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Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors

World Journal of Gastroenterology 2017年第17期23卷 3092-3098页

作者： sa.va.ore pa.ella.ha.mony impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev paola Capelli sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto salvia Luca Landoni General and pancreatic Surgery Department Pancreas InstituteUniversity and Hospital Trust of Verona Department of Public Health and Community Medicine University and Hospital Trust of Verona Department of Radiology Casa di Cura Pederzoli Department of Radiology Pancreas InstituteUniversity and Hospital Trust of Verona Department of Diagnostics and Public Health Section of PathologyUniversity and Hospital Trust of Verona ARC-NET Research Center University and Hospital Trust of Verona Department of Oncology Pancreas InstituteUniversity and Hospital Trust of Verona Hepato-bilio-pancreatic Surgery Unit Casa di Cura Pederzoli Section of Endocrinology Medicina Generale e Malattie Aterotrombotiche e DegenerativeDepartment of MedicineUniversity and Hospital Trust of Verona Gastroenterology B Department Pancreas InstituteUniversity and Hospital Trust of Verona

AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(pan NET) in a caseload of a tertiary referral *** patients submitted to surgery for pan NET at the Surgical Unit of the pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. passing-Bablok(PB) regression analysis was used to check the agreement between MR and *** Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and *** MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of pan NET.

关键词： pancreatic neoplasms Neuroendocrine tumors Magnetic resonance imaging Diagnostic imaging pathological dimensions

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Gastroesophageal reflux and congenital gastrointestinal malformations

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World Journal of Gastroenterology 2015年第28期21卷 8508-8515页

作者： Lucia Marseglia sara Manti Gabriella D'Angelo Eloisa Gitto Carmelo salpietro Antonio Centorrino Gianfranco Scalfari Giuseppe santoro Pietro impellizzeri Carmelo Romeo Neonatal Intensive Care Unit Department of Pediatrics University of Messina Unit of paediatric Genetics and Immunology Department of Paediatrics University of Messina Unit of Pediatric Surgery Department of Pediatrics University of Messina Department of Biomedical Sciences and Morpho-Functional Images University of Messina

Although the outcome of newborns with surgical congenital diseases(e.g.,diaphragmatic hernia;esophageal atresia;omphalocele;gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery,infant survivors often require intensive treatment after birth,have prolonged hospitalizations,and,after discharge,may have longterm sequelae including gastro-intestinal comorbidities,above all,gastroesophageal reflux(GER).This condition involves the involuntary retrograde passage of gastric contents into the esophagus,with or without regurgitation or *** is a well-recognized condition,typical of infants,with an incidence of 85%,which usually resolves after physiological maturation of the lower esophageal sphincter and lengthening of the intra-abdominal esophagus,in the first few months after *** the exact cause of abnormal esophageal function in congenital defects is not clearly understood,it has been hypothesized that common(increased intra-abdominal pressure after closure of the abdominal defect) and/or specific(e.g.,motility disturbance of the upper gastrointestinal tract,damage of esophageal peristaltic pump) pathological mechanisms may play a role in the etiology of GER in patients with birth *** of knowledge could positively impact the long-term prognosis of patients with surgical congenital *** present manuscript provides a literature review focused on pathological and clinical characteristics of GER in patients who have undergone surgical treatment for congenital abdominal malformations.

关键词： Gastroesophageal reflux Congenital diaphragmatichernia Esophageal atresia Omphalocele Gastroschisis

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