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portable ultrasonography in mass casualty incidents:The CAVEAT examination

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World Journal of Orthopedics 2010年第1期1卷 10-19页

作者： Stanislaw peter Stawicki James M Howard John p pryor david p bahner Melissa l Whitmill Anthony J Dean Department of Surgery Division of Critical CareTraumaand BurnThe Ohio State University Medical CenterColumbusOH 43210United States Department of Surgery Division of Traumatology and Surgical Critical CareUniversity of Pennsylvania School of MedicinePhiladelphiaPA 19104United States Department of Emergency Medicine The Ohio State University Medical CenterColumbusOH 43210United States Department of Emergency Medicine University of Pennsylvania School of MedicinePhiladelphiaPA 19104United States

Ultrasonography used by practicing clinicians has been shown to be of utility in the evaluation of time-sensitive and critical illnesses in a range of environments,including pre-hospital triage,emergency department,and critical care *** increasing availability of lightweight,robust,user-friendly,and low-cost portable ultrasound equipment is particularly suited for use in the physically and temporally challenging environment of a multiple casualty incident(MCI).Currently established ultrasound applications used to identify potentially lethal thoracic or abdominal conditions offer a base upon which rapid,focused protocols using hand-carried emergency ultrasonography could be *** a detailed review of the current use of portable ultrasonography in military and civilian MCI settings,we propose a protocol for sonographic evaluation of the chest,abdomen,vena cava,and extremities for acute *** protocol is two-tiered,based on the urgency and technical difficulty of the sonographic *** addition to utilization of well-established bedside abdominal and thoracic sonography applications,this protocol incorporates extremity assessment for long-bone *** of the proposed protocol will need to be conducted to determine its utility in simulated and actual MCI settings.

关键词： Focused Assessment with Sonography in Trauma Chest,abdomen,vena cava,and extremities for acute triage Ultrasonography Disaster Field triage pre-hospital care Mass casualty incident

结合U-net与FpN的地震初至波拾取算法

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测绘地理信息 2024年第1期49卷 82-87页

作者：何彬周云耀吕永清中国地震局地震研究所湖北武汉430071 中国地震局地震大地测量重点实验室湖北武汉430071

精确识别初至波以及拾取地震初至波初至时间对于地震的精确定位、地震孕震机制的解释、地震预警等都具有很大的意义。单纯地依靠地震学专家进行分析会耗费大量的人力和时间。本文将U-net模型编码、解码语义分割的思想与特征图金字塔网络... 详细信息

精确识别初至波以及拾取地震初至波初至时间对于地震的精确定位、地震孕震机制的解释、地震预警等都具有很大的意义。单纯地依靠地震学专家进行分析会耗费大量的人力和时间。本文将U-net模型编码、解码语义分割的思想与特征图金字塔网络(feature pyramid networks,FpN)的思想结合,提出了一种新的初至波初至时间拾取算法,满足高精度识别与拾取初至波的需求。算法模型分为编码、解码两部分,编码部分分为四层,用于捕获特征,通过卷积核大小、步长等参数实现特征由低层级到高层级的抽象和提取。解码部分分为四层,通过对前一层进行反卷积上采样实现。最后,将编码、解码部分对应层级特征图组合,通过两层全连接神经网络实现最终结果输出。与传统算法相比,U-net FpN模型在对初至波初至时间的分类与定位上都有着显著提升。

关键词：初至波拾取 U-net FpN

NMR identification of anti-influenza lead compound targeting at pa_C subunit of H5N1 polymerase

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Chinese Chemical letters 2012年第1期23卷 89-92页

作者： lin li Sheng Hai Chang Jun Feng Xiang Qian li Huan Huan liang ya lin Tang Ying Fang liu State Key laboratory for Structural Chemistry of Unstable and Stable Species Institute of ChemistryChinese Academy of SciencesBeijing 100190China National laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University Chinese Academy of SciencesBeijing 100049China

pa_C subunit from avian influenza（H5N1） viral RNA polymerase was used in this work as a target in the screening for anti-influenza agents from licorice-derived *** a result,18β-glycyrrhetinic acid was suggested to be pa_C ligand by flexible docking,and was then confirmed by relaxation-edited *** result of ApG primer extension assay indicated that this pa_C ligand can inhibit the polymerase activity,and thus may potentially be valuable as anti-influenza lead *** work validated the possibility of screening polymerase inhibitors by using pa_C as a target,and provided a starting point for the further discovery of new anti-influenza drugs.

关键词： paC RNA polymerase inhibitor Anti-influenza agent licorice-derived compounds

A　CONSTITUTIVE　THEORY　FOR　THE　REYNOlDS－STRESS　ClOSURES　IN　TURBUlENCE　MODEllING

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Journal of Hydrodynamics 1996年第1期8卷 103-109页

作者： l. Y. Tao,(Department of Mechanical Engineering, University of pittsburgh, pa15261,Usa)G. Q. Chen(Centre for Environmental Sciences, peking University, Beijing 100871,p. R. China)K. R. Rajagopal(Department of Mechanical Engineering, University of pittsbur

For the Reynolds-stress closures in turbulence modelling, a constitutive theory is developed based on the principle of frame indifference and the theory of invariants. The present study sheds light on existing closure... 详细信息

关键词： turbulence modelling Reynolds-Stress constitutive theory

Design of a Sliding Mode Control for a DC-to-DC Buck-Boost Converter

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Design of a Sliding Mode Control for a DC-to-DC Buck-Boost C...

血管加压素受体Ⅰ在实验性糖尿病大鼠肾脏和肝脏的调节

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作者： pablo salazar paúl Ayala Susset Guerra Jiménez Alexander Fernández Correa ESpE CUJAE

This paper studies DC-to-DC buck-boost converter, as well as of the most important features asociated with the sliding mode control, such as adding robustness to the system with respect to variations of its parameters... 详细信息

ISBN: (纸本)9781467355339

关键词： buck-boost converter sliding mode control

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上海医科大学学报 1993年第4期20卷 268-272页

作者：高鑫 phillips pa 上海医科大学中山医院内分泌科澳大利亚墨尔本大学医学系澳斯汀医院

本文利用链脲佐菌素诱导的实验性糖尿病大鼠,在糖尿病形成2周时分别测定血糖、肾小球滤过率(GFR)、血浆精氨酸血管加压素(AVp)、血钠及血浆渗透压,并用选择性AVp受体Ⅰ(V1)的放射配体^(125)I[d(CH_2)_5-sarcosine^7]AVp对肾髓质膜和肝... 详细信息

本文利用链脲佐菌素诱导的实验性糖尿病大鼠,在糖尿病形成2周时分别测定血糖、肾小球滤过率(GFR)、血浆精氨酸血管加压素(AVp)、血钠及血浆渗透压,并用选择性AVp受体Ⅰ(V1)的放射配体^(125)I[d(CH_2)_5-sarcosine^7]AVp对肾髓质膜和肝细胞膜V1受体进行结合分析。实验分三组:糖尿病组(D组)、胰岛素治疗组(T组)和对照组(C组)。结果表明,糖尿病形成2周时,各组血糖值为:D=37±7.5mmol/l;T=19±5.78mmol/l: C=7.63±0.59mmol/l。DT两组的GFR均增加,血浆AVp在D组明显高于对照组。膜受体结合试验显示:肾髓质膜V1受体最大结合容量(Bmax)在各组均无明显差异,解离常数(Kd值)D组大于T、C两组,肝细胞膜Bmax在T组增加,而Kd值在各组均未见改变。

关键词：糖尿病精氨酸血管加压素受体

Efficient first-principles prediction of solid stability:Towards chemical accuracy

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npj Computational Materials 2018年第1期4卷 591-596页

作者： Yubo Zhang daniil A.Kitchaev Julia yang Tina Chen Stephen T.dacek Rafael A.sarmiento-pérez Maguel A.l.Marques Haowei peng Gerbrand Ceder John p.perdew Jianwei Sun Department of physics and Engineering physics Tulane UniversityNew OrleansLA 70118USA Department of Materials Science and Engineering MITCambridgeMA 02139USA Materials Science Division LBNLBerkeleyCA 94720USA Department of Materials Science and Engineering UC BerkeleyBerkeleyCA 94720USA Institute of physical Chemistry and National Center for Computational Design and Discovery of Novel Materials Department of ChemistryUniversity of BaselKlingelbergstrBasel 804056Switzerland Institut für physik Martin-Luther-Universität Halle-WittenbergHalle D-06099Germany Department of physics Temple UniversityPhiladelphiaPA 19122USA Department of Chemistry Temple UniversityPhiladelphiaPA 19122USA

The question of material stability is of fundamental importance to any analysis of system properties in condensed matter physics and materials *** ability to evaluate chemical stability,i.e.,whether a stoichiometry will persist in some chemical environment,and structure selection,*** crystal structure a stoichiometry will adopt,is critical to the prediction of materials synthesis,reactivity and ***,we demonstrate that density functional theory,with the recently developed strongly constrained and appropriately normed(SCAN)functional,has advanced to a point where both facets of the stability problem can be reliably and efficiently predicted for main group compounds,while transition metal compounds are improved but remain a *** therefore offers a robust model for a significant portion of the periodic table,presenting an opportunity for the development of novel materials and the study of fine phase transformations even in largely unexplored systems with little to no experimental data.

关键词： properties stability chemical

柚皮苷通过抑制ERK1/2活化和DRp1表达减轻棕榈酸处理后脂肪细胞炎症

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南昌大学学报（医学版） 2024年第1期64卷 32-37,106页

作者：曾文靖王超文王莉张亚琴刘阿花黄起壬江西省基础药理学重点实验室南昌大学江西医学院药学院药理学教研室南昌330006 南昌大学江西医学院药学院南昌330006

目的探讨柚皮苷(Nar)对棕榈酸(pa)处理后成熟脂肪细胞炎症反应的影响及机制。方法3T3-l1前脂肪细胞经成脂化诱导为成熟脂肪细胞后采用不同浓度(0、25、50、100、200μmol·l^(-1))pa处理细胞48 h,CCK-8检测细胞活力,ElIsa检测细胞上清I... 详细信息

目的探讨柚皮苷(Nar)对棕榈酸(pa)处理后成熟脂肪细胞炎症反应的影响及机制。方法3T3-l1前脂肪细胞经成脂化诱导为成熟脂肪细胞后采用不同浓度(0、25、50、100、200μmol·l^(-1))pa处理细胞48 h,CCK-8检测细胞活力,ElIsa检测细胞上清Il-6水平,确定后续实验最佳pa浓度。不同浓度(0、12.5、25、50、100μmol·l^(-1))Nar处理成熟脂肪细胞,CCK-8检测细胞活力,确定后续实验最佳Nar浓度。单独pa处理实验分为2组:Ctrl组、pa组;联合Nar处理实验分为4组:Ctrl组、pa组、Nar组、pa+Nar组;western blotting法检测各组p-ERK1/2和DRp1蛋白表达水平。联合线粒体裂变抑制剂Mdivi-1处理实验分为7组:Ctrl组、pa组、Nar组、Mdivi-1组、pa+Nar组、pa+Mdivi-1组、pa+Nar+Mdivi-1组,ElIsa和western blotting法分别检测7组细胞上清Il-6水平和p-ERK1/2、DRp1蛋白表达水平。结果后续实验pa和Nar分别选择50和25μmol·l^(-1)。与Ctrl组比较,pa组p-ERK1/2和DRp1表达水平均升高(ppa组比较,pa+Nar组、pa+Mdivi-1组、pa+Nar+Mdivi-1组Il-6水平、p-ERK1/2和DRp1表达均更低(ppa+Nar组比较,pa+Nar+Mdivi-1组Il-6水平差异无统计学意义(p>0.05),但p-ERK1/2和DRp1表达水平均降低(ppa处理后成熟脂肪细胞的炎症反应,其机制是通过抑制ERK1/2激活和DRp1表达实现的。

关键词：柚皮苷棕榈酸脂肪细胞成脂分化炎症

Use of focus stacking and SfM techniques in the process of registration of a small object hologram

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Chinese Optics letters 2020年第6期18卷 19-23页

作者： Sławomir pasko Marek Sutkowski Ramunas bakanas Institute of Micromechanics and photonics Warsaw University of Technology02-525 WarsawPoland 2Institute of Microelectronics and OptoelectronicsWarsaw University of Technology00-665 WarsawPoland 3Geola Digital uab.Vilnius 03227Lietuva

In this letter,a method for shape visualization of small objects(microscopic)in the form of a hologram is *** consists of a standard optical set-up for small object registration(i.e.,stereoscopic or biological microscope).The focus stacking technique is used to obtain a series of images with increased depth of field and on them a shape reconstruction procedure(structure from motion,SfM)is *** use of a dense cloud of points,a sequence of parallax-related images suitable for Geola’s digital holographic printing is *** holographic printer produces single-parallax holographic(full three-dimensional)images of real or virtual objects.

关键词： digital holography three-dimensional image acquisition photography