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Interleukin-28 and hepatitis C virus genotype-4:Treatment-induced clearance and liver fibrosis

World Journal of Gastroenterology 2012年第47期18卷 7003-7008页

作者： Moutaz Derbala Nasser Rizk Fatima Shebl saad alkaabi Nazeeh Eldweik Anil John Manik Sharma Rafie Yaqoob Muneera Almohanadi Mohammed Butt Khaled Alejji Department of Gastroenterology and Hepatology Hamad HospitalDoha 3050Qatar Department of Gastroenterology and Hepatology Weill Cornell Medical CollegeDoha 3050Qatar Department of Health Sciences Qatar UniversityDoha 2713Qatar Chronic Disease Epidemiology Division Yale School of Public HealthNew HavenCT 06520United States

AIM:To investigate the association between interleukin-28B(IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus(HCV) genotype ***:Two hundred and one HCV-genotype 4 patients were *** patients were treated with Peginterferon alph2a/Ribavirin for 48 *** of treatment response(ETR) was defined as loss of detectable serum HCV RNA at the end of *** viral response(SVR) was defined as loss of detectable serum HCV RNA at the end of 24 wk follow *** of IL28B rs12979860 was performed using the TaqMan *** used logistic regression to estimate the adjusted odds ratio(aOR) and 95%***:The study included 201 HCV-genotype 4 *** majority of patients were men(89.6%),with a median age of 47 years,inter-quartile range(40-51).Approximately 62.5% of patients had ETR,and 49.6% had *** who achieved SVR were more likely to be younger(χ 2 = 4.91,P = 0.027),and less likely to have fibrosis(χ 2 = 15.54,P < 0.0001),or inflammation(χ 2 = 7.58,P = 0.006).The genotype distribution of rs12979860 was 36.2%,49.0% and 14.8% for genotypes CC,CT,and TT,*** these participants,rs12979860 genotype distribution did not differ by gender(P = 0.466),pretreatment viral load(P = 0.600),inflammation(P = 0.435),or fibrosis(P = 0.291).The frequencies of IL28B rs12979860 genotypes were TT(14.8%),CT(49.0%),and CC(36.2%).Compared to rs12979860 genotype TT,aORs(95%CI) for ETR and SVR were:CC genotype,[17.55(5.34-57.69) and 5.92(2.09-16.76),respectively];CT genotype,[5.15(1.80-14.78) and 2.48(0.94-6.52),respectively].In the current study,the patients who did not achieve ETR or SVR had a lower prevalence of rs12979860 CC(17.4% and 23.3%,respectively) than individuals who had ETR or SVR(47.9% and 47.2%,respectively).Individuals with rs12979860 CC genotype had approximately 6 times the odds of SVR compared to individuals with TT genotype(aOR = 5.92;95%CI:2.09-16.76).Similarly,patients with CT

关键词： Genotype 4 Hepatic fibrosis Hepatitis C virus Interleukin-28B rs12979860

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