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Metabolic puzzle: Exploring liver fibrosis differences in Asian metabolic-associated fatty liver disease subtypes

World Journal of Hepatology 2024年第1期16卷 54-64页

作者： Sabhita Shabir Shaikh Fakhar Ali Qazi-Arisar saba nafay Sidra Zaheer Hafeezullah Shaikh Zahid Azam National Institute of Liver and GI Diseases Dow University of Health SciencesSindhKarachi 75330Pakistan School of Public Health Dow University of Health SciencesSindhKarachi 75330Pakistan

BACKGROUND Metabolic-associated fatty liver disease(MAFLD)is a liver condition marked by excessive fat buildup in the absence of heavy alcohol *** is primarily linked with metabolic issues like insulin resistance,obesity,and abnormal lipid levels,and is often observed with other conditions such as type 2 diabetes and cardiovascular ***,whether the subtypes of MAFLD based on the metabolic disorder differentially impact liver fibrosis is not well explicated,especially in the Asian *** To compare the severity of liver fibrosis among different MAFLD *** A total of 322 adult patients of either gender with fatty liver on ultrasound were enrolled between January to December *** was defined as per the Asian Pacific Association for the Study of the Liver ***-4 index(Fib-4)and nonalcoholic fatty liver disease fibrosis score(NFS)were employed to evaluate liver *** The mean age was 44.84±11 ***-two percent of the patients were *** hundred and seventy-three patients were classified as having MAFLD,of which 110(40.3%)carried a single,129(47.3%)had two,and 34(12.5%)had all three metabolic *** cumulative number of metabolic conditions was related to elevated body mass index,triglyceride(TG)levels,and glycated hemoglobin,lower high-density lipoprotein(HDL)levels,higher liver inflammation(by aspartate aminotransferase andγ-glutamyl transferase),and higher likelihood of fibrosis(by NFS and Fib-4 scores)(P<0.05 for all).The proportion of advanced fibrosis also increased with an increase in the number of metabolic conditions(4.1%,25.5%,35.6%,and 44.1%by NFS and 6.1%,10.9%,17%,and 26.5%by Fib-4 for no MAFLD and MAFLD with 1,2,and 3 conditions,respectively).Among MAFLD patients,those with diabetes alone were the eldest and had the highest mean value of NFS score and Fib-4 score(P<0.05),while MAFLD patients diagnosed with lean metabolic dysfunction exhibited the highest levels of TG and a

关键词： Metabolic syndrome Diabetes Fatty liver disease Dyslipidemia Obesity

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