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Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

World Journal of Pediatrics 2019年第1期15卷 78-84页

作者： Nadia Dehbokri Gholamreza Noorazar Aida Ghaffari Gita Mehdizadeh Parvin Sarbakhsh saba ghaffary Faculty of Pharmacy Tabriz University of Medical SciencesTabrizIran Research Center of Psychiatry and Behavioral Sciences Tabriz University of Medical SciencesTabrizIran Pediatrics Health Research Center Tabriz University of Medical SciencesTabrizIran Road Traffic Injury Research Center Tabriz University of Medical SciencesTabrizIran Department of Pharmacotherapy Drug Applied Research CenterTabriz University of Medical SciencesTabrizIran

Background In this research the symptom improvement of attention-deficit hyperactivity disorder (ADHD) of children was assessed by oral vitamin D administration in Tabriz,*** In this double-blind,randomized clinical trials,96 children (2-18 years) were enrolled to placebo and vitamin D *** took vitamin D pearl (50,000 IU/week) or placebo for 6 ***,who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the *** symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after *** Conners divided into inattention (IA),hyperactivity/impulsivity (H/I) and combination type (C) *** D serum level was assessed at baseline and after 8 weeks in both *** The differences between CPRS and its subscales were not significant at baseline (P > 0.05).The Conners IA score was decreased in vitamin D group (P < 0.05;adjusted with age and baseline values).ADHD Conners and all subscale scores reduced remarkably after intervention in patients with insufficient level of vitamin D compared to placebo (P < 0.05).Conclusions Oral vitamin D improved ADHD symptoms with a particular effect on inattention *** addition,symptoms related to all subscales were improved remarkably in patients with insufficient level of vitamin *** D treatment in children with ADHD could be considered due to the expand benefit of vitamin D in body.

关键词： Attention-deficit hyperactivity disorder Children Conners parent rating scale Vitamin D

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