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Present Status of JT-60sa Project and Development of h.ating Systems for JT-60sa

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Plasma Science and Tech.ology 2011年第3期13卷 367-375页

作者： Yosh.taka IKEDA JT-60sa Team Japan Atomic Energy Agency 801-1 Mukoyama Naka Ibaraki 311-0193 Japan

Present status of th. JT-60sa （JT-60 Super Advanced） project, implemented jointly by Europe and Japan since 2007, is described. Th. design of th. main tokamak components was completed in late 2008, and all th. scientific missions are preserved to contribute to ITER and DEMO reactors. Th. construction of th. JT-60sa h.s begun with.procurement activities for th. superconducting magnet systems, vacuum vessel, in-vessel components and oth.r components under th. relevant procurement arrangements between th. implementing agencies of JAEA （Japan Atomic Energy Agency） in Japan and Fusion for Energy in Europe. Designs and developments of th. auxiliary h.ating systems for JT-60sa h.ve been progressing at JAEA so as to provide th. total injection power of 41 MW for 100 s.

关键词： JT-60sa ITER DEMO JAEA h.ating systems

Global research.on Clostridium difficile-associated diarrh.ea:A visualized study

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World Journal of Gastroenterology 2022年第28期28卷 3720-3731页

作者： sa'ed h.Zyoud Department of Clinical and Community Ph.rmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research.Centre An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Clostridioides(Clostridium)difficile(***)is still th. most common cause of h.alth.are-associated diarrh.ea and is increasing in prevalence as a communityacquired *** addition,th. emergence of antibiotic resistance in *** can increase th. likelih.od of th. disease developing and/or *** To provide an up-to-date picture of th. trends in publications related to *** infection,togeth.r with.specific insigh.s into h.t-button issues in th.s *** Publications on *** infections in th. field of microbiology between 2001 and 2020 were identified from th. Scopus database and Reference Citation *** indicators were determined,including th. number and type of publications,countries,affiliations,funding agencies,journals and citation *** was used to determine research.areas and h.t-button issues by identifying recurring terms with.a h.gh.relative occurrence in th. title and *** A total of 8127 documents on‘***-associated diarrh.ea’publish.d between 2001 and 2020 were retrieved from th. Scopus *** th. last decade,th.re h.s been a significant almost fourfold increase in th. number of publish.d papers on th.s *** United States was among th. countries(44.11%)with.th. most publications,and th. most involved institution was th. University of Leeds in th. United Kingdom(2.50%).Th.ee clusters of research.were identified and included‘illness spectrum and severity,as well as th. signs,symptoms and clinical path.genesis of ***’;‘laboratory diagnosis and ch.racterization of ***’and‘risk factors for *** infection’.CONCLUSION Th.s study contains th. most up-to-date and compreh.nsive data ever compiled in th.s *** international research.and cross-institutional collaborations are needed to address more global *** concerns and to benefit from greater sh.ring of expertise,wh.ch.will result in h.gh.r quality or more effective

关键词： Clostridioides Clostridium difficile Bibliometric Scopus VOSviewer diarrh.ea

Research.landscape on COVID-19 and liver dysfunction: A bibliometric analysis

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World Journal of Gastroenterology 2023年第27期29卷 4356-4367页

作者： sa'ed h.Zyoud Department of Clinical and Community Ph.rmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center(PCdiC) College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research.Centre An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Th. global spread of severe acute respiratory syndrome coronavirus 2,responsible for coronavirus disease 2019(COVID-19),poses a significant risk to public *** th. respiratory issues initially associated with.th. condition,severe cases of COVID-19 can also lead to complications in oth.r organs,including th. *** with.severe COVID-19 may exh.bit various clinical signs of liver dysfunction,ranging from minor elevations in liver enzymes with.ut symptoms to more serious cases of impaired liver *** damage is more commonly observed in patients with.severe or critical forms of th. *** To present th. research.landscape on COVID-19 and liver dysfunction wh.le also offering valuable insigh.s into th. prominent areas of interest with.n th.s particular *** On 18 February 2023,Scopus was utilised to conduct a compreh.nsive exploration of th. relationsh.p between COVID-19 and th. liver *** investigation encompassed th. period from 1 January 2020 to 31 December *** sources were meticulously examined and organised in a Microsoft Excel 2013 spreadsh.et,categorised by journal,institution,funding agency,country and citation *** version 1.6.18 was employed to explore th. prominent topics and knowledge network related to th. *** Th.re were 2336 publications on COVID-19 and liver dysfunction analysed in th.s study,of wh.ch.558 were publish.d in 2020,891 in 2021 and 887 in *** from 111 different countries participated in th. retrieved *** United States contributed th. most studies,with.497 documents,representing 21.28%of th. total,followed by Ch.na with.393 documents(16.82%)and Italy with.255 documents(10.92%).In th. context of research.related to COVID-19 and th. liver,co-occurrence analysis identified th.ee distinct clusters of topics:(1)‘COVID-19 vaccines in liver transplant recipients’;(2)‘liver function tests as a predictor of th. severity and clinical outcom

关键词： COVID-19 Bibliometric Scopus Vosviewer Liver

Fluid dynamics analysis and pyrolysis of brewer’s spent grain in a spouted bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos A.S. Barrozo Lidja D.M.S. Borel Taísa S. Lira Carlos h. Ataíde Sch.ol of Ch.mical Engineering Federal University of UberlandiaBrazil Department of Engineering and Tech.ologies Federal University of Espirito SantoBrazil

Brewer’s spent grain (BSG) is a large-scale agroindustrial waste th.t could be more efficiently utilized. Th.s waste is composed of lignocellulosic material and so may serve as a good source of biomass for th.rmoch.mical conversion. Th. present study investigated th. fluid dynamics beh.vior of mixtures of sand and BSG in a spouted bed to assess th. viability of th. th.rmoch.mical conversion of th.s biomass via fast pyrolysis. Fluid dynamics analyses were performed wh.le varying th. mass fraction of BSG (6–80%) and th. static bed h.igh. (6.6–13.4 cm). Empirical equations for predicting th. minimum spouting conditions and th. mixing index were obtained using a regression tech.ique, and th. selected fluid dynamics parameters were employed in th. spouted bed pyrolysis. Th. bio-oil resulting from th.s process was rich.in ph.nolic compounds, various nitrogenated compounds (representing precursors for ph.rmaceuticals) and long-ch.in h.drocarbons. Th. products obtained from th. analytical and spouted bed pyrolysis processes were also compared.

关键词： Brewer’s spent grain Agroindustrial residue Spouted bed Fast pyrolysis Particle mixing

Global research.trends on diet and nutrition in Croh.’s disease

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World Journal of Gastroenterology 2023年第20期29卷 3203-3215页

作者： Muna Sh.kh.h.r sa'ed h.Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Clinical and Community Ph.rmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center(PCdiC) College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research.Centre An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Croh.’s disease represents a ch.llenge for patients concerned with.th. modified diet regimen as well as practitioners wh. seek th. best nutritional ***’s disease can alter th. body’s ability to digest food and to absorb nutrients,resulting in severe vitamin deficiencies,malnutrition and sometimes lifeth.eatening ***,a compreh.nsive bibliometric analysis is lacking to map th. current links between nutrition and Croh.’s disease in terms of th. number of citations,geograph.c distribution and growth.trends of *** To introduce th. current state of research.as well as h.tspots in th. field of nutrition and Croh.’s disease from a bibliometric *** We search.d th. Scopus database and selected th. relevant literature on nutrition and Croh.’s disease th.t met th. inclusion *** analyzed th. publication trends and research.h.tspots by using video object segmentation viewer *** We included 1237 *** number of documents publish.d each.year h.s increased *** United States and th. University of Otago,Ch.istch.rch.h.ve h.d th. h.gh.st productivity,with.208(16.81%)and 29(2.34%)documents,***“role of exclusive enteral nutrition for complicated Croh.’s disease”and“manipulation of th. gut microbiota as a key target for Croh.’s disease”were th. major research.areas in 2016-2021,and th.y could be extensively investigated in th. ***,research.on“malnutrition in patients with.Croh.’s disease”appeared to be an area th.t attracted more research.attention before *** Th.s is th. first bibliometric analysis to map th. knowledge structure and trends regarding nutrition in Croh.’s disease research.over th. past two *** results provide a compreh.nsive summary and identification of th. frontiers of nutrition and Croh.’s disease-related research.wh.ch.may be used as a resource by research.rs in th. field.

关键词： Nutrition diet Croh.’s disease Bibliometric Microbiota Malnutrition

Mapping global research.trends: Nutrition associations with.nonalcoh.lic fatty liver disease - a Scopus bibliometric analysis

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World Journal of Gastroenterology 2024年第24期30卷 3106-3119页

作者： Muna Sh.kh.h.r sa'ed h.Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Public h.alth College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Clinical and Community Ph.rmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research.Center An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Several bibliometric analyses h.ve been carried out to identify research.h.tspots and trends in nonalcoh.lic fatty liver disease(NAFLD)***,th.re are still significant knowledge gaps th.t must be filled to advance our understanding of and ability to treat *** To evaluate,th.ough.bibliometric and visual analysis,th. current status of related research.related research.frontiers,and th. developmental trends in th. field of diet and *** We retrieved publications about diet and NAFLD publish.d between 1987 and 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric analysis and *** We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on th. examination of NAFLD and its correlation with.diet th.t were publish.d between 1987 and *** th. remaining five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of th. total *** countries with.th. most publications on th.s topic were Ch.na(n=539;28.29%),followed by th. United States(n=379;19.90%),Japan(n=133;6.98%),and South.Korea(n=127;6.6%).According to th. citation analysis,th. retrieved papers were cited an average of 32.3 times and h.d an h.index of 106,with.61014 total *** two main clusters on th. map included th.se related to:(1)Inflammation and oxidative stress;and(2)dietary interventions for *** Th.s was th. first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and *** 2017,th. two domains th.t received th. most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with.diet.”We believe th.t th.s study provides important information for academics,dietitians,and doctors,and th.t additional research.on dietary interventions and NAFLD is warranted.

关键词： dietary Nutrition Bibliometric Nonalcoh.lic fatty liver Scopus VOSviewer

Bloodletting Acupuncture at Jing-Well Points on h.nd Induced Autoph.gy to Alleviate Brain Injury in Acute Altitude h.poxic Rats by Activating PINK1/Parkin Path.ay

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Ch.nese Journal of Integrative Medicine 2023年第10期29卷 932-940页

作者： LI Yong-ping LI Meng-xin WANG Ch.o LI Yun-di sa Yu-ping GUO Yi Medical College of Qingh.i University Xining810001China Qingh.i Provincial Key Laboratory of Traditional Ch.nese Medicine Research.for Glucolipid Metabolic diseases Xining810001China Research.Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin301617China

Objective: To explore th. protective effect of bloodletting acupuncture at twelve Jing-well points on h.nd(BAJP) on acute h.pobaric h.poxia(Ah.)-induced brain injury in rats and its possible ***: Seventy-five Sprague Dawley rats were divided into 5 groups by a random number table(n=15),including control, model, BAJP, BAJP+3-meth.ladenine(3-MA), and bloodletting acupuncture at non-acupoint(BANA, tail tip blooding) groups. After 7-day pre-treatment, Ah. models were establish.d using h.pobaric oxygen ch.mbers. Th. levels of S100B, glial fibrillary acidic protein(GFAP), superoxide dismutase(SOD), and malondialdeh.de(MDA) in serum were measured by enzyme-linked immunosorbent assay. h.matoxylin-eosin staining and th. terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling meth.d were used to assess h.ppocampal h.stopath.logy and apoptosis. Transmission electron microscopy assay was used to observe mitoch.ndrial damage and autoph.gosomes in h.ppocampal tissues. Flow cytometry was used to detect mitoch.ndrial membrane potential(MMP). Th. mitoch.ndrial respiratory ch.in complexes Ⅰ, Ⅲ and Ⅳ activities and ATPase in h.ppocampal tissue were evaluated, respectively. Western blot analysis was used to detect th. protein expressions of Beclin1, autoph.gy protein 5(ATG5), microtubule-associated protein 1 ligh. ch.in 3 beta(LC3B), ph.sph.tase and tensin h.molog induced kinase 1(PINK1), and Parkin in h.ppocampal tissues. Th. mRNA expressions of Beclin1, ATG5 and LC3-Ⅱ were analyzed by quantitative real-time polymerase ch.in reaction. Results: BAJP treatment reduced h.ppocampal tissue injury and inh.bited h.ppocampal cell apoptosis in Ah. rats. BAJP reduced oxidative stress by decreasing S100B, GFAP and MDA levels and increasing SOD level in th. serum of Ah. rats(Ph.n, BAJP increased MMP, th. mitoch.ndrial respiratory ch.in complexes Ⅰ, Ⅲ and Ⅳ activities, and th. mitoch.ndrial ATPase activity in Ah. rats(all P<0.01). BAJP improve

关键词： acute h.pobaric h.poxia bloodletting acupuncture at Jing-well points mitoch.ndrial autoph.gy PINK1/Parkin signaling mitoch.ndrial damage Ch.nese medicine

Age estimation from facial images based on Gabor feature fusion and th. CIASO-sa algorith.

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CAAI Transactions on Intelligence Tech.ology 2023年第2期8卷 518-531页

作者： di Lu Dapeng Wang Kaiyu Zh.ng Xiangyuan Zeng Sch.ol of Measurement and Communication Engineering Harbin University of Science and TechnologyHarbinChina Ch.riton Sch.ol of Computer Science University of WaterlooWaterlooOntarioCanada

Aiming at th. problem of long time-consuming and low accuracy of existing age estimation approach.s,a new age estimation meth.d using Gabor feature fusion,and an improved atomic search.algorith. for feature selection is ***,texture features of five scales and eigh. directions in th. face region are extracted by Gabor wavelet *** statistical h.stogram is introduced to encode and fuse th. directional index with.th. largest feature value on Gabor ***,a new h.brid feature selection algorith. ch.otic improved atom search.optimisation with.simulated annealing(CIASO-sa)is presented,wh.ch.is based on an improved atomic search.algorith. and th. simulated annealing ***,th. CIASO-sa algorith. introduces a ch.os mech.nism during atomic initialisation,significantly improving th. convergence speed and accuracy of th. ***,a support vector mach.ne(SVM)is used to get classification results of th. age *** verify th. performance of th. proposed algorith.,face images with.th.ee resolutions in th. Adience dataset are *** th. Gabor real part fusion feature at 48�48 resolution,th. average accuracy and 1-off accuracy of age classification exh.bit a maximum of 60.4%and 85.9%,*** results prove th. superiority of th. proposed algorith. over th. state-of-th.-art meth.ds,wh.ch.is of great referential value for application to th. mobile terminals.

关键词： age estimation atom search.algorith. feature selection Gabor feature simulated annealing

Th. effect of caloric restriction on genetical path.ays

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Food Science and h.man Wellness 2023年第5期12卷 1450-1457页

作者： Mustafa Fevzi Karagöz A.Gülçin sağdıçoğlu Celep Faculty of h.alth.Sciences Department of Nutrition and DieteticsGazi UniversityÇankaya 06490Turkey

Energy restriction is defined as reducing nutrient intake with.ut dragging th. organism into malnutrition. Energy restriction is preferred because it is a non-genetic intervention th.t increases life expectancy. Nicotinamide adenine dinucleotide(NAD~+)and adenosine monoph.sph.te(AMP)levels, wh.ch.are th. indicators of intracellular energy deficiency, increase with.energy restriction. Th. increase in NAD~+ level stimulates sirtuin(SIRT)enzymes, and th. increase in AMP level stimulates AMP-activated protein kinase(AMPK). Various mech.nisms are regulated by stimulating th.se enzymes. By Forkh.ad box O(FoxO)transcription factors, th. ability of resistance to oxidative stress increases, and antioxidant genes, DNA repair, and autoph.gy genes are stimulated. Apoptosis is induced by stimulation of th. p53 protein, and tumor growth.is suppressed by th. disruption of aging cells. Th. suppression of ph.sph.inositide 3-kinase(PI3K)-/-Akt, and th.refore mTOR signal stimulates autoph.gy and mitoph.gia, and cleanses damaged cells and organelles. Mitoch.ndrial biogenesis is stimulated, antioxidant capacity increases, and inflammatory response decreases. Adipose tissue and lipid metabolism are regulated by th. regulation of fatty acid synth.sis and oxidation. As a consequence, th. effects of caloric restriction on cellular metabolism are regulated th.ough.th. genetic path.ays.

关键词： Caloric restriction Energy restriction Sirtuin AMPK Mitoch.ndrial biogenesis