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Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?

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Journal of Biosciences and Medicines 2021年第1期9卷 64-85页

作者： J. F. Nnang Essone K. Nzé Pascal G. Edjo Nkhilli N. Ekegue Diaw Mor C. P. Akagha Kondé P. Nzoghe nguéma E. Anyunzok E. R. Obame C. Allognon B. nguéma Asseko F. Ovono Abessolo E. Ngou Milama Department of Physiology Faculty of Medicine and Health Sciences of Libreville (USS) Libreville Gabon Department of Anesthesia and Emergency Resuscitation The University Hospital of Owendo Libreville Gabon Department of Anesthesia and Emergency Resuscitation The Mother Child University Hospital Center Libreville Gabon Department of Anesthesia and Resuscitation The Army Instruction Hospital Libreville Gabon Laboratory of Biology and Physiological Functional Explorations UCAD Dakar Senegal Department of Medicine The University Hospital of Libreville Libreville Gabon Department of Epidemiology Biostatistics and Medical Mathematics USS Libreville Gabon Department of Surgery The University Hospital of Libreville Libreville Gabon Department of Chemistry-Biochemistry Faculty of Medicine and Health Sciences USS Libreville Gabon

Introduction: The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (sa. has not been established. Objective: To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after sa. Population and Methods: The study concerned 40 people who were to benefit from a programmed herniorrhaphy under sa.and 40 controls (sa.sup>-). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from sa.sup>+ one hour before (H0), then 15 minutes after the sa.(H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p Results: CmET-1 and CmVCAM-1 of sa.sup>- were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in sa.sup>+ at H0 and H15. In sa., at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In sa.sup>-, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438;p = 0.005). Conversely, in sa.sup>+, whether at H0 (r = -0.31;p = 0.051) or at H15 (r = 0.024;p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111;p = 0.325). Conclusion: These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post sa. CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post sa.

关键词： Endothelin-1 VCAM-1 Hypotension Endothelial Dysfunction Spinal Anesthesia

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