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Rare Metals 2021年第10期40卷 2964-2974页

作者： Zhen-Yi Wei Kang-Ming Hu Bai-Sheng sa Bo Wu Multiscale Computational Materials Facility School of Materials Science and EngineeringFuzhou UniversityFuzhou 350100China

Effects of pressure on lattice parameters, electronic, thermodynamic and mechanical properties of the fully ordered Ti_(2)AlNb orthorhombic phase were studied using first-principles calculations based on density functional theory(DFT). The bonding nature for ordering orthorhombic Ti_(2)AlNb was revealed quantitatively through the electronic structure analyzing. The external pressures play limited roles in the elastic anisotropy of the alloy due to the outstanding dynamical and mechanical stabilities under pressure. However, the shear modulus of O phase manifests anisotropic, where {010} shear planes are the easiest planes to cleave among the principal planes under all *** heat capacities, volume expansions and thermal expansion coefficients were calculated using the quasi-harmonic approximation model based on the phonon dispersion curves. Meanwhile, the bulk modulus, Young’s modulus,shear modulus and the hardness are promptly enhanced under pressure. The predicted results give hints to design Ti_(2)AlNb-based alloy as high-pressure applications.

关键词： Ti2AlNb-based orthorhombic phase Pressure-induced effect Thermodynamic properties Mechanical properties First-principles calculations

Computational Prediction of Micro RNAs from Toxoplasma gondii Potentially Regulating the Hosts' Gene Expression

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 228-238页

作者： Müs?erref Duygu saar Caner Bagc? Jens Allmer Molecular Biology and Genetics Izmir Institute of Technology Urla Izmir 35430 Turkey Biotechnology Izmir Institute of Technology Urla Izmir 35430 Turkey Bionia Incorporated IZTEKGEB A8 Urla Izmir 35430 Turkey

MicroRNAs （miRNAs） were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene reg- ulation. It may also regulate its hosts＇ gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.

关键词： Toxoplasma gondii MicroRNA Regulation Host interaction Parasite

Transcription Factor WRKY70 Displays Important but No Indispensable Roles in jasmonate and salicylic Acid Signaling

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Journal of Integrative Plant Biology 2008年第5期50卷 630-637页

作者： Chun-Mei Ren Qi Zhu Bi-da Gao Shao-Ying Ke Wan-Cong Yu dao-Xin Xie Wen Peng College of Bioscience and Biotechnology Hunan Agncultural University Changsha 410128 China Crop Gene Engineering Key Laboratory of Hunan Province Hunan Agncultural University Changsha 410128 China College of Horticulture and Gardening Hunan Agncultural University Changsha 410128 China College of Bio-safety Science and Technology Hunan Agricultural University Changsha 410128 China Department of Biological Sciences Tangshan Normal College Tangshan 063000 China Ministry of Education Key Laboratory of Bioinformatics Department of Biological Sciences and Biotechnology Tsinghua University Beijing 100084 China

The transcription factor WRKY70 was previously reported to be a common component in salicylic acid （sa） and jasmonate （ja） mediated signal pathways in Arabidopsis. Here, we present that the inactivation of the WRKY70 gene in wrky70-1 mutant does not alter the responses of both ja and sa, and that wrky70 mutation is unable to restore the coil mutant in ja responses. However, overexpression of WRKY70 reduces ja responses such as expression of ja-induced genes and ja-inhibitory root growth, and activates expression of sa-inducible PR1. These data indicate that the WRKY70 is important but not indispensable for ja and sa signaling, and that other regulators may display the redundant role with WRKY70 in modulation of ja and sa responses in Arabidopsis. Furthermore, we showed that ja inhibits expression of WRKY70 and PR1 by both COi1-dependent and COi1-independent pathways.

关键词： Arabidopsis COl 1 jasmonate salicylic acid signaling WRKY70.

番茄木虱取食对含Mi-1.2番茄抗氧化酶活性及防御反应相关基因表达的影响

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园艺学报 2016年第7期43卷 1286-1294页

作者：嘎奥云朝伦牛一丁包文化哈斯阿古拉哈达内蒙古大学生命科学学院呼和浩特010021

Mi-1.2基因编码CC-NBS-LRR家族抗病蛋白,对线虫及刺吸式昆虫具有广谱抗性。以番茄木虱和携带Mi-1.2基因的番茄品系‘Motelle’作为研究体系,研究番茄木虱取食对番茄叶片抗氧化酶活性及防御反应相关基因表达的影响。结果表明:番茄木虱的... 详细信息

Mi-1.2基因编码CC-NBS-LRR家族抗病蛋白,对线虫及刺吸式昆虫具有广谱抗性。以番茄木虱和携带Mi-1.2基因的番茄品系‘Motelle’作为研究体系,研究番茄木虱取食对番茄叶片抗氧化酶活性及防御反应相关基因表达的影响。结果表明:番茄木虱的取食显著提高了番茄叶片抗氧化酶POD、CAT、APX等的活性,同时诱导Mi-1.2基因表达;番茄木虱的取食上调sa合成有关基因PAL、sa信号途径标志基因PR-1(P4)及与Mi-1.2功能相关基因WRKY70、WRKY72a、WRKY72b的表达。ja/systemin信号途径和伤害有关的Pin II、TPI-1、PR-6、PR-7、PR-5等及Prosystemin编码基因Psy的表达未发生变化;ja合成途径相关酶编码基因AOS2、Lox D下调表达,AOC的表达没有变化。sa信号途径可能参与Mi-1.2介导的番茄对于刺吸式昆虫番茄木虱的防御反应。另外,Mi-1.2的RNAi沉默不会改变上述基因的m RNA水平,说明Mi-1.2基因产物对这些基因的表达无调控作用。

关键词：番茄 Mi-1.2 木虱抗氧化酶防御反应 sa信号途径

Further recommendations for trauma training of Indian medical officers and medical students

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World Journal of Emergency Medicine 2011年第2期2卷 85-87页

作者： Robert J Douglas Tonia M Mezzini GAnand Kumar Andrew ja Giles Sportsmed sa 32 Payneham Road Stepney South Australia 5069 Clinic 275 Royal Adelaide Hospital Adelade South Australia 5000 Vinayaka Missions Kirubananda Variyar Medical College Hospital Salem Tamil Nadu India Emergency Department Royal Adelaide Hospital Adelaide South Australia 5000

In a recent article,1 we have demonstrated a significant difference in the theoretical knowledge of both junior and senior emergency department （ED） medical officers （M0s） from salem, Tamil Nadu, India, and the Royal Adelaide Hospital （RAH） Adelaide, South Australia, in the management of severely injured trauma patients, when comparing M0s who had completed an ATLS-type program with those who had not undertaken such a program.

关键词： Further recommendations trauma training of Indian medical

2007年ACC／Aha非心脏手术围手术期心血管评估与管理指南：实施概要

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麻醉与镇痛 2010年第6期6卷 1-28页

作者： Fleisher LA Beckman ja Brown KA Calkins H Chaikof E Fleischmann KE Freeman WK Froehlich JB Kasper EK Kersten JR Riegel B Robb JF Smith SC Jr jacobs AK Adams CD Anderson JL Antman EM Buller CE Creager MA Ettinger SM Faxon DP Fuster V halperin JL Hiratzka LF Hunt sa Lytle BW Nishimura R Ornato JP Page RL Tarkington LG Yancy CW

美国心脏病学院镁国心脏协会工作组有关实践指南的一份报告（编写委员会对2002年非心脏手术围手术期心血管评估指南的修改）

关键词：非心脏手术管理指南血管评估围手术期 ACC/Aha 美国心脏病学院实践指南心脏协会

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添加糖与儿童心血管病风险的关系

中华高血压杂志 2016年第10期24卷 937-937页

作者：刘莉叶鹏 Vos MB Kaar JL Welsh ja Van Horn LV Feig DI Anderson CA Patel MJ Cruz Munos J Krebs NF Xanthakos sa Johnson RK American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health Council on Clinical Cardiology Council on Cardiovascular Disease in the Young Council on Cardiovascular and Stroke Nurs-ing Council on Epidemiology and Prevention Council on Func-tional Genomics and Translational Biology Council on Hypertension

不良的生活方式行为是导致全球可预防疾病的原因。膳食中添加糖可使其富含能量但营养差,且可增加发展为肥胖、心血管病、高血压、肥胖相关的癌症和龋齿的风险。方法和结果：美国心脏协会对目前的科学证据进行审查和分级,探讨添加糖对儿... 详细信息

不良的生活方式行为是导致全球可预防疾病的原因。膳食中添加糖可使其富含能量但营养差,且可增加发展为肥胖、心血管病、高血压、肥胖相关的癌症和龋齿的风险。方法和结果：美国心脏协会对目前的科学证据进行审查和分级,探讨添加糖对儿童心血管健康的影响。

关键词：心血管病风险儿童糖美国心脏协会心血管健康预防疾病生活方式

TM-Zn金属间化合物结构稳定性的第一性原理研究

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福州大学学报（自然科学版） 2017年第3期45卷 424-431页

作者：方圆陈祖华萨百晟吴波福州大学材料科学与工程学院福建福州350116

基于能带结构,提出jahn-Teller效应的诱发条件.基于声子色散曲线,揭示晶格动态稳定性和简并振动模式产生劈裂的物理特征.基于电子局域化函数和束缚能,揭示原子成键特性.结果表明,TM-Zn(TM=Ni,Pd,Pt,Cu,Ag,Au)金属间化合物发生立方到四... 详细信息

基于能带结构,提出jahn-Teller效应的诱发条件.基于声子色散曲线,揭示晶格动态稳定性和简并振动模式产生劈裂的物理特征.基于电子局域化函数和束缚能,揭示原子成键特性.结果表明,TM-Zn(TM=Ni,Pd,Pt,Cu,Ag,Au)金属间化合物发生立方到四方的相变变形过程中,结构保持稳定.

关键词： TM-Zn金属间化合物相变变形 jahn-Teller效应结构稳定性第-性原理计算

茉莉酸调控马铃薯离体块茎发育的主要代谢物变化

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中国农业科学 2024年第13期57卷 2525-2538页

作者：梁丽娟程李香袁剑龙撒刚张峰甘肃农业大学农学院/省部共建干旱生境作物学国家重点实验室

【目的】茉莉酸（jasmonic acid,ja）是马铃薯块茎发育过程中重要调控激素之一，研究ja调控块茎发育机理将为块茎产量及品质性状形成提供重要理论基础。【方法】采用马铃薯离体匍匐茎作为供试材料，外源添加ja(0、0.5、5和50μmol·L-1... 详细信息

【目的】茉莉酸（jasmonic acid,ja）是马铃薯块茎发育过程中重要调控激素之一，研究ja调控块茎发育机理将为块茎产量及品质性状形成提供重要理论基础。【方法】采用马铃薯离体匍匐茎作为供试材料，外源添加ja(0、0.5、5和50μmol·L-1)处理，分析ja诱导离体块茎表型形态、组织显微结构、碳水化合物积累及蛋白质组变化。【结果】随ja处理浓度升高，单个匍匐茎形成块茎数目、块茎直径及干鲜重、环髓区细胞面积、淀粉及可溶性糖含量在0.5和5μmol·L-1ja处理后逐渐增加（Pja处理后块茎直径及干鲜重、淀粉含量显著减少（Pja浓度升高逐渐降低（Pja调控块茎发育密切相关的35个差异表达蛋白质（Pja处理后下调表达，而在5μmol·L-1ja处理后上调表达，主要参与生物能量与代谢、蛋白质生物合成与贮藏、信号转导、转录；第二类包括10个蛋白质，随ja浓度升高上调表达，主要参与细胞防御、生物能量与代谢、转录；第三类包括8个蛋白质，ja处理后均下调表达，主要参与生物能量与代谢、细胞防御、蛋白质生物合成与贮藏。【结论】低浓度ja(0.5和5μmol·L-1)主要通过诱导块茎环髓区细胞膨大、细胞内蔗糖及多糖积累、细胞防御能力来促进块茎形态建成，而高浓度ja(50μmol·L-1)则表现为抑制作用。

关键词：马铃薯茉莉酸蛋白质组块茎发育脂氧合酶质谱

肺静脉和左心房后部完全隔离治疗慢性房颤的长期临床预后研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 41-42页

作者： sanders P. Hocini M. ja■s P. 吴超能 Cardiovascular Research Centre Department of Cardiology Royal Adelaide Hospital Adelaide SA 5000 Australia.Dr

目的:探讨左心房(LA)后部在慢性房颤(AF)中的作用。方法和结果:有27例慢性AF患者入选。在肺静脉隔离后,采用盐水灌注导管施行连接左右肺静脉的消融以实现对LA后部的隔离。LA后部电活动消失、该区域不能被起搏则为成功隔离。根据心动周... 详细信息

目的:探讨左心房(LA)后部在慢性房颤(AF)中的作用。方法和结果:有27例慢性AF患者入选。在肺静脉隔离后,采用盐水灌注导管施行连接左右肺静脉的消融以实现对LA后部的隔离。LA后部电活动消失、该区域不能被起搏则为成功隔离。根据心动周期长度(CL)的改变和AF的终止确定消融效果。

关键词：慢性房颤左心房肺静脉