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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： jackson Powell Tobias steinschaden Rose Horowitz Yuanquan song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNs)and the poor regenerative capacity of the central nervous system(CNs)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

GANana:Unsupervised Domain Adaptation for Volumetric Regression of Fruit

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Plant Phenomics 2021年第1期3卷 326-336页

作者： Zane K.J.Hartley Aaron s.jackson Michael Pound Andrew P.French school of Computer science University of NottinghamNG71BBUK school of Biosciences University of NottinghamLE125RDUK

3D reconstruction of fruit is important as a key component of fruit grading and an important part of many size estimation *** many computer vision challenges,the 3D reconstruction task suffers from a lack of readily available training data in most domains,with methods typically depending on large datasets of high-quality image-model *** this paper,we propose an unsupervised domain-adaptation approach to 3D reconstruction where labelled images only exist in our source synthetic domain,and training is supplemented with different unlabelled datasets from the target real *** approach the problem of 3D reconstruction using volumetric regression and produce a training set of 25,000 pairs of images and volumes using hand-crafted 3D models of bananas rendered in a 3D modelling environment(Blender).Each image is then enhanced by a GAN to more closely match the domain of photographs of real images by introducing a volumetric consistency loss,improving performance of 3D reconstruction on real *** solution harnesses the cost benefits of synthetic data while still maintaining good performance on real world *** focus this work on the task of 3D banana reconstruction from a single image,representing a common task in plant phenotyping,but this approach is general and may be adapted to any 3D reconstruction task including other plant species and organs.

关键词： image render adapted

Piling up multidecker pyrgos[n]cages as antibacterial materials

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science China Materials 2025年第01期 314-316页

作者： Miguel A.Liuzzi-Vaamonde jackson B.Lancaster sa.a.tha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant staphylococcus aureus (MRsa) strains are presently impacting community and healthcare systems across the globe [4].

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Challenges in elucidating cholangiocarcinoma etiology

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Hepatobiliary surgery and Nutrition 2020年第4期9卷 537-539页

作者： sa.a. s.jackson Andrea A.Florio Katherine A.McGlynn Jessica L.Petrick Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMDUSA slone Epidemiology Center Boston UniversityBostonMAUSA

Cholangiocarcinomas(CCAs)are rare tumors that originate from cholangiocytes in the bile ducts and are classified as intra-or extrahepatic(ICC or ECC).ICCs account for 10–12%of liver cancers,while ECCs account for approximately one-third of biliary tract cancers(1).Incidence rates of CCA are geographically variable,with the highest rates in ***,even in the highest incidence country(south Korea)the rates are only 2.8 and 2.2 per 100,000 person-years for ICC and ECC,respectively(2).Incidence rates of both ICC and ECC have been increasing in most countries globally,which potentially indicates a changing etiology(2).

关键词： etiology Incidence dating

salinity Distribution at Canal Istanbul and Its Possible Impacts on the Northern Marmara sea

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China Ocean Engineering 2020年第6期34卷 881-888页

作者： Şehriban saÇU Tarkan ERDIK OlgayŞEN Istanbul Technical University MaslakIstanbul 34467Turkey

Turkey has announced its plan to construct a new waterway, Canal Istanbul, parallel to the Bosphorus. In this study,the influence of Canal Istanbul on salinity distribution in the northern Marmara sea is investigated using a previously calibrated 3 D hydrodynamic and salinity model. Moreover, the salinity field of the canal and its propagation are examined based on various meteorological cases. Finally, the flow structure of the canal is determined. It is calculated that at the southern end of the canal, mainly unidirectional flow(from the Black sea to the Marmara sea)occurs during 68% of the simulation period. A two-layer flow is seen only 28% of the time with a weak lower layer flow, whereas this value decreases to 4% at the north end of the canal. In the southward direction(to the Marmara sea), velocities higher than 1.5 m/s are rarely observed along the canal. The average surface salinity difference in the northern Marmara sea due to the construction of the canal is calculated to be smaller than 0.50 ppt. The salinity difference gradually diminishes as water depth increases and after 25 m(from the surface) almost no difference is observed.

关键词： Canal Istanbul Marmara sea salinity distribution hydrodynamic modeling

Concept of a Pitot Tube Able to Detect Blockage by Ice, Volcanic Ash, sand and Insects, and to Clear the Tube

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Photonic sensors 2015年第4期5卷 298-303页

作者： David A. jackson school of Physical sciences Applied Optics Groups University of Kent UK

A conceptual coaxial Pitot tube （PT） has been developed using fiber optic sensors combined with actuators to monitor and maintain its correct operation under different environmental conditions. Experiments were performed showing that the dynamic and static tubes can be cleared of ice. It was also demonstrated that the dynamic tube could be cleared of dust and sand which was not the case for the static tube in the coaxial configuration. An approach was proposed to overcome this problem involving a conventional configuration where the static tube was operated independently orthogonal to the dynamic tube, and a second set of sensors and actuators was used. sensors and associated actuators were developed for temperature and intensity for a linear PT. The aim of this work is to propose a solution for a problem that has caused the loss of the lives of many passengers and crew of aircraft. Resources were not available to test a full implementation of a PT incorporating the proposed modifications.

关键词： Pitot tube instrumentation FBG spectrometer pressure temperature optical intensity

High-quality aluminum turbocharger impellers produced by thixocasting

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Transactions of Nonferrous Metals society of China 2010年第9期20卷 1786-1791页

作者： G.WALLACE A.P.jackson s.P.MIDsON Q.ZHU Aluminum Complex Components Inc The Midson Group Inc. Cummins Turbo Techno logies

The thixocasting process was chosen to produce the impellers as it is capable of producing castings with extremely high internal *** cut from the DC cast bars are re-heated to the semi-solid casting temperature, and a specially-designed runner and gating system is used to prevent oxide from the surface of the slugs from becoming incorporated into the *** technology used to produce the semi-solid impellers is described in *** semi-solid cast impellers, produced from an Al-si-Mg-Cu alloy, are heat treated to the T6 *** from testing are presented demonstrating that the impellers are free of porosity and other internal *** mechanical property and fatigue data are presented showing that the semi-solid impellers have better properties than impellers produced by conventional casting and similar properties to forged and machined impellers.A short study is also described which identified suitable processing parameters to minimize hot tearing in the complex-shaped turbocharger impellers semi-solid cast from alloy *** surfaces of the impellers were examined using penetrant testing, and the results of modifying processing parameters on the propensity for surface cracking are *** aging study was performed to identify optimum mechanical strength.

关键词： semi-solid casting turbocharger impeller fatigue properties alloy 201

Fluid dynamics analysis and pyrolysis of brewer’s spent grain in a spouted bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos A.s. Barrozo Lidja D.M.s. Borel Taísa s. Lira Carlos H. Ataíde school of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s spent grain (BsG) is a large-scale agroindustrial waste that could be more efficiently utilized. This waste is composed of lignocellulosic material and so may serve as a good source of biomass for thermochemical conversion. The present study investigated the fluid dynamics behavior of mixtures of sand and BsG in a spouted bed to assess the viability of the thermochemical conversion of this biomass via fast pyrolysis. Fluid dynamics analyses were performed while varying the mass fraction of BsG (6–80%) and the static bed height (6.6–13.4 cm). Empirical equations for predicting the minimum spouting conditions and the mixing index were obtained using a regression technique, and the selected fluid dynamics parameters were employed in the spouted bed pyrolysis. The bio-oil resulting from this process was rich in phenolic compounds, various nitrogenated compounds (representing precursors for pharmaceuticals) and long-chain hydrocarbons. The products obtained from the analytical and spouted bed pyrolysis processes were also compared.

关键词： Brewer’s spent grain Agroindustrial residue spouted bed Fast pyrolysis Particle mixing

PYRIDINATION OF POLY(VINYL CHLORIDE) via A HOMOLYTIC PATHWAY

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Chinese Journal of Polymer science 2007年第3期25卷 297-302页

作者： sad Moulay Zakia Zeffouni Laboratoire de Chimie-Physique Moléculaire et Macromoléculaire Faculté des sciences de l'Ingénieur Département de Chimie IndustrielleUniversité Sad Dahlab de BlidaRoute de SoumaB. P. 270Blida 09000Algeria

PVC was subjected to a chemical modification aiming at replacing the chlorine atoms by pyridine groups via a homolytic route. Pyridine groups were peculiarly affixed to the PVC matrix via a carbon-carbon bond rather than a carbonnitrogen one. PVC was first iodinated using the Conant-Finkelstein reaction, followed by the application of the homolytic conditions of Minisci to generate pyridinated PVC with a varying degree of substitution. The extent of substitution was not high; the reaction on 30% iodinated PVC afforded a degree of modification no greater than 3%.

关键词： Conditions of Minisci Iodinated PVC Pyridinated PVC