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Rare Metals 2021年第10期40卷 2964-2974页

作者： Zhen-Yi Wei Kang-Ming Hu Bai-Sheng sa Bo Wu Multiscale Computational Materials Facility School of Materials Science and EngineeringFuzhou UniversityFuzhou 350100China

Effects of pressure on lattice parameters, electronic, thermodynamic and mechanical properties of the fully ordered Ti_(2)AlNb orthorhombic phase were studied using first-principles calculations based on density functional theory(DFT). The bonding nature for ordering orthorhombic Ti_(2)AlNb was revealed quantitatively through the electronic structure analyzing. The external pressures play limited roles in the elastic anisotropy of the alloy due to the outstanding dynamical and mechanical stabilities under pressure. However, the shear modulus of O phase manifests anisotropic, where {010} shear planes are the easiest planes to cleave among the principal planes under all *** heat capacities, volume expansions and thermal expansion coefficients were calculated using the quasi-harmonic approximation model based on the phonon dispersion curves. Meanwhile, the bulk modulus, Young’s modulus,shear modulus and the hardness are promptly enhanced under pressure. The predicted results give hints to design Ti_(2)AlNb-based alloy as high-pressure applications.

关键词： Ti2AlNb-based orthorhombic phase Pressure-induced effect Thermodynamic properties Mechanical properties First-principles calculations

Computational Prediction of Micro RNAs from Toxoplasma gondii Potentially Regulating the Hosts' Gene Expression

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 228-238页

作者： Müs?erref Duygu saar Caner Bagc? Jens Allmer Molecular Biology and Genetics Izmir Institute of Technology Urla Izmir 35430 Turkey Biotechnology Izmir Institute of Technology Urla Izmir 35430 Turkey Bionia Incorporated IZTEKGEB A8 Urla Izmir 35430 Turkey

MicroRNAs （miRNAs） were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene reg- ulation. It may also regulate its hosts＇ gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.

关键词： Toxoplasma gondii MicroRNA Regulation Host interaction Parasite

Further recommendations for trauma training of Indian medical officers and medical students

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World Journal of Emergency Medicine 2011年第2期2卷 85-87页

作者： Robert J Douglas Tonia M Mezzini GAnand Kumar Andrew ja Giles Sportsmed sa 32 Payneham Road Stepney South Australia 5069 Clinic 275 Royal Adelaide Hospital Adelade South Australia 5000 Vinayaka Missions Kirubananda Variyar Medical College Hospital Salem Tamil Nadu India Emergency Department Royal Adelaide Hospital Adelaide South Australia 5000

In a recent article,1 we have demonstrated a significant difference in the theoretical knowledge of both junior and senior emergency department （ED） medical officers （M0s） from salem, Tamil Nadu, India, and the Royal Adelaide Hospital （RAH） Adelaide, South Australia, in the management of severely injured trauma patients, when comparing M0s who had completed an ATLS-type program with those who had not undertaken such a program.

关键词： Further recommendations trauma training of Indian medical

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添加糖与儿童心血管病风险的关系

中华高血压杂志 2016年第10期24卷 937-937页

作者：刘莉叶鹏 Vos MB Kaar JL Welsh ja Van Horn LV Feig DI Anderson CA Patel MJ Cruz Munos J Krebs NF Xanthakos sa Johnson RK American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health Council on Clinical Cardiology Council on Cardiovascular Disease in the Young Council on Cardiovascular and Stroke Nurs-ing Council on Epidemiology and Prevention Council on Func-tional Genomics and Translational Biology Council on Hypertension

不良的生活方式行为是导致全球可预防疾病的原因。膳食中添加糖可使其富含能量但营养差,且可增加发展为肥胖、心血管病、高血压、肥胖相关的癌症和龋齿的风险。方法和结果：美国心脏协会对目前的科学证据进行审查和分级,探讨添加糖对儿... 详细信息

不良的生活方式行为是导致全球可预防疾病的原因。膳食中添加糖可使其富含能量但营养差,且可增加发展为肥胖、心血管病、高血压、肥胖相关的癌症和龋齿的风险。方法和结果：美国心脏协会对目前的科学证据进行审查和分级,探讨添加糖对儿童心血管健康的影响。

关键词：心血管病风险儿童糖美国心脏协会心血管健康预防疾病生活方式

TM-Zn金属间化合物结构稳定性的第一性原理研究

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福州大学学报（自然科学版） 2017年第3期45卷 424-431页

作者：方圆陈祖华萨百晟吴波福州大学材料科学与工程学院福建福州350116

基于能带结构,提出jahn-Teller效应的诱发条件.基于声子色散曲线,揭示晶格动态稳定性和简并振动模式产生劈裂的物理特征.基于电子局域化函数和束缚能,揭示原子成键特性.结果表明,TM-Zn(TM=Ni,Pd,Pt,Cu,Ag,Au)金属间化合物发生立方到四... 详细信息

基于能带结构,提出jahn-Teller效应的诱发条件.基于声子色散曲线,揭示晶格动态稳定性和简并振动模式产生劈裂的物理特征.基于电子局域化函数和束缚能,揭示原子成键特性.结果表明,TM-Zn(TM=Ni,Pd,Pt,Cu,Ag,Au)金属间化合物发生立方到四方的相变变形过程中,结构保持稳定.

关键词： TM-Zn金属间化合物相变变形 jahn-Teller效应结构稳定性第-性原理计算

肺静脉和左心房后部完全隔离治疗慢性房颤的长期临床预后研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 41-42页

作者： sanders P. Hocini M. ja■s P. 吴超能 Cardiovascular Research Centre Department of Cardiology Royal Adelaide Hospital Adelaide SA 5000 Australia.Dr

目的:探讨左心房(LA)后部在慢性房颤(AF)中的作用。方法和结果:有27例慢性AF患者入选。在肺静脉隔离后,采用盐水灌注导管施行连接左右肺静脉的消融以实现对LA后部的隔离。LA后部电活动消失、该区域不能被起搏则为成功隔离。根据心动周... 详细信息

目的:探讨左心房(LA)后部在慢性房颤(AF)中的作用。方法和结果:有27例慢性AF患者入选。在肺静脉隔离后,采用盐水灌注导管施行连接左右肺静脉的消融以实现对LA后部的隔离。LA后部电活动消失、该区域不能被起搏则为成功隔离。根据心动周期长度(CL)的改变和AF的终止确定消融效果。

关键词：慢性房颤左心房肺静脉

南海南部sa09-040孔孢粉记录及古气候

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海洋学研究 2012年第3期30卷 29-34页

作者：张玉兰彭学超贾丽戴璐同济大学海洋与地球科学学院上海200092 广州海洋地质调查局广东广州510760 上海应用技术学院上海201418

依据南海低纬地区sa09-040孔高分辨率的孢粉记录,自下至上划分了4个孢粉组合带。从孢粉成分的变化,重建了22.25ka B P以来的植被与气候变化历史。结果表明:孢粉主要来源于婆罗洲和周围岛屿,孢粉1带(22.25～16.6ka B P),低山雨林植被发育... 详细信息

依据南海低纬地区sa09-040孔高分辨率的孢粉记录,自下至上划分了4个孢粉组合带。从孢粉成分的变化,重建了22.25ka B P以来的植被与气候变化历史。结果表明:孢粉主要来源于婆罗洲和周围岛屿,孢粉1带(22.25～16.6ka B P),低山雨林植被发育,为暖热气候,从测年时间看,当时为末次冰期晚期。孢粉2带(16.6～10.82ka B P,为末次冰消期),植被以热带低山雨林和低地雨林为主,针叶的松数量较多,当时的气温比现在低。孢粉3带(全新世早期,10.82～6.43ka B P),植被以热带低山雨林和低地雨林为主,针叶松属数量减少,气温比前期升高,海平面也上升。孢粉4带(全新世中晚期,6.43ka B P至今),全新世中期为炎热、湿润的气候环境,全新世晚期可能与婆罗洲现今的植被景观相近,为热、湿的气候环境。

关键词：南海孢粉古气候

手针内关穴对急性心肌缺血大鼠心率变异性影响

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辽宁中医药大学学报 2015年第7期17卷 78-80页

作者：萨喆燕朱小香万隆许金森福建省中医药研究院福建福州350003

目的:观察手针对急性心肌缺血大鼠心率变异性(HRV)的影响。方法:通过结扎冠状动脉左前降支建立大鼠急性心肌缺血模型,手针内关穴并记录心电图,分析造模以及针刺前后HRV的差异。结果:急性心肌缺血模型复制后,HRV分析显示造模后低频成分/... 详细信息

目的:观察手针对急性心肌缺血大鼠心率变异性(HRV)的影响。方法:通过结扎冠状动脉左前降支建立大鼠急性心肌缺血模型,手针内关穴并记录心电图,分析造模以及针刺前后HRV的差异。结果:急性心肌缺血模型复制后,HRV分析显示造模后低频成分/高频成分(LF/HF)比值升高;针刺内关穴后,LF/HF比值降低。结论:手针内关穴可改善急性心肌缺血引起的HRV改变。

关键词：手针内关急性心肌缺血心率变异性

术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除（英文）

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中华神经外科疾病研究杂志 2016年第5期15卷 465-465页

作者： Neira ja Ung TH Sims J Malone HR Chow DS samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth sa McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN Department of Neurological Surgery Columbia University Medical Center Department of Neuroradiology Columbia University Medical Center Department of Pathology and Cell Biology Columbia University Medical Center Department of Radiology Columbia University Medical Center

Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 *** localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of *** Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the u

关键词：神经外科学疾病研究医学研究临床分析

强化与标准血压控制对痴呆的影响:随机临床试验

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中华高血压杂志 2019年第4期27卷 367-367页

作者：刘青叶鹏 Williamson JD Pajewski NM Auchus AP Bryan RN Chelune G Cheung AK Cleveland ML Coker LH Crowe MG Cushman WC Cutler ja Davatzikos C Desiderio L Erus G Fine LJ Gaussoin sa Harris D Hsieh MK Johnson KC Kimmel PL Tamura MK Launer LJ Lerner AJ Lewis CE Martindale-Adams J Moy CS Nasrallah IM Nichols LO Oparil S Ogrocki PK Rahman M Rapp SR Reboussin DM Rocco MV sachs BC Sink KM Still CH Supiano MA Snyder JK Wadley VG Walker J Weiner DE Whelton PK Wilson VM Woolard N Wright JT Jr Wright CB SPRINT MIND investigators for theSPRINT research group

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开... 详细信息

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。

关键词：随机临床试验老年痴呆血压控制轻度认知障碍标准心血管事件治疗方法研究人员