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Progress in Natural Science:Materials International 2017年第5期27卷 289-296页

作者： Hankwon lim Sher Bahadur Rawal Department of Advanced Materials and Chemical Engineering Catholic University of Daegu

An integrated Bi2O3（i-Bi2O3） nanostructure with a particle size 10 nm inducing agglomerated structure were synthesized by dissolving bismuth nitrate pentahydrate in diethylene glycol at 180 ℃ with post heat *** prepared i-Bi2O3nanostructures were employed for the construction of Au/i-Bi2O3composite system and characterized by X-ray diffraction pattern,UV-visible diffuse reflectance spectroscopy（DRS）,and transmission electron microscopy,X-ray photoemission spectroscopy（XPS） and Energy dispersive X-ray spectroscopy（EDS）.The i-Bi2O3nanostructure and Au/i-Bi2O3composite system were found to exhibit high photocatalytic activity than commercial Bi2O3in decomposing salicylic acid under visible light *** high catalytic activity of i-Bi2O3nanostructure was deduced to be caused by charge separation facilitated by electron hopping between the particles within the integrated structure and space-charge separation between i-Bi2O3and *** charge separation behavior in i-Bi2O3nanostructure was further bolstered by comparing the *** radical produced in the solution with i-Bi2O3nanostructure,commercial Bi2O3and Au/i-Bi2O3composite which readily react with 1,4-terephthalic acid（TA） inducing 2-hydroxy terephthalic acid（TAOH） that shows unique fluorescence peak at 426 *** space-charge separation between i-Bi2O3and An was confirmed by measuring the electron spin resonance（ESR） spectra.

关键词： Integrated Bi2O3 nanostructure Organic pollutant mineralization Photocatalyst salicylic Acid(sa) Visible light

Transport of chemical signals in systemic acquired resistance

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Journal of Integrative Plant Biology 2017年第5期59卷 336-344页

作者： Archana Singh Gah-Hyun lim Pradeep Kachroo Department of Plant Pathology University of Kentucky Lexington Kentucky USA

Systemic acquired resistance （saR） is a form of broad-spectrum resistance induced in response to local infections that protects uninfected parts against subsequent secondary infections by related or unrelated pathogens. saR signaling requires two parallel branches, one regulated by salicylic acid （sa）. and theother by azelaic acid （AzA） and glycerol-3-phosphate （G3P）. AzA and G3P function downstream of the free radicals nitric oxide （NO） and reactive oxygen species （ROS）. During saR, sa, AzA and G3P accumulate in the infected leaves, but only a small portion of these is transported to distal uninfected leaves. sa is preferen- tially transported via the apoplast, whereas phloem loading of AzA and G3P occurs via the symplast. The symplastic transport of AzA and G3P is regulated by gating of the plasmodesmata （PD）. The PD localizing proteins, PDLP1 and PDLP5, regulate saR by regulating PD gating as well as the subcellular partitioning of a saR-associated protein.

关键词： William J. Lucas University of California Davis Usa

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Development and Characterization of New Microsatellite Markers for <i>Perilla frutescens</i>(L.) Britton

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American Journal of Plant Sciences 2019年第9期10卷 1623-1630页

作者： Kyu Jin sa Su Eun lim Ik-Young Choi Kyong-Cheul Park Ju Kyong Lee Department of Applied Plant Sciences College of Agriculture and Life Sciences Kangwon National University Chuncheon Korea Department of Agriculture and Life Industry Kangwon National University Chuncheon Korea

Based on RNA sequences using transcriptome analysis, 37 new simple sequence repeat (SSR) primer sets were developed for Perilla species. These new SSR markers were applied to analyze the genetic diversity among 15 accessions of Perilla species. A total of 182 alleles were confirmed in 37 loci, with an average of 4.9 alleles per locus and from 2 to 9 alleles per locus. The MAF (major allele frequency) per locus varied from 0.200 to 0.733, with an average of 0.463. The gene diversity (GD) ranged from 0.391 to 0.853, with an average of 0.670. The average polymorphic information content (PIC) was 0.624, ranging from 0.315 to 0.838. The new SSR markers of Perilla species reported in this study may provide potential markers to analyze the genetic diversity and genetic relationships of Perilla species. In addition, new Perilla SSR markers developed from transcriptome analysis can be useful for the identification of cultivars, conservation of Perilla germplasm resources, and genetic mapping and designating of important genes/QTLs for future Perilla crop breeding programs.

关键词： Perilla frutescens Oil Crop Vegetable Crop Genetic Diversity Microsatellites RNA-Seq

9-Hydroxy-6,7-dimethoxydalbergiquinol suppresses hydrogen peroxide-induced senescence in human dermal fibroblasts through induction of sirtuin-1 expression

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Asian Pacific Journal of Tropical Biomedicine 2021年第2期11卷 89-96页

作者： Seok-Hee lim Bing Si Li Ri Zhe Zhu Byung-Min Choi Department of Biochemistry School of MedicineInstitute of BiotechnologyWonkwang University460 Iksandae-roIksanJeonbuk 54538Republic of Korea

Objective:To investigate the potential anti-aging mechanism of9-hydroxy-6,7-dimethoxydalbergiquinol(HDDQ)on hydrogen peroxide(H2O2)-induced oxidative stress in human dermal fibroblasts(HDFs).Methods:The effect of HDDQ on cell viability was assessed by MTT assay,and the effects of HDDQ on senescence-like phenotypes were determined by senescence-associatedβ-galactosidase(sa-β-gal)staining,Western blotting analysis,and a cell proliferation *** expression level and activity of sirtuin-1(SIRT1)induced by HDDQ were also ***:HDDQ reversed senescence-like phenotypes in the oxidant-challenged model,through reducing sa-β-gal activity and promoting cell ***,decreases in ac-p53,p21Cip1/WAF1,and p16Ink4a and an increase in p Rb were *** induced the expression of SIRT1 in a concentration-and time-dependent ***,HDDQ inhibited H2O2-induced phosphorylation of Akt by SIRT1 up-regulation and reduced sa-β-gal ***:HDDQ inhibits H2O2-induced premature senescence and upregulation of SIRT1 expression plays a vital role in the inhibition of the senescence phenotype in HDFs.

关键词： 9-Hydroxy-6,7-dimethoxydalbergiquinol Hydrogen peroxide Senescence Sirtuin-1 Human dermal fibroblasts

Scalp Acupuncture for Parkinson's Disease:A Systematic Review of Randomized Controlled Trials

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Chinese Journal of Integrative Medicine 2013年第4期19卷 297-306页

作者： Hun-Soo Lee Hye-lim Park Seung-Jin Lee Byung-Cheul Shin Jun-Yong Choi Myeong Soo Lee School of Korean Medicine Pusan National UniversityYangsanSouth Korea School of Korean Medical Science Pusan National University YangsanSouth Korea Hospital of Korean Medicine Pusan National UniversityYangsanSouth Korea School of Korean Medical Science Pusan National UniversityYangsanSouth Korea Medical Research Division Korea Institute of Oriental MedicineDaejeonSouth Korea

Objective： To evaluate the effectiveness of scalp acupuncture （sa）, a modern acupuncture technique specialized to neurological disorders, in managing motor function and symptoms for Parkinson＇s disease （PD） patients. Methods： Two independent reviewers extracted data from all of the randomized clinical trials （RCTs） that assessed the efficacy of sa for PD compared with conventional therapies （CTs）. Sixteen electronic databases were searched. The risk of bias was appraised with the Cochrane Collaboration tool, and the reporting of the included studies was evaluated by the Consolidated Standards of Reporting Trials （CONSORT） 2010 checklist and the revised Standards for Reporting Interventions in Clinical Trials of Acupuncture （STRICTA） guidelines. Results： In total, 4 RCTs met the inclusion criteria. As assessed by the Unified PD Rating Scale （UPDRS）, 2 RCTs showed that sa combined with CTs proved superior to CTs alone [60 cases; weighted mean difference, -3.94; 95% confidence interval （CI）, -6.05 to -1.64, P=0.01; 12=0%]. Based on the Webster scale, however, 3 RCTs showed no superior effect of sa when combined with CTs with high heterogeneity （154 cases; risk ratio, 1.29; 95% CI, 0.79 to 2.12, P=0.30; 12=84%）. The Cochrane risk of bias, adherence to the CONSORT and the STRICTA checklist showed that the quality of all the included RCTs was generally low. Conclusions： The result of our systematic review and meta-analysis suggested that the effectiveness of sa for PD is promising, however, the evidence is not convincing. A sham-controlled RCT design that adheres to the CONSORT and STRICTA guidelines to overcome methodological weakness and that includes a large sample size is strongly recommended to confirm the precise effect of sa on PD.

关键词： scalp acupuncture Parkinson's disease randomized controlled trials systematic review metaanalysis

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Convalescent plasma: A potential therapeutic option for COVID-19 patients

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Asian Pacific Journal of Tropical Medicine 2020年第11期13卷 477-486页

作者： Swee Li Ng Tsuey Ning Soon Wei Hsum Yap Kai Bin Liew Ya Chee lim Long Chiau Ming Yin-Quan Tang Bey Hing Goh Biofunctional Molecule Exploratory Research Group(BMEX) School of PharmacyMonash University MalaysiaBandar SunwayMalaysia School of Biosciences Faculty of Medical and Health SciencesTaylor’s UniversitySubang JayaSelangorMalaysia Faculty of Pharmacy University of CyberjayaCyberjayaSelangorMalaysia PAP Rashidah sa'adatul Bolkiah Institute of Health Sciences Universiti Brunei DarussalamGadongBrunei Darussalam College of Pharmaceutical Sciences Zhejiang UniversityHangzhouP.R.China

The new coronavirus disease(COVID-19)outbreak has challenged us to take unprecedented steps to bring this pandemic under *** view of the urgency of this situation,convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current *** is mainly due to the fact that convalescent plasma has been studied in a few case series with promising *** addition,on-going large clinical trials aimed to further evaluate the effectiveness,safety,and optimal dosage,duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising ***,this article aims to provide an overview of possible mechanisms of actions of convalescent plasma,its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.

关键词： Coronavirus Convalescent plasma COVID-19 saRS-COV-2 Neutralizing antibody Immunomodulation Convalescent plasma transfusion

Effect of Water Activity, Yuza (<i>Citrus junos</i>Sieb. ex Tanaka) Powder and the Mixture of Sodium Lactate and Sodium Acetate on Quality and safety in Beef Jerky

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Food and Nutrition Sciences 2019年第6期10卷 588-605页

作者： Yeon Ho Kim Ju Young lim Ki Sun Yoon Department of Food and Nutrition Kyung Hee University Seoul Republic of Korea

Despite its low water activity (Aw), food poisoning accidents associated with beef jerky consumption and problems due to mold growth have been reported. The objects of this study were to investigate the effect of yuza powder and the mixture of sodium lactate (SL) and sodium acetate (sa) to prevent the growth of S. aureus and A. flavus, as well as aflatoxin production in beef jerky. Different concentrations of the SL and sa (0, 0.75, and 1%) mixture were added to sliced beef and the Aws were adjusted to 0.70, 0.75, and 0.80. The effect of yuza powder and the SL and sa mixture on S. aureus in beef jerky (Aw 0.80) was also investigated at 10°C and 25°C. A rapid decline is that S. aureus population was observed in beef jerky containing yuza powder and mixtures of SL and sa. Antifungal effects against A. flavus were observed in beef jerky containing the SL and sa mixture at Aw below 0.75. The growth of A. flavus and aflatoxin production were prevented in beef jerky containing the yuza powder and a 1% mixture of SL and sa at 10°C and 0.80 Aw. The addition of yuza powder increased the hardness score of the beef jerky. Under current Aw regulations (0.80), beef jerky may pose a public health risk due to the growth of A. flavus and the presence of aflatoxin.

关键词： Beef Jerky Yuza Staphylococcus aureus Aspergillus flavus Aflatoxin

Currency-based Iterative Multi-Agent Bidding Mechanism Based on Genetic Algorithm

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厦门大学学报（自然科学版） 2002年第S1期41卷 113-页

作者： M K lim Z ZHANG School of Engineering & Computer Science University of ExeteSchool of Engineering & Computer Science University of Exete UKUK

This paper introduces a multi-agent system which i nt egrates process planning and production scheduling, in order to increase the fle xibility of manufacturing systems in coping with rapid changes in dynamic market and dealing with internal uncertainties such as machine breakdown or resources shortage. This system consists of various autonomous agents, each of which has t he capability of communicating with one another and making decisions based on it s knowledge and if necessary on information provided by other agents. Machine ag ents which represent the machines play an important role in the system in that t hey negotiate with each other to bid for jobs. An iterative bidding mechanism is proposed to facilitate the process of job assignment to machines and handle the negotiation between agents. This mechanism enables near optimal process plans a nd production schedules to be produced concurrently, so that dynamic changes in the market can be coped with at a minimum cost, and the utilisation of manufactu ring resources can be optimised. In addition, a currency scheme with currency-l ike metrics is proposed to encourage or prohibit machine agents to put forward t heir bids for the jobs announced. The values of the metrics are adjusted iterati vely so as to obtain an integrated plan and schedule which result in the minimum total production cost while satisfying products due dates. To deal with the optimisation problem, i.e. to what degree and how the currencies should be adj usted in each iteration, a genetic algorithm (GA) is developed. Comparisons are made between GA approach and simulated annealing (sa) optimisation technique.

关键词： agile manufacturing multi-agent systems geneti c algorithm simulated annealing

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Theoretical study of a new category of transition metal silicates as the promising NLO materials

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Theoretical study of a new category of transition metal sili...

Evidence of Synergistic Activity of Medicinal Plant Extracts against Neuraminidase Inhibitor Resistant Strains of Influenza Viruses

第十三届全国量子化学会议

作者： Jinyu Hu Zuju Ma Rongjian sa Kechen Wu Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Applications in laser frequency conversion and advanced optical communication have triggered a real interest about the properties of nonlinear optical（NLO） materials. However, to find a better NLO material meeting all requirements is still a challenge. Recently, a new category of transition-metal silicates lim[（TiO）SiO]（M = K, Rb）,meeting the requirements for efficient second harmonic generation, was reported as the promising NLO material. In present work, the geometric structure and bonding character, electronic and optical properties of the two compounds have been systematically determined based on the density functional theory. Particularly, the unique 3D framework structures give a polar structure superposition of the individual moments for [TiO]-units, and thus the maximum magnitudes of the total microscopic dipole are achieved, resulting in the large SHG responses for them. The results provide the detailed electronic and optical properties for them, and it may promote future applications of transition-metal silicates in optoelectronic technologies. Additionally,the structure-property relationship of titanosilicates is unraveled to analyze and guide the design of new more potential and competitive NLO materials in future work.

关键词： titanosilicates NLO materials DFT calculations optical properties structure-property relationship

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Advances in Microbiology 2014年第16期4卷 1260-1277页

作者： Dhivya Rajasekaran Enzo A. Palombo Tiong Chia Yeo Diana lim Siok Ley Chu Lee Tu Francois Malherbe Lara Grollo Department of Chemistry and Biotechnology Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn Australia sarawak Biodiversity Centre Kuching Malaysia

The frequent emergence of drug resistant influenza viral strains emphasizes the urgent and continual need to develop new antiviral drugs. Given the encouraging findings of previous studies on antiviral compounds from plant sources, this study focused on medicinal plants from Borneo that were traditionally used to treat symptoms of influenza infection. Following the promising results of earlier investigations, four plant extracts that demonstrated multiple modes of viral inhibition were studied against wild-type and neuraminidase (NA) inhibitor-resistant strains of Types A and B influenza viruses. The extracts exhibited more pronounced activities against the wild-type viruses than the NA inhibitor-resistant strains. Variations in the antiviral potential of the extracts collected from different parts of the same plant were also evidenced in the in vitro micro-inhibition assays. Even though all plant extracts affected NA activity of all viruses, only two extracts demonstrated hemagglutination inhibitory (HI) activities against Type A pandemic H1N1 and Type B viruses. Furthermore, Receptor Destroying Enzyme (RDE) treatments of extracts exhibiting HI activities indicated the presence of sialic acid (sa)-like component(s) that may be responsible for HI activity. Since the antiviral potential of extracts was not completely suppressed by RDE, the possibility of non sa-like antiviral components cannot be ruled out. Therefore, synergistic activity between sa-like and non sa-like components contained in the plant extracts may be responsible for the demonstrated antiviral potential. The results also indicated the presence of non sa-like components that may act against other viral proteins apart from hemagglutinin (HA) and NA. Hence, this study supports the presence of multiple antiviral components that act against different viral proteins or interfere with different stages of viral replication. Our results suggest that these plant extracts have the potential to be developed as

关键词： Influenza Antivirals Medicinal Plant Extracts Hemagglutination Inhibition Neuraminidase Inhibition Sialic Acid-Like RDE