. scanning electron microscopy, transmission electron microscopy, powder X-Ray diffraction, Mossbauer spectroscopy, thermogravimetric analysis, XPS, etc. The wonderful feature of layered double hydroxides is the pliancy of interlayer space enabling them to accommodate various anionic species, and high surface area making them efficient in numerous applications such as adsorbents, anion exchange, catalysts, and biological compatible.

关键词： layered double hydroxides(LDHs) synthesis application

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Analysis of b→cτν¯_(τ)anomalies using weak effective Hamiltonian with complex couplings and their impact on various physical observables

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Chinese Physics C 2024年第8期48卷 56-75页

作者： Muhammad Arslan Tahira Yasmeen saba Shafaq Ishtiaq Ahmed Muhammad jamil Aslam Department of Physics Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Physics International Islamic UniversityIslamabad 44000Pakistan National Center for Physics Islamabad 44000Pakistan

Recently,the experimental measurements of the branching ratios and different polarization asymmetries for processes occurring through flavor-changing-charged current(b→cτν¯_(τ))transitions by BABAR,Belle,and LHCb have revealed some significant differences from the corresponding Standard Model(SM)*** has triggered an interest to search for physics beyond the SM in the context of various new physics(NP)models and using the model-independent weak effective Hamiltonian(WEH).Assuming left-handed neutrinos,we add the dimension-six vector,(pseudo-)scalar,and tensor operators with complex Wilson coefficients(WCs)to the SM *** 60%,30%,and 10%constraints resulting from the branching ratio of B_(c)→τν¯_(τ),we reassess the parametric space of these new physics WCs accommodating the current anomalies based on the most recent HFLAV data of R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*))and Belle data of F_(L)(D^(*))and P_(τ)(D^(*)).We find that the allowed parametric region of left-handed scalar couplings strongly depends on the constraints of the B_(c)→τν¯_(τ)branching ratio,and the maximum pull from the SM predictions results from the<60%branching ratio ***,the parametric region changes significantly if we extend the analysis by adding LHCb data of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(Λ_(c)).Furthermore,due to the large uncertainties in the measurements of R_(τ/μ)(J/ψ)and R_(τ/ℓ)(X_(c)),we derive the sum rules which complement them with R_(τ/μ,e)(D)and R_(τ/μ,e)(D^(*)).Using the best-fit points of the new complex WCs along with the latest measurements of R_(τ/μ,e)(D(^(*))),we predict the numerical values of the observable R_(τ/ℓ)(Λ_(c)),R_(τ/μ)(J/ψ),and R_(τ/ℓ)(X_(c))from the sum *** simultaneous dependence of abovementioned physical observables on the NP WCs is established by plotting their correlation with R_(D) and R_(D^(*)),which are useful to discriminate between various NP *** find that the most significant impact of NP results from the WC C^(S)_(L)=4C^(T).Fi

关键词： B meson anomalies new physics complex coupling HFLAV

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2D Carbon Fiber Reinforced High Density Polyethylene Multi-Layered Laminated Composite Panels:Structural,Mechanical,Thermal,and Morphological Profile

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Journal of Materials Science & Technology 2016年第10期32卷 1077-1082页

作者： Shahzad Maqsood Khan Nafisa Gull Muhammad Azeem Munawar Atif Islam saba Zia Muhammad Shafiq Aneela Sabir Syed Muhammad Awais Muhammad Arif Butt Muhammad Taqi Zahid Butt Tahir jamil Department of Polymer Engineering and Technology University of the PunjabLahore 54590Pakistan King Edward Medical University Lahore 54590Pakistan College of Engineering and Emerging Technologies University of the PunjabLahore 54590Pakistan

Carbon fiber reinforced high density polyethylene multi-layered laminated composite panels（HDPE/CF MLCP） with excellent in-plane properties along transverse direction have been formulated. Composite architectures with carbon fiber（CF） designed in 2D layout in conventional composites can alleviate their properties in thickness direction, but all attempts so far developed have achieved restrained success. Here,we have exposed an approach to the high strength composite challenge, without altering the 2D stack design on the basis of concept of fiber reinforced laminated composites that would provide enhanced mechanical and thermal properties along transverse direction. CF sheets allowed the buckling of adjoining plies in 2D MLCP. We fabricated 2D MLCP by stacking the alternative CF and HDPE layers under different loading conditions, which resulted in high strength composites. These plies of CF and HDPE served as unit cells for MLCP, with CF offering much-needed fracture toughness and hardness to these *** 2D HDPE/CF MLCP, we demonstrated noteworthy improvement in physical and chemical interaction between CF and HDPE, in-plane fracture strain, flexural strength（30.684 MPa）, bending modulus（7436.254 MPa）, thermal stability（40.94%）, and surface morphology, upon increasing the CF layers up to twenty, enabling these composites truly for high temperature and high strength applications.

关键词： Multi-layered composite panels Mechanical properties Thermal stability

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Analysis of b→cτ■ anomalies using weak effective Hamiltonian with complex couplings and their impact on various physical observables

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Chinese Physics C 2024年第8期 59-78页

作者： Muhammad Arslan Tahira Yasmeen saba Shafaq Ishtiaq Ahmed Muhammad jamil Aslam Department of Physics Quaid-i-Azam University Department of Physics International Islamic University National Center for Physics

Recently,the experimental measurements of the branching ratios and different polarization asymmetries for processes occurring through flavor-changing-charged current（b→cτvτ）transitions by BABAR,Belle,and LHCb have revealed some significant differences from the corresponding Standard Model（SM） *** has triggered an interest to search for physics beyond the SM in the context of various new physics（NP） models and using the model-independent weak effective Hamiltonian（WEH）.Assuming left-handed neutrinos,we add the dimension-six vector,（pseudo-）scalar,and tensor operators with complex Wilson coefficients（WCs） to the SM *** 60%,3 0%,and 10% constraints resulting from the branching ratio of Bc→τvτ,we reassess the parametric space of these new physics WCs accommodating the current anomalies based on the most recent HFLAV data of Rτ/μ,e（D） and Rτ/μ,e（D*） and Belle data of FL（D*） and Pτ（D*）.We find that the allowed parametric region of lefthanded scalar couplings strongly depends on the constraints of the Bc→τvτbranching ratio,and the maximum pull from the SM predictions results from the <60% branching ratio ***,the parametric region changes significantly if we extend the analysis by adding LHCb data of Rτ/μ（J/ψ） and Rτ/l（Λc）.Furthermore,due to the large uncertainties in the measurements of Rτ/μ（J/ψ） and Rτ/l（Xc）,we derive the sum rules which complement them with Rτ/μ,e（D） and Rτ/μ,e（D*）.Using the best-fit points of the new complex WCs along with the latest measurements of Rτ/μ,e(D（*）),we predict the numerical values of the observable Rτ/l（Λc）,Rτ/μ（J/ψ）,and Rτ/l（Xc） from the sum *** simultaneous dependence of abovementioned physical observables on the NP WCs is established by plotting their correlation with RDand RD*,which are useful to discriminate between various NP *** find that the most significant impact of NP results from the WC CLS=***,we study the impact of these NP couplings on various angular and CP triple product asym

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