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Clinical features and prognostic factors of duodenal neuroendocrine tumours:A comparative study of ampullary and nonampullary regions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 907-918页

作者： sa Fang Yu-Peng shi Lu Wang Shuang Han Yong-Quan shi Department of Gastroenterology Honghui HospitalXi’an Jiaotong UniversityXi'an 710054Shanxi ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710032Shaanxi ProvinceChina Department of Gastroenterology Xijing Hospital Affiliated to Air Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND Duodenal neuroendocrine tumours(DNETs)are rare ***,the incidence of DNETs has been increasing in recent years,especially as an incidental finding during endoscopic ***,there is no consensus regarding the ideal treatment of *** there are few studies on the clinical features and survival analysis of *** To analyze the clinical characteristics and prognostic factors of patients with duodenal neuroendocrine *** The clinical data of DNETs diagnosed in the First Affiliated Hospital of Air Force Military Medical University from June 2011 to July 2022 were ***-docrine tumours located in the ampulla area of the duodenum were divided into the ampullary region group;neuroendocrine tumours in any part of the duo-denum outside the ampullary area were divided into the nonampullary region *** a retrospective study,the clinical characteristics of the two groups and risk factors affecting the survival of DNET patients were *** Twenty-nine DNET patients were *** male to female ratio was 1:1.9,and females comprised the *** ampullary region group accounted for 24.1%(7/29),while the nonampullary region group accounted for 75.9%(22/29).When diagnosed,the clinical symptoms of the ampullary region group were mainly abdominal pain(85.7%),while those of the nonampullary region groups were mainly abdominal distension(59.1%).There were differences in the composition of staging of tumours between the two groups(Fisher's exact probability method,P=0.001),with nonampullary stage II tumours(68.2%)being the main stage(P<0.05).After the diagnosis of DNETs,the survival rate of the ampullary region group was 14.3%(1/7),which was lower than that of 72.7%(16/22)in the nonampullary region group(Fisher's exact probability method,P=0.011).The survival time of the ampullary region group was shorter than that of the nonampullary region group(P<0.000).The median survival time of the ampullary

关键词： Duodenum Neuroendocrine Tumour Ampullary Nonampullary Clinical features Prognostic

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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： Yi Yu Guo-Ping Liu Yi Huang Peng shi IEEE Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

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Periodic event-triggered secure consensus for networked mechanical systems under Denial-of-Service attacks

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Control Theory and Technology 2024年第1期22卷 1-13页

作者： shiqi Zheng Zhipeng Li Chao Zhai Peng shi School of Automation China University of GeosciencesWuhan430074HubeiChina School of Electrical and Electronic Engineering The University of AdelaideAdelaideSA5005Australia School of Electronic Electrical Engineering and PhysicsFujian University of TechnologyFuzhou350100FujianChina

This paper concentrates on the secure consensus problem of networked mechanical/Euler–Lagrange ***,a new periodic event-triggered(PET)secure distributed observer is proposed to estimate the leader *** proposed distributed observer only relies on the PET data from its neighbors,which can significantly reduce the communication and computational *** importantly,it is secure in the sense that it can work normally regardless of the Denial-of-Service(DoS)***,based on the proposed distributed observer,an adaptive fuzzy control law is proposed for each Euler–Lagrange system.A PET mechanism is integrated into the controller,which can reduce the control *** is helpful for both energy saving and fault tolerance of ***,the PET mechanism naturally makes the controller easy to be implemented in digital *** property of fuzzy logic systems and Gronwall inequality are skillfully utilized to show the stability of the closed-loop ***,the proposed control scheme is verified on real Euler–Lagrange systems,which contain a robot manipulator and several servo motors.

关键词： Output regulation Mechanical/Euler-Lagrange systems Periodic event-triggered mechanism Denial-of-Service attacks

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Permeable and robust polymer-silica hybrid armor on cell catalyst for sustainable biomanufacturing

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Particuology 2024年第9期92卷 106-112页

作者： Yiran Cheng Zhenhua Wu Boyu Zhang Jiaxu Zhang Jiafu shi Zhongyi Jiang School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China

Inactivated cell catalysis is one of several central techniques in green biomanufacturing ***,the instability and leakage of enzymes in inactivated cell severely restrict the practical applications of inactivated cell *** armor on the surface of inactivated cells affords a feasible and effective strategy to enhance the stability of cells while commonly lowering the ***,polymer-silica hybrid armor(PSHA)is directly generated on the surface of enzyme-containing *** branched structure of PEI enables higher porosity of cell@PSHA,exhibiting 1.52-fold enhancement in substrate permeability by contrast with cell@silica armor(sa).The electrostatic interactions(NH_(3)^(+)with O^(−))and hydrogen bonding(N⋯H or O⋯H)interactions between structural units enables higher stability of cell@PSHA,showing 3.13-fold elevation in Young's modulus compared with cell@*** a result,the cell@PSHA can catalyze continuous conversion of starch to tagatose for 15 batches over 969 h,with an average yield of 77.76 g L^(−1).

关键词： Biomanufacturing Wholecell catalysis Polymer-silica hybrid armor Tagatose production Starch conversion

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Critical roles of control engineering in the development of intelligent and connected vehicles

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第2期7卷 79-85页

作者： Yang Fei Peng shi Yang Liu Liang Wang School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China School of Electrical and Mechanical Engineering The University of AdelaideAdelaide SA 5005Australia Research and Innovation Centre Obuda UniversityBudapest 1034Hungary Department of Architecture and Civil Engineering Chalmers University of TechnologyGothenburg SE-41296Sweden

1 Introduction In recent years,advancements in onboard computing hardware and wireless communication technology have remarkably stimulated the development of intelligent and connected vehicles(ICVs).Specifically,some researchers have investigated the issue of employing various advanced control techniques to optimize the performance of autonomous vehicles in practice(Sun et al.,2023;Zhang et al.,2023a,2023b).Therefore,this article aims to discuss why and how control engineering plays an essential role in the development of ICVs.

关键词： connected hardware intelligent

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瑞马唑仑对心脏瓣膜置换术全麻诱导期间血流动力学及术后认知功能的影响研究

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中国医学工程 2024年第1期32卷 67-71页

作者：史梦圆肖洒郑州市第七人民医院麻醉科河南郑州450000 郑州大学第二附属医院肿瘤科河南郑州450000

目的观察瑞马唑仑对心脏瓣膜置换术患者全麻诱导期间的血流动力及术后即刻认知功能的影响。方法本文为前瞻性研究,病例纳入时间为2020年6月至2023年5月,研究对象为郑州市第七人民医院收治的98例心脏瓣膜置换术患者,采用随机数字表法对... 详细信息

目的观察瑞马唑仑对心脏瓣膜置换术患者全麻诱导期间的血流动力及术后即刻认知功能的影响。方法本文为前瞻性研究,病例纳入时间为2020年6月至2023年5月,研究对象为郑州市第七人民医院收治的98例心脏瓣膜置换术患者,采用随机数字表法对入组患者进行分组,分别列为观察组(49例)和对照组(49例),对照组实施常规全身麻醉,观察组采用瑞马唑仑辅助全身麻醉,比较两组患者全麻诱导期间的血流动力学变化情况,麻醉镇静深度,术后即刻认知功能及麻醉相关副反应发生情况。结果给药前(T0),给药后即刻(T1),诱导5 min时(T2)两组的心率(HR)、平均动脉压(MAP)差异无统计学意义(P>0.05);气管插管即刻(T3)时,观察组的HR为(79.25±10.17)次/min,MAP为(115.74±20.61)mmHg,均低于对照组[(85.75±10.24)次/min、(130.41±20.77)mmHg];插管后5 min时(T4),观察组的HR为(78.62±10.61)次/min,MAP为(108.44±20.25)mmHg,均低于对照组[(84.27±10.32)次/min、(120.25±20.27)mmHg],差异有统计学意义(P0.05)。结论瑞马唑仑辅助全身麻醉能有效维持心脏瓣膜置换术患者诱导期间的血流动力学稳定,对帮助患者更快达到满意麻醉深度并降低术后即刻认知障碍均有积极意义,联合应用此药未明显增加不良反应发生风险,安全性较高。

关键词：心脏瓣膜置换术全身麻醉瑞马唑仑血流动力学认知功能

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胸横肌平面阻滞对体外循环下心脏瓣膜置换术的应用研究

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青岛医药卫生 2024年第2期56卷 121-124页

作者：史梦圆肖洒郑州市第七人民医院麻醉科河南郑州450000 郑州大学第二附属医院肿瘤科河南郑州45000

目的观察胸横肌平面阻滞(TTP)对体外循环(CPB)下心脏瓣膜置换术的应用效果。方法本研究为前瞻性研究,选择的研究对象为2021年6月~2023年9月期间至郑州市第七人民医院接受CPB心脏瓣膜置换术治疗的98例患者,以计算机随机分组法将其分为常... 详细信息

目的观察胸横肌平面阻滞(TTP)对体外循环(CPB)下心脏瓣膜置换术的应用效果。方法本研究为前瞻性研究,选择的研究对象为2021年6月~2023年9月期间至郑州市第七人民医院接受CPB心脏瓣膜置换术治疗的98例患者,以计算机随机分组法将其分为常规组(49例)和TTP组(49例),常规组实施常规全身麻醉,TTP组采用TTP辅助麻醉,比较两组患者围手术期基础体征,术前术后应激指标变化情况,术后6h、12h等时间点下静息或咳嗽时的疼痛情况,及术后并发症发生情况。结果TTP组切皮时(T1)的心率(HR)、平均动脉压(MAP)均低于常规组;锯胸骨时(T2)的HR、MAP、血管紧张素Ⅱ(AngⅡ)、β-内啡肽(β-EP),术后6h、12h静息时的视觉模拟疼痛量表(VAS)评分、咳嗽时的VAS评分均低于常规组,差异均具有统计学意义(P0.05)。结论TTP联合全身麻醉能稳定CBP下心脏瓣膜置换术患者的基础体征,并减轻应激损伤,对缓解患者术后疼痛并降低并发症发生风险均有积极意义。

关键词：体外循环心脏瓣膜置换术胸横肌平面阻滞应激损伤术后并发症

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A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2263-2280页

作者： Leilei Wang Shanshan He Rong Liu Yuan Xue Yuan Quan Rongying shi Xueying Yang Qing Lin Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Chemotherapeutics can induce immunogenic cell death(ICD)in tumor cells,offering new possibilities for cancer ***,the efficiency of the immune response generated is insufficient due to the inhibitory nature of the tumor microenvironment(TME).Here,we developed a pH/reactive oxygen species(ROS)dual-response system to enhance chemoimmunotherapy for *** system productively accumulated in tumors by specific binding of phenylboronic acid(PBA)to sialic acids(sa).The nanoparticles(NPs)rapidly swelled and released quercetin(QUE)and doxorubicin(DOX)upon the stimulation of tumor microenvironment(TME).The in vitro and in vivo results consistently demonstrated that the NPs improved anti-tumor efficacy and prolonged survival of mice,significantly enhancing the effects of the *** study revealed DOX was an ICD inducer,stimulating immune responses and promoting maturation of dendritic cells(DCs).Additionally,QUE served as a TME regulator by inhibiting the cyclooxygenase-2(COX2)-prostaglandin E2(PGE2)axis,which influenced various immune cells,including increasing cytotoxic T cells(CLTs)infiltration,promoting M1 macrophage polarization,and reducing regulatory T cells(Tregs)*** combination synergistically facilitated chemoimmunotherapy efficacy by remodeling the immunosuppressive *** work presents a promising strategy to increase anti-tumor efficiency of chemotherapeutic agents.

关键词： Quercetin Nanoparticle Responsiveness Chemoimmunotherapy Tumor immune microenvironment

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Characteristics of rural domestic sewage discharge and their driving mechanisms: evidence from the Northern Region, China

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 47-58页

作者： Jianguo Liu Ziyu Zhou Pengyu Li Zixuan Wang Ying Yan Xuezheng Yu Wenkai Li Tianlong Zheng Yingnan Cao Wenjun Wu Wenqian Cai Zhining shi Junxin Liu Key Laboratory of Environmental Pollution Control and Remediation at Universities of Inner Mongolia Autonomous Region College of Resources and Environmental EngineeringInner Mongolia University of TechnologyHohhot 010051China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China SCEGC No.12 Construction Engineering Group Co. Ltd.Ankang 725000China State Environmental Protection Key Laboratory of Environmental Planning and Policy Simulation Chinese Academy of Environmental PlanningBeijing 100041China Technical Centre for Soil Agriculture and Rural Ecology and EnvironmentMinistry of Ecology and EnvironmentBeijing 100012China Sustainable Infrastructure and Resource Management(SIRM) UniSA STEMUniversity of South AustraliaSouth AustraliaMawson LakesSA 5095Australia

The traits of rural domestic sewage emission are unclear,negatively affecting rural domestic sewage treatment and sewage *** study used data from the Second National Pollution Source Census Bulletin to establish a data *** spatial distribution characteristics and main factors influencing rural sewage discharge in the Northern Region were studied using spatial autocorrelation analysis and structural *** findings demonstrated that(l)a significant Spearman correlation between drainage water volume(DwV),chemical oxygen demand(COD),ammonia nitrogen(NH_(3)-N),total nitrogen(TN),and total phosphorus(TP)and that the correlation coefficients between DWV and COD,NH,-N,TNand TP were 0.87**,1.0**,0.99**,0.99**,respectively;(2)rural sewage discharge showed spatial autocorrelation,and rural domestic sewage discharge in the districts and counties with an administration was significantly higher than in the surrounding areas;and(3)social development was the main driver rural domestic sewage changes(path coefficient was 0.407**),and the main factors influencing rural domestic sewage discharge were the urbanization rate,years of education,and population age *** study obtained the spatial variation law and clarified the main influencing factors of rural domestic sewage to provide data support and a theoretical basis for subsequent rural sewage collection and *** of the Inner Mongolia Autonomous Region in northern China as a typical case,provides a theoretical foundation for scientific decision-making on rural domestic sewage treatment at the national and regional levels and offers new perspectives for managing pollutants.

关键词： Rural domestic sewage Emission characteristics Spatial autocorrelation analysis Influencing factors

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Genome-wide identification of the CONSTANS-LIKE(COL)family and mechanism of fruit senescence regulation by PpCOL8 in sand pear(Pyrus pyrifolia)

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Journal of Integrative Agriculture 2024年第4期23卷 1222-1237页

作者： Yue Xu Shurui Song Huiying Wang Xilong Cao Xinran Zhao Wenli Wang Liyue Huo Yawei Li Misganaw Wassie Bin Lu Liang Chen Haiyan shi College of Horticulture Hebei Agricultural UniversityBaoding 071001China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China

Pyrus pyrifolia Nakai‘Whangkeumbae'is a sand pear fruit with excellent nutritional quality and ***,the industrial development of pear fruit is significantly limited by its short shelf *** acid(sa),a well-known phytohormone,can delay fruit senescence and improve shelf ***,the mechanism by which sa regulates CONSTANS-LIKE genes(COLs)during fruit senescence and the role of COL genes in mediating fruit senescence in sand pear are poorly *** this study,22 COL genes were identified in sand pear,including four COLs(Pp COL8,Pp COL9a,Pp COL9b,and Pp COL14)identified via transcriptome analysis and 18 COLs through genome-wide *** COL genes were divided into three subgroups according to the structural domains of the COL *** COL8,with two B-box motifs and one CCT domain,belonged to the first *** contrast,the other three Pp COLs,Pp COL9a,Pp COL9b,and Pp COL14,with similar conserved protein domains and gene structures,were assigned to the third *** four COLs showed different expression patterns in pear tissues and were preferentially expressed at the early stage of fruit ***,the expression of Pp COL8 was inhibited by exogenous sa treatment,while sa up-regulated the expression of Pp COL9a and Pp ***,Pp COL8 interacts with Pp MADS,a MADS-box protein preferentially expressed in fruit,and sa up-regulated its *** the production of ethylene and the content of malondialdehyde(MDA)were increased in Pp COL8-overexpression sand pear fruit,the antioxidant enzyme(POD and SOD)activity and the expression of Pp POD1 and Pp SOD1 in the sand pear fruits were down-regulated,which showed that Pp COL8 promoted sand pear fruit *** contrast,the corresponding changes were the opposite in Pp MADS-overexpression sand pear fruits,suggesting that Pp MADS delayed sand pear fruit *** co-transformation of Pp COL8 and Pp MADS also delayed sand pear fruit *** re

关键词： Pyrus pyrifolia CONSTANS-LIKE gene salicylic acid fruit senescence MADS

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