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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

NuMDG:A New Tool for Multiway Decision Graphs Construction

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Journal of Computer Science & Technology 2011年第1期26卷 139-152页

作者： sa'ed Abed yassine Mokhtari Otmane Ait-mohamed Sofiene Tahar Department of Computer Engineering Hashemite UniversityZarqaJordan Department of Electrical and Computer Engineering Concordia UniversityMontrealCanada

Multiway Decision Graphs （MDGs） are a canonical representation of a subset of many-sorted first-order logic. This subset generalizes the logic of equality with abstract types and uninterpreted function symbols. The distinction between abstract and concrete sorts mirrors the hardware distinction between data path and control. Here we consider ways to improve MDGs construction. Efficiency is achieved through the use of the Generalized-If-Then-Else （GITE） commonly operator in Binary Decision Diagram packages. Consequently, we review the main algorithms used for MDGs verification techniques. In particular, Relational Product and Pruning by Subsumption are algorithms defined uniformly through this single CITE operator which will lead to a more efficient implementation. Moreover, we provide their correctness proof. This work can be viewed as a way to accommodate the ROBBD algorithms to the realm of abstract sorts and uninterpreted functions. The new tool, called NuMDG, accepts an extended SMV language, supporting abstract data sorts. Finally, we present experimental results demonstrating the efficiency of the NuMDG tool and evaluating its performance using a set of benchmarks from the SMV package.

关键词： infinite state model checking multiway decision graphs uninterpreted functions

Shielding and corrosion properties of the Alloy 709 as canister material for spent nuclear fuel dry casks

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Defence Technology（防务技术） 2023年第3期21卷 116-124页

作者： Zeinab y.Alsmadi mohamed A.Bourham Department of Nuclear Engineering North Carolina State UniversityRaleighNC 27695-7909USA

The shielding and corrosion properties of the Alloy 709 advanced austenitic stainless steel have been investigated as a candidate canister material in spent fuel dry *** results revealed that the experimental and computational data of the linear and mass attenuation coefficients of the alloy are in good agreement,in which the attenuation coefficient values decreased with increasing photon *** 709 was shown to exhibit the highest linear attenuation coefficient against gamma rays when compared to 304 and 316 stainless *** the other hand,Alloy 709 exhibited no considerable weight change over a 69-day period in circulating salt brines corrosion testing,while it showed an exponential increase of corrosion current density with temperature in acidic and basic corrosive solutions during electrochemical polarization corrosion ***,Alloy 709 was the least corroded steel compared to other austenitic stainless steels in both acidic and basic *** optimistic results of the shielding and corrosion properties of Alloy 709 due to its chemical composition,suggest utilizing it as a canister material in spent nuclear fuel dry casks.

关键词： corrosion steel austenitic

Ensuring the possibility of using thorium as a fuel in a pressurized water reactor(PWR)

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Nuclear Science and Techniques 2021年第12期32卷 37-52页

作者： mohamed y.M.Mohsen mohamed A.E.a.del-Rahman Aa.delghafar Galahom Nuclear Engineering Department Military Technical CollegeKobry ElkobbahCairoEgypt Higher Technological Institute 10th of Ramadan CityEgypt

The possibility of utilizing thorium as a fuel in a pressurized water reactor(PWR)has been proven from the neutronic perspective in our previously published work without assessing the thermal hydraulic(TH)and solid structure ***,the TH and solid structure performances must be studied to confirm these results and ensure the possibility of using a thorium-based fuel as an excellent accident-tolerant *** TH and solid structure performances of thorium-based fuels were investigated and compared with those of UO_(2).The radial and axial power peaking factors(PPFs)for UO_(2),(^(232)Th,^(235)U)O_(2),and(^(232)Th,^(233)U)O_(2)were examined with a PWR assembly to determine the total PPF of each *** Gd_(2)O_(3)and Er_(2)O_(3)were tested as burnable absorbers(bas)to manage the excess reactivity at the beginning of the fuel cycle(BOC)and reduce the total ***_(2)O_(3)resulted in a more significant reduction to the total PPF and,therefore,a greater reduction to the temperature distribution compared to Gd_(2)O_(3).Given these results,we analyzed the effects of adding Er_(2)O_(3)to thorium-based fuels on their TH and solid structure performances.

关键词： Thermal hydraulic(TH) Solid structure Thorium-based fuel Gd2O3 Er_(2)O_(3)

Series solution of a natural convection flow for a Carreau fluid in a vertical channel with peristalsis

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Journal of Hydrodynamics 2015年第6期27卷 969-979页

作者： ABD ELMABOUD y. MEKHEIMER Kh.S. mohamed mohamed S. Mathematics Department Faculty of Science and ArtsKhulaisUniversity Of Jeddah Mathematics Department Faculty of ScienceAl-Azhar University(Assiut Branch) Mathematics Department Faculty of ScienceTaif University Hawia Mathematics Department Faculty of ScienceAl-Azhar University

An analysis has been achieved to study the natural convection of a non-Newtonian fluid （namely a Carreau fluid） in a vertical channel with rhythmically contracting walls. The Navier-Stokes and the energy equations are reduced to a system of non- linear PDE by using the long wavelength approximation. The optimal homotopy analysis method （OHAM） is introduced to obtain the exact solutions for velocity and temperature fields. The convergence of the obtained OHAM solution is discussed explicitly. Numerical calculations are carried out for the pressure rise and the features of the flow and temperature characteristics are analyzed by plotting graphs and discussed in detail.

关键词： homotopy analysis method (HAM) peristaltic transport carreau fluid heat transfer natural convection flow

Comparative study of three types of controllers for DFIG in wind energy conversion system

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Protection and Control of Modern Power Systems 2018年第1期3卷 223-234页

作者： saïd Boubzizi Hafedh Abid Ahmed El hajjaji mohamed Chaabane Lab-STA Laboratory National Engineering School of SfaxRoute de la Soukra3029 SfaxTunisia MIS Laboratory University of Picardie Jules Verne33Rue Saint-Leu80039 AmiensFrance

This paper presents an enhanced control strategy for Wind Energy Conversion System(WECS)using Doubly-Fed Induction Generator(DFIG).A robust Super-Twisting(STW)sliding mode control for variable speed wind turbine is developed to produce the optimal aerodynamic torque and improve the dynamic performance of the *** electromagnetic torque of the DFIG is directly tracked using the proposed control to achieve maximum power *** performance and the effectiveness of the STW control strategy are compared to conventional Sliding Mode(SM)and Proportional-Integral(PI)*** proposed STW algorithm shows interesting features in terms of chattering reduction,finite convergence time and robustness against parameters variations and system disturbances.

关键词： Wind turbine(WT) Doubly-fed induction generator(DFIG) Power generation STW(super-twisting) Second order sliding mode control(SOSMC) PI controller

Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound

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Natural Products and Bioprospecting 2022年第1期12卷 567-572页

作者： Abdallah Rhihil youness Aichi mohamed Zahouily saïd Sebti mohamed El Guendouzi Laboratory of Chemistry Physics Materials and Catalysis(LCPMC) Faculty of Sciences Ben M’sik of CasablancaHassan II University of CasablancaCasablancaMorocco Financial Engineering Governance and Development LaboratoryNational School of Business and Management of CasablancaHassan II University of CasablancaCasablancaMorocco Laboratory of Materials Catalysis and Valorization of Natural ResourcesFaculty of Sciences and Technology of MohammediaHassan II University of CasablancaCasablancaMorocco

Spiropyrimidines vanquish a significant situation in the field of heterocyclic chemistry, they are broadly utilized as an antibacterial, an inhibitor of multidrug opposition, or an antiplatelet and antithrombotic drug. Phosphate, the principal Moroccan mineral wealth occupies a vital spot in the economic sector and its valuation is a goal continually looked for. Among the conceivable outcomes of valorization, its utilization in heterogeneous catalysis which thought about an exceptionally encouraging new way. In this context, the focus on the reaction of the synthesis of spiropy-rimidine, catalyzed by natural phosphate (NP) and by fluoroapatite (Fap), are used alone or doped by cobalt. These phosphate catalysts were characterized by XRD, IR and SEM, while the synthesized spiropyrimidine was identified by IR, GC-MS and NMR. The obtained yield with fluorapatite doped by cobalt (Co/Fap), at room temperature in ethanol is very high and shows a high impact performance induced by a synergistic effect compared to that of NP alone.

关键词： Spiropyrimidine Natural phosphate Co/Fap Heterogeneous catalysis Multicomponent reaction

Analysis of 3D localization in underwater optical wireless networks with uncertain anchor positions

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Science China(Information Sciences) 2020年第10期63卷 174-181页

作者： Nasir saEED Abdulkadir CELIK mohamed-Slim ALOUINI Tareq y.AL-NAFFOURI Computer ElectricalMathematical Sciences & Engineering (CEMSE) DivisionKing Abdullah University of Science and Technology (KAUST)

Localization accuracy is of paramount importance for the proper operation of underwater optical wireless sensor networks(UOWSNs). However, underwater localization is prone to hostile environmental impediments such as drifts owing to the surface and deep currents. These cause uncertainty in the deployed anchor node positions and pose daunting challenges to achieve accurate location estimations. Therefore, this paper analyzes the performance of three-dimensional(3D) localization for UOWSNs and derives a closedform expression for the Cramer Rao lower bound(CRLB) by using time of arrival(ToA) and angle of arrival(AoA) measurements under the presence of uncertainty in anchor node positions. Numerical results validate the analytical findings by comparing the localization accuracy in scenarios with and without anchor nodes position uncertainty. Results are also compared with the linear least square(LLS) method and weighted LLS(WLLS) method.

关键词： underwater optical wireless sensor networks localization three-dimensional uncertainty

Power Quality Improvement Using ANN Controller For Hybrid Power Distribution Systems

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Intelligent Automation & Soft Computing 2023年第6期36卷 3469-3486页

作者： Abdul Quawi y.mohamed Shuaib M.Manikandan B.S.Abdur Rahman Crescent Institute of Science and Technology A Deemed To Be UniversityChennaiTamil Nadu600048India Jyothishmathi Institute of Technology and Science KarimnagerTelangana505481India

In this work,an Artificial Neural Network(ANN)based technique is suggested for classifying the faults which occur in hybrid power distribution ***,which is generated by the solar and wind energy-based hybrid system,is given to the grid at the Point of Common Coupling(PCC).A boost converter along with perturb and observe(P&O)algorithm is utilized in this system to obtain a constant link *** contrast,the link voltage of the wind energy conversion system(WECS)is retained with the assistance of a Proportional Integral(PI)*** grid synchronization is tainted with the assis-tance of the d-q *** the analysis of faults like islanding,line-ground,and line-line fault,the ANN is *** voltage signal is observed at the PCC,and the Discrete Wavelet Transform(DWT)is employed to obtain different *** on the collected features,the ANN classifies the faults in an effi-cient *** simulation is done in MATLAB and the results are also validated through the hardware *** fault analysis is carried out and the results are compared with the existing ***,the Total harmonic distortion(THD)is lessened by 4.3%by using the proposed methodology.

关键词： Artificial neural network discrete wavelet transform hybrid power distribution system power quality power quality disturbances